G. Fernando

发表

Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination.

D. Moss, A. Suhrbier, L. Brown, 1998, Journal of immunology.

The vaccinia virus K2L gene encodes a serine protease inhibitor which inhibits cell-cell fusion.

I. Frazer, G. Fernando, J. Zhou, 1992, Virology.

Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin.

Michael S Roberts, Tarl W Prow, I. Frazer, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses

Stefano C. Meliga, I. Frazer, M. Kendall, 2019, npj Vaccines.

Potent response of QS-21 as a vaccine adjuvant in the skin when delivered with the Nanopatch, resulted in adjuvant dose sparing

M. Kendall, G. Fernando, Hwee-Ing Ng, 2016, Scientific Reports.

Efficient Delivery of Dengue Virus Subunit Vaccines to the Skin by Microprojection Arrays

M. Kendall, P. Young, S. Corrie, 2019, Vaccines.

Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8(+) T cell responses.

M. Kendall, G. Fernando, Sally R. Yukiko, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T‐cell suppression mediated by CD4+CD25+ T cells

I. Frazer, R. Linedale, G. Fernando, 2009, European journal of immunology.

Presence of Skin Disease E 6 / E 7-transgenic Mice to E 7 Protein Correlate with the Immunological Responses in Human Papillomavirus 16 Updated

I. Frazer, P. Lambert, W. Phelps, 2006 .

Human growth hormone presented by K14hGH‐transgenic skin grafts induces a strong immune response but no graft rejection

I. Frazer, G. Fernando, G. Leggatt, 2004, Immunology and cell biology.

Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation

I. Frazer, G. Fernando, G. Leggatt, 2004, Immunology and cell biology.

in a Primed Host Response to a Novel Viral Epitope g Cell IFN-IL-10 Mediates Suppression of the CD8 T

I. Frazer, G. Fernando, G. Leggatt, 2003 .

Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activity.

I. Frazer, K. Zhao, W. Liu, 2002, Virology.

Advances in Brief Peripheral Tolerance to Human Papillomavirus E 7 Oncoprotein Occurs by Cross-Tolerization , Is Largely Th2-independent , and Is Broken by Dendritic Cell Immunization 1

P. Lambert, G. Fernando, R. Tindle, 2000 .

Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunization.

P. Lambert, G. Fernando, R. Tindle, 2000, Cancer research.

Human Papillomavirus Type 16 E7 Oncoprotein Expressed in Peripheral Epithelium Tolerizes E7-Directed Cytotoxic T-Lymphocyte Precursors Restricted through Human (and Mouse) Major Histocompatibility Complex Class I Alleles

P. Lambert, G. Fernando, K. Herd, 1999, Journal of Virology.

Mice expressing the E7 oncogene of HPV16 in epithelium show central tolerance, and evidence of peripheral anergising tolerance, to E7-encoded cytotoxic T-lymphocyte epitopes.

P. Lambert, M. Chambers, G. Fernando, 1998, Virology.

Tumor Model Suppress Antitumor CTL Activity in a Mouse Cells Neither Enhance nor + Th2-Type CD4

I. Frazer, G. Fernando, R. Tindle, 1998 .

Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes

I. Frazer, P. Lambert, G. Fernando, 1998, European journal of immunology.

E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein.

I. Frazer, P. Lambert, G. Fernando, 1997, Virology.

Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease.

I. Frazer, P. Lambert, W. Phelps, 1995, Cancer research.

A "public" T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes.

I. Frazer, G. Fernando, R. Tindle, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern

Maria J. Wurm, J. Hobson-Peters, P. Young, 2022, Vaccines.

T-helper epitopes identified within the E6 transforming protein of cervical cancer-associated human papillomavirus type 16.

I. Frazer, G. Fernando, R. Tindle, 1999, Viral immunology.

T-helper epitopes of the E7 transforming protein of cervical cancer associated human papillomavirus type 18 (HPV18).

I. Frazer, G. Fernando, R. Tindle, 1995, Virus research.

Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice.

Michael S Roberts, Tarl W Prow, David C. Chang, 2010, Small.

An Ultrahigh‐Density Microneedle Array for Skin Vaccination: Inducing Epidermal Cell Death by Increasing Microneedle Density Enhances Total IgG and IgG1 Immune Responses

Jacob W. Coffey, N. van der Burg, M. Kendall, 2022, Advanced NanoBiomed Research.

High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses

M. Kendall, P. Young, W. Weldon, 2017, Scientific Reports.

The changing shape of vaccination: improving immune responses through geometrical variations of a microdevice for immunization

Jacob W. Coffey, M. Kendall, G. Fernando, 2016, Scientific Reports.

Advances in Brief Antigen-specific CD 4 T-Cell Help Is Required to Activate a Memory CD 8 T Cell to a Fully Functional Tumor Killer Cell 1

I. Frazer, W. Liu, G. Fernando, 2002 .

Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding.

Simon R Corrie, M. Kendall, M. Brunck, 2010, Lab on a chip.

Safety, tolerability, and immunogenicity of influenza vaccination with a high-density microarray patch: Results from a randomized, controlled phase I clinical trial

A. Wheatley, J. Hickling, S. Rockman, 2020, PLoS medicine.

Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy.

I. Frazer, W. Liu, G. Fernando, 2001, Vaccine.

Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes

I. Frazer, G. Fernando, G. Leggatt, 2004, Journal of leukocyte biology.

Functional memory CD8+ T cells can be generated in vivo without evident T help.

I. Frazer, G. Fernando, G. Leggatt, 2004, Vaccine.

Low level expression of human papillomavirus type 16 (HPV16) E6 in squamous epithelium does not elicit E6 specific B- or T-helper immunological responses, or influence the outcome of immunisation with E6 protein.

I. Frazer, P. Lambert, G. Fernando, 2001, Virus research.

Cellular responses at the application site of a high-density microarray patch delivering an influenza vaccine in a randomized, controlled phase I clinical trial

J. Hickling, S. Rockman, M. Veitch, 2021, PloS one.

Developing a Stabilizing Formulation of a Live Chimeric Dengue Virus Vaccine Dry Coated on a High-Density Microarray Patch

J. Hobson-Peters, P. Young, R. Hall, 2021, Vaccines.

A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice

J. Hobson-Peters, P. Young, R. Hall, 2021, npj Vaccines.

Differences in the post‐translational modifications of human papillomavirus type 6b major capsid protein expressed from a baculovirus system compared with a vaccinia virus system

I. Frazer, G. Fernando, N. Fang, 2000, Biotechnology and applied biochemistry.

Cell-mediated immune responses to E7 peptides of human papillomavirus (HPV) type 16 are dependent on the HPV type infecting the cervix whereas serological reactivity is not type-specific.

M. Van Ranst, R. Burk, R. Ledwidge, 1994, The Journal of general virology.

The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine.

T. Prow, G. Fernando, M. Crichton, 2010, Biomaterials.

Novel coating of micro-nanoprojection patches for targeted vaccine delivery to skin

M. Kendall, T. Prow, G. Fernando, 2008, 2008 International Conference on Nanoscience and Nanotechnology.

Site‐Selectively Coated, Densely‐Packed Microprojection Array Patches for Targeted Delivery of Vaccines to Skin

L. Brown, M. Kendall, T. Prow, 2011 .

Formulations for microprojection/microneedle vaccine delivery: Structure, strength and release profiles.

Stefano C. Meliga, Robert J. Falconer, Anthony P. Raphael, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Papillomavirus virus-like particles can deliver defined CTL epitopes to the MHC class I pathway.

I. Frazer, G. Fernando, J. Zhou, 1998, Virology.

Skin Vaccination against Cervical Cancer Associated Human Papillomavirus with a Novel Micro-Projection Array in a Mouse Model

I. Frazer, M. Kendall, G. Fernando, 2010, PloS one.

Chimeric hepatitis B core antigen particles containing B- and Th-epitopes of human papillomavirus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice.

G. Dougan, G. Fernando, R. Tindle, 1994, Virology.

Post translational modifications of recombinant human papillomavirus type 6b major capsid protein.

I. Frazer, G. Fernando, J. Zhou, 1999, Virus research.

TLR7 stimulation augments T effector‐mediated rejection of skin expressing neo‐self antigen in keratinocytes

I. Frazer, G. Fernando, G. Leggatt, 2008, European journal of immunology.

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

N. McMillan, P. Young, H. Bielefeldt-Ohmann, 2021, bioRxiv.

IL-10 Mediates Suppression of the CD8 T Cell IFN-γ. Response to a Novel Viral Epitope in a Primed Host

I. Frazer, G. Fernando, G. Leggatt, 2004, The Journal of Immunology.

Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization.

I. Frazer, L. Brown, M. Kendall, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses.

I. Frazer, L. Brown, M. Kendall, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin.

I. Frazer, L. Brown, M. Kendall, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays.

M. Kendall, T. Prow, A. P. Raphael, 2010, Small.

Dry-Coated Live Viral Vector Vaccines Delivered by Nanopatch Microprojections Retain Long-Term Thermostability and Induce Transgene-Specific T Cell Responses in Mice

Adrian V. S. Hill, Michael L. Crichton, Mark A. F. Kendall, 2013, PloS one.

Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays.

Dexiang Chen, Courtney Jarrahian, M. Kendall, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Potent Immunity to Low Doses of Influenza Vaccine by Probabilistic Guided Micro-Targeted Skin Delivery in a Mouse Model

I. Frazer, M. Roberts, L. Brown, 2010, PloS one.

Depth-resolved characterization of diffusion properties within and across minimally-perturbed skin layers.

Stefano C. Meliga, M. Kendall, C. Flaim, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

N. McMillan, H. Bielefeldt-Ohmann, G. Fernando, 2021, Science advances.

Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell.

I. Frazer, W. Liu, G. Fernando, 2002, Cancer research.

Overcoming Original Antigenic Sin to Generate New CD8 T Cell IFN-γ Responses in an Antigen-Experienced Host1

I. Frazer, Ranjeny Thomas, G. Fernando, 2006, The Journal of Immunology.

Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16

I. Frazer, S. Rodda, W. Liu, 2003, Immunology and cell biology.

Induction of potent CD8⁺ T cell responses through the delivery of subunit protein vaccines to skin antigen-presenting cells using densely packed microprojection arrays.

M. Kendall, G. Fernando, Hwee-Ing Ng, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Secondary immunisation with high‐dose heterologous peptide leads to CD8 T cell populations with reduced functional avidity

G. Fernando, G. Leggatt, Sharmal Narayan, 2007, European journal of immunology.

Impaired antigen presentation and effectiveness of combined active/passive immunotherapy for epithelial tumors.

I. Frazer, P. Lambert, Xiaosong Liu, 2004, Journal of the National Cancer Institute.

The number of long‐lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation

I. Frazer, W. Liu, G. Fernando, 2002, European journal of immunology.

Presentation of the HPV16E7 protein by skin grafts is insufficient to allow graft rejection in an E7-primed animal.

I. Frazer, P. Lambert, M. Evander, 1997, Virology.

Th2-type CD4+ cells neither enhance nor suppress antitumor CTL activity in a mouse tumor model.

I. Frazer, G. Fernando, R. Tindle, 1998, Journal of immunology.

Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses

I. Frazer, M. Kendall, G. Fernando, 2019, npj Vaccines.

Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism

M. Brunck, G. Fernando, Xiao Song Liu, 2009 .

High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses

M. Kendall, P. Young, W. Weldon, 2017, Scientific Reports.

Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™).

I. Frazer, J. Hickling, S. Rockman, 2018, Vaccine.

Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses

M. Kendall, P. Young, W. Weldon, 2016, Scientific Reports.

Peptide polymerisation facilitates incorporation into ISCOMs and increases antigen-specific IgG2a production.

I. Frazer, G. Fernando, D. Stenzel, 1995, Vaccine.

IL-10 Mediates Suppression of the CD8 T Cell IFN-γ Response to a Novel Viral Epitope in a Primed Host1

I. Frazer, G. Fernando, G. Leggatt, 2003, The Journal of Immunology.

Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins.

R. Young, I. Frazer, A. Aldovini, 2000, Vaccine.

ISCOMATRIX adjuvant: an adjuvant suitable for use in anticancer vaccines.

I. Frazer, S. Edwards, G. Fernando, 2004, Vaccine.

Expression, purification and immunological characterization of the transforming protein E7, from cervical cancer‐associated human papillomavirus type 16

I. Frazer, G. Fernando, Zhou, 1999, Clinical and experimental immunology.

Targeted epidermal delivery of vaccines from coated micro-nanoprojection patches

M. Roberts, M. Kendall, T. Prow, 2008, 2008 International Conference on Nanoscience and Nanotechnology.

Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells

I. Frazer, M. Smyth, G. Fernando, 2003 .

Vaccine‐Induced Th1‐Type Responses are Dominant over Th2‐Type Responses in the Short Term whereas Pre‐existing Th2 Responses are Dominant in the Longer Term

G. Fernando, R. Tindle, Stewart, 1998, Scandinavian journal of immunology.

Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™).

I. Frazer, J. Hickling, S. Rockman, 2018, Vaccine.

Safety and Immunogenicity of HPV16 E7/Algammulin

I. Frazer, G. Fernando, P. Cooper, 1999 .

Inhibition of early tumor growth requires J alpha 18-positive (natural killer T) cells.

I. Frazer, M. Smyth, G. Fernando, 2003, Cancer research.

Potent Immunity to Low Doses of Influenza Vaccine by Probabilistic Guided Micro-Targeted Skin Delivery in a Mouse Model

I. Frazer, M. Roberts, L. Brown, 2010, PLoS ONE.

Formulations for microprojection/microneedle vaccine delivery: Structure, strength and release profiles.

Stefano C. Meliga, M. Kendall, R. Falconer, 2016, Journal of controlled release : official journal of the Controlled Release Society.