S. Somanathan

发表

Targeting of PCNA to sites of DNA replication in the mammalian cell nucleus.

R. Berezney, A. Siegel, S. Somanathan, 2001, Journal of cellular biochemistry.

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

Ravi A. Desai, Lili Wang, Christopher S. Chen, 2006, Nature Medicine.

BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.

James M. Wilson, S. Somanathan, E. Breous, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Three-Dimensional Visualization of Transcription Sites and Their Association with Splicing Factor–Rich Nuclear Speckles

Ronald Berezney, R. Berezney, J. Samarabandu, 1999, The Journal of cell biology.

Nuclear matrix bound fibroblast growth factor receptor is associated with splicing factor rich and transcriptionally active nuclear speckles

R. Berezney, E. Stachowiak, M. Stachowiak, 2003, Journal of cellular biochemistry.

Targeting of PCNA to sites of DNA replication in the mammalian cell nucleus *

R. Berezney, A. Siegel, S. Somanathan, 2001 .

A New Genetic Vaccine Platform Based on an Adeno-Associated Virus Isolated from a Rhesus Macaque

James M. Wilson, L. Vandenberghe, S. Somanathan, 2009, Journal of Virology.

AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia

D. Rader, James M. Wilson, Q. Wang, 2014, Circulation research.

Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.

Sadik H. Kassim, D. Rader, James M. Wilson, 2013, Human gene therapy.

Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia.

Sadik H. Kassim, D. Rader, M. Lock, 2013, Human gene therapy. Clinical development.

Lung homing CTLs and their proliferation ability are important correlates of vaccine protection against influenza.

James M. Wilson, S. Somanathan, R. Calcedo, 2010, Vaccine.

Developing a second-generation clinical candidate AAV vector for gene therapy of familial hypercholesterolemia

Lili Wang, James M. Wilson, Hongwei Yu, 2021, Molecular therapy. Methods & clinical development.

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

James M. Wilson, L. Vandenberghe, S. Somanathan, 2009, Hepatology.

Mapping an Adeno-associated Virus 9-Specific Neutralizing Epitope To Develop Next-Generation Gene Delivery Vectors

A. Giles, L. Govindasamy, James M. Wilson, 2018, Journal of Virology.

Host Immune Responses to Chronic Adenovirus Infections in Human and Nonhuman Primates

Lili Wang, James M. Wilson, L. Vandenberghe, 2008, Journal of Virology.

TLR9 signaling mediates adaptive immunity following systemic AAV gene therapy.

A. Giles, James M. Wilson, S. Somanathan, 2019, Cellular immunology.

Novel adenoviral vectors coding for GFP-tagged wtCFTR and ΔF508-CFTR: characterization of expression and electrophysiological properties in A549 cells

James M. Wilson, G. Gao, S. Somanathan, 2004, Pflügers Archiv.

Inflammation promotes the loss of adeno-associated virus-mediated transgene expression in mouse liver.

James M. Wilson, S. Somanathan, P. Bell, 2011, Gastroenterology.

AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cells.

James M. Wilson, S. Somanathan, P. Bell, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Connecting nuclear architecture and genomic function

Sinno Jialin Pan, P. Cheng, R. Berezney, 1996, Journal of cellular biochemistry.

Alternative Start Sites Downstream of Non-Sense Mutations Drive Antigen Presentation and Tolerance Induction to C-Terminal Epitopes

James M. Wilson, S. Somanathan, C. Draper, 2017, The Journal of Immunology.

Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency

T. Flotte, M. Betts, James M. Wilson, 2017, Proceedings of the National Academy of Sciences.

Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids.

Lili Wang, James M. Wilson, Hongwei Yu, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.

T. Flotte, B. Trapnell, James M. Wilson, 2013, The Journal of clinical investigation.

Higher Seroprevalence of Anti-Adeno-Associated Viral Vector Neutralizing Antibodies Among Racial Minorities in the United States

S. Somanathan, Shunjie Guan, R. Shelke, 2022, Human Gene Therapy.

Adeno-associated viruses undergo substantial evolution in primates during natural infections

M. R. Delgado Alvira, James M. Wilson, L. Vandenberghe, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial.

James M. Wilson, S. Somanathan, R. Calcedo, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol.

D. Rader, James M. Wilson, J. Billheimer, 2016, Cardiovascular research.

In vivo overexpression of frataxin causes toxicity mediated by iron-sulfur cluster deficiency

C. Bulawa, Chunyan Su, I. Pardo, 2022, Molecular therapy. Methods & clinical development.

In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection.

S. Diamond, James M. Wilson, S. Somanathan, 2014, Human gene therapy.

Complement Activation by Adeno-Associated Virus-Neutralizing Antibody Complexes

Joel D. Federspiel, S. Somanathan, A. D'Antona, 2023, Human gene therapy.

Higher Seroprevalence of Anti-Adeno-Associated Viral Vector Neutralizing Antibodies Among Racial Minorities in the United States

S. Somanathan, Shunjie Guan, R. Shelke, 2021, Human gene therapy.

Binding and neutralizing anti-AAV antibodies: Detection and implications for rAAV-mediated gene therapy

B. Byrne, C. Petropoulos, Seng H. Cheng, 2023, Molecular therapy : the journal of the American Society of Gene Therapy.

Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.

T. Flotte, B. Trapnell, James M. Wilson, 2013, The Journal of clinical investigation.

Rationale for using centralized transduction inhibition assays in three phase 3 rAAV gene therapy clinical trials

S. Somanathan, G. Bashirians, Martin Schulz, 2023, Molecular Therapy. Methods & Clinical Development.

Three-Dimensional Visualization of Transcription Sites and Their Association with Splicing Factor–Rich Nuclear Speckles

R. Berezney, J. Samarabandu, S. Somanathan, 1999, The Journal of cell biology.