G. Quack

发表

Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data

C. Parsons, W. Danysz, G. Quack, 1999, Neuropharmacology.

Modulation of NMDA receptors by glycine — introduction to some basic aspects and recent developments

C. Parsons, W. Danysz, G. Quack, 2005, Amino Acids.

Glutamate in CNS disorders as a target for drug development: an update.

C. Parsons, W. Danysz, G. Quack, 1998, Drug news & perspectives.

Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists

A. A. Fokin, C. Parsons, P. Schreiner, 2012, Medicinal Chemistry Research.

Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization.

C. Parsons, W. Danysz, P. Headley, 1997, The Journal of pharmacology and experimental therapeutics.

Microdialysis studies with amantadine and memantine on pharmacokinetics and effects on dopamine turnover.

R. Spanagel, W. Danysz, G. Quack, 1995, Journal of neural transmission. Supplementum.

Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-d-aspartate-induced destruction of retinal neurones

N. Osborne, G. Quack, Neville N. Osborne, 1992, Neurochemistry International.

Memantine, amantadine, and L-deprenyl potentiate the action of L-DOPA in monoamine-depleted rats

W. Danysz, G. Quack, G. Skuza, 2005, Journal of Neural Transmission / General Section JNT.

Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists –in vitro characterisation

C. Parsons, W. Danysz, G. Quack, 2000, Amino Acids.

GlycineB antagonists as potential therapeutic agents

C. Parsons, P. Popik, W. Danysz, 1998, Amino Acids.

Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behaviour of MPTP-treated mice

T. Archer, W. Danysz, A. Fredriksson, 2009, Journal of Neural Transmission.

Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

J. Miguel-Hidalgo, R. Cacabelos, G. Quack, 2002, Brain research.

Infusion of (+) -MK-801 and memantine -- contrasting effects on radial maze learning in rats with entorhinal cortex lesion.

W. Danysz, G. Quack, W. Zajaczkowski, 1996, European journal of pharmacology.

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

C. Parsons, W. Danysz, G. Quack, 1995, Neuropharmacology.

Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization

C. Parsons, W. Danysz, G. Quack, 1999, Neuropharmacology.

L‐Ornithine‐L‐aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure

R. Butterworth, A. Michalak, C. Rose, 1999, Hepatology.

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

C. Parsons, J. Kornhuber, W. Schmidt, 1997, Neuroscience & Biobehavioral Reviews.

Are NMDA antagonistic properties relevant for antiparkinsonianlike activity in rats?—Case of amantadine and memantine

W. Danysz, G. Quack, W. Zajaczkowski, 1994, Journal of neural transmission. Parkinson's disease and dementia section.

Therapeutic brain concentration of the NMDA receptor antagonist amantadine

K. Jellinger, J. Kornhuber, P. Riederer, 1995, Neuropharmacology.

Potential antidepressive properties of amantadine, memantine and bifemelane.

W. Danysz, G. Quack, E. Moryl, 1993, Pharmacology & toxicology.

Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system.

J. Kreuter, G. Quack, B. Lorenz, 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Neuroprotection by memantine against neurodegeneration induced by β-amyloid(1–40)

J. Miguel-Hidalgo, R. Cacabelos, G. Quack, 2002, Brain Research.

Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man

J. Kornhuber, G. Quack, Johannes Kornhuber, 1995, Neuroscience Letters.

Neuroprotective and symptomatological action of memantine relevant for alzheimer’s disease — a unified glutamatergic hypothesis on the mechanism of action

C. Parsons, W. Danysz, A. Stöffler, 2009, Neurotoxicity Research.

No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use.

W. Danysz, G. Wenk, G. Quack, 2000, Life sciences.

PET studies of 18F-memantine in healthy volunteers.

A. Buck, S. Kneifel, S. Ametamey, 2002, Nuclear medicine and biology.

Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists

C. Parsons, P. Schreiner, G. Quack, 2012, Medicinal Chemistry Research.

Evidence for lysosomotropism of memantine in cultured human cells: cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and beta-adrenergic transmission.

G. Quack, U. Honegger, U E Honegger, 1993, Pharmacology & toxicology.

Effect of the antioxidant Nicanartine on the proliferative and inflammatory response after experimental balloon angioplasty

G. Quack, W. Seibold, H. Hanke, 1998, Coronary artery disease.

Electrophysiological study, biodistribution in mice, and preliminary PET evaluation in a rhesus monkey of 1-amino-3-[18F]fluoromethyl-5-methyl-adamantane (18F-MEM): a potential radioligand for mapping the NMDA-receptor complex.

C. Parsons, K. Leenders, S. Ametamey, 1998, Nuclear medicine and biology.

NMDA channel blockers: memantine and amino-aklylcyclohexanes –In vivo characterization

C. Parsons, W. Danysz, G. Quack, 2000, Amino Acids.

Investigation on possible antioxidative properties of the NMDA-receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro.

G. Quack, A. Lupp, W. Klinger, 1998, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Fluorine-18 radiolabelling, biodistribution studies and preliminary PET evaluation of a new memantine derivative for imaging the NMDA receptor.

C. Parsons, K. Leenders, S. Ametamey, 1999, Journal of receptor and signal transduction research.