Qun Wang

发表

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

K. Ye, Yu Luo, Z. Yue, 2016, Oncotarget.

Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response

Qian-Qian Jiang, Xin-an Liu, Q. Tian, 2012, Apoptosis.

Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus

Dao-Wen Wang, Xinwen Zhou, Q. Tian, 2008, Neurobiology of Aging.

Phosphorylation of SET mediates apoptosis via P53 hyperactivation and NM23-H1 nuclear import

Jian-Zhi Wang, Xiaochuan Wang, Bin Zhang, 2018, Neurobiology of Aging.

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

Bin Zhang, Jian-Zhi Wang, Xiaochuan Wang, 2019, Acta Neuropathologica Communications.

Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.

B. Liu, Xiong Wang, X. Yao, 2011, The Biochemical journal.

Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A)*

Jian-Zhi Wang, Qun Wang, Youming Lu, 2012, The Journal of Biological Chemistry.

In vitro analysis of tau phosphorylation sites and its biological activity.

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2002, Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.

Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.

Xin-an Liu, Rong-zhen Liu, Q. Tian, 2010, Journal of Alzheimer's disease : JAD.

Upregulation of astrocytes protein phosphatase‐2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice

Jian-Zhi Wang, Xiu-Ping Liu, Qun Wang, 2012, Glia.

Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.

Q. Tian, Jian-Zhi Wang, Xiaochuan Wang, 2011, Journal of Alzheimer's disease : JAD.

High salt induced hypertension leads to cognitive defect

Bin Zhang, Jian-Zhi Wang, Qun Wang, 2017, Oncotarget.

Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration

Jian-Zhi Wang, Qiuzhi Zhou, Shihong Li, 2022, EBioMedicine.

Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice

Jian-Zhi Wang, Xiaochuan Wang, Qun Wang, 2020, Translational Psychiatry.

Inflammation-dependent ISG15 upregulation mediates MIA-induced dendrite damages and depression by disrupting NEDD4/Rap2A signaling.

Jian-Zhi Wang, Dong-sheng Sun, Yu Hu, 2019, Biochimica et biophysica acta. Molecular basis of disease.

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

Jian-Zhi Wang, Xin Wang, Ying Yang, 2020, Signal Transduction and Targeted Therapy.

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

K. Ye, Yu Luo, Jian-Zhi Wang, 2016, Scientific Reports.

Inhibition of protein phosphatases induces transport deficits and axonopathy

Q. Tian, Jian-Zhi Wang, Ying Yang, 2007, Journal of neurochemistry.

Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.

Jian-Zhi Wang, Xiaochuan Wang, Bin Zhang, 2018, Current Alzheimer research.

Silencing I2PP2A Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice

Jian-Zhi Wang, Xia-Chun Li, Qun Wang, 2014, Front. Aging Neurosci..

Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms

X. Yao, Jian-Zhi Wang, Qun Wang, 2008, Neurobiology of Aging.

Effect of melatonin on calyculin A-induced tau hyperphosphorylation.

Jian-Zhi Wang, Xia-Chun Li, Qun Wang, 2005, European journal of pharmacology.

Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2

Jian-Zhi Wang, Qun Wang, Ling-Qiang Zhu, 2010, The Journal of Neuroscience.

Relationship of Adult Neurogenesis with Tau Phosphorylation and GSK-3β Activity in Subventricular Zone

Q. Tian, Jian-Zhi Wang, Qun Wang, 2011, Neurochemical Research.

Glycogen synthase kinase‐3β regulates leucine‐309 demethylation of protein phosphatase‐2A via PPMT1 and PME‐1

B. Liu, X. Yao, Jian-Zhi Wang, 2012, FEBS letters.

Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer’s Disease-Like Features in Rats

Xinwen Zhou, Q. Tian, Jian-Zhi Wang, 2018, The international journal of neuropsychopharmacology.

Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration

Jian-Zhi Wang, Xiaochuan Wang, Qun Wang, 2021, Molecular Neurobiology.

Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin.

Q. Tian, Jian-Zhi Wang, Qun Wang, 2009, Journal of Alzheimer's disease : JAD.

Effect of PP-2A on neurite outgrowth in neuronal cells

Qun Wang, Ling-Qiang Zhu, Dan Liu, 2010, In Vitro Cellular & Developmental Biology - Animal.

P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities

Qiuzhi Zhou, Shihong Li, Ying Yang, 2022, Clinical and translational medicine.

Knockdown of phosphotyrosyl phosphatase activator induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation

Jian-Zhi Wang, Dong-sheng Sun, Zhi-hao Wang, 2014, Journal of neurochemistry.

Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats

X. Yao, Jian-Zhi Wang, Xiu-Ping Liu, 2015, Neuroscience Letters.

Effects of endogenous β‐amyloid overproduction on tau phosphorylation in cell culture

Huaxi Xu, Q. Tian, Jian-Zhi Wang, 2006, Journal of neurochemistry.

Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response

Qian-Qian Jiang, Xin-an Liu, Q. Tian, 2012, Apoptosis.

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice

Jian-Zhi Wang, Xiaochuan Wang, Bin Zhang, 2018, Front. Mol. Neurosci..

Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case–Control Study

Jian-Zhi Wang, Xin Wang, Qiuzhi Zhou, 2016, EBioMedicine.

Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 × TgAD Mice

Jian-Zhi Wang, Dong-sheng Sun, Qun Wang, 2016, Molecular Neurobiology.

Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice

Xia Jiang, Zhi-wei Ma, Jian-Zhi Wang, 2015, Scientific Reports.

Betaine attenuates Alzheimer‐like pathological changes and memory deficits induced by homocysteine

Xia Jiang, Xiang-Shu Cheng, Zhi-wei Ma, 2013, Journal of neurochemistry.

Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats

Jian-Zhi Wang, Xiaochuan Wang, Bin Zhang, 2018, Aging.

Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats.

Jian-Zhi Wang, Hao Liu, Qun Wang, 2010, Journal of Alzheimer's disease : JAD.

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

Yu Luo, Jian-Zhi Wang, Ying Yang, 2020, Autophagy.

17β-estradiol attenuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner

Xin-an Liu, Q. Tian, Jian-Zhi Wang, 2008, Journal of Neural Transmission.

Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells

Qian-Qian Jiang, Q. Tian, Jian-Zhi Wang, 2013, PloS one.

Protection of melatonin against acidosis‐induced neuronal injuries

Xinwen Zhou, Q. Tian, Peng Zeng, 2020, Journal of cellular and molecular medicine.

GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory

Qiuzhi Zhou, Shujuan Zhang, Shihong Li, 2017, Scientific Reports.

LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro.

Qian-Qian Jiang, Q. Tian, Jian-Zhi Wang, 2010, Journal of Alzheimer's disease : JAD.

CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment

K. Ye, Jian-Zhi Wang, Xiaochuan Wang, 2018, Frontiers in Molecular Neuroscience.

PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.

Jian-Zhi Wang, Qun Wang, Gong-Ping Liu, 2013, Biochimica et biophysica acta.

Inhibition of Melatonin Biosynthesis Induces Neurofilament Hyperphosphorylation with Activation of Cyclin-dependent Kinase 5

Q. Tian, Jian-Zhi Wang, Qun Wang, 2007, Neurochemical Research.

Peroxynitrite induces Alzheimer‐like tau modifications and accumulation in rat brain and its underlying mechanisms

Ying-Hua Liu, Jian-Zhi Wang, Qun Wang, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell

Jian-Zhi Wang, Qun Wang, Ling-Qiang Zhu, 2005, Acta Pharmacologica Sinica.

Melatonin attenuates beta-amyloid-induced inhibition of neurofilament expression.

Jian-Zhi Wang, Qun Wang, Yi-peng Wang, 2004, Acta pharmacologica Sinica.

Melatonin attenuates β-amyloid-induced inhibition of neurofilament expression 1

Jian-Zhi Wang, Qun Wang, Yi-peng Wang, 2004 .

Overactivation of glycogen synthase kinase‐3 by inhibition of phosphoinositol‐3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory

W. Netzer, Huaxi Xu, Qun Wang, 2003, Journal of neurochemistry.

Acetyl-L-carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities.

Peng Zhou, Jian-Zhi Wang, Qun Wang, 2011, Rejuvenation research.

Tau accumulation triggers STAT1‐dependent memory deficits by suppressing NMDA receptor expression

K. Ye, Jian-Zhi Wang, Shujuan Zhang, 2019, EMBO reports.

Tau accumulation activates STAT1 triggering memory deficits via suppressing NMDA receptor expression

K. Ye, Jian-Zhi Wang, Shujuan Zhang, 2018, bioRxiv.

I2 PP2A regulates p53 and Akt correlatively and leads the neurons to abort apoptosis

X. Yao, Jian-Zhi Wang, Qun Wang, 2012, Neurobiology of Aging.

Blockage of AEP attenuates TBI-induced tau hyperphosphorylation and cognitive impairments in rats

Jian-Zhi Wang, Xiaochuan Wang, Qun Wang, 2020, Aging.

CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment

K. Ye, Jian-Zhi Wang, Xiaochuan Wang, 2018, Front. Mol. Neurosci..

BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease

Bin Zhang, K. Ye, Jian-Zhi Wang, 2018, Proceedings of the National Academy of Sciences.

Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain*

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2004, Journal of Biological Chemistry.

Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3β and preservation of postsynaptic components.

Xiong Wang, Jian-Zhi Wang, Qun Wang, 2013, Journal of Alzheimer's disease : JAD.

14-3-3ζ Captures SET in the Cytoplasm, Mediating Tau Pathology and Cognitive Impairments

Bin Zhang, V. Haroutunian, E. Wang, 2021 .

Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice.

X. Yao, Jian-Zhi Wang, Xia-Chun Li, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Xinwen Zhou, Q. Tian, Xiao-ming Wang, 2016, Molecular Neurobiology.

Activation of Glycogen Synthase Kinase-3 Inhibits Long-Term Potentiation with Synapse-Associated Impairments

Jian-Guo Chen, Q. Tian, Jian-Zhi Wang, 2007, The Journal of Neuroscience.

Repeated Restraint Stress Led to Cognitive Dysfunction by NMDA Receptor-Mediated Hippocampal CA3 Dendritic Spine Impairments in Juvenile Sprague-Dawley Rats

Dong-sheng Sun, Yu Hu, Qun Wang, 2020, Frontiers in Molecular Neuroscience.

Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice

Jian-Zhi Wang, Xiaochuan Wang, Qun Wang, 2020, Aging.

Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation

Xiong Wang, Q. Tian, Jian-Zhi Wang, 2017, Neuroscience Bulletin.

STAT3 ameliorates cognitive deficits via regulation of NMDAR expression in an Alzheimer's disease animal model

Jian-Zhi Wang, Qun Wang, Gong-Ping Liu, 2021, Theranostics.

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit

Jian-Zhi Wang, Xiaochuan Wang, Qun Wang, 2017, Scientific Reports.

Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice

Xia Jiang, Jian-Zhi Wang, Dong-sheng Sun, 2017, Neuropharmacology.

Neuroglobin attenuates Alzheimer‐like tau hyperphosphorylation by activating Akt signaling

Jian-Zhi Wang, Li-Ming Chen, Qun Wang, 2012, Journal of neurochemistry.

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

Jian-Zhi Wang, Xin Wang, Qiuzhi Zhou, 2021, Theranostics.

CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease

Xia Jiang, Zhi-wei Ma, Jian-Zhi Wang, 2015, Neurobiology of Aging.

Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats.

Jian-Zhi Wang, Xiaochuan Wang, Qun Wang, 2017, Current Alzheimer research.

Monosodium glutamate exposure during the neonatal period leads to cognitive deficits in adult Sprague-Dawley rats

Jian-jun Liu, Dong-sheng Sun, Qiong Feng, 2018, Neuroscience Letters.

Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats

Li Wang, D. Mousseau, Zhi-wei Ma, 2014, Neuroscience Bulletin.

Essential role of tau phosphorylation in adult hippocampal neurogenesis

Q. Tian, X. Yao, Jian-Zhi Wang, 2010, Hippocampus.

Pesticides induce spatial memory deficits with synaptic impairments and an imbalanced tau phosphorylation in rats.

Yi Wang, X. Yao, Jian-Zhi Wang, 2012, Journal of Alzheimer's disease : JAD.

Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer’s Disease-Like Pathology and Cognitive Impairments

Jian-Zhi Wang, Xiaochuan Wang, Bin Zhang, 2018, Journal of Alzheimer's disease : JAD.

The Down-Expression of ACE and IDE Exacerbates Exogenous Amyloid-β Neurotoxicity in CB2R-/- Mice.

Xinwen Zhou, Q. Tian, Jian-Zhi Wang, 2018, Journal of Alzheimer's disease : JAD.

Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase

Qing Tian, Lu Wang, Ying Yang, 2014, Neurobiology of Aging.

Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.

Q. Tian, Jian-Zhi Wang, Qun Wang, 2014, Journal of Alzheimer's disease : JAD.

GSK-3β Inhibits Presynaptic Vesicle Exocytosis by Phosphorylating P/Q-Type Calcium Channel and Interrupting SNARE Complex Formation

F. Wang, Jian-Guo Chen, Jian-Zhi Wang, 2010, The Journal of Neuroscience.

Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors.

Jian-Zhi Wang, Qun Wang, Rong Liu, 2010, Journal of Alzheimer's disease : JAD.

Proteasome inhibition increases tau accumulation independent of phosphorylation

Jian-Zhi Wang, Qun Wang, Gong-Ping Liu, 2009, Neurobiology of Aging.

Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration

Huaxi Xu, Q. Tian, Jian-Zhi Wang, 2007, Proceedings of the National Academy of Sciences.

Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats.

D. Mousseau, Q. Tian, Jian-Zhi Wang, 2011, Journal of Alzheimer's disease : JAD.

Estradiol Attenuates Tau Hyperphosphorylation Induced by Upregulation of Protein Kinase-A

Xin-an Liu, Jian-Zhi Wang, Qun Wang, 2008, Neurochemical Research.

Poststress social isolation exerts anxiolytic effects by activating the ventral dentate gyrus

Hua-qing Shu, Ying Yang, Qun Wang, 2023, Neurobiology of Stress.

SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress

Jian-Zhi Wang, Qun Wang, Jie Song, 2015, Molecular Neurobiology.

Opposite monosynaptic scaling of BLP–vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory

X. Wang, Jian-Zhi Wang, Enjie Liu, 2016, Nature Communications.

Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

Jian-Zhi Wang, Qiuzhi Zhou, Dong-sheng Sun, 2019, Translational Neurodegeneration.

Olfactory deficits induce neurofilament hyperphosphorylation

Qun Wang, Ling-Qiang Zhu, Juan Hu, 2012, Neuroscience Letters.

Estrogen Receptor α Agonist is Beneficial for Young Female Rats Against Chronic Unpredicted Mild Stress-Induced Depressive Behavior and Cognitive Deficits.

Q. Tian, Qun Wang, Fu-yuan Cao, 2020, Journal of Alzheimer's disease : JAD.

Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke

Xinwen Zhou, Jian-Zhi Wang, Qun Wang, 2018, Cell Death and Disease.

Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

Jian-Zhi Wang, Qiuzhi Zhou, Dong-sheng Sun, 2019, Translational Neurodegeneration.

GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory

Jian-Zhi Wang, Qiuzhi Zhou, Shujuan Zhang, 2017, Scientific Reports.

Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke

Xinwen Zhou, Jian-Zhi Wang, Qun Wang, 2018, Cell Death & Disease.

Tau acetylates and stabilizes β‐catenin thereby promoting cell survival

Jian-Zhi Wang, Li Li, Qiuzhi Zhou, 2020, EMBO reports.

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

Bin Zhang, Jian-Zhi Wang, Xiaochuan Wang, 2019, Acta neuropathologica communications.

Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.

Jian-Zhi Wang, Qun Wang, Caixia Peng, 2009, Journal of Alzheimer's disease : JAD.

Helicobacter pylori filtrate impairs spatial learning and memory in rats and increases β-amyloid by enhancing expression of presenilin-2

Yu-Jian Liu, Jian-Zhi Wang, Qun Wang, 2014, Alzheimer's & Dementia.

Concanavalin agglutinin levels are decreased in peripheral blood of Alzheimer's disease patients.

X. Shang, X. Yao, Jian-Zhi Wang, 2015, Journal of Alzheimer's Disease.

Protein phosphatase-2A inhibitor-2 up-regulates p53 and Akt-implication for a new mechanism for Alzheimer's neurodegeneration

X. Yao, Jian-Zhi Wang, Qun Wang, 2009, Alzheimer's & Dementia.

SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress

Q. Tian, Jian-Zhi Wang, Qun Wang, 2016, Molecular Neurobiology.

Zinc mediates the neuronal activity–dependent anti-apoptotic effect

Xinwen Zhou, H. Man, Jian-Zhi Wang, 2017, PloS one.

Inhibition of melatonin biosynthesis activates protein kinase a and induces Alzheimer-like tau hyperphosphorylation in rats.

Jian-Zhi Wang, Qun Wang, Ling-Qiang Zhu, 2005, Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.

[Mechanism of tau hyperphosphorylation in brain cortex of diabetic rats and effect of LiCl].

Xinwen Zhou, Q. Tian, Jian-Zhi Wang, 2006, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.