Bettina Appel

发表

Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries

Ruth Suchsland, Bettina Appel, S. Müller, 2018, Beilstein journal of organic chemistry.

Bettina Appel, S. Müller, 2017, RNA biology.

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4.

K. Preissner, A. Greinacher, S. Block, 2013, Blood.

THROMBOSIS AND HEMOSTASIS Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

K. Preissner, A. Greinacher, S. Block, 2013 .

Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?

Bettina Appel, S. Müller, D. Balke, 2016, F1000Research.

Potential of Aptamers as Artificial Receptors in Chemical Sensors

Bettina Appel, S. Müller, Sabine Stingel, 2010 .

Kinetic characterization of hairpin ribozyme variants.

Bettina Appel, S. Müller, T. Marschall, 2012, Methods in molecular biology.

Synthesis of Specifically Modified Oligonucleotides for Application in Structural and Functional Analysis of RNA

Hien M. Nguyen, Bettina Appel, S. Müller, 2011, Journal of nucleic acids.

Structural Requirements for the Procoagulant Activity of Nucleic Acids

K. Preissner, A. Greinacher, J. Gansler, 2012, PloS one.

Synthesis of guanosine 5'-conjugates and their use as initiator molecules for transcription priming.

Bettina Appel, S. Müller, J. Wolf, 2008, Organic & biomolecular chemistry.

Domino Michael/Retro‐Michael/Mukaiyama‐Aldol Reactions of 1,3‐Bis‐Silyl Enol Ethers with 3‐Acyl‐ and 3‐Formylbenzopyrylium Triflates – Synthesis of Functionalised 2,4′‐Dihydroxybenzophenones

P. Langer, Bettina Appel, H. Reinke, 2006 .

Generation and selection of ribozyme variants with potential application in protein engineering and synthetic biology

Bettina Appel, S. Müller, Darko Balke, 2014, Applied Microbiology and Biotechnology.

Synthesis of 7-hydroxy-2-(2-hydroxybenzoyl)benzo[c]chromen-6-ones by sequential application of domino reactions of 1,3-bis(silyl enol ethers) with benzopyrylium triflates

P. Langer, Bettina Appel, C. Fischer, 2006 .

Synthesis of 7-hydroxy-6H-benzo[c]chromen-6-ones based on a ‘[3+3] cyclization/domino retro-Michael–aldol–lactonization’ strategy

P. Langer, Bettina Appel, C. Fischer, 2006 .

Domino reactions of 1,3-bis-silyl enol ethers with benzopyrylium triflates: efficient synthesis of fluorescent 6H-benzo[c]chromen-6-ones, dibenzo[c,d]chromen-6-ones, and 2,3-dihydro-1H-4,6-dioxachrysen-5-ones.

P. Langer, Bettina Appel, N. N. Saleh, 2006, Chemistry.

Synthesis of chromanes by sequential ‘[3+3]-cyclization/Williamson’ reactions of 1,3-bis(trimethylsilyloxy)-7-chlorohepta-1,3-dienes

P. Langer, Bettina Appel, V. T. H. Nguyen, 2006 .

Domino ‘Michael-retro-Michael-aldol’ reactions of 1,3-bis-silyl enol ethers with 3-formylchromones

P. Langer, Bettina Appel, 2003 .

Efficient Synthesis of Functionalised 4-Hydroxycyclopent-2-en-1-ones by Cyclisation of 1,3-Bis(silyl) Enol Ethers and 1,3-Dicarbonyl Dianions with 1,2-Diketones

P. Langer, Bettina Appel, V. Köhler, 2005 .

Synthesis of 1-azaxanthones by condensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-(cyano)benzopyrylium triflates and subsequent domino ‘retro-Michael/nitrile-addition/heterocyclization’ reaction

V. Karapetyan, P. Langer, M. Adeel, 2008 .

Efficient synthesis of benzopyrano[2,3-b]pyridines by sequential reactions of 1,3-bis-silyl enol ethers with 3-cyanobenzopyrylium triflates

P. Langer, Bettina Appel, 2003 .

Synthesis of 4-hydroxy-and 2,4-dihydroxy-homophthalates by [4+2] cycloaddition of 1,3-bis(silyloxy)-1,3-butadienes with dimethyl allene-1,3-dicarboxylate

P. Langer, Ibrar Hussain, Bettina Appel, 2008 .

Synthesis of chromones and 4-hydroxyquinolines based on uncatalyzed condensations of 1-methoxy-1,3-bis(trimethylsilyloxy)-1,3-butadiene with 2-alkoxy- and 2-nitrobenzoyl chlorides and related reactions.

A. Börner, P. Langer, H. Jiao, 2009, Organic & biomolecular chemistry.

Sugar-Edge Interactions in a DNA-RNA G-Quadruplex: Evidence of Sequential C-H⋅⋅⋅O Hydrogen Bonds Contributing to RNA Quadruplex Folding.

Bettina Appel, S. Müller, J. Dickerhoff, 2016, Angewandte Chemie.

Synthesis of 2,3-benzoxepins by sequential cyclopropanation/ring-enlargement reactions of benzopyrylium triflates with diazoesters

P. Langer, Bettina Appel, S. Rotzoll, 2005 .

Solid Phase Assembly of Fully Protected Trinucleotide Building Blocks for Codon-Based Gene Synthesis

Sabine Müller, Ruth Suchsland, Bettina Appel, 2019, Applied Sciences.

RNA Aminoacylation Mediated by Sequential Action of Two Ribozymes and a Nonactivated Amino Acid

Jiacui Xu, Bettina Appel, S. Müller, 2014, Chembiochem : a European journal of chemical biology.

RNA Hairpin Folding in the Crowded Cell

S. Ebbinghaus, R. Winter, F. Narberhaus, 2016, Angewandte Chemie.

Ribozymes that can be regulated by external stimuli.

Sabine Müller, Bettina Appel, Bettina Appel, 2015, Current opinion in biotechnology.

Accurate distance determination of nucleic acids via Förster resonance energy transfer: implications of dye linker length and rigidity.

Sabine Müller, Stanislav Kalinin, Hien M. Nguyen, 2011, Journal of the American Chemical Society.

Engineering of Hairpin Ribozymes for RNA Processing Reactions

Bettina Appel, S. Müller, R. Hieronymus, 2021, Ribozymes.

The many faces of the hairpin ribozyme: Structural and functional variants of a small catalytic rna

Bettina Appel, S. Müller, S. Petkovic, 2012, IUBMB life.

Synthesis of Site-Specifically Modified Long-mer RNAs

Bettina Appel, S. Müller, J. Frommer, 2014 .

Mixed oligonucleotides for random mutagenesis: best way of making them.

Bettina Appel, S. Müller, Claudia Wichert, 2012, Organic & biomolecular chemistry.

A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites.

H. Fritz, Bettina Appel, S. Müller, 2012, Organic & biomolecular chemistry.

Preparation of modified long-mer RNAs and analysis of FMN binding to the ypaA aptamer from B. subtilis

Bettina Appel, S. Müller, M. Jenckel, 2014, RNA biology.

Synthesis of 7‐Hydroxy‐6H‐benzo[c]chromen‐6‐ones Based on a “[3 + 3] Cyclization/Domino retro‐Michael—Aldol—Lactonization” Strategy.

P. Langer, Bettina Appel, C. Fischer, 2007 .

Domino Reactions of 1,3‐Bis‐silyl Enol Ethers with Benzopyrylium Triflates: Efficient Synthesis of Fluorescent 6H‐Benzo[c]chromen‐6‐ones, Dibenzo[c,d]chromen‐6‐ones, and 2,3‐Dihydro‐1H‐4,6‐dioxachrysen‐5‐ones.

P. Langer, Bettina Appel, N. N. Saleh, 2006 .

Synthesis of 7-Hydroxy-2-(2-hydroxybenzoyl)benzo[c]chromen-6-ones by Sequential Application of Domino Reactions of 1,3-Bis(silyl enol ethers) with Benzopyrylium Triflates.

P. Langer, Bettina Appel, C. Fischer, 2007 .

RNA self-ligation: from oligonucleotides to full length ribozymes.

Bettina Appel, S. Müller, S. Gwiazda, 2012, Biochimie.

Challenges and Opportunities in the Development of Aptamers for TNFα

G. Nelles, L. Petruschka, Bettina Appel, 2016, Applied Biochemistry and Biotechnology.

Reinforcement of the Tumor Suppressing Properties of microRNA-1 by Substitution at the C2′ Position of Varying Ribose Residues in Chemically Synthesized microRNA-1 Molecules

Bettina Appel, M. Stope, S. Müller, 2023, AntiCancer Research.

CAG-Repeat RNA Hairpin Folding and Recruitment to Nuclear Speckles with a Pivotal Role of ATP as a Cosolute

A. Schug, S. Ebbinghaus, K. Weis, 2023, Journal of the American Chemical Society.

Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support

Ruth Suchsland, Bettina Appel, S. Müller, 2021, RSC advances.

Ligand-induced conformational capture of a synthetic tetracycline riboswitch revealed by pulse EPR.

Heinz-Jürgen Steinhoff, Sabine Müller, Beatrix Suess, 2011, RNA.

Tumor-specific delivery of 5FU-incorporated EGFR-targeted aptamers as an efficient treatment in pancreatic ductal adenocarcinoma models.

C. Belka, J. Mayerle, M. Lerch, 2021, Gastroenterology.

Accurate distance determination of nucleic acids via Förster resonance energy transfer: implications of dye linker length and rigidity.

Hien M. Nguyen, C. Seidel, S. Kalinin, 2011, Journal of the American Chemical Society.

In vitro circularization of RNA

Bettina Appel, S. Müller, 2017, RNA biology.

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4.

K. Preissner, A. Greinacher, C. Helm, 2013, Blood.

Generation and selection of ribozyme variants with potential application in protein engineering and synthetic biology

Bettina Appel, S. Müller, Darko Balke, 2014, Applied Microbiology and Biotechnology.

Magnesium Ion-Driven Folding and Conformational Switching Kinetics of Tetracycline Binding Aptamer: Implications for in vivo Riboswitch Engineering.

B. Suess, J. Wachtveitl, Bettina Appel, 2023, Journal of molecular biology.

Synthesis of Trinucleotide Building Blocks in Solution and on Solid Phase

Ruth Suchsland, Bettina Appel, S. Müller, 2018, Current protocols in nucleic acid chemistry.