P. Bernard

发表

Reverse Pharmacognosy: Application of Selnergy, a New Tool for Lead Discovery. The Example of ε-Viniferin

Q. Do, Isabelle Renimel, P. André, 2005 .

Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors.

T. Scior, P. Bernard, M. Hibert, 2001, Phytochemistry.

Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin.

Philippe Bernard, Quoc-Tuan Do, Claire Lugnier, 2005, Current drug discovery technologies.

Validation of protein-based alignment in 3D quantitative structure-activity relationships with CoMFA models.

A. Golbraikh, J. Chrétien, P. Bernard, 2000, European journal of medicinal chemistry.

Protein‐based virtual screening of chemical databases. II. Are homology models of g‐protein coupled receptors suitable targets?

Didier Rognan, Philippe Bernard, Marcel Hibert, 2002, Proteins.

Optimization and validation of a docking-scoring protocol; application to virtual screening for COX-2 inhibitors.

Luc Morin-Allory, Philippe Bernard, Jean-Christophe Mozziconacci, 2005, Journal of medicinal chemistry.

Molecular modeling of the GABA/GABA(B) receptor complex.

D. Guédin, P. Bernard, M. Hibert, 2001, Journal of medicinal chemistry.

Non‐supervised Neural Networks: A New Classification Tool to Process Large Databases

Philippe Bernard, Jacques R. Chrétien, Dmitri B. Kireev, 2007 .

Reverse Pharmacognosy: A Tool to Accelerate the Discovery of New Bioactive Food Ingredients

N. Seeram, A. Slitt, T. Peppard, 2014 .

Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.

Philippe Bernard, Florence Popowycz, Laurent Meijer, 2009, Journal of medicinal chemistry.

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

L. Meijer, J. Endicott, G. Fournet, 2008, Molecular Cancer Therapeutics.

Synthesis of 8‐Substituted Pyrazolo[1,5‐a]‐1,3,5‐triazine Derivatives by Palladium‐Catalyzed Cross‐Coupling Reactions.

P. Bernard, F. Popowycz, P. Raboisson, 2007 .

Development of Hinoline® as a natural preservative for cosmetic product using bioinspiration and Greenpharma Database

Q. Do, P. Bernard, Thibaut Saguet, 2021, Journal of applied microbiology.

Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

H. Abdallah, T. Scior, Q. Do, 2010, Drug design, development and therapy.

Modulating testosterone pathway: a new strategy to tackle male skin aging?

T. Scior, Q. Do, P. Bernard, 2012, Clinical interventions in aging.

A strategy to discover decoy chemokine ligands with an anti-inflammatory activity

J. Galzi, N. Frossard, J. Haiech, 2015, Scientific Reports.

Are vanadium compounds drugable? Structures and effects of antidiabetic vanadium compounds: a critical review.

T. Scior, Q. Do, P. Bernard, 2005, Mini reviews in medicinal chemistry.

Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.

C. Galmarini, F. Kozielski, Q. Do, 2009, Journal of medicinal chemistry.

New imidazo[1,2-b]pyrazoles as anticancer agents: synthesis, biological evaluation and structure activity relationship analysis.

R. Kiss, V. Mathieu, C. Jarry, 2014, European journal of medicinal chemistry.

Purple tulip extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied

P. Bernard, N. Hajem, J. Choulot, 2020, Journal of cosmetic dermatology.

para-Sulfonated Calixarenes Used as Synthetic Receptors for Complexing Photolabile Cholinergic Ligand

Ling Peng, F. Ziarelli, P. Bernard, 2005 .

3D Model of the Acetylcholinesterase Catalytic Cavity Probed by Stereospecific Organophosphorous Inhibitors

J. Chrétien, P. Bernard, D. Kireev, 1998 .

Efficient synthesis and first regioselective C-3 direct arylation of imidazo[1,2-b]pyrazoles.

J. Leger, C. Jarry, P. Bernard, 2012, Chemistry.

Why Antidiabetic Vanadium Complexes are Not in the Pipeline of “Big Pharma” Drug Research? A Critical Review

T. Scior, Q. Do, P. Bernard, 2016, Current medicinal chemistry.

A new synthetic approach to the imidazo[1,5-a]imidazole-2-one scaffold and effective functionalization through Suzuki–Miyaura cross coupling reactions

P. Bernard, M. Akssira, G. Guillaumet, 2016 .

Ligandless Palladium-Catalyzed Regioselective Direct C-H Arylation of Imidazo[1,2-a]imidazole Derivatives.

C. Jarry, P. Bernard, G. Guillaumet, 2015, The Journal of organic chemistry.

Access to Imidazo[1,2‐a]imidazolin‐2‐ones and Functionalization through Suzuki–Miyaura Cross‐Coupling Reactions

J. Leger, C. Jarry, P. Bernard, 2013 .

Structural analysis of 21-hydroxypregn-4-ENE-3,20-dione (deoxycorticosterone) derivative compounds. Part I: Synthesis and circular dichroism identification

P. Bernard, M. Petit-Ramel, Luc Kouadio, 1988, Steroids.

Efficient C-7 or C-3/C-7 Direct Arylation of Tri- or Disubstituted Imidazo[1,2-b]pyrazoles

P. Bernard, G. Guillaumet, Sandrine Grosse, 2013 .

Cyclic nucleotide phosphodiesterase type 4 inhibitors: evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere.

R. DesJarlais, J. Bourguignon, J. Reimund, 2003, European journal of medicinal chemistry.

Mutually induced formation of host-guest complexes between p-sulfonated calix[8]arene and photolabile cholinergic ligands.

Ling Peng, P. Bernard, M. Goeldner, 2002, Angewandte Chemie.

Preliminary screening of some tropical plants for anti-tyrosinase activity.

T Scior, T. Scior, Q. Do, 2002, Journal of ethnopharmacology.

The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells

S. Faure, Q. Do, P. Bernard, 2016, Scientific Reports.

Large compound databases for structure-activity relationships studies in drug discovery.

Thomas Scior, Philippe Bernard, J. Medina-Franco, 2007, Mini reviews in medicinal chemistry.

Inframolecular Protonation Process of myo-Inositol 1,4,5-Tris(phosphate) and Related Compounds: Dynamics of the Intramolecular Interactions and Evidence of C−H···O Hydrogen Bonding

P. Bernard, B. Spiess, M. Felemez, 2000 .

New Biological Activities of Lythrum salicaria L.: Effects on Keratinocytes, Reconstructed Epidermis and Reconstructed Skins, Applications in Dermo-Cosmetic Sciences

P. Bernard, C. Elfakir, F. Bernard, 2017 .

Application of drug repositioning strategy to TOFISOPAM.

T. Scior, Q. Do, C. Lugnier, 2008, Current medicinal chemistry.

Protein-based alignment in 3D QSAR of 26 indole inhibitors of human pancreatic phospholipase A2.

M. Pintore, J. Chrétien, P. Bernard, 2001, European journal of medicinal chemistry.

Pharmacognosy and reverse pharmacognosy: a new concept for accelerating natural drug discovery.

Philippe Bernard, Quoc-Tuan Do, Q. Do, 2004, IDrugs : the investigational drugs journal.

Comparison of chemical databases : Analysis of molecular diversity with self Organising maps (SOM)

Alexander Golbraikh, Philippe Bernard, Jacques R. Chrétien, 1998 .

Application of Kohonen Neural Networks in classification of biologically active compounds.

J R Chretien, D B Kirew, P Bernard, 1998, SAR and QSAR in environmental research.

Automated docking of 82 N-benzylpiperidine derivatives to mouse acetylcholinesterase and comparative molecular field analysis with 'natural' alignment

Philippe Bernard, Jacques R. Chrétien, Dmitri B. Kireev, 1999, J. Comput. Aided Mol. Des..

A Cornflower Extract Containing N-Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX

Q. Do, P. Bernard, C. Rakers, 2021, Mediators of inflammation.

Fluorescence resonance energy transfer to probe human M1 muscarinic receptor structure and drug binding properties

J. Galzi, J. Bourguignon, B. Ilien, 2003, Journal of neurochemistry.

Convergent Modeling Strategies to Account for SAR on 3-aminopyridazines Binding to m1 Muscarinic Receptor

Philippe Bernard, Marcel Hibert, C. Wermuth, 2000 .

How to Valorize Biodiversity? Letʼs Go Hashing, Extracting, Filtering, Mining, Fishing

José L Medina-Franco, Thomas Scior, Quoc Tuan Do, 2015, Planta Medica.

The Combination of Marketed Antagonists of α1b-Adrenergic and 5-HT2A Receptors Inhibits Behavioral Sensitization and Preference to Alcohol in Mice: A Promising Approach for the Treatment of Alcohol Dependence

J. Bizot, A. Puech, J. Tassin, 2016, PloS one.

How to recognize and workaround pitfalls in QSAR studies: a critical review.

T Scior, J L Medina-Franco, Q-T Do, 2009, Current medicinal chemistry.

A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A2.

M. Pintore, J. Chrétien, P. Bernard, 2001, European journal of medicinal chemistry.

Structural analysis of 21-hydroxypregn-4-ENE-3,20-dione (deoxycorticosterone) derivative compounds. Part II: Proton NMR spectra

P. Bernard, M. Petit-Ramel, H. Pinatel, 1988, Steroids.

Reverse pharmacognosy: identifying biological properties for plants by means of their molecule constituents: application to meranzin.

Luc Morin-Allory, Philippe Bernard, Quoc-Tuan Do, 2007, Planta medica.

How to Valorize Biodiversity? Letʼs Go Hashing, Extracting, Filtering, Mining, Fishing

J. Medina-Franco, T. Scior, Q. Do, 2015, Planta Medica.

Efficient synthesis and first regioselective C-3 direct arylation of imidazo[1,2-b]pyrazoles.

J. Leger, C. Jarry, P. Bernard, 2012, Chemistry.

Using 2.2-cyclolignans as agents promoting the pigmentation of the skin or hair

P. Bernard, 2007 .