P. Chames

发表

A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells.

A. Zanghellini, E. Lacroix, J. Epinat, 2003, Nucleic acids research.

Therapeutic antibodies: successes, limitations and hopes for the future

Etienne Weiss, Patrick Chames, Daniel Baty, 2009, British journal of pharmacology.

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

H. Daniel, E. Valjent, J. Pin, 2017, Nature Communications.

Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions

S. Benichou, J. Bouchet, I. Maridonneau-Parini, 2012, Journal of Virology.

Isolation of human antibodies to tumor-associated endothelial cell markers by in vitro human endothelial cell selection with phage display libraries.

J. Arends, H. Lichtenbeld, H. Hoogenboom, 2004, Journal of immunological methods.

[The future of antibody fragments, made of a single immunoglobulin domain].

P. Chames, D. Baty, 2009, Medecine sciences : M/S.

Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response

E. Vigne, P. Chames, D. Baty, 2020, Oncoimmunology.

Production of a soluble and active MBP‐scFv fusion: favorable effect of the leaky tolR strain

P. Chames, D. Baty, J. Fieschi, 1997, FEBS letters.

Bispecific Single Domain Antibodies

P. Chames, D. Baty, 2011 .

Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays.

I. Nabiev, A. Sukhanova, V. Oleinikov, 2010, Critical reviews in oncology/hematology.

Engineering of ultra-small diagnostic nanoprobes through oriented conjugation of single-domain antibodies and quantum dots

M. Artemyev, I. Nabiev, A. Sukhanova, 2012 .

Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells

B. Robert, G. Béhar, A. Pèlegrin, 2013, Molecular Cancer Therapeutics.

Bispecific antibodies for cancer therapy

P. Chames, D. Baty, 2009, Current opinion in drug discovery & development.

Drift of the HIV-1 Envelope Glycoprotein gp120 toward Increased Neutralization Resistance over the Course of the Epidemic: a Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies

F. Barin, M. Nussenzweig, A. Moreau, 2014, Journal of Virology.

Antibody Engineering

P. Chames, Damien Nevoltris, 2018, Methods in Molecular Biology.

Phage display and selections on purified antigens.

P. Chames, J. Matz, 2012, Methods in molecular biology.

Antibody engineering and its applications in tumor targeting and intracellular immunization.

P. Chames, D. Baty, 2000, FEMS microbiology letters.

Production Antigen-Specific Cytotoxicity and Cytokine Costimulatory Domain Enhances I-Restricted Antibodies : The CD 28 T Cell Retargeting with MHC Class Debets and

R. Debets, P. Chames, C. Ronteltap, 2005 .

TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity1

G. Schuler, H. Hoogenboom, P. Chames, 2002, The Journal of Immunology.

Affinity-Dependent Cytolytic Activity Human CTLs Mediate Antibody TCR-Like Human Antibodies Expressed on

G. Schuler, H. Hoogenboom, P. Chames, 2002 .

Detection of carcinoembryonic antigen using single-domain or full-size antibodies stained with quantum dot conjugates.

I. Nabiev, A. Sukhanova, P. Chames, 2015, Analytical biochemistry.

Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity

Avital Lev, H. Hoogenboom, P. Chames, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Optimizing the exogenous antigen loading of monocyte-derived dendritic cells.

G. Schuler, H. Hoogenboom, P. Chames, 2005, International immunology.

Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytic subunit.

K. Skorecki, Avital Lev, M. Tzukerman, 2002, Cancer research.

Isolation and Characterization of Human Recombinant Antibodies Endowed with the Antigen-specific , Major Histocompatibility Complex-restricted Specificity of T Cells Directed toward the Widely Expressed Tumor T-cell Epitopes of the Telomerase Catalytic Subunit 1

K. Skorecki, Avital Lev, M. Tzukerman, 2002 .

antibody Inhibition of the Nef regulatory protein of HIV-1 by a single-domain

S. Benichou, P. Chrobak, O. Fackler, 2012 .

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.

S. Benichou, P. Chrobak, O. Fackler, 2011, Blood.

Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

P. Chames, D. Baty, 2009, mAbs.

Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots

A. Wege, M. Mitkovski, I. Nabiev, 2018, Scientific Reports.

Parsimonious Mutagenesis and Phage Display Specificity of an Anti-Cortisol Antibody by Improving the Affinity and the Fine

P. Chames, D. Baty, S. Coulon, 1998 .

Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain

J. Pin, J. González-Maeso, P. Rondard, 2022, Nature Chemical Biology.

Special Issue: Nanobody

U. Rothbauer, P. Chames, 2020, Antibodies.

Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cells.

C. Sautès-Fridman, G. Béhar, P. Chames, 2008, Protein engineering, design & selection : PEDS.

Isolation and characterization of anti-FcγRIII (CD16) llama single-domain antibodies that activate natural killer cells

C. Sautès-Fridman, G. Béhar, P. Chames, 2007 .

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

L. Álvarez-Vallina, P. Chames, C. Corbacho, 2022, Oncoimmunology.

Methode de determination de l'activite de clivage d'une endonuclease

E. Lacroix, S. Arnould, P. Chames, 2003 .

Phage Display and Selections on Biotinylated Antigens

P. Chames, D. Baty, 2010 .

Selections on Biotinylated Antigens

H. Hoogenboom, P. Chames, P. Henderikx, 2001 .

Engineering of an Anti-Steroid Antibody: Amino Acid Substitutions Change Antibody Fine Specificity from Cortisol Estradiol

P. Chames, D. Baty, D. Baty, 1998, Clinical chemistry and laboratory medicine.

Antibody Engineering

P. Chames, 2012, Methods in Molecular Biology.

Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds

Y. J. Wang, F. Rico, T. Strick, 2022, bioRxiv.

[Bispecific antibodies, novel therapeutic candidates harnessing the immune system].

T. Wurch, P. Chames, P. Chames, 2019, Medecine sciences : M/S.

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1

D. Ho, M. Nussenzweig, A. Moreau, 2016, Journal of acquired immune deficiency syndromes.

Nanobody-CD16 Catch Bond Reveals NK Cell Mechanosensitivity.

P. Chames, D. Baty, L. Limozin, 2019, Biophysical journal.

Taking up Cancer Immunotherapy Challenges: Bispecific Antibodies, the Path Forward?

P. Chames, D. Baty, B. Kerfelec, 2015, Antibodies.

Llama single‐domain antibodies directed against nonconventional epitopes of tumor‐associated carcinoembryonic antigen absent from nonspecific cross‐reacting antigen

F. Roquet, G. Béhar, A. Gruaz-Guyon, 2009, The FEBS journal.

Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library.

S E Hufton, P. Coulie, S. Hufton, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers

L. Prézeau, J. Pin, F. Acher, 2021, Proceedings of the National Academy of Sciences.

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

H. Daniel, E. Valjent, J. Pin, 2017, Nature Communications.

A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences

P. Duchateau, G. Montoya, J. Bravo, 2006, Nucleic acids research.

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets.

P. Duchateau, L. Serrano, F. Stricher, 2006, Journal of molecular biology.

Masked Selection: A Straightforward and Flexible Approach for the Selection of Binders Against Specific Epitopes and Differentially Expressed Proteins by Phage Display*

J. Borg, S. Audebert, P. Chames, 2013, Molecular & Cellular Proteomics.

Therapeutic Antibodies for the Treatment of Pancreatic Cancer

P. Chames, D. Baty, B. Kerfelec, 2010, TheScientificWorldJournal.

State of the Art in Tumor Antigen and Biomarker Discovery

P. Chames, D. Baty, Klervi Even-Desrumeaux, 2011, Cancers.

A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

L. Pardo, R. Kontermann, K. Pfizenmaier, 2020, Frontiers in Pharmacology.

Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer

P. Chames, T. Chanier, 2019, Antibodies.

T Cell Retargeting with MHC Class I-Restricted Antibodies: The CD28 Costimulatory Domain Enhances Antigen-Specific Cytotoxicity and Cytokine Production1

R. Debets, P. Chames, R. Bolhuis, 2005, The Journal of Immunology.

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR

J W Gratama, Z. Eshhar, J. Gratama, 2000, Gene Therapy.

A phage display selected Fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes

R. Debets, P. Chames, H. Hoogenboom, 2001, Gene Therapy.

Selection of human antibody fragments directed against tumor T‐cell epitopes for adoptive T‐cell therapy

J. Gratama, R. Debets, P. Chames, 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

A Major Histocompatibility Complex·Peptide-restricted Antibody and T Cell Receptor Molecules Recognize Their Target by Distinct Binding Modes

P. Coulie, W. Saenger, R. Stanfield, 2005, Journal of Biological Chemistry.

Genetic engineering of T cell specificity for immunotherapy of cancer.

R. Debets, P. Chames, R. Bolhuis, 2003, Human immunology.

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

P. Bruhns, P. Chames, D. Baty, 2014, Oncotarget.

Tissue clearing and 3D reconstruction of digitized, serially sectioned slides provide novel insights into pancreatic cancer.

L. Wood, E. Fishman, R. Hruban, 2023, Med.

In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination

Patrick Chames, Emmanuel Lacroix, Frédéric Pâques, 2005, Nucleic acids research.

In vivo detection of small tumour lesions by multi-pinhole SPECT applying a 99mTc-labelled nanobody targeting the Epidermal Growth Factor Receptor

C. Dullin, F. Alves, P. Chames, 2016, Scientific Reports.

Improving the affinity and the fine specificity of an anti-cortisol antibody by parsimonious mutagenesis and phage display.

P. Chames, D. Baty, S. Coulon, 1998, Journal of immunology.

Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches.

P. Fourquet, P. Chames, D. Baty, 2012, Molecular bioSystems.

A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

R. Castellano, P. Chames, D. Baty, 2019, Front. Immunol..

Antibody Phage Display Technology

Hennie R. Hoogenboom, Patrick Chames, H. Hoogenboom, 2002 .

Selection of Intracellular Single-Domain Antibodies Targeting the HIV-1 Vpr Protein by Cytoplasmic Yeast Two-Hybrid System

Patrick Chames, Daniel Baty, Serge Benichou, 2014, PloS one.

Natural and designer binding sites made by phage display technology.

H R Hoogenboom, H. Hoogenboom, P. Chames, 2000, Immunology today.

Nanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays

I. Nabiev, A. Sukhanova, F. Alves, 2019, Fourth International Conference on Applications of Optics and Photonics.

Oriented Conjugates of Single-domain Antibodies and Fluorescent Quantum Dots for Highly Sensitive Detection of Tumor-associated Biomarkers in Cells and Tissues

I. Nabiev, A. Sukhanova, P. Chames, 2015 .

Multiphoton imaging of tumor biomarkers with conjugates of single-domain antibodies and quantum dots.

I. Nabiev, A. Sukhanova, J. Millot, 2014, Nanomedicine : nanotechnology, biology, and medicine.

Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells.

S. Maier, A. Prina‐Mello, Y. Volkov, 2014, ACS nano.

Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes.

Igor Nabiev, Mikhail Artemyev, Alyona Sukhanova, 2012, Nanomedicine : nanotechnology, biology, and medicine.

Intracellular Immunization of Prokaryotic Cells against a Bacteriotoxin

D. Duché, P. Chames, D. Baty, 1998, Journal of bacteriology.

Multiphoton Deep-Tissue Imaging of Micrometastases and Disseminated Cancer Cells Using Conjugates of Quantum Dots and Single-Domain Antibodies.

I. Nabiev, A. Sukhanova, F. Alves, 2021, Methods in molecular biology.

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

J. Mascola, I. Georgiev, P. Acharya, 2013, Journal of Virology.

Oriented conjugates of monoclonal and single-domain antibodies with quantum dots for flow cytometry and immunohistochemistry diagnostic applications

Igor Nabiev, Mikhail Artemyev, Alyona Sukhanova, 2012, BiOS.

Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120

J. Bouchet, P. Kessler, P. Chames, 2012, Retrovirology.

Straightforward Selection of Broadly Neutralizing Single-Domain

Patrick Chames, Daniel Baty, Francis Barin, 2012 .

Selection of antibodies against biotinylated antigens.

H. Hoogenboom, P. Chames, P. Henderikx, 2002, Methods in molecular biology.

Multiphoton Imaging of Tumor Biomarkers in situ Using Single-domain Antibodies Conjugated with Quantum Dots in a Set Orientation☆

I. Nabiev, A. Sukhanova, J. Millot, 2016 .

Conformational nanobodies reveal tethered epidermal growth factor receptor involved in EGFR/ErbB2 predimers.

G. Mathis, P. Chames, D. Baty, 2015, ACS nano.

Rapid nanobody-based imaging of mesothelin expressing malignancies compatible with blocking therapeutic antibodies

R. Castellano, P. Chames, A. Goubard, 2023, Frontiers in Immunology.

Anti-Mesothelin Nanobodies for Both Conventional and Nanoparticle-Based Biomedical Applications.

P. Chames, N. Scholler, D. Baty, 2015, Journal of biomedical nanotechnology.

Nanobody-antigen catch-bond reveals NK cell mechanosensitivity

P. Chames, D. Baty, L. Limozin, 2018, bioRxiv.

Llama single‐domain antibodies directed against nonconventional epitopes of tumor‐associated carcinoembryonic antigen absent from nonspecific cross‐reacting antigen

F. Roquet, G. Béhar, A. Pèlegrin, 2009, The FEBS journal.

Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells.

S. Maier, A. Prina‐Mello, Y. Volkov, 2014, ACS nano.

Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches.

P. Fourquet, P. Chames, D. Baty, 2012, Molecular bioSystems.

Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation.

P. Chames, D. Baty, Klervi Even-Desrumeaux, 2010, Molecular bioSystems.

Antibody Engineering

P. Chames, 2012, Methods in Molecular Biology.

Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions

J. Bouchet, I. Maridonneau-Parini, K. Saksela, 2012, Journal of Virology.

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120

J. Bouchet, P. Kessler, P. Chames, 2012, Retrovirology.

Specific Targeting of Mesothelin-Expressing Malignant Cells Using Nanobody-Functionalized Magneto-Fluorescent Nanoassemblies

C. Blanquart, P. Chames, Tina Briolay, 2024, International Journal of Nanomedicine.