C. Garwood

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Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

C. Brayne, R. Raman, F. Matthews, 2011, Neurobiology of Aging.

Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response

P. Heath, S. Wharton, J. Simpson, 2020, International journal of molecular sciences.

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

Evangelia Karyka, P. Heath, H. Mortiboys, 2018, Neuroscience.

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population‐based study in the Medical Research Council Cognitive Function and Ageing Study (MRC‐CFAS) cohort

C. Brayne, F. Matthews, S. Wharton, 2014, Neuropathology and applied neurobiology.

Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function

P. Heath, H. Mortiboys, S. Wharton, 2021, The European journal of neuroscience.

Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype

C. Brayne, R. Raman, G. Forster, 2011, Alzheimer's & Dementia.

Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease

P. Heath, S. Wharton, P. Ince, 2019, Neuropathology and applied neurobiology.

Kinase activities increase during the development of tauopathy in htau mice

W. Noble, D. Hanger, I. Kelleher, 2007, Journal of neurochemistry.

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding

W. Noble, D. Hanger, C. Garwood, 2009, Prion.

Proteomic and cellular localisation studies suggest non‐tight junction cytoplasmic and nuclear roles for occludin in astrocytes

P. Heath, S. Wharton, P. Ince, 2018, The European journal of neuroscience.

Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions

C. Garwood, Emma J. Mead, G. Sharman, 2019, Pure and Applied Chemistry.

The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): protocol for a prospective longitudinal cohort study of healthcare and ancillary workers in UK healthcare settings

L. Wain, M. Tobin, K. Khunti, 2021, BMJ Open.

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

C. Brayne, F. Matthews, P. Heath, 2020, International journal of molecular sciences.

Glucosylpolyphenols as inhibitors of Aβ-induced Fyn kinase activation and Tau phosphorylation: synthesis, membrane permeability, and exploratory target assessment within the scope of type 2 diabetes and Alzheimer's disease.

N. Colabufo, B. Ernst, C. Gomes, 2020, Journal of medicinal chemistry.

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

C. Brayne, F. Matthews, T. Minett, 2015, Neuroscience Letters.

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases*

M. Zvelebil, D. Hanger, P. Sheppard, 2008, Journal of Biological Chemistry.

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease

W. Noble, D. Hanger, B. Anderton, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer’s disease research

L. Ferraiuolo, J. Simpson, S. Wharton, 2021, Journal of neurochemistry.

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort

C. Brayne, F. Matthews, G. Savva, 2011, Neuroscience Letters.

Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain

C. Brayne, F. Matthews, P. Heath, 2018, Glia.

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

C. Brayne, F. Matthews, A. Higginbottom, 2015, Neuropathology and applied neurobiology.

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

C. Brayne, F. Matthews, T. Minett, 2015, PloS one.

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

P. Ince, P. Heath, P. Ince, 2017, Neuropathology and applied neurobiology.

Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology

M. Rattray, C. Brayne, F. Matthews, 2015, Neuropathology and applied neurobiology.

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

P. Heath, S. Wharton, P. Ince, 2015, Molecular Brain.

Astrocytes and neuroinflammation in Alzheimer's disease.

M. Hutton, W. Noble, D. Hanger, 2014, Biochemical Society transactions.

Calcium dysregulation in relation to Alzheimer‐type pathology in the ageing brain

C. Brayne, G. Forster, F. Matthews, 2013, Neuropathology and applied neurobiology.

Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy

J. Cooper, W. Noble, D. Hanger, 2010, Front. Psychiatry.

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

P. Heath, P. Ince, J. Simpson, 2015, Molecular Brain.

Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways†

Matthew P. Baumgartner, V. Gillet, N. Colabufo, 2021, Chemical science.

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer’s disease

A. Jeromin, W. Noble, D. Hanger, 2013, Aging cell.

Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort.

C. Brayne, F. Matthews, T. Minett, 2020, Journal of neuropathology and experimental neurology.

Insulin and IGF 1 signalling pathways in human astrocytes in vitro and in vivo ; characterisation , subcellular localisation and modulation of thereceptors

P. Heath, S. Wharton, P. Ince, 2018 .

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

W Noble, W. Noble, D. Hanger, 2011, Cell Death and Disease.

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort

C. Brayne, F. Matthews, G. Savva, 2011, Neuroscience Letters.

A size selective vascular barrier in the rat area postrema formed by perivascular macrophages and the extracellular matrix

D. Ray, C. Garwood, C. L. Willis, 2007, Neuroscience.

Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology

C. Garwood, S. B. Wharton, L. Ratcliffe, 2015, Neuropathology and applied neurobiology.

UK-REACH: United Kingdom research study into ethnicity and COVID-19 outcomes in healthcare workers

M. Pareek, C. Garwood, 2020, http://isrctn.com/.