Ikuo Miyahisa

发表

Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli.

S. Horinouchi, Yohei Katsuyama, N. Funa, 2007, Chemistry & biology.

Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster

S. Horinouchi, N. Funa, Ikuo Miyahisa, 2005, Applied Microbiology and Biotechnology.

Combinatorial biosynthesis of flavones and flavonols in Escherichia coli

S. Horinouchi, T. Moriguchi, N. Funa, 2006, Applied Microbiology and Biotechnology.

Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.

Yuta Tanaka, T. Kawamoto, T. Ishikawa, 2013, Journal of medicinal chemistry.

One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells

S. Horinouchi, Yohei Katsuyama, N. Funa, 2007, Applied Microbiology and Biotechnology.

Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface.

Kotaro Sakamoto, Ikuo Miyahisa, S. Sogabe, 2018, Biochemistry.

Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors.

Tomohiro Andou, Rei Okamoto, Ikuo Miyahisa, 2017, Journal of medicinal chemistry.

T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time.

A. Mizukami, M. Hixon, Ikuo Miyahisa, 2016, ACS medicinal chemistry letters.

A Single Target Is Sufficient To Account for the Biological Effects of the A-Factor Receptor Protein of Streptomyces griseus

S. Horinouchi, J. Kato, Ikuo Miyahisa, 2004, Journal of bacteriology.

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.

R. Nishigaki, T. Miyazaki, Naoki Tomita, 2017, Bioorganic & medicinal chemistry.

A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.

M. Hixon, Ikuo Miyahisa, J. Matsui, 2014, Bioorganic & medicinal chemistry letters.

Small-scale panel comprising diverse gene family targets to evaluate compound promiscuity.

M. Yoshikawa, R. Naven, Ikuo Miyahisa, 2019, Chemical research in toxicology.

Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

T. Kawamoto, Masanori Watanabe, Y. Moritoh, 2019, Pharmacology research & perspectives.

In vitro and in vivo antitumor activities of T‐3764518, a novel and orally available small molecule stearoyl‐CoA desaturase 1 inhibitor

Ikuo Miyahisa, Hiroyuki Sumi, Kazunobu Aoyama, 2017, European journal of pharmacology.

A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice

Masanori Watanabe, Ikuo Miyahisa, J. Matsui, 2016, PloS one.

Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay.

M. Hixon, Ikuo Miyahisa, Tomoya Sameshima, 2015, Angewandte Chemie.

T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time.

A. Mizukami, M. Hixon, Ikuo Miyahisa, 2016, ACS medicinal chemistry letters.

A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.

M. Hixon, Ikuo Miyahisa, J. Matsui, 2014, Bioorganic & medicinal chemistry letters.

Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.

M. Yoshikawa, Ikuo Miyahisa, Tomoya Sameshima, 2019, Bioorganic & medicinal chemistry letters.