J. Taskinen

发表

Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.

I. Ulmanen, K. Melén, I. Julkunen, 1995, Biochemistry.

Prediction of physicochemical properties based on neural network modelling.

Jouko Yliruusi, J. Yliruusi, J. Taskinen, 2003, Advanced drug delivery reviews.

A modification of the Hammett equation for predicting ionisation constants of p-vinyl phenols.

Julius Sipilä, Jouni Hirvonen, Jari Yli-Kauhaluoma, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

QSAR and Binding Model for Inhibition of Rat Liver Catechol-O-Methyl-Transferase by 1,5-Substituted-3,4-Dihydroxybenzenes

Martti Ovaska, J. Vidgren, J. Taskinen, 1989 .

In Silico Predictions of Solubility

U. Norinder, J. Taskinen, 2007 .

Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s).

H. Vainio, J. Taskinen, E. Elovaara, 1997, Pharmacology & toxicology.

Iron(III)-chelating properties of the novel catechol O-methyltransferase inhibitor entacapone in aqueous solution.

T. Lotta, J. Taskinen, M. Orama, 1997, Journal of pharmaceutical sciences.

X-ray Crystal Structure of Human Dopamine Sulfotransferase, SULT1A3

A. Hersey, R. Cooke, H. Jhoti, 1999, The Journal of Biological Chemistry.

Enzyme‐assisted synthesis of a bivalent high‐affinity dodecasaccharide inhibitor of mouse gamete adhesion The length of the chains carrying distal α1,3‐bonded galactose residues is critical

H. Maaheimo, J. Taskinen, A. Seppo, 1995, FEBS letters.

Direct analysis of nitrocatechol-type glucuronides in urine by capillary electrophoresis-electrospray ionisation mass spectrometry and tandem mass spectrometry.

R. Kostiainen, J. Taskinen, H. Keski-Hynnilä, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Characteristics of catechol O-methyl-transferase (COMT) and properties of selective COMT inhibitors.

S. Kaakkola, J. Tenhunen, I. Ulmanen, 1992, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Identification of major metabolites of the catechol-O-methyltransferase-inhibitor nitecapone in human urine.

L. Kanner, T. Lotta, J. Taskinen, 1991, Drug Metabolism And Disposition.

The specificity of glucuronidation of entacapone and tolcapone by recombinant human UDP-glucuronosyltransferases.

B. Burchell, J. Taskinen, P. Lautala, 2000, Drug metabolism and disposition: the biological fate of chemicals.

High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase.

J. Taskinen, J. Salonen, S. Kaivosaari, 2001, Analytical biochemistry.

Quantitative determination of erythromycin 2'-ethylsuccinate in human plasma by fast atom bombardment mass spectrometry.

J. Taskinen, P. Ottoila, 1987, Biomedical & environmental mass spectrometry.

Characterization of catechol glucuronidation in rat liver.

J. Magdalou, B. Burchell, J. Taskinen, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Studies on calcium-dependent binding of simendan to troponin complex and troponin C

J. Taskinen, I. Lindén, M. Ovaska, 1992 .

Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results.

J. Taskinen, O. Salo, A. Lassus, 1981, Acta dermato-venereologica.

A model for human cardiac troponin C and for modulation of its Ca2+ affinity by drugs

J. Taskinen, M. Ovaska, Jyrki Taskinen, 1991, Proteins.

Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase.

I. Ulmanen, J. Taskinen, P. Lautala, 2001, Molecular pharmacology.

Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation.

R. Kostiainen, S. Alakurtti, J. Yli-Kauhaluoma, 2007, Biochemical pharmacology.

Pharmacokinetics and side-effects of clonidine

J. Taskinen, S. Nykänen, A. Keränen, 1978, European Journal of Clinical Pharmacology.

Composition of the essential oil of Cymbopogon flexuosus

J. Taskinen, C. Mathela, D. K. Mathela, 1983 .

12-METHYL-OMEGA-TRIDECANOLIDE, A NEW MACROCYCLIC LACTONE FROM ANGELICA ROOT OIL

J. Taskinen, R. Servin, T. Midtvedt, 1975 .

Application of quantum chemical calculations to chemical ionisation mass spectrometry. Protonation and adduct formation in stereoisomeric 7-norbornenyl compounds

C. Glidewell, J. Jalonen, J. Taskinen, 1983 .

Hydrolysis of 2'-esters of erythromycin.

J. Taskinen, P. Ottoila, 1988, The Journal of antimicrobial chemotherapy.

Identification of major metabolites of the catechol-O-methyltransferase inhibitor nitecapone in the rat and dog.

J. Taskinen, T. Wikberg, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs.

J. Taskinen, J Taskinen, T Salminen, 1997, Journal of pharmaceutical and biomedical analysis.

Radiochemical high-performance liquid chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates.

I. Ulmanen, J. Taskinen, P. Lautala, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Simultaneous determination of carbidopa, levodopa and 3,4-dihydroxyphenyl-acetic acid using high-performance liquid chromatography with electrochemical detection.

J. Taskinen, E. Nissinen, 1982, Journal of chromatography.

Enzyme-assisted synthesis and structural characterization of nitrocatechol glucuronides.

I. Kilpeläinen, H. Kangas, J. Taskinen, 1999, Bioconjugate chemistry.

Organic chemistry of gas-phase ions. Part 1. Effect of the protonation site in stereoisomeric norbornenols

J. Jalonen, J. Taskinen, 1985 .

Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans.

J. Taskinen, A. Vuorela, P. Ottoila, 1993, Drug metabolism and disposition: the biological fate of chemicals.

CoMFA Modeling of Human Catechol O-Methyltransferase Enzyme Kinetics

Jyrki Taskinen, Julius Sipilä, J. Taskinen, 2004, J. Chem. Inf. Model..

Determination of biperiden in human serum by glass capillary gas chromatography with isothermal splitless injection and nitrogen-sensitive detection.

J. Taskinen, P. Ottoila, 1981, Journal of chromatography.

Conjugation of catechols by recombinant human sulfotransferases, UDP-glucuronosyltransferases, and soluble catechol O-methyltransferase: structure-conjugation relationships and predictive models.

B. Burchell, M. Coughtrie, J. Taskinen, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Glucuronidation of 1-hydroxypyrene by human liver microsomes and human UDP-glucuronosyltransferases UGT1A6, UGT1A7, and UGT1A9: development of a high-sensitivity glucuronidation assay for human tissue.

J. Taskinen, P. Taavitsainen, E. Elovaara, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase.

M. Finel, P. Vuorela, J. Taskinen, 2004, Analytical biochemistry.

Structure and Function of Sulfotransferases

M. Coughtrie, J. Taskinen, 2005 .

Quantitative determination of nitroglycerin in human plasma by capillary gas chromatography negative ion chemical ionization mass spectrometry.

J. Taskinen, P. Ottoila, A. Sothmann, 1982, Biomedical mass spectrometry.

Neural network modeling for estimation of the aqueous solubility of structurally related drugs.

J. Taskinen, J. Huuskonen, J Huuskonen, 1997, Journal of pharmaceutical sciences.

N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes.

J. Taskinen, J. Salonen, S. Kaivosaari, 2002, Drug Metabolism And Disposition.

Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted access media column and liquid chromatography-tandem mass spectrometry.

R. Kostiainen, J. Taskinen, M. Forsberg, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Mass spectrometric and tandem mass spectrometric behavior of nitrocatechol glucuronides: A comparison of atmospheric pressure chemical ionization and electrospray ionization

R. Kostiainen, J. Taskinen, L. Luukkanen, 1999, Journal of the American Society for Mass Spectrometry.

Analysis of catechol-type glucuronides in urine samples by liquid chromatography-electrospray ionization-tandem mass spectrometry

R. Kostiainen, J. Taskinen, L. Luukkanen, 1998 .

Production of human UDP-glucuronosyltransferases 1A6 and 1A9 using the Semliki Forest virus expression system.

B. Burchell, I. Ulmanen, J. Taskinen, 2000, Life sciences.

Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study.

N. Kalkkinen, I. Ulmanen, C. Tilgmann, 1994, The Journal of biological chemistry.

ASSESSMENT OF CATECHOL INDUCTION AND GLUCURONIDATION IN RAT LIVER MICROSOMES

J. Magdalou, B. Burchell, J. Taskinen, 2004, Drug Metabolism and Disposition.

Expression and Characterization of Recombinant Human UDP-glucuronosyltransferases (UGTs)

M. Finel, M. Baumann, R. Kostiainen, 2003, The Journal of Biological Chemistry.

CoMFA Modeling of Enzyme Kinetics: Km Values for Sulfation of Diverse Phenolic Substrates by Human Catecholamine Sulfotransferase SULT1A3

Jyrki Taskinen, Julius Sipilä, Alan M. Hood, 2003, J. Chem. Inf. Comput. Sci..

Aqueous Solubility Prediction of Drugs Based on Molecular Topology and Neural Network Modeling

Jyrki Taskinen, Jarmo Huuskonen, Marja Salo, 1998, J. Chem. Inf. Comput. Sci..

Aqueous Solubility Prediction of Drugs Based on Molecular Topology and Neutral Network Modeling.

J. Taskinen, J. Huuskonen, M. Salo, 1998 .

KINETIC CHARACTERIZATION OF THE 1A SUBFAMILY OF RECOMBINANT HUMAN UDP-GLUCURONOSYLTRANSFERASES

M. Finel, R. Kostiainen, J. Hirvonen, 2005, Drug Metabolism and Disposition.

Pharmacokinetics of sustained-release verapamil after a single administration and at steady state

J. Taskinen, R. Mäntylä, J. Mattila, 1985, European Journal of Drug Metabolism and Pharmacokinetics.

Oxidation of Antipsoriatic 10‐Acyldithranol Derivatives and Dithranol to 1,8‐Dihydroxyanthraquinone

J. Taskinen, J. Halmekoski, Jorma Haarala, 1988, Archiv der Pharmazie.

Comparison of electrospray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization in the identification of apomorphine, dobutamine, and entacapone phase II metabolites in biological samples.

J. Magdalou, R. Kostiainen, J. Taskinen, 2002, Analytical chemistry.

COMPOSITION OF THE ESSENTIAL OIL OF SWEET MARJORAM OBTAINED BY DISTILLATION WITH STEAM AND BY EXTRACTION AND DISTILLATION WITH ALCOHOL-WATER MIXTURE

B. Mannervik, J. Taskinen, S. Josephson, 1975 .

Chemical composition of angelica root oil.

J. Taskinen, L. Nykänen, 1975, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry.

Glucuronidation of Entacapone, Nitecapone, Tolcapone, and Some Other Nitrocatechols by Rat Liver Microsomes

J. Taskinen, E. Elovaara, P. Lautala, 1997, Pharmaceutical Research.

VOLATILE CONSTITUENTS OBTAINED BY THE EXTRACTION WITH ALCOHOL-WATER MIXTURE AND BY STEAM DISTILLATION OF CORIANDER FRUIT

G. Schroll, S. Liaaen-Jensen, C. Altona, 1975 .

PLS modelling of structure—activity relationships of catechol O-methyltransferase inhibitors

Timo Lotta, Jyrki Taskinen, Reijo Bäckström, 1992, J. Comput. Aided Mol. Des..

Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog

J. Taskinen, P. Ottoila, T. Wikberg, 1993, European Journal of Drug Metabolism and Pharmacokinetics.

Determination of nitecapone and (13C6)nitecapone in human plasma by gas chromatography/mass spectrometry.

C. Karlsson, J. Taskinen, P. Ottoila, 1991, Biological mass spectrometry.

Determination of a catechol-O-methyltransferase inhibitor, nitecapone, in human plasma and urine by liquid chromatography.

J. Taskinen, T. Wikberg, 1991, Journal of pharmaceutical and biomedical analysis.

Parameter Refinement for Molecular Docking

Jyrki Taskinen, Jukka-Pekka Salo, Ari Yliniemelä, 1998, J. Chem. Inf. Comput. Sci..