Chuo Chen

发表

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

L. Lum, Courtney M. Karner, T. Carroll, 2011, Development.

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Lawrence Lum, Michael G. Roth, Jianming Lu, 2008, Nature chemical biology.

Label-free detection of small-molecule-protein interactions by using nanowire nanosensors.

Charles M Lieber, Charles M. Lieber, Keng-hui Lin, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Catalytic asymmetric [3+2] cycloaddition of azomethine ylides. Development of a versatile stepwise, three-component reaction for diversity-oriented synthesis.

S. Schreiber, Xiaodong Li, Chuo Chen, 2003, Journal of the American Chemical Society.

Convergent diversity-oriented synthesis of small-molecule hybrids.

Stuart L Schreiber, S. Schreiber, Xiaodong Li, 2005, Angewandte Chemie.

Identification and characterization of β-sitosterol target proteins.

B. Lomenick, Jing Huang, Chuo Chen, 2015, Bioorganic & medicinal chemistry letters.

Avoid the trap: targeting PARP1 beyond human malignancy.

Yonghao Yu, Chuo Chen, Chiho Kim, 2021, Cell chemical biology.

Dimeric pyrrole-imidazole alkaloids: synthetic approaches and biosynthetic hypotheses.

Chuo Chen, Zhiqiang Ma, Xiao Wang, 2014, Chemical communications.

Syntheses of Sceptrins and Nakamuric Acid and Insights into the Biosyntheses of Pyrrole-Imidazole Dimers.

Chuo Chen, Zhi‐Xiang Yu, Yang Gao, 2015, Organic chemistry frontiers : an international journal of organic chemistry.

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN)

L. Lum, Chuo Chen, James Kim, 2019, The Journal of Biological Chemistry.

Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine*

L. Lum, Courtney M. Karner, Alessandro Mongera, 2012, The Journal of Biological Chemistry.

A Highly Selective Vanadium Catalyst for Benzylic C-H Oxidation.

Chuo Chen, K. Cormier, J. Xia, 2012, Chemical science.

Visible light-promoted metal-free C-H activation: diarylketone-catalyzed selective benzylic mono- and difluorination.

Chuo Chen, Chen Zhu, J. Xia, 2013, Journal of the American Chemical Society.

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis

She Chen, Chuo Chen, Zhigao Wang, 2020, Proceedings of the National Academy of Sciences.

Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles

C. Zhang, Chuo Chen, Lin You, 2016, Molecules.

Vanadium-Catalyzed C(sp3)-H Fluorination Reactions.

Chuo Chen, Yuyong Ma, J. Xia, 2014, Organic chemistry frontiers : an international journal of organic chemistry.

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.

L. Lum, M. Roth, E. Hirsch, 2014, Chemistry & biology.

Chemical and biological studies of nakiterpiosin and nakiterpiosinone.

L. Lum, Chuo Chen, Shuanhu Gao, 2010, Journal of the American Chemical Society.

Tankyrase is necessary for canonical Wnt signaling during kidney development

L. Lum, Courtney M. Karner, T. Carroll, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

Nickel-Catalyzed Carbonylative Negishi Cross-Coupling Reactions.

Chuo Chen, Qiaoling Wang, 2008 .

(+)-1(S), 5(R), 8(S)-8-phenyl-2-azabicyclo[3.3.0]octan-8-ol n,o-methylboronate (2) and its enantiomer, chiral chemzymes which serve as catalysts for their own enantioselective synthesis

E. Corey, Chuo Chen, G. Reichard, 1989 .

Synthesis of (+)-CP-263,114 [20]

Chuo Chen, M. Shair, S. Sheehan, 2000 .

Synthesis and structure revision of nakiterpiosin.

Chuo Chen, Shuanhu Gao, Qiaoling Wang, 2009, Journal of the American Chemical Society.

Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

L. Lum, N. Williams, Chuo Chen, 2009, Bioorganic & medicinal chemistry letters.

Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog

Jingcheng Wang, Jin Ye, Chuo Chen, 2021, The Journal of biological chemistry.

The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids.

L. Lum, Jie Liu, B. Lomenick, 2012, Synlett : accounts and rapid communications in synthetic organic chemistry.

Ketone-catalyzed photochemical C(sp3)-H chlorination.

Chuo Chen, J. Xia, Lin You, 2017, Tetrahedron.

Visible light-promoted metal-free sp(3)-C-H fluorination.

Chuo Chen, Chen Zhu, J. Xia, 2014, Chemical communications.

Visible Light‐Promoted Metal‐Free C—H Activation: Diarylketone‐Catalyzed Selective Benzylic Mono‐ and Difluorination.

Chuo Chen, Chen Zhu, J. Xia, 2014 .

Abnormal and regioselective Wacker oxidation of 1,5-dienes

Chuo Chen, T. Ho, M. Chang, 2003 .

Natural products as inspiration for the development of new synthetic methods.

Chuo Chen, Zhiqiang Ma, 2018, Journal of the Chinese Chemical Society. Zhongguo hua xue hui.

Syntheses of Cyclic Guanidine-Containing Natural Products.

Chuo Chen, Saptarshi De, Yuyong Ma, 2015, Tetrahedron.

Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F.

Chuo Chen, Shuanhu Gao, Qiaoling Wang, 2015, Tetrahedron letters.

Palladium-catalyzed direct functionalization of imidazolinone: synthesis of dibromophakellstatin.

Chuo Chen, Jianming Lu, Xianghui Tan, 2007, Journal of the American Chemical Society.

Vanadium-catalyzed oxidative Strecker reaction: α-C-H cyanation of para-methoxyphenyl (PMP)-protected primary amines.

Chuo Chen, Chen Zhu, J. Xia, 2014, Tetrahedron letters.

Rapid access to the core skeleton of the [3 + 2]-type dimeric pyrrole-imidazole alkaloids by triplet ketone-mediated C-H functionalization.

Chuo Chen, Lin You, 2018, Tetrahedron.

Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the Spirocenter.

Chuo Chen, Zhiqiang Ma, Lin You, 2017, The Journal of organic chemistry.

Syntheses of Cyclic Guanidine‐Containing Natural Products

Chuo Chen, Saptarshi De, Yuyong Ma, 2015 .

An approach for the synthesis of nakamuric acid.

Chuo Chen, Xiaolei Wang, 2015, Tetrahedron.

Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence

P. Baran, A. Rheingold, Chuo Chen, 2014, Science.

A biomimetic route for construction of the [4+2] and [3+2] core skeletons of dimeric pyrrole-imidazole alkaloids and asymmetric synthesis of ageliferins.

Chuo Chen, Zhiqiang Ma, Jianming Lu, 2012, Journal of the American Chemical Society.

Asymmetric synthesis of ageliferin.

Chuo Chen, Zhiqiang Ma, Jianming Lu, 2011, Journal of the American Chemical Society.

Revisiting the Kinnel-Scheuer hypothesis for the biosynthesis of palau'amine.

Chuo Chen, Zhiqiang Ma, Jianming Lu, 2011, Chemical communications.

Regiocontrol in Mn(III)-mediated oxidative heterobicyclizations: access to the core skeletons of oroidin dimers.

Chuo Chen, Xianghui Tan, 2006, Angewandte Chemie.

Asymmetric Synthesis of Axinellamines A and B.

Chuo Chen, Zhiqiang Ma, Xiao Wang, 2016, Angewandte Chemie.

The past, present, and future of the Yang reaction.

Chuo Chen, 2016, Organic & biomolecular chemistry.

An approach to the core skeleton of lancifodilactone F.

Chuo Chen, Chuo Chen, Qiaoling Wang, 2008, Organic letters.

10th anniversary of discovering cGAMP: synthesis and beyond.

Chuo Chen, 2023, Organic chemistry frontiers : an international journal of organic chemistry.

Tumor-targeted delivery of a STING agonist improves cancer immunotherapy

Zhijian J. Chen, Youtong Wu, Chuo Chen, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING

Zhijian J. Chen, Chuo Chen, Jiaxi Wu, 2015, Proceedings of the National Academy of Sciences.

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.

Zhijian J. Chen, Xuewu Zhang, Lijun Sun, 2013, Molecules and Cells.

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Zhijian J. Chen, Lijun Sun, Xiang Chen, 2013, Science.

A simple method for the electrophilic cyanation of secondary amines.

Chuo Chen, Chen Zhu, J. Xia, 2014, Organic letters.

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

T. Graeber, T. Cloughesy, H. Christofk, 2015, Cell metabolism.

cGAS is essential for the antitumor effect of immune checkpoint blockade

Zhijian J. Chen, Lijun Sun, Xiang Chen, 2017, Proceedings of the National Academy of Sciences.

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains.

L. Lum, D. Beis, Alessandro Mongera, 2012, Developmental biology.

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

L. Lum, J. Shay, Z. Otwinowski, 2015, Molecular and Cellular Biology.

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

L. Lum, Jian Xu, C. Zhang, 2018, EBioMedicine.

2-Hydroxyglutarate Inhibit s ATP Synthase andmTOR Signaling Graphical

T. Graeber, T. Cloughesy, H. Christofk, 2015 .

Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation

L. Lum, E. Olson, Courtney M. Karner, 2013, Nature Cell Biology.

The development of highly potent inhibitors for porcupine.

L. Lum, N. Williams, T. Carroll, 2013, Journal of medicinal chemistry.

Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

Yonghao Yu, Peng Li, Chuo Chen, 2019, Nature Chemical Biology.

Response to Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence”

P. Baran, A. Rheingold, Chuo Chen, 2015, Science.

Potent inhibitors of the hedgehog signaling pathway

Chuo Chen, 2008 .

Stereospecific Synthesis of the CP-263,114 Core Structure

Chuo Chen, M. Shair, M. E. Layton, 1998 .

Development of a triazole class of highly potent Porcn inhibitors.

L. Lum, N. Williams, Chuo Chen, 2016, Bioorganic & medicinal chemistry letters.

Synthesis, preliminary biological evaluation and 3D-QSAR study of novel 1,5-disubstituted-2(1H)-pyridone derivatives as potential anti-lung cancer agents

Qianbin Li, Gaoyun Hu, Chuo Chen, 2016 .

Visible light-promoted metal-free C-H activation: diarylketone-catalyzed selective benzylic mono- and difluorination.

Chuo Chen, Chen Zhu, J. Xia, 2013, Journal of the American Chemical Society.

A synthetic combinatorial approach to disabling deviant Hedgehog signaling

L. Lum, Chuo Chen, Chih-wei Fan, 2018, Scientific Reports.

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.

Zhijian J. Chen, Xuewu Zhang, Lijun Sun, 2013, Molecular cell.

Tankyrase is necessary for canonical Wnt signaling during kidney development

L. Lum, Courtney M. Karner, T. Carroll, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation.

L. Lum, M. Roth, E. Hirsch, 2015, Chemistry & biology.

Chemical and biological studies of nakiterpiosin and nakiterpiosinone.

L. Lum, Chuo Chen, Shuanhu Gao, 2010, Journal of the American Chemical Society.

Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration.

Chuo Chen, Wei‐chen Chang, Yong Lu, 2023, Angewandte Chemie.