C. Mohr

发表

Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.

P. Charifson, L. Shewchuk, W. Rocque, 1997, Biochemistry.

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

J. Zondlo, R. Syed, N. Oldham, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.

Kristin L. Andrews, B. Herberich, Matthew R. Lee, 2016, Bioorganic & medicinal chemistry letters.

The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.

Kristin L. Andrews, B. Herberich, Matthew R. Lee, 2015, Bioorganic & medicinal chemistry letters.

Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).

Zhulun Wang, C. Mohr, F. Garces, 2020, Cell reports.

Discovery of Ligands for Nurr1 by Combined Use of NMR Screening with Different Isotopic and Spin-Labeling Strategies

L. Poppe, T. Harvey, J. Zondlo, 2007, Journal of biomolecular screening.

Suppression of LPS-induced tumor necrosis factor-alpha gene expression by microtubule disrupting agents.

D. Gemsa, M. Nain, C. Mohr, 1996, Immunobiology.

Inhibition of LPS-induced tumor necrosis factor-alpha production by colchicine and other microtubule disrupting drugs.

D. Gemsa, M. Nain, C. Mohr, 1996, Immunobiology.

Coxsackievirus B3-induced production of tumor necrosis factor-alpha, IL-1 beta, and IL-6 in human monocytes.

D. Gemsa, H. Sprenger, M. Nain, 1992, Journal of immunology.

Potent dipeptide inhibitors of the pp60c-src SH2 domain.

P. Charifson, K. Lackey, L. Shewchuk, 1998, Journal of medicinal chemistry.

Modeling receptor flexibility in the structure-based design of KRASG12C inhibitors

Kai Zhu, C. Mohr, Xun Li, 2022, Journal of Computer-Aided Molecular Design.

Reduced release of leukotrienes B4 and C4 from alveolar macrophages of rats with silicosis.

D. Gemsa, S. Amann, C. Mohr, 1992, American journal of respiratory cell and molecular biology.

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

J. Zondlo, R. Syed, N. Oldham, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced release of prostaglandin E2 from macrophages of rats with silicosis.

D. Gemsa, C. Mohr, D. Hemenway, 1992, American journal of respiratory cell and molecular biology.

(4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors.

V. Viswanadhan, J. Cheetham, A. Tasker, 2004, Bioorganic & medicinal chemistry letters.

Characterization of the acute immune response in the retina of Borna disease virus infected Lewis rats

A. Reichenbach, T. Pannicke, J. Kacza, 2003, Journal of Neuroimmunology.

Changes of the organotypic retinal organization in Borna virus-infected Lewis rats

A. Reichenbach, T. Pannicke, J. Kacza, 2001, Journal of neurocytology.

Identification of triazolopyridazinones as potent p38α inhibitors.

S. Chmait, B. Herberich, Matthew R. Lee, 2012, Bioorganic & medicinal chemistry letters.

Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.

S. Chmait, K. Miner, Matthew R. Lee, 2010, Bioorganic & medicinal chemistry letters.

Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.

Christopher Mohr, Lisa Sherman, S. Chmait, 2010, Journal of medicinal chemistry.

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

N. Chen, J. McCarter, K. Rex, 2019, Journal of medicinal chemistry.

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.

Iain D G Campuzano, R. Fucini, Andrew M. Sawayama, 2019, ACS medicinal chemistry letters.

The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.

Matthew R. Lee, Xin Huang, A. Tasker, 2015, Bioorganic & medicinal chemistry letters.

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

J. Desai, R. Govindan, W. Ouyang, 2019, Nature.

The formation of a covalent complex between a dipeptide ligand and the src SH2 domain.

P. Charifson, L. Shewchuk, W. Rocque, 1998, Bioorganic & medicinal chemistry letters.

Modeling receptor flexibility in the structure-based design of KRASG12C inhibitors

Kai Zhu, C. Mohr, Xun Li, 2022, Journal of Computer-Aided Molecular Design.

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.

A. Tasker, R. Kendall, J. Lipford, 2015, ACS medicinal chemistry letters.

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.

Xin Huang, Christopher Mohr, Paul Hughes, 2009, Bioorganic & medicinal chemistry letters.

Systemic macrophage stimulation in rats with silicosis: enhanced release of tumor necrosis factor-alpha from alveolar and peritoneal macrophages.

K. Leslie, D. Gemsa, C. Mohr, 1991, American journal of respiratory cell and molecular biology.

Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.

K. Rex, J. Canon, B. Herberich, 2019, Journal of medicinal chemistry.

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

K. Rex, B. Herberich, Matthew R. Lee, 2016, Journal of medicinal chemistry.

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

K. Rex, B. Herberich, Matthew R. Lee, 2016, ACS medicinal chemistry letters.

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.

Matthew R. Lee, A. Tasker, Bin Wu, 2015, Bioorganic & medicinal chemistry letters.

Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.

S. Chmait, K. Miner, Matthew R. Lee, 2009, Bioorganic & medicinal chemistry letters.

Spin-Labeling Strategies Discovery of Ligands for Nurr1 by Combined Use of NMR Screening with Different Isotopic and

L. Poppe, T. Harvey, J. Zondlo, 2013 .

Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.

S. Chmait, B. Herberich, Matthew R. Lee, 2010, Journal of medicinal chemistry.

Identification of triazolopyridazinones as potent p38α inhibitors.

S. Chmait, B. Herberich, Matthew R. Lee, 2012, Bioorganic & medicinal chemistry letters.