H. Umeyama

发表

Community‐wide evaluation of methods for predicting the effect of mutations on protein–protein interactions

Julie C. Mitchell, Jeffrey J. Gray, Z. Weng, 2013, Proteins.

Protein modelling using a chimera reference protein derived from exons.

H. Umeyama, A. Kajihara, H. Komooka, 1993, Protein engineering.

Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target

Kun-Yi Hsin, Hiroaki Kitano, Y-h. Taguchi, 2015, Scientific Reports.

A predicted tertiary structure of a thrombin inhibitor-trypsin complex explains the mechanisms of the selective inhibition of thrombin, factor Xa, plasmin, and trypsin.

H. Umeyama, T. Matsuzaki, C. Sasaki, 1988, Journal of biochemistry.

X-ray analysis of a thrombin inhibitor-trypsin complex.

H. Umeyama, T. Matsuzaki, C. Sasaki, 1989, Journal of biochemistry.

HUMAN FAMSD-BASE: high quality protein structure model database for the human genome using the FAMSD homology modeling method.

Genki Terashi, Mayuko Takeda-Shitaka, M. Iwadate, 2010, Chemical & pharmaceutical bulletin.

New protein structure model evaluation methods that include a side-chain consensus score for the protein modeling.

Genki Terashi, Mayuko Takeda-Shitaka, H. Umeyama, 2010, Chemical & pharmaceutical bulletin.

FAMSD: A powerful protein modeling platform that combines alignment methods, homology modeling, 3D structure quality estimation and molecular dynamics.

Genki Terashi, Mitsuo Iwadate, Hideaki Umeyama, 2009, Chemical & pharmaceutical bulletin.

A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Shogo D. Suzuki, Hironori K. Nakamura, Kazuki Z. Yamamoto, 2019, Scientific Reports.

Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi

K. Komatsu, A. Yoshimi, D. Hagiwara, 2019, Applied and Environmental Microbiology.

In silico Spleen Tyrosine Kinase Inhibitor Screening by ChooseLD

Y-h. Taguchi, M. Iwadate, H. Umeyama, 2015, Inf. Media Technol..

Development of a novel anti-hepatitis B virus agent via Sp1

T. Honda, A. Tamori, Y. Yano, 2020, Scientific Reports.

Dynamic character of human growth hormone and its receptor: normal mode analysis.

Hideaki Umeyama, Mayuko Takeda-Shitaka, Kenshu Kamiya, 2003, Chemical & pharmaceutical bulletin.

Dynamic influence of the two membrane-proximal immunoglobulin-like domains upon the peptide-binding platform domain in class I and class II major histocompatibility complexes: normal mode analysis.

Mayuko Takeda-Shitaka, H. Umeyama, K. Kamiya, 2009, Chemical & pharmaceutical bulletin.

Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design.

Mayuko Takeda-Shitaka, M. Iwadate, H. Umeyama, 2004, Chemical & pharmaceutical bulletin.

Hydrophobic Effect on the Protein-Ligand Interaction; Hydrophobic Field-Effect Index and Hydrophobic Correlation Index

H. Umeyama, K. Akahane, Yasuo Nagano, 1989 .

Three-dimensional model of the human PAF receptor.

T. Shimizu, H. Umeyama, A. Kajihara, 1994, Journal of lipid mediators and cell signalling.

Motion of an antiviral compound in a rhinovirus capsid under rotational symmetry boundary conditions.

Y. Kurihara, H. Umeyama, T. Yoneda, 2002, Journal of molecular graphics & modelling.

Bacterial Type III Secretion System Effector Proteins are Distinct between Plant Symbiotic, Plant Pathogenic and Animal Pathogenic Bacteria

Y-h. Taguchi, M. Iwadate, H. Umeyama, 2014 .

Modulation of thrombin-induced platelet aggregation by inhibition of calpain by a synthetic peptide derived from the thiol-protease inhibitory sequence of kininogens and S-(3-nitro-2-pyridinesulfenyl)-cysteine.

R. Colman, H. Umeyama, H. Bradford, 1993, European journal of biochemistry.

Topology of AspT, the Aspartate:Alanine Antiporter of Tetragenococcus halophilus, Determined by Site-Directed Fluorescence Labeling

T. Uchida, P. Maloney, Xicheng Wang, 2007, Journal of bacteriology.

Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification

M. Takeuchi, H. Umeyama, K. Nagata, 2018, PloS one.

The origin of hydrogen bonding. An energy decomposition study

K. Morokuma, H. Umeyama, 1977 .

Ab initio study on the transition state of acylation step of trypsin catalysis.

H. Umeyama, H. Kubodera, S. Nakagawa, 1990, Journal of pharmacobio-dynamics.

Arg260‐Cys mutation in severe factor XIII deficiency: conformational change of the A subunit is predicted by molecular modelling and mechanics

J. Takamatsu, H. Umeyama, H. Saito, 1998, British journal of haematology.

Aggregation of washed platelets by plasminogen and plasminogen activators is mediated by plasmin and is inhibited by a synthetic peptide disulfide.

R. Colman, H. Umeyama, C. Hu, 1992, Thrombosis research.

Non-Arrhenius temperature dependence of the rate constant for the H + H2S reaction

M. Koshi, H. Matsui, H. Umeyama, 1992 .

Molecular orbital study of the effects of ionic amino acid residues on proton transfer energetics in the active site of carboxypeptidase a

H. Umeyama, S. Nakagawa, 1981 .

Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide

M. Sata, H. Yamana, H. Umeyama, 2017, Translational oncology.

Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome.

E. Ito, T. Miyata, K. Kokame, 2003, Blood.

Method for predicting homology modeling accuracy from amino acid sequence alignment: the power function.

Genki Terashi, Mayuko Takeda-Shitaka, M. Iwadate, 2010, Chemical & pharmaceutical bulletin.

Driving forces of biomolecular organisation specific to nanometer scale: protein orientation on the surface, controlled by pH level

Y. Shirshov, B. Snopok, P. Boltovets, 2001 .

The pKa value of His 57-Asp 102 couple in the active site of bovine pancreatic beta-trypsin: a molecular orbital study.

H. Umeyama, S. Nakagawa, 1982, Journal of theoretical biology.

The role of the environment around the catalytic triad in β-trypsin: A molecular orbital study

H. Umeyama, S. Nakagawa, 1982 .

Role of local induced‐fit of Ser 195 in β‐trypsin

H. Umeyama, S. Nakagawa, 1982 .

Core I97L mutation in conjunction with P79Q is associated with persistent low HBV DNA and HBs antigen clearance in patients with chronic hepatitis B.

Y. Hirooka, H. Goto, T. Honda, 2017, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Ab Initio Calculation of Force Constants of Hydroxylamine

M. Tsuboi, H. Umeyama, Y. Hamada, 1980 .

Ab Initio Molecular Orbital Studies on the Aspirin Solvolysis and Ester Hydrolysis

H. Umeyama, S. Nakagawa, 1977 .

Development of novel hepatitis B virus capsid inhibitor using in silico screening.

A. Tamori, Y. Yano, N. Kawada, 2015, Biochemical and biophysical research communications.

Kinetics of the SiH3 + O2 reaction: A new transition state for SiO production

M. Koshi, H. Matsui, Y. Murakami, 1996 .

Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity.

S. Iwanaga, H. Umeyama, T. Miyata, 1992, Biochemistry.

Factor IX Bm Kiryu: a Val‐313‐to‐Asp substitution in the catalytic domain results in loss of function due to a conformational change of the surface loop: evidence obtained by chimaeric modelling

T. Miyata, H. Kato, A. Yoshioka, 1994, British journal of haematology.

Molecular mechanisms of type II factor XIII deficiency: novel Gly562-Arg mutation and C-terminal truncation of the A subunit cause factor XIII deficiency as characterized in a mammalian expression system.

F. Rodeghiero, G. Castaman, H. Umeyama, 1998, Blood.

Molecular defect in factor IX Tokyo: substitution of valine-182 by alanine at position P2' in the second cleavage site by factor XIa resulting in impaired activation.

N. Miura, A. Yoshioka, H. Umeyama, 1993, Biochemistry.

Factor IX Amagasaki: a new mutation in the catalytic domain resulting in the loss of both coagulant and esterase activities.

A. Yoshioka, H. Umeyama, M. Sugimoto, 1991, Biochemistry.

New human renin inhibitors containing an unnatural amino acid, norstatine.

Y. Kiso, H. Umeyama, K. Akahane, 1988, Journal of medicinal chemistry.

Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.

T. Ishida, Y. Kiso, H. Umeyama, 1990, Journal of medicinal chemistry.

Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine

Y. Kiso, H. Umeyama, K. Akahane, 1989 .

Enzymic dynamics and molecular orbital study on the roles of arginines in carboxypeptidase A, a sliding mechanism

H. Umeyama, S. Nakagawa, 1978 .

The origin of the internal rotation barrier of borane compounds.

H. Umeyama, T. Matsuzaki, 1979 .

M Ohya, M. Ohya, H. Umeyama, 1998, Journal of molecular graphics & modelling.

An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes

Daisuke Kihara, Takashi Ishida, Masakazu Sekijima, 2017, Scientific Reports.

The origin of hydrogen bonding. An energy decomposition study

Hideaki Umeyama, Keiji Morokuma, K. Morokuma, 1977 .

Alanine Exchanges of Polar Amino Acids in the Transmembrane Domains of a Platelet-activating Factor Receptor Generate Both Constitutively Active and Inactive Mutants*

Takao Shimizu, M. Ui, H. Umeyama, 1997, The Journal of Biological Chemistry.

Energy decomposition analysis along the reaction coordinate. Theory and example: F− + HF → [FHF]−

K. Morokuma, K. Kitaura, H. Umeyama, 1975 .

Molecular Orbital Study of Proton Transfer Energetics in the Active Site of Papain by Using Methanethiol-Imidazole-Formic Acid Complex as a Model

H. Umeyama, S. Nakagawa, 1981 .

Molecular Dynamics Simulations to Determine the Structure and Dynamics of Hepatitis B Virus Capsid Bound to a Novel Anti-viral Drug.

M. Iwadate, H. Umeyama, Y. Murakami, 2016, Chemical & pharmaceutical bulletin.

Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules

K. Komatsu, H. Tomoda, H. Umeyama, 2016, The Journal of Antibiotics.

Molecular orbital study on the interaction between coenzymes and enzymes; NAD+ or NADH and dehydrogenases.

A. Imamura, H. Umeyama, C. Nagata, 1974, Journal of theoretical biology.

Roles of the aromatic residues conserved in the active center of Saccharomycopsis alpha-amylase for transglycosylation and hydrolysis activity.

K. Ishikawa, I. Matsui, S. Fukui, 1994, Biochemistry.

A new method for induced fit docking (GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors.

Masahiko Ito, Daisuke Takaya, Hideaki Umeyama, 2011, Bioorganic & Medicinal Chemistry.

A ab initio moleular orbital study of molecular interactions between formic acid and ammonia.

H. Umeyama, T. Nomoto, 1979 .

Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics.

Y. Ebizuka, N. Kawano, Mayuko Takeda-Shitaka, 2004, Bioorganic & medicinal chemistry.

Discovering novel direct acting antiviral agents for HBV using in silico screening.

A. Tamori, Y. Yano, N. Kawada, 2015, Biochemical and biophysical research communications.

Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleava

T. Ishida, Y. Kiso, H. Umeyama, 1991 .

Molecular orbital studies of electron donor-acceptor complexes. 3. Energy and charge decomposition analyses for several strong complexes: carbon monoxide-borane, ammonia-borane, methylamine-borane, trimethylamine-borane, and ammonia-boron trifluoride

K. Morokuma, H. Umeyama, 1976 .

Energy decomposition analysis of borane monoammoniate: origin of the rotational barrier to nonrigid rotation

H. Umeyama, K. Akahane, S. Nakagawa, 1985 .

Ab initio molecular orbital study on the effects of zinc ion, its ligands and ionic amino acid residues for proton transfer energetics between Glu 270 and Zn co-ordinated water molecule in carboxypeptidase A.

H. Umeyama, H Umeyama, S Nakagawa, 1982, Journal of theoretical biology.

The origin of barriers to internal rotation. An energy decomposition study for CH3CH3, CH3NH2 and CH3OH

K. Morokuma, H. Umeyama, 1977 .

Molecular orbital studies of electron donor-acceptor complexes. 4. Energy decomposition analysis of halo-complexes: ammonia-fluorine, -chlorine, -chlorine fluoride, methanamine-chlorine fluoride, formaldehyde-fluorine, hydrogen fluoride-chlorine fluoride, and fluorine-fluorine

K. Morokuma, H. Umeyama, S. Yamabe, 1977 .

Origin of alkyl substituent effect in the proton affinity of amines, alcohols, and ethers

K. Morokuma, H. Umeyama, 1976 .

Molecular Orbital Study on the Structure and Barrier to Internal Rotation of Phosphine-Borane

T. Kudo, H. Umeyama, S. Nakagawa, 1981 .

Energy Decomposition Analysis of Borazane at the Molecular Orbital Level : Origin of the Internal Rotation Barrier of H3X-YH3

H. Umeyama, T. Matsuzaki, 1979 .

Enlarged FAMSBASE: protein 3D structure models of genome sequences for 41 species

Akihiro Yamaguchi, Kei Yura, Mitsuo Iwadate, 2003, Nucleic Acids Res..

Dynamic flexibility of a peptide-binding groove of human HLA-DR1 class II MHC molecules: normal mode analysis of the antigen peptide-class II MHC complex.

Mayuko Takeda-Shitaka, H. Umeyama, K. Kamiya, 2003, Chemical & pharmaceutical bulletin.

Role of Asp102 in the enzymatic reaction of bovine beta-trypsin. A molecular orbital study.

T. Kudo, H. Umeyama, S. Nakagawa, 1981, Journal of molecular biology.

Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets

Y-h. Taguchi, Mitsuo Iwadate, Hideaki Umeyama, 2014, BMC Systems Biology.

MOLECULAR ORBITAL STUDIE

K. Morokuma, H. Umeyama, S. Yamabe, 1977 .

Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation.

T. Miki, N. Okada, H. Danbara, 2007, Microbiology.

Principal component analysis-based unsupervised feature extraction applied to in silico drug discovery for posttraumatic stress disorder-mediated heart disease

Y-h. Taguchi, M. Iwadate, H. Umeyama, 2015, BMC Bioinformatics.

Genetic Characterization of Protein C Deficiency in Japanese Subjects Using a Rapid and Nonradioactive Method for Single-Strand Conformational Polymorphism Analysis and a Model Building

T. Miyata, A. Yoshioka, H. Umeyama, 1996, Thrombosis and Haemostasis.

Six missense mutations associated with type I and type II protein C deficiency and implications obtained from molecular modelling

T. Miyata, H. Kato, H. Umeyama, 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

The carboxyl-terminal region of protein C is essential for its secretion.

T. Senda, H. Umeyama, I. Sugiura, 2000, Blood.

Congenital Coagulation Factor IX, Protein C and Antithrombin III Structural Aspects from Three Dimensional Model

T. Miyata, Koji Suzuki, H. Umeyama, 1997 .

Specificity of the sequence in Phe-Gln-Val-Val-Cys (-3-nitro-2-pyridinesulfenyl)-Gly-NH2--a selective inhibitor of thrombin-induced platelet aggregation.

R. Colman, H. Umeyama, R. Matsueda, 1993, Thrombosis research.

Characterization of N-linked oligosaccharides attached to human renin expressed in COS cells.

K. Murakami, H. Umeyama, Y. Ishizuka, 1988, Clinical and experimental hypertension. Part A, Theory and practice.

Electrostatic Complementarities between Guest Ligands and Host Enzymes

Haruki Nakamura, K. Komatsu, H. Umeyama, 1985 .

Visualization of electrostatic recognition by enzymes for their ligands and cofactors

Haruki Nakamura, Hideaki Umeyama, Setsuko Nakagawa, 1985 .

Electrostatic forces in the inhibition of dihydrofolate reductase by methotrexate. A field potential study.

H. Umeyama, K. Komatsu, H. Nakamura, 1984, Chemical & pharmaceutical bulletin.

Mechanism by which the lectin actinohivin blocks HIV infection of target cells

S. Ōmura, A. Kuno, J. Hirabayashi, 2009, Proceedings of the National Academy of Sciences.

Principal component analysis based unsupervised feature extraction applied to bioinformatics analysis

Yoshiki Murakami, Y-h. Taguchi, Mitsuo Iwadate, 2017 .

SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer

Y-h. Taguchi, M. Iwadate, H. Umeyama, 2016, BMC Medical Genomics.

Heuristic principal component analysis-based unsupervised feature extraction and its application to gene expression analysis of amyotrophic lateral sclerosis data sets

Y-h. Taguchi, Mitsuo Iwadate, Hideaki Umeyama, 2015, 2015 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB).

TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer

Mitsuo Iwadate, Hideaki Umeyama, Y-h. Taguchi, 2014, BMC Genomics.

Heuristic principal component analysis based unsupervised feature extraction and its application to bioinformatics

Yoshiki Murakami, Y-h. Taguchi, Akira Okamoto, 2014 .

Bioinformatic Screening of Autoimmune Disease Genes and Protein Structure Prediction with FAMS for Drug Discovery

Mitsuo Iwadate, Hideaki Umeyama, Shigeharu Ishida, 2013, Protein and peptide letters.

TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer

Y-h. Taguchi, M. Iwadate, H. Umeyama, 2014, BMC Genomics.

Design and synthesis of affinity labeling peptide inhibitors to receptors or proteases

H. Umeyama, I. Takayanagi, K. Koike, 1993 .

Dynamic characteristics of a peptide-binding groove of human HLA-A2 class I MHC molecules: normal mode analysis of the antigen peptide-class I MHC complex.

Mayuko Takeda-Shitaka, H. Umeyama, K. Kamiya, 2002, Chemical & pharmaceutical bulletin.

Dynamic interaction among the platform domain and two membrane-proximal immunoglobulin-like domains of class I major histocompatibility complex: normal mode analysis.

Hideaki Umeyama, Mayuko Takeda-Shitaka, Kenshu Kamiya, 2008, Chemical & pharmaceutical bulletin.

Mechanism of Adsorption of Phenols by Carbon Black from Aqueous Solution

T. Nagai, H. Umeyama, H. Nogami, 1971 .

Bioinformatics based Ligand-Docking and in-silico screening.

Genki Terashi, Mitsuo Iwadate, Daisuke Takaya, 2008, Chemical & pharmaceutical bulletin.

Elucidation of the cause for reduced activity of abnormal human plasmin containing an Ala55‐Thr mutation: importance of highly conserved Ala55 in serine proteases

Mayuko Takeda-Shitaka, H. Umeyama, Mayuko Takeda-Shitaka, 1998, FEBS letters.

A Computer Modeling Study of the Interaction Between Tissue Factor Pathway Inhibitor and Blood Coagulation Factor Xa

H. Umeyama, H. Komooka, T. Yoneda, 1997, Journal of protein chemistry.

Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics

Y-h. Taguchi, Mitsuo Iwadate, Hideaki Umeyama, 2012, BIOINFORMATICS.

Drug design based on receptor modeling using a system “BIOCES [E]”

H. Umeyama, K. Akahane, 1995 .

Potent affinity labeling peptide inhibitors of calpain.

R. Colman, H. Umeyama, H. Bradford, 1990 .

Augmentation of Human Immunodeficiency Virus Type 1 Subtype E (CRF01_AE) Multiple-Drug Resistance by Insertion of a Foreign 11-Amino-Acid Fragment into the Reverse Transcriptase

S. Oka, Y. Takebe, Y. Nagai, 2001, Journal of Virology.

Supporting Information : Previous studies that reported the relationship between cancers / tumors and top most feasible drug canridate compounds selected for ALK , ELGN 3 and NUAK 1

M. Iwadate, H. Umeyama, Y-h. Taguchi, 2013 .

A molecular orbital study on the enzymic reaction mechanism of α-chymotrypsm

A. Imamura, H. Umeyama, C. Nagata, 1973 .

The molecular orbital study on the role of hydrogen bonding system in the active site of serine proteases.

T. Kudo, H. Umeyama, S. Nakagawa, 1980 .

A molecular orbital study on the effects of substituents on the proton transfer from ser-195 to his-57 in the hydrolysis of alpha-chymotrypsin.

A. Imamura, H. Umeyama, C. Nagata, 1975, Chemical & pharmaceutical bulletin.

Three-dimensional structure of human renin.

I. Moriguchi, S. Hirose, H. Umeyama, 1985, Hypertension.

Dynamic character of the complex of human blood coagulation factor VIIa with the extracellular domain of human tissue factor: a normal mode analysis

H. Umeyama, K. Kamiya, K. Soejima, 1999, FEBS letters.

Three Dimensional Structure of Activated Protein C

T. Miyata, Mayuko Takeda-Shitaka, H. Umeyama, 1999 .

Role of catalytic residues in the formation of a tetrahedral adduct in the acylation reaction of bovine beta-trypsin. A molecular orbital study.

H. Umeyama, S. Nakagawa, Hideaki Umeyama, 1984, Journal of molecular biology.

Charge state of His-57-Asp-102 couple in a transition state analogue-trypsin complex: a molecular orbital study.

S. Hirono, H. Umeyama, S. Nakagawa, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Model Quality Assessment Using a Statistical Program that Adopts a Side Chain Environment Viewpoint

Genki Terashi, Mayuko Takeda-Shitaka, Kazuhiko Kanou, 2010 .

Fams‐ace: A combined method to select the best model after remodeling all server models

Genki Terashi, Mayuko Takeda-Shitaka, Kazuhiko Kanou, 2007, Proteins.

Cysteine protease inhibitors with S-(3-nitro-2-pyridinesulfenyl)-cysteine residue in affinity analogs of peptide substrates.

N. Katunuma, E. Kominami, H. Umeyama, 1989, Advances in experimental medicine and biology.

Substitution of Gly-548 to Ala in the Substrate Binding Pocket of Prothrombin Perijá Leads to the Loss of Thrombin Proteolytic Activity

A. Ruiz-Sáez, N. D. de Bosch, H. Umeyama, 2002, Thrombosis and Haemostasis.

Molecular Orbital Studies on the CH 3 CN-BH 3 , HCN-BH 3 , CH 3 NC-BH 3 and HNC-BH 3 Complexes

H. Umeyama, T. Nomoto, 1980 .

An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes

Shogo D. Suzuki, Kazuki Z. Yamamoto, D. Kihara, 2017, Scientific Reports.

Controlling Substrate Preference and Transglycosylation Activity of Neopullulanase by Manipulating Steric Constraint and Hydrophobicity in Active Center*

J. Shimada, H. Kaneko, T. Kuriki, 1996, The Journal of Biological Chemistry.

The role played by environmental residues on sidechain torsional angles within homologous families of proteins: A new method of sidechain modeling

H. Umeyama, K. Ogata, H Umeyama, 1998, Proteins.

Reproduction of ab Initio Electrostatic Potential with Classical Fractional Point Charges

H. Umeyama, H. Kubodera, S. Nakagawa, 1987 .

Electrostatic potential images of drugs targetting dopamine receptors.

S. Hirono, I. Moriguchi, H. Umeyama, 1984, Chemical & pharmaceutical bulletin.

Binding specificity of papain and cathepsin B.

H. Umeyama, K. Akahane, 1986, Enzyme.

Factors X Nice I and II: Two Novel Missense Mutations (Met-40Val and Pro304Ser) in Patient with Coagulation Factor X Deficiency

T. Miyata, H. Kato, H. Umeyama, 1998, Thrombosis and Haemostasis.

Factor X Nagoya 1 and Nagoya 2: a CRM– Factor X Deficiency and a Dysfunctional CRM+ Factor X Deficiency Characterized by Substitution of Arg306 by Cys and of Gly366 by Ser, respectively

T. Miyata, Kyoko Suzuki, H. Umeyama, 1998, Thrombosis and Haemostasis.

Protein structure prediction in structure based drug design.

Daisuke Takaya, Hideaki Umeyama, Mayuko Takeda-Shitaka, 2004, Current medicinal chemistry.

Interaction between the antigen and antibody is controlled by the constant domains: Normal mode dynamics of the HEL–HyHEL‐10 complex

Mayuko Takeda-Shitaka, H. Umeyama, K. Kamiya, 2003, Protein science : a publication of the Protein Society.

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

Charles L. Brooks, Adrian W. R. Serohijos, John Moult, 2009, Nature Reviews Drug Discovery.

FAMS and FAMSBASE for Protein Structure

Hideaki Umeyama, Mitsuo Iwadate, M. Iwadate, 2003, Current protocols in bioinformatics.

The Carboxyl-Terminal Region of Protein C Is Essential for Its Secretion

H. Saito, T. Senda, H. Umeyama, 1998 .

Principal component analysis-based unsupervised feature extraction applied to in silico drug discovery for posttraumatic stress disorder-mediated heart disease

Y-h. Taguchi, Mitsuo Iwadate, Hideaki Umeyama, 2015, BMC Bioinformatics.

An automatic homology modeling method consisting of database searches and simulated annealing.

H. Umeyama, K. Ogata, H Umeyama, 2000, Journal of molecular graphics & modelling.

Design and synthesis of cathepsin B inhibitors by an affinity labeling approach.

N. Katunuma, E. Kominami, H. Umeyama, 1988 .

A homology modeling method of an icosahedral viral capsid: inclusion of surrounding protein structures.

H. Umeyama, T. Yoneda, S. Yoneda, 1999, Journal of molecular graphics & modelling.

Design and synthesis of a kininogen-based selective inhibitor of thrombin-induced platelet aggregation.

R. Colman, H. Umeyama, H. Bradford, 1994, Peptide research.

The Study of Partition Coefficients. The Prediction of Log P Value Based on Molecular Structure

Hideaki Umeyama, Atsushi Tomonaga, H. Umeyama, 1988 .