P. de Boer

发表

Pharmacological fMRI: Effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network☆

G. Winterer, N. Zacharias, F. Musso, 2018, NeuroImage: Clinical.

Digging deeper in the differential effects of inflammatory and psychosocial stressors in remitted depression: Effects on cognitive functioning.

S. Claes, B. Sabbe, G. Dumont, 2019, Journal of affective disorders.

Ketamine effects on default mode network activity and vigilance: A randomized, placebo‐controlled crossover simultaneous fMRI/EEG study

G. Winterer, N. Zacharias, F. Musso, 2019, Human brain mapping.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Caleb Webber, Guy B. Williams, Mara Cercignani, 2019, Brain : a journal of neurology.

Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects

G. Golor, P. de Boer, P. Nandy, 2018, Journal of psychopharmacology.

Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

M. V. van Leeuwen, P. Limburg, J. Westra, 2004, Arthritis research & therapy.

Suppression of the clinical and cytokine response to endotoxin by RWJ‐67657, a p38 mitogen‐activated protein‐kinase inhibitor, in healthy human volunteers

J. Ligtenberg, J. Zijlstra, J. C. Cohen Tervaert, 2001, Clinical and experimental immunology.

Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.

H. Wikström, P. de Boer, G. Bartoszyk, 2000, Journal of medicinal chemistry.

No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing

E. Bullmore, P. Cowen, M. Lynall, 2020, Translational Psychiatry.

Profiling classical neuropsychiatric biomarkers across biological fluids and following continuous lumbar puncture: A guide to sample type and time

H. Kolb, G. Triana-Baltzer, M. Timmers, 2022, Comprehensive psychoneuroendocrinology.

Desensitisation of 5-HT autoreceptors upon pharmacokinetically monitored chronic treatment with citalopram.

H. Wikström, B. Westerink, J. D. den Boer, 2000, European journal of pharmacology.

State-associated changes in longitudinal [18F]-PBR111 TSPO PET imaging of psychosis patients: Evidence for the accelerated ageing hypothesis?

S. Stroobants, B. Sabbe, S. Staelens, 2019, Brain, Behavior, and Immunity.

Inflammatory biomarkers in Alzheimer's disease plasma

Magda Tsolaki, Edward T. Bullmore, Gareth J. Barker, 2019, Alzheimer's & Dementia.

Peripheral blood cell immunophenotyping reveals distinct subgroups of inflamed depression

E. Bullmore, P. Cowen, M. Lynall, 2019, bioRxiv.

Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts

P. Limburg, J. Westra, M. V. van Rijswijk, 2004, Annals of the rheumatic diseases.

Peripheral Blood Cell–Stratified Subgroups of Inflamed Depression

E. Bullmore, P. Cowen, M. Lynall, 2019, Biological Psychiatry.

p38-MAPK inhibition and endotoxin induced tubular dysfunction in men.

J. Ligtenberg, J. Zijlstra, T. S. van der Werf, 2004, Journal of endotoxin research.

Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies

Vikash K. Sinha, P. de Boer, L. van Nueten, 2015, Journal of psychopharmacology.

An improved synthesis of the enantiomers of BM-5 and their effects on the central in vivo release of acetylcholine.

U. Hacksell, P. de Boer, C. Grol, 1992, Chirality.

Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants

M. Furey, G. Triana-Baltzer, A. Bhattacharya, 2018, Journal of psychopharmacology.

Inhibition of p38 mitogen-activated protein kinase: Dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans*

J. Ligtenberg, J. Zijlstra, A. M. Muller Kobold, 2002, Critical care medicine.

The effects of a glycine reuptake inhibitor R231857 on the central nervous system and on scopolamine-induced impairments in cognitive and psychomotor function in healthy subjects

P. Boer, J. Gerven, K. Franson, 2010, Journal of psychopharmacology.

Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.

H. Wikström, P. de Boer, G. Bartoszyk, 2000, Journal of medicinal chemistry.

New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.

G. Campiani, A. Cagnotto, A. Garofalo, 1998, Journal of medicinal chemistry.

Dimensions in major depressive disorder and their relevance for treatment outcome.

D. Pizzagalli, E. Vrieze, K. Demyttenaere, 2014, Journal of affective disorders.

Immune and Neuroendocrine Trait and State Markers in Psychotic Illness: Decreased Kynurenines Marking Psychotic Exacerbations

D. Fuchs, E. Fransen, B. Sabbe, 2020, Frontiers in Immunology.

Lack of a dopamine autoreceptor selective profile of B-HT 920 in functional in vitro model systems of D2 receptors in rat striatum.

J. C. Stoof, B. Drukarch, P. de Boer, 1990, European journal of pharmacology.

Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681

J. V. van Gerven, M. D. de Kam, M. Moerland, 2012, Journal of psychopharmacology.

An M3-like muscarinic autoreceptor regulates the in vivo release of acetylcholine in rat striatum.

P. de Boer, H. Rollema, J. Zaagsma, 1990, European journal of pharmacology.

The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

W. Drevets, R. Luthringer, J. V. van Gerven, 2019, Translational Psychiatry.

Treatment-resistant depression and peripheral C-reactive protein

E. Bullmore, P. Cowen, W. Drevets, 2017, bioRxiv.

A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression.

R. Shelton, M. Fava, W. Drevets, 2016, The American journal of psychiatry.

Evidence for activation of histamine H3 autoreceptors during handling stress in the prefrontal cortex of the rat

B. Westerink, P. de Boer, J. D. de Vries, 2002, Synapse.

Augmentation with a 5-HT(1A), but not a 5-HT(1B) receptor antagonist critically depends on the dose of citalopram.

H. Wikström, B. Westerink, J. D. den Boer, 2000, European journal of pharmacology.

PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways

A. Megens, G. Vanhoof, P. de Boer, 2014, Pharmacology research & perspectives.

Markers of Inflammation and Monoamine Metabolism Indicate Accelerated Aging in Bipolar Disorder

D. Fuchs, B. Sabbe, M. Timmers, 2018, Front. Psychiatry.

Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial

W. Drevets, J. V. van Gerven, M. D. de Kam, 2020, Journal of psychopharmacology.

Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum.

H. Wikström, B. Westerink, C. Kruse, 2001, European journal of pharmacology.

Antipsychotic drugs induce similar effects on the release of dopamine and noradrenaline in the medial prefrontal cortex of the rat brain.

B. Westerink, C. Kruse, P. de Boer, 1998, European journal of pharmacology.

The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects

P. Boer, J. Gerven, K. Franson, 2010, Journal of psychopharmacology.

Pharmacokinetic-pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects.

J. V. van Gerven, M. Timmers, P. de Boer, 2011, British journal of clinical pharmacology.

Implicit motor sequence learning in schizophrenia and in old age: reduced performance only in the third session

W. Hulstijn, B. Sabbe, G. Dumont, 2016, Experimental Brain Research.

Acute nicotine improves social decision-making in non-smoking but not in smoking schizophrenia patients

P. Boer, W. Hulstijn, E. D. de Bruijn, 2013, Front. Neurosci..

Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study

E. Bullmore, P. Cowen, W. Drevets, 2020, Translational Psychiatry.

Differential Effects of Inflammatory and Psychosocial Stress on Mood, Hypothalamic-Pituitary-Adrenal Axis, and Inflammation in Remitted Depression

S. Claes, E. Fransen, B. Sabbe, 2017, Neuropsychobiology.

Neuroendocrine and Inflammatory Effects of Childhood Trauma Following Psychosocial and Inflammatory Stress in Women with Remitted Major Depressive Disorder

S. Claes, E. Fransen, B. Sabbe, 2019, Brain sciences.

In vivo quantification of striatal dopamine D2 receptor occupancy by JNJ-37822681 using [11C]raclopride and positron emission tomography

A. Lammertsma, J. V. van Gerven, A. Windhorst, 2012, Journal of psychopharmacology.

Basal acetylcholine release in freely moving rats detected by on-line trans-striatal dialysis: pharmacological aspects.

P. de Boer, G. Damsma, J. D. de Vries, 1988, Life sciences.

The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia

W. Drevets, R. Luthringer, J. V. van Gerven, 2019, Journal of psychopharmacology.

A randomized Phase 2 study to evaluate the orexin-2 receptor antagonist seltorexant in individuals with insomnia without psychiatric comorbidity

W. Drevets, R. Luthringer, G. Dorffner, 2018, Journal of psychopharmacology.

Dopamine D(2) activity of R-(-)-apomorphine and selected analogs: a microdialysis study.

H. Wikström, P. Boer, P. de Boer, 2000, European journal of pharmacology.

A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Karen H. Adams, E. Bullmore, F. Turkheimer, 2021, Biological psychiatry. Cognitive neuroscience and neuroimaging.

Pharmacology of JNJ-42314415, a Centrally Active Phosphodiesterase 10A (PDE10A) Inhibitor: A Comparison of PDE10A Inhibitors with D2 Receptor Blockers as Potential Antipsychotic Drugs

A. Megens, X. Langlois, G. Vanhoof, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Metabolic and body mass parameters after treatment with JNJ-37822681, a novel fast-dissociating D2 receptor antagonist, vs olanzapine in patients with schizophrenia.

J. Newcomer, L. Tritsmans, L. Janssens, 2013, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

Correction: Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study

E. Bullmore, P. Cowen, W. Drevets, 2020, Translational Psychiatry.

Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder

P. Bonaventure, C. Dvorak, T. Lovenberg, 2012, Journal of Pharmacology and Experimental Therapeutics.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Tobias C. Wood, Karen H. Adams, C. Webber, 2019, Brain : a journal of neurology.

Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

W. Drevets, J. V. van Gerven, M. Browning, 2023, Translational psychiatry.

Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease

Karen H. Adams, E. Bullmore, F. Turkheimer, 2023, Journal of Neuroinflammation.

p38-MAPK inhibition and endotoxin induced tubular dysfunction in men

J. Ligtenberg, J. Zijlstra, T. S. van der Werf, 2004 .