D. Valenzuela

发表

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses

G. Yancopoulos, N. Gale, S. Stevens, 2007, Nature Biotechnology.

Multiple knockout mouse models reveal lincRNAs are required for life and brain development

Michael Morse, J. Rinn, Manolis Kellis, 2013, eLife.

The mammalian gene function resource: the international knockout mouse consortium

Steve D. M. Brown, Hamsa D. Tadepally, Mark W. Moore, 2012, Mammalian Genome.

The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis

M. Neurath, P. Galle, A. Murphy, 2008, The Journal of experimental medicine.

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.

F. Alt, R. Krauss, Danica Chen, 2013, Cell reports.

Genome wide conditional mouse knockout resources

Mark W. Moore, J. Eppig, M. Ringwald, 2016 .

Atypical angiopoietin-like protein that regulates ANGPTL3

Jonathan C. Cohen, N. Grishin, E. Boerwinkle, 2012, Proceedings of the National Academy of Sciences.

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

Jonathan C. Cohen, H. Hobbs, J. Gromada, 2013, Proceedings of the National Academy of Sciences.

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke.

C. Duyckaerts, S. Germain, J. Serfaty, 2013, European heart journal.

Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy.

C. Henderson, A. Murphy, C. Lutz, 2011, The Journal of clinical investigation.

Modeling the Initiation and Progression of Human Acute Leukemia in Mice

Nikolaus Rajewsky, David Frendewey, Klaus Rajewsky, 2022 .

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

S. Gygi, A. Goldberg, C. Gartner, 2009, The Journal of cell biology.

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.

S. Rafii, P. Pandolfi, S. Chavala, 2007, Nature.

Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development

G. Yancopoulos, R. Kimble, W. Poueymirou, 2000, Nature Genetics.

Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis

Hsin C. Lin, G. Yancopoulos, N. Gale, 2009, Proceedings of the National Academy of Sciences.

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Francis J. Huber, Judy H. Cho, Wei Zhang, 2012, Nature.

Protection against Myocardial Infarction and No-reflow through Preservation of Vascular Integrity by Angiopoietin-like 4 Running Title: Galaup Et Al.; Protecting Vascular Integrity in Heart Ischemia

S. Germain, A. Murphy, G. Yancopoulos, 2022 .

Vascular Integrity by Angiopoietin-Like 4 Protection Against Myocardial Infarction and No-Reflow Through Preservation of

S. Germain, A. Murphy, G. Yancopoulos, 2011 .

Alteration of Developmental and Pathological Retinal Angiogenesis in angptl4-deficient Mice*

S. Germain, A. Murphy, G. Yancopoulos, 2011, The Journal of Biological Chemistry.

Long form of latent TGF-β binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

A. Murphy, G. Yancopoulos, D. Rifkin, 2007 .

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.

A. Murphy, T. Sakurai, G. Yancopoulos, 2008, Kidney international.

Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

A. Murphy, G. Yancopoulos, N. Gale, 2007, Proceedings of the National Academy of Sciences.

Experimental Colitis Production in T Cell-Dependent Cutting Edge : IL-23 Cross-Regulates IL-12

P. Galle, A. Murphy, G. Yancopoulos, 2006 .

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

A. Murphy, R. Flavell, G. Yancopoulos, 2010, Proceedings of the National Academy of Sciences.

Mice completely lacking immunoproteasomes display major alterations in antigen presentation

K. Rock, A. Murphy, G. Yancopoulos, 2011, Nature Immunology.

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome

S. Mundlos, G. Yancopoulos, M. Sleeman, 2008, Development.

Peptide YY regulates bone turnover in rodents.

J. Herman, A. Murphy, M. Tschöp, 2007, Gastroenterology.

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

A. F. Stewart, L. Macdonald, A. Murphy, 2003, Nature Biotechnology.

Angiomodulin Is a Specific Marker of Vasculature and Regulates Vascular Endothelial Growth Factor-A–Dependent Neoangiogenesis

S. Rafii, S. Chavala, A. Murphy, 2009, Circulation research.

Tim‐1 regulates Th2 responses in an airway hypersensitivity model

A. Murphy, D. Meyerholz, J. Colgan, 2012, European journal of immunology.

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys.

A. Murphy, Jinrang Kim, H. Okamoto, 2015, Endocrinology.

Localization and regulation of MuSK at the neuromuscular junction.

P. Distefano, G. Yancopoulos, S. Bodine, 1998, Developmental biology.

Developmental expression and upregulation of muscle-specific kinase (MuSK) in denervated skeletal muscle of the chick and rat

G. Yancopoulos, N. Ip, D. Glass, 1996 .

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.

A. Murphy, K. Lyons, G. Yancopoulos, 2009, Molecular endocrinology.

Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B

G. Yancopoulos, A. Wilkie, S. Mansour, 2000, Nature Genetics.

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

A. Murphy, R. Flavell, G. Yancopoulos, 2011, Proceedings of the National Academy of Sciences.

The loss-of-allele assay for ES cell screening and mouse genotyping.

A. Murphy, G. Yancopoulos, D. Frendewey, 2010, Methods in enzymology.

Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature

A. Murphy, G. Yancopoulos, D. Vestweber, 2017, PloS one.

Goblet Cell-Derived Resistin-Like Molecule β Augments CD4+ T Cell Production of IFN-γ and Infection-Induced Intestinal Inflammation1

A. Murphy, G. Yancopoulos, D. Artis, 2008, The Journal of Immunology.

Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.

A. Murphy, G. Yancopoulos, D. Artis, 2006, The Journal of allergy and clinical immunology.

Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

A. Murphy, G. Yancopoulos, E. Pearce, 2009, The Journal of experimental medicine.

Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation

Eric Verdin, Jakob Bunkenborg, Robert V Farese, 2007, Molecular and Cellular Biology.

Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor.

R. Espinosa, M. L. Le Beau, N. Copeland, 1995, Genomics.

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain

A. Murphy, G. Yancopoulos, T. Wynn, 2008, Nature Immunology.

TLR8 deficiency leads to autoimmunity in mice.

A. Murphy, R. Flavell, G. Yancopoulos, 2010, The Journal of clinical investigation.

Generation and functional characterization of mice with a conditional BMP7 allele.

A. Economides, D. Graf, D. Valenzuela, 2009, The International journal of developmental biology.

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

L. Macdonald, A. Murphy, G. Yancopoulos, 2014, Proceedings of the National Academy of Sciences.

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.

A. Murphy, R. Flavell, G. Yancopoulos, 2007, Immunity.

Interleukin-22 promotes fibroblast- mediated wound repair in the skin

A. Murphy, R. Flavell, G. Yancopoulos, 2012, The Journal of investigative dermatology.

Conditionals by inversion provide a universal method for the generation of conditional alleles

Joseph M. Cruz, P. Lengyel, A. Murphy, 2013, Proceedings of the National Academy of Sciences.

Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis

A. Soza, D. Valenzuela, E. Ciampi, 2017, PloS one.

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

Shahin Rafii, Till Milde, Kevin G Bath, 2010, Nature Medicine.

and Infection-Induced Intestinal γ Augments CD4+ T Cell Production of IFN- β Goblet Cell-Derived Resistin-Like Molecule

G. Yancopoulos, D. Artis, S. Stevens, 2013 .

Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.

N. Ip, M. Goldfarb, D. Valenzuela, 1995, Oncogene.

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

F. Alt, L. Macdonald, A. Murphy, 2014, Proceedings of the National Academy of Sciences.

Peripheral Myelin Protein 22 Is in Complex with α6β4 Integrin, and Its Absence Alters the Schwann Cell Basal Lamina

A. Murphy, G. Yancopoulos, L. Notterpek, 2006, The Journal of Neuroscience.

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.

H. Higgs, F. Wang, D. Valenzuela, 2016, Kidney international.

The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

P. Distefano, G. Yancopoulos, D. Glass, 1996, Cell.

Leucine Aminopeptidase Is Not Essential for Trimming Peptides in the Cytosol or Generating Epitopes for MHC Class I Antigen Presentation1

K. Rock, A. Murphy, G. Yancopoulos, 2005, The Journal of Immunology.

Agrin Acts via a MuSK Receptor Complex

P. Distefano, G. Yancopoulos, C. Radziejewski, 1996, Cell.

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

B. Becher, M. Neurath, A. Murphy, 2009, Gastroenterology.

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.

A. Murphy, R. Flavell, G. Yancopoulos, 2008, Immunity.

Efficient differentiation and function of human macrophages in humanized CSF-1 mice.

A. Murphy, R. Flavell, G. Yancopoulos, 2011, Blood.

Functional Characterization of Mouse RDH11 as a Retinol Dehydrogenase Involved in Dark Adaptation in Vivo*

A. Edwards, A. Murphy, G. Yancopoulos, 2005, Journal of Biological Chemistry.

Lhx6 Delineates a Pathway Mediating Innate Reproductive Behaviors from the Amygdala to the Hypothalamus

David J. Anderson, Hong-wei Dong, L. Swanson, 2005, Neuron.

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.

L. Macdonald, A. Murphy, G. Yancopoulos, 2005, Proceedings of the National Academy of Sciences of the United States of America.

EphA2 Promotes Infiltrative Invasion of Glioma Stem Cells in vivo through Crosstalk with Akt and Regulates Stem Properties

A. Murphy, G. Yancopoulos, J. Rich, 2014, Oncogene.

Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis1

M. Neurath, P. Galle, A. Murphy, 2006, The Journal of Immunology.

Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs

J. Rinn, G. Yancopoulos, G. Droguett, 2015, PloS one.

The long non-coding RNAs : a new ( p ) layer in the “ dark matter ”

Michael Morse, J. Rinn, Manolis Kellis, 2014 .

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

A. F. Stewart, L. Macdonald, A. Murphy, 2003, Nature Biotechnology.

Regulation of the Germinal Center Response by MicroRNA-155

N. Rajewsky, J. Kutok, K. Rajewsky, 2007, Science.

Interleukin‐19 protects mice from innate‐mediated colonic inflammation

A. Murphy, G. Yancopoulos, M. Karow, 2010, Inflammatory bowel diseases.

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis.

M. Neurath, P. Galle, A. Murphy, 2006, Journal of immunology.

The receptor for ciliary neurotrophic factor.

G. Yancopoulos, D. Valenzuela, S. Davis, 1991, Science.

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.

Ian A. White, S. Rafii, A. Murphy, 2008, The Journal of clinical investigation.

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

Gavin Thurston, A. Murphy, G. Yancopoulos, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Pingfang Liu, David Frendewey, Caitlin Kennedy, 2006, Cell.

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

N. Copeland, D. Gilbert, N. Jenkins, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury

P. Distefano, M. L. Beau, N. Copeland, 1995, Neuron.

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

A. Flenniken, T. Pawson, D. Wilkinson, 1996, Neuron.

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

P. Distefano, G. Yancopoulos, C. Radziejewski, 1991, Cell.

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

D J Glass, G. Yancopoulos, Z. Pan, 2001, Science.

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

F. Alt, R. Weindruch, T. Prolla, 2006, Cell.

Producing fully ES cell-derived mice from eight-cell stage embryo injections.

G. Yancopoulos, W. Poueymirou, W. Auerbach, 2010, Methods in enzymology.

VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos.

G. Yancopoulos, W. Poueymirou, W. Auerbach, 2009, Methods in molecular biology.

Unified Nomenclature for Eph Family Receptors and Their Ligands, the Ephrins

T Pawson, C. Goodman, T. Pawson, 1997, Cell.

Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice.

A. Murphy, Yurong Xin, H. Okamoto, 2015, Endocrinology.

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice

A. Murphy, Yurong Xin, G. Yancopoulos, 2015, Proceedings of the National Academy of Sciences.

Alternative forms of rat TrkC with different functional capabilities

G. Yancopoulos, N. Ip, D. Glass, 1993, Neuron.

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S]

Jonathan C. Cohen, H. Hobbs, A. Murphy, 2015, Journal of Lipid Research.

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

R. Siliciano, S. Salzberg, J. Margolick, 2015, Nature.

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice

C. Siao, A. Murphy, G. Yancopoulos, 2016, Scientific Reports.

Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice.

A. Murphy, G. Yancopoulos, R. Liu-Bryan, 2010, Arthritis and rheumatism.

Poueymirou, W.T. et al. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat. Biotechnol. 25, 91-99

G. Yancopoulos, N. Gale, S. Stevens, 2007 .

Generation of fertile and fecund F0 XY female mice from XY ES cells

C. Siao, G. Yancopoulos, J. Kuno, 2015, Transgenic Research.

Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation.

A. Murphy, G. Yancopoulos, D. Artis, 2008, Journal of immunology.

Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection.

A. Murphy, G. Yancopoulos, M. Karow, 2011, Journal of pharmacological sciences.

Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections1

K. Rock, A. Murphy, G. Yancopoulos, 2008, The Journal of Immunology.

during Viral Infections but Does Not Affect CD8 T Cell Responses MHC Class I Presentation in Dendritic Cells Puromycin-Sensitive Aminopeptidase Limits

K. Rock, A. Murphy, G. Yancopoulos, 2008 .

A. Murphy, G. Yancopoulos, M. Sleeman, 2005, Cell metabolism.

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1

A. Murphy, C. Vorhees, G. Yancopoulos, 2010, Psychoneuroendocrinology.

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor

Johnathon R. Walls, L. Macdonald, A. Murphy, 2011, Proceedings of the National Academy of Sciences.

Pathogenicity of Lupus Anti–Ribosomal P Antibodies: Role of Cross‐Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model

N. Inestrosa, C. Retamal, J. Parodi, 2015, Arthritis & rheumatology.

ANGPTL4–αvβ3 interaction counteracts hypoxia‐induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2

S. Ricard-Blum, S. Germain, A. Murphy, 2016, The Journal of pathology.

Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein α Subunit Membrane Association

A. Murphy, G. Yancopoulos, G. Tall, 2011, Science Signaling.

Identification of Mammalian Nervous System Noggin and Its Expression in the Adult

M. L. Beau, N. Copeland, D. Gilbert, 1995 .

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

A. Murphy, G. Yancopoulos, M. Sleeman, 2010, Proceedings of the National Academy of Sciences.

Generating Epitopes for MHC Class I Trimming Peptides in the Cytosol or Leucine Aminopeptidase Is Not Essential for Yancopoulos

K. Rock, A. Murphy, G. Yancopoulos, 2005 .

Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

U. Wyneken, L. Varela-Nallar, D. Valenzuela, 2020, BMC biology.

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses

A. Murphy, G. Yancopoulos, Jennifer S Griffiths, 2007, PAIN.

Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel

Zhe Zhang, D. Valenzuela, F. Sepúlveda, 2015, PloS one.

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

A. Murphy, G. Yancopoulos, L. Notterpek, 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection.

A. Murphy, G. Yancopoulos, M. Karow, 2011, Journal of Pharmacological Sciences.

173 Interleukin-22 Provides Protection to Tissues during Inflammation

A. Murphy, R. Flavell, G. Yancopoulos, 2007 .

The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin.

P. Distefano, G. Yancopoulos, D. Glass, 1996, Cold Spring Harbor symposia on quantitative biology.

Production of large, defined genome modifications in rats by targeting rat embryonic stem cells

E. Chiao, C. Romano, W. Auerbach, 2022, Stem cell reports.