P. Primakoff

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Mouse egg integrin α6β1functions as a sperm receptor

A. Sonnenberg, A. Mercurio, J. White, 1995, Cell.

Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion

P. Primakoff, H. Hyatt, J. Tredick-Kline, 1987, The Journal of cell biology.

Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor.

A. Sonnenberg, L. Shaw, A. Mercurio, 1995, Cell.

ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain.

T. Wolfsberg, J. White, A. Huovila, 1995, Developmental biology.

Testase 1 (ADAM 24) a plasma membrane-anchored sperm protease implicated in sperm function during epididymal maturation or fertilization.

P. Primakoff, D. Myles, G. Zhu, 2001, Journal of cell science.

Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion.

G. Dveksler, P. Primakoff, D. Myles, 2003, Molecular biology of the cell.

Infertility in female mice with an oocyte-specific knockout of GPI-anchored proteins

P. Primakoff, D. Myles, J. A. Alfieri, 2003, Journal of Cell Science.

None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion.

J. Kreidberg, R. Fässler, C. Brakebusch, 2003, Developmental biology.

Proteomic analysis of sperm regions that mediate sperm‐egg interactions

William Arbuthnot Sir Lane, P. Primakoff, D. Myles, 2006, Proteomics.

A role for sperm surface protein disulfide isomerase activity in gamete fusion: evidence for the participation of ERp57.

P. Primakoff, D. Myles, D. Ellerman, 2006, Developmental cell.

Positive control of lac operon expression in vitro by guanosine 5'-diphosphate 3'-diphosphate.

P. Primakoff, S. Artz, 1979, Proceedings of the National Academy of Sciences of the United States of America.

In vivo role of the relA+ gene in regulation of the lac operon

P. Primakoff, 1981, Journal of bacteriology.

Rearrangement of Sperm Surface Antigens prior to Fertilization a

D. Koppel, P. Primakoff, D. Myles, 1987, Annals of the New York Academy of Sciences.

Localized surface antigens of guinea pig sperm migrate to new regions prior to fertilization

P. Primakoff, D. Myles, 1984, The Journal of cell biology.

Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.

C. Blobel, J. White, P. Primakoff, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Sperm surface protein PH-20 is bifunctional: one activity is a hyaluronidase and a second, distinct activity is required in secondary sperm-zona binding.

G. Hunnicutt, P. Primakoff, D. Myles, 1996, Biology of reproduction.

ADAM and ADAMTS Proteins

P. Primakoff, D. Myles, G. Zhu, 2002 .

Penetration, Adhesion, and Fusion in Mammalian Sperm-Egg Interaction

P. Primakoff, D. Myles, 2002, Science.

Location of the PH-20 protein on acrosome-intact and acrosome-reacted spermatozoa of cynomolgus macaques.

A. I. Yudin, D. Katz, J. Overstreet, 1995, Biology of reproduction.

A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida

P. Primakoff, D. Myles, H. Hyatt, 1985, The Journal of cell biology.

Why did the sperm cross the cumulus? To get to the oocyte. Functions of the sperm surface proteins PH-20 and fertilin in arriving at, and fusing with, the egg.

P. Primakoff, D. Myles, 1997, Biology of reproduction.

Sperm Proteins That Serve as Receptors for the Zona Pellucida and Their Post‐Testicular Modification a

P. Primakoff, D. Myles, PAUL PRIMAKOFF, 1991, Annals of the New York Academy of Sciences.

Identification of an ADAM2-ADAM3 Complex on the Surface of Mouse Testicular Germ Cells and Cauda Epididymal Sperm*

P. Primakoff, D. Myles, H. Nishimura, 2007, Journal of Biological Chemistry.

Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence

C. Blobel, J. White, P. Primakoff, 1990, The Journal of cell biology.

Surface domains of the guinea pig sperm defined with monoclonal antibodies

P. Primakoff, D. Myles, A. Bellvé, 1981, Cell.

Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice

Surabhi Gupta, P. Primakoff, D. Myles, 2009, Molecular reproduction and development.

The PH-20 protein in human spermatozoa.

A. I. Yudin, J. Overstreet, P. Primakoff, 1997, Journal of andrology.

Restricted lateral diffusion of PH-20, a PI-anchored sperm membrane protein.

D. Koppel, P. Primakoff, D. Myles, 1988, Science.

In vitro processing of E. coli tRNA precursors

P. Schedl, P. Primakoff, J. Roberts, 1976, Cell.

Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20

P. Primakoff, D. Myles, A. Cowan, 1988, Nature.

Sperm exocytosis increases the amount of PH-20 antigen on the surface of guinea pig sperm

P. Primakoff, D. Myles, A. Cowan, 1986, The Journal of cell biology.

Molecular cloning of the human and monkey sperm surface protein PH-20 ( ferlzation / contraceptive vaccine )

P. Primakoff, D. Myles, Y. Lin, 2005 .

Evidence that proteolysis of the surface is an initial step in the mechanism of formation of sperm cell surface domains

D. Koppel, P. Primakoff, D. Myles, 1990, The Journal of cell biology.

The PH-20 protein in cynomolgus macaque spermatozoa: identification of two different forms exhibiting hyaluronidase activity.

A. I. Yudin, J. Overstreet, C. Vandevoort, 1996, Developmental biology.

A localized surface protein of guinea pig sperm exhibits free diffusion in its domain

D. Koppel, P. Primakoff, D. Myles, 1984, The Journal of cell biology.

Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion.

J. White, P. Primakoff, D. Myles, 1996, Genomics.

Can the presence of wild‐type oocytes during insemination rescue the fusion defect of CD9 null oocytes?

Surabhi Gupta, P. Primakoff, D. Myles, 2009, Molecular reproduction and development.

Mutants of Escherichia coli thermosensitive for the synthesis of transfer RNA.

P. Schedl, P. Primakoff, Paul Schedl, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Species specificity of hybridoma antibodies to surface antigens of guinea pig sperm

P. Primakoff, D. Myles, M. R. Heaton, 1983 .

Species Specificity of Antibodies to Surface Guinea Pig Sperm Hybridoma Antigens of

P. Primakoff, D. Myles, M. R. Heaton, 2022 .

Actin filaments, localized to the region of the developing acrosome during early stages, are lost during later stages of guinea pig spermiogenesis.

P. Primakoff, D. Myles, R. Halenda, 1987, Biology of reproduction.

A cholera toxin-sensitive G-protein stimulates exocytosis in sea urchin eggs.

L. Jaffe, P. Primakoff, P. Turner, 1987, Developmental biology.

A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg

P. Primakoff, D. Myles, W. Lathrop, 1994, The Journal of cell biology.

The Mouse Spam1 maps to proximal Chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)lAld heterozygotes

N. Copeland, D. Gilbert, N. Jenkins, 1997, Mammalian Genome.

Loss of surface EWI‐2 on CD9 null oocytes

Surabhi Gupta, P. Primakoff, D. Myles, 2009, Molecular reproduction and development.

Mechanism of infertility in male guinea pigs immunized with sperm PH-20.

K. Tung, P. Primakoff, D. Myles, 1997, Biology of reproduction.

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

T. Wolfsberg, C. Blobel, C. Turck, 1992, Nature.

Sperm Surface Domains

P. Primakoff, D. Myles, 1985 .

Relief of Polarity in E. coli by “suA”

P. Primakoff, Daniel E. Morse, 1970, Nature.

cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals

P. Primakoff, D. Myles, W. Lathrop, 1990, The Journal of cell biology.

Binding of both acrosome-intact and acrosome-reacted guinea pig sperm to the zona pellucida during in vitro fertilization.

P. Primakoff, D. Myles, H. Hyatt, 1987, Developmental biology.

Inhibition of monkey sperm hyaluronidase activity and heterologous cumulus penetration by flavonoids.

A. I. Yudin, J. Overstreet, C. Vandevoort, 1997, Biology of reproduction.

Structural relationship of sperm soluble hyaluronidase to the sperm membrane protein PH-20.

G. Hunnicutt, P. Primakoff, D. Myles, 1996, Biology of reproduction.

An antisperm monoclonal antibody inhibits sperm fusion with zona-free hamster eggs but not homologous eggs.

P. Primakoff, H. Hyatt, 1986, Fertility and sterility.

Reversible contraceptive effect of PH-20 immunization in male guinea pigs.

K. Tung, P. Primakoff, D. Myles, 1997, Biology of reproduction.

Cell–cell membrane fusion during mammalian fertilization

P. Primakoff, D. Myles, 2007, FEBS letters.

A map of the guinea pig sperm surface constructed with monoclonal antibodies.

P. Primakoff, D. Myles, 1983, Developmental biology.

Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution.

H. Stahlberg, Surabhi Gupta, K. McDonald, 2007, Developmental biology.

Fertilization defects in sperm from mice lacking fertilin beta.

E. M. Eddy, E. Goulding, D. Bunch, 1998, Science.

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion.

R. Hynes, P. Primakoff, D. Myles, 2002, Development.

Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm

J. Pei, W. Snell, Surabhi Gupta, 2009, Molecular Reproduction and Development.

Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins.

Surabhi Gupta, P. Primakoff, D. Myles, 2011, Reproduction.

Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta.

P. Primakoff, D. Myles, H. Nishimura, 2001, Developmental biology.

Sperm-egg fusion: events at the plasma membrane

P. Primakoff, D. Myles, Kathryn K. Stein, 2004, Journal of Cell Science.

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell- matrix interactions

T G Wolfsberg, T. Wolfsberg, J. White, 1995, The Journal of cell biology.

The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.

T. Wolfsberg, C. Blobel, J. Bazan, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-Dependent

P. Primakoff, D. Myles, E. Georges‐Labouesse, 2000, The Journal of cell biology.

The frequency of calcium oscillations in mouse eggs at fertilization is modulated by the number of fused sperm.

P. Primakoff, D. Myles, J. Faure, 1999, Developmental biology.

Analysis of Mouse Fertilin in Wild-Type and Fertilin β−/− Sperm: Evidence for C-terminal Modification, α/β Dimerization, and Lack of Essential Role of Fertilin α in Sperm–Egg Fusion

P. Primakoff, D. Myles, C. Cho, 2000 .

The ADAM gene family: surface proteins with adhesion and protease activity.

P. Primakoff, D. Myles, 2000, Trends in genetics : TIG.

Precursor Pool of Ribosome

P. Palade, M. Santer, T. Ruebush, 2022 .

Identification of a Precursor Pool of Ribosome Protein in Escherichia coli

P. Palade, M. Santer, T. Ruebush, 1968, Journal of bacteriology.

Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization.

P. Primakoff, D. Myles, G. Zhu, 1999, Gene.

Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion.

P. Primakoff, D. Myles, C. Cho, 2000, Developmental biology.

Identification of human sperm surface glycoproteins recognized by autoantisera from immune infertile men, women, and vasectomized men.

R. Bronson, P. Primakoff, W. Lathrop, 1990, Biology of reproduction.

Immunization of female cynomolgus macaques with a synthetic epitope of sperm‐specific lactate dehydrogenase results in high antibody titers but does not reduce fertility

J. Overstreet, P. Primakoff, T. Tollner, 2002, Molecular reproduction and development.

Immunological response of female macaques to the PH-20 sperm protein following injection of recombinant proteins or synthesized peptides.

A. I. Yudin, J. Overstreet, S. Meyers, 2002, Journal of reproductive immunology.

ECD peptides inhibit in vitro fertilization in mice

N. Sampson, P. Primakoff, D. Myles, 1997 .

A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion

P. Primakoff, D. Myles, Ruiyong Yuan, 1997, The Journal of cell biology.

A role for a TIMP-3-sensitive, Zn(2+)-dependent metalloprotease in mammalian gamete membrane fusion.

P. Primakoff, D. Myles, L. Correa, 2000, Developmental biology.

Purification of the guinea pig sperm PH-20 antigen and detection of a site-specific endoproteolytic activity in sperm preparations that cleaves PH-20 into two disulfide-linked fragments.

P. Primakoff, D. Myles, H. Hyatt, 1988, Biology of reproduction.

A role for the WH-30 protein in sperm-sperm adhesion during rouleaux formation in the guinea pig.

P. Primakoff, D. Myles, N. J. Swann, 1993, Developmental biology.

Review: Sperm Proteins Being Studied for Use in a Contraceptive Vaccine

P. Primakoff, 1994, American Journal of Reproductive Immunology.

Defects in Secretory Pathway Trafficking During Sperm Development in Adam2 Knockout Mice1

P. Primakoff, D. Myles, Kathryn K. Stein, 2005, Biology of reproduction.

Genomic organization of the mouse fertilin beta gene that encodes an ADAM family protein active in sperm-egg fusion.

P. Primakoff, D. Myles, L. Turner, 1997, Developmental genetics.

A PCR method for distinguishing cells from mouse strains 129 and C57BL/6 for gene knockout studies

P. Primakoff, D. Myles, C. Cho, 1997 .

A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg

P. Primakoff, D. Myles, Ying Lin, 1994, The Journal of cell biology.

Multiple roles for PH-20 and fertilin in sperm-egg interactions

P. Primakoff, D. Myles, C. S. Ramarao, 1994 .

Initial evaluation of fertilin as an immunocontraceptive antigen and molecular cloning of the cynomolgus monkey fertilin β subunit

P. Primakoff, D. Myles, C. S. Ramarao, 1996, Molecular reproduction and development.

Gamete Fusion in Mammals

P. Primakoff, D. Myles, 2002 .

A localized surface protein of guinea pig sperm exhibits free diffusion in its domain

D. Koppel, P. Primakoff, D. Myles, 1984, The Journal of cell biology.