P. Sancho

发表

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells

P. Jagust, B. de Luxán-Delgado, B. Parejo-Alonso, 2019, Front. Pharmacol..

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

I. Fabregat, P. Sancho, L. Caja, 2009, Biochimica et biophysica acta.

Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells.

I. Fabregat, P. Sancho, L. Caja, 2012, Cellular signalling.

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells.

I. Fabregat, P. Sancho, 2011, Biochemical pharmacology.

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity.

I. Fabregat, N. Fausto, C. Roncero, 2008, Journal of hepatology.

Overactivation of the TGF‐β pathway confers a mesenchymal‐like phenotype and CXCR4‐dependent migratory properties to liver tumor cells

I. Fabregat, G. Egea, T. Serrano, 2013, Hepatology.

Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes*

Á. Valverde, Á. González-Rodríguez, I. Fabregat, 2012, The Journal of Biological Chemistry.

Snail1 suppresses TGF-β-induced apoptosis and is sufficient to trigger EMT in hepatocytes

I. Fabregat, M. Nieto, P. Sancho, 2010, Development.

Differential effects of catalase on apoptosis induction in human promonocytic cells. Relationships with heat-shock protein expression.

P. Sancho, E. de Blas, C. Fernández, 2003, Molecular pharmacology.

Pharmacological inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells

A. Ramos, P. Sancho, C. Fernández, 2005 .

The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis

I. Fabregat, P. Sancho, 2013 .

Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli

I. Fabregat, Jean S. Campbell, N. Fausto, 2012, Journal of cellular physiology.

Overactivation of the Mek/erk Pathway in Liver Tumor Cells Confers Resistance to Tgf-b–induced Cell Death through Impairing Up-regulation of the Nadph Oxidase Nox4

D. Iglesias-Serret, J. Gil, I. Fabregat, 2022 .

Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation.

A. Ramos, P. Sancho, M. Palacios, 2005, Biochimica et biophysica acta.

Effect of Glutathione Depletion on Antitumor Drug Toxicity (Apoptosis and Necrosis) in U-937 Human Promonocytic Cells

P. Sancho, E. de Blas, C. Fernández, 2001, The Journal of Biological Chemistry.

Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress

A. Ramos, V. Yuste, P. Sancho, 2006, Apoptosis.

12-O-Tetradecanoylphorbol-13-acetate May Both Potentiate and Decrease the Generation of Apoptosis by the Antileukemic Agent Arsenic Trioxide in Human Promonocytic Cells

A. Ramos, P. Sancho, E. de Blas, 2004, Journal of Biological Chemistry.

A mesenchymal‐like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells

G. Giannelli, I. Fabregat, A. Álvarez-Barrientos, 2015, International journal of cancer.

The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells

P. Bernardi, P. Sancho, E. D. Blas, 2003, Cell Death and Differentiation.

Metabolic determinants of stemness in medulloblastoma

P. Sancho, L. Caja, Paula Martín-Rubio, 2022, World journal of stem cells.

Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway.

I. Fabregat, P. Sancho, P. Martı́n-Sanz, 2011, Free radical biology & medicine.

ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells

C. Heeschen, K. Olive, B. Parejo-Alonso, 2022, bioRxiv.

World Journal of Stem Cells Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells

C. Heeschen, P. Jagust, P. Sancho, 2020 .

Snail1 suppresses TGF-β-induced apoptosis and is sufficient to trigger EMT in hepatocytes

I. Fabregat, M. Nieto, P. Sancho, 2010, Journal of Cell Science.

Drp1 Mediates Caspase-Independent Type III Cell Death in Normal and Leukemic Cells

S. Baudet, G. Roué, H. Merle-Béral, 2007, Molecular and Cellular Biology.

The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression.

I. Fabregat, P. Sancho, Margarita Fernández, 2014, Free radical biology & medicine.

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

C. Heeschen, Katherine Sellers, O. Graña, 2015, Cell metabolism.

TGF-beta signaling in cancer treatment.

I. Fabregat, P. Sancho, J. Mainez, 2014, Current pharmaceutical design.

ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

A. Carrato, P. Sancho, P. Martinelli, 2020, Nature Communications.

Hallmarks of cancer stem cell metabolism

C. Heeschen, P. Sancho, David Barneda, 2016, British Journal of Cancer.

Mitochondrial determinants of chemoresistance

P. Sancho, Ansooya A. Bokil, 2019, Cancer drug resistance.

Cancer associated fibroblast FAK regulates malignant cell metabolism

T. Schall, T. Graham, F. Balkwill, 2020, Nature Communications.

Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton

S. Baudet, G. Roué, L. Châtre, 2009, Haematologica.

Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification

P. Sancho, S. Courtois, Pilar Espiau-Romera, 2020, Journal of clinical medicine.

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

C. Heeschen, J. Rubiolo, P. Cabezas-Sáinz, 2020, Nature Communications.

ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

A. Carrato, P. Sancho, P. Martinelli, 2020, Nature Communications.

Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential

C. Heeschen, J. Rubiolo, L. Sánchez, 2021, bioRxiv.

Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

A. Moustakas, P. Sancho, L. Caja, 2021, Frontiers in Pharmacology.

The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

I. Fabregat, N. Fausto, P. Sancho, 2011, Biochemical pharmacology.

NADPH Oxidase NOX1 Controls Autocrine Growth of Liver Tumor Cells through Up-regulation of the Epidermal Growth Factor Receptor Pathway*

I. Fabregat, P. Sancho, 2010, The Journal of Biological Chemistry.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

F. Real, M. Barbacid, C. Heeschen, 2014, Gastroenterology.

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

C. Heeschen, P. Sancho, E. Lonardo, 2015, Journal of visualized experiments : JoVE.

Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta.

I. Fabregat, P. Sancho, L. Caja, 2009, Cellular signalling.

Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells

C. Heeschen, P. Jagust, P. Sancho, 2020, World journal of stem cells.

The ever-changing landscape of pancreatic cancer stem cells.

P. Sancho, P. Hermann, B. Sáinz, 2016, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment

J. Kleeff, M. Hidalgo, M. Tatari, 2015, Gut.

Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells.

A. Ramos, P. Sancho, E. de Blas, 2005, Blood.

Pharmacologic inhibitors of PI 3 K / Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells

A. Ramos, P. Sancho, C. Fernández, 2005 .

Drp 1 Mediates Caspase-Independent Type III Cell Death in Normal and Leukemic Cells †

S. Baudet, G. Roué, H. Merle-Béral, 2007 .

Pharmacological targeting of the receptor ALK inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma.

C. Heeschen, K. Olive, P. Sancho, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

R. Eferl, H. Huber, W. Mikulits, 2012, PloS one.

Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release

J. d'Alayer, V. Yuste, P. Sancho, 2005, Cell Death and Differentiation.

ROS Production Is Essential for the Apoptotic Function of E2F1 in Pheochromocytoma and Neuroblastoma Cell Lines

I. Fabregat, S. Ambrosio, Sebastián M. Real, 2012, PloS one.

Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer

P. Sancho, S. Courtois, Pilar Espiau-Romera, 2021, World journal of stem cells.

Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma

A. Carrato, C. Heeschen, F. Portillo, 2022, Gut.

Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells

M. Hidalgo, C. Heeschen, P. Sancho, 2013, PloS one.

PPAR-delta acts as a metabolic master checkpoint for metastasis in pancreatic cancer

U. Schmitz, C. Heeschen, Á. Lanas, 2021, bioRxiv.

Phenotype and Plasticity of Pancreatic Cancer Stem Cells

C. Heeschen, Katherine Sellers, O. Graña, 2022 .

Combination light-based therapies to treat pancreatic cancer: a proof of concept

P. Acedo, A. J. MacRobert, S. P. Pereira, 2019, World Congress of the International Photodynamic Association.

Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion.

I. Fabregat, P. Sancho, L. Caja, 2008, Biochemical pharmacology.

Estimates of the incidence of hematological neoplasms in Spain, 2021: Study of the Spanish Network of Cancer Registries (REDECAN)

A. Cañete, M. Carulla, E. Ardanaz, 2022, Medicina Clínica (English Edition).

Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

I. Fabregat, P. Sancho, L. Caja, 2011, Journal of hepatology.

MYC / PGC-1 a Balance Det ermines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells Graphical