T. Hammond

发表

J. Valentin, C. Lawrence, C. Pollard, 2008, British journal of pharmacology.

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.

A. Camm, R. Wallis, T. Hammond, 2003, Cardiovascular research.

Nonclinical proarrhythmia models: predicting Torsades de Pointes.

J. Valentin, C. Lawrence, C. Pollard, 2005, Journal of pharmacological and toxicological methods.

An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk

J. Valentin, A. Easter, C. Pollard, 2010, British journal of pharmacology.

Strategies to reduce the risk of drug‐induced QT interval prolongation: a pharmaceutical company perspective

J. Valentin, C. Pollard, T. Hammond, 2008, British journal of pharmacology.

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug‐induced torsades de pointes

C. January, D. Roden, P. Sager, 2008, British journal of pharmacology.

Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.

B. Small, E. Sullivan, J. Valentin, 2006, Journal of pharmacological and toxicological methods.

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

J. Valentin, C. Pollard, T. Hammond, 2004, Fundamental & clinical pharmacology.

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs.

Jean-Pierre Valentin, J. Valentin, T. Hammond, 2004, Journal of pharmacological and toxicological methods.

Spectrum of effects detected in the rat functional observational battery following oral administration of non-CNS targeted compounds.

J. Valentin, T. Hammond, W. Redfern, 2005, Journal of pharmacological and toxicological methods.

Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society.

J. Valentin, A. Bass, L. Kinter, 2011, Journal of pharmacological and toxicological methods.

Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, β‐adrenoceptor stimulation, pacing rate and gender

B. Small, J. Valentin, C. Lawrence, 2006, British journal of pharmacology.

Predicting Human Adverse Drug Reactions from Nonclinical Safety Studies

J. Valentin, T. Hammond, M. Keisu, 2010 .

Correction of QT values to allow for increases in heart rate in conscious Beagle dogs in toxicology assessment.

J. Valentin, T. Hammond, M. L. Tattersall, 2006, Journal of pharmacological and toxicological methods.

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres

B. Small, J. Valentin, C. Lawrence, 2004, British journal of pharmacology.

First‐in‐human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection

T. Hammond, J. Möhrle, U. Lorch, 2020, British journal of clinical pharmacology.

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

W Suter, M Pirmohamed, M. Pirmohamed, 2011, British journal of pharmacology.

A framework to assess the translation of safety pharmacology data to humans.

Rob Wallis, Jean-Pierre Valentin, Lorna Ewart, 2009, Journal of pharmacological and toxicological methods.

Safety and secondary pharmacology: successes, threats, challenges and opportunities.

Jean-Pierre Valentin, J. Valentin, T. Hammond, 2008, Journal of pharmacological and toxicological methods.

History of Clinical Trial Development and the Pharmaceutical Industry

J. Peppercorn, T. Hammond, T. Roberts, 2010 .

A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

J. Valentin, C. Lawrence, C. Pollard, 2006, British journal of pharmacology.

Safety pharmacology – a progressive approach

Helen Prior, J. Valentin, C. Pollard, 2002, Fundamental & clinical pharmacology.

The application of in vitro methods to safety pharmacology

J. Valentin, C. Pollard, T. Hammond, 2002, Fundamental & clinical pharmacology.

Safety Pharmacology: Past, Present, and Future

Jean-Pierre Valentin, J. Valentin, T. Hammond, 2006 .

Impact and prevalence of safety pharmacology-related toxicities throughout the pharmaceutical life cycle

Jean-Pierre Valentin, Lorna Ewart, J. Valentin, 2010 .