G. Dinos

发表

High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition

M. Svetlov, E. Plessa, Chih-Wei Chen, 2019, RNA.

Kinetic study of irreversible inhibition of an enzyme consumed in the reaction it catalyses. Application to the inhibition of the puromycin reaction by spiramycin and hydroxylamine.

G. Dinos, C. Coutsogeorgopoulos, 1997, Journal of enzyme inhibition.

Distinct Mode of Interaction of a Novel Ketolide Antibiotic That Displays Enhanced Antimicrobial Activity

Daniel N. Wilson, G. Dinos, D. Kalpaxis, 2009, Antimicrobial Agents and Chemotherapy.

Time-resolved binding of azithromycin to Escherichia coli ribosomes.

Daniel N. Wilson, A. Starosta, G. Dinos, 2009, Journal of molecular biology.

Stepwise Binding of Tylosin and Erythromycin to Escherichia coli Ribosomes, Characterized by Kinetic and Footprinting Analysis*

G. Dinos, D. Kalpaxis, E. Kouvela, 2008, Journal of Biological Chemistry.

On the Mechanism of Action of 9-O-Arylalkyloxime Derivatives of 6-O-Mycaminosyltylonolide, a New Class of 16-Membered Macrolide Antibiotics

Daniel N. Wilson, G. Dinos, L. Katz, 2006, Molecular Pharmacology.

Polyamines Affect Diversely the Antibiotic Potency

Daniel N. Wilson, G. Dinos, D. Kalpaxis, 2004, Journal of Biological Chemistry.

Erythromycin, roxithromycin, and clarithromycin: use of slow-binding kinetics to compare their in vitro interaction with a bacterial ribosomal complex active in peptide bond formation.

S. Connell, K. Nierhaus, G. Dinos, 2003, Molecular pharmacology.

Dissecting the ribosomal inhibition mechanism of a new ketolide carrying an alkyl-aryl group at C-13 of its lactone ring.

O. N. Kostopoulou, M. Krokidis, G. Dinos, 2010, International journal of antimicrobial agents.

Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex.

G. Dinos, D. Kalpaxis, M. Michelinaki, 2001, Molecular pharmacology.

Biomonitoring of Gulf of Patras, N. Peloponnesus, Greece. Application of a biomarker suite including evaluation of translation efficiency in Mytilus galloprovincialis cells.

G. Dinos, M. Leotsinidis, D. Kalpaxis, 2004, Environmental research.

Azithromycin through the Lens of the COVID-19 Treatment

G. Dinos, G. G. Kournoutou, Georgia G. Kournoutou, 2022, Antibiotics.

Investigating the entire course of telithromycin binding to Escherichia coli ribosomes

O. N. Kostopoulou, T. Choli-Papadopoulou, G. Dinos, 2012, Nucleic acids research.

New Chloramphenicol Derivatives with a Modified Dichloroacetyl Tail as Potential Antimicrobial Agents

A. Bougas, G. Dinos, C. Athanassopoulos, 2021, Antibiotics.

Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding.

Daniel N. Wilson, Witold Szaflarski, K. Nierhaus, 2004, Molecular cell.

Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions

Georgios E. Papadopoulos, G. Dinos, D. Kalpaxis, 2016, Antibiotics.

The macrolide antibiotic renaissance

G. Dinos, 2017, British journal of pharmacology.

Interaction between the antibiotic spiramycin and a ribosomal complex active in peptide bond formation.

G. Dinos, C. Coutsogeorgopoulos, D. Synetos, 1993, Biochemistry.

On the use of the antibiotic chloramphenicol to target polypeptide chain mimics to the ribosomal exit tunnel.

Daniel N. Wilson, A. Starosta, M. Krokidis, 2013, Biochimie.

Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.

O. N. Kostopoulou, G. Dinos, M. Leotsinidis, 2015, Bioorganic & medicinal chemistry.

Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol

Georgios E. Papadopoulos, O. N. Kostopoulou, M. Rodi, 2014, Nucleic acids research.

Localization of spermine binding sites in 23S rRNA by photoaffinity labeling: parsing the spermine contribution to ribosomal 50S subunit functions

Dimitrios L. Kalpaxis, G. Dinos, Maria A. Xaplanteri, 2005, Nucleic acids research.

Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action.

G. Dinos, D. Kalpaxis, M. Xaplanteri, 2003, Nucleic acids research.

Mechanism of Tet(O)‐mediated tetracycline resistance

S. Connell, K. Nierhaus, G. Dinos, 2003, The EMBO journal.

Changes in the conformation of 5S rRNA cause alterations in principal functions of the ribosomal nanomachine

G. Dinos, D. Kalpaxis, E. Kouvela, 2007, Nucleic acids research.

Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu

Daniel N. Wilson, K. Nierhaus, G. Dinos, 2005, Nucleic acids research.

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Daniel S. Terry, Daniel N. Wilson, T. Steitz, 2015, Molecular cell.

Linezolid-Dependent Function and Structure Adaptation of Ribosomes in a Staphylococcus epidermidis Strain Exhibiting Linezolid Dependence

C. Stathopoulos, S. Pournaras, G. Dinos, 2014, Antimicrobial Agents and Chemotherapy.

Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity

G. Dinos, C. Athanassopoulos, G. G. Kournoutou, 2023, Antibiotics.

Dual effect of chloramphenicol peptides on ribosome inhibition

A. Bougas, G. Dinos, S. Arenz, 2017, Amino Acids.

Oxidative Damage of Mussels Living in Seawater Enriched with Trace Metals, from the Viewpoint of Proteins Expression and Modification

G. Dinos, E. Sazakli, M. Leotsinidis, 2020, Toxics.

New Chloramphenicol Derivatives from the Viewpoint of Anticancer and Antimicrobial Activity

Georgios E. Papadopoulos, G. Dinos, E. Sazakli, 2019, Antibiotics.

The slow dissociation rate of K-1602 contributes to the enhanced inhibitory activity of this novel alkyl–aryl-bearing fluoroketolide

Maria Stavropoulou, A. Bougas, M. Krokidis, 2016, Journal of enzyme inhibition and medicinal chemistry.

Insights into the Mode of Action of Novel Fluoroketolides, Potent Inhibitors of Bacterial Protein Synthesis

Daniel N. Wilson, V. Márquez, M. Krokidis, 2013, Antimicrobial Agents and Chemotherapy.

Synthesis and Evaluation of Chloramphenicol Homodimers: Molecular Target, Antimicrobial Activity, and Toxicity against Human Cells

Georgios E. Papadopoulos, O. N. Kostopoulou, A. Mouzaki, 2015, PloS one.

Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding.

Daniel N. Wilson, Witold Szaflarski, K. Nierhaus, 2004, Molecular cell.

Insights into the Mode of Action of Novel Fluoroketolides, Potent Inhibitors of Bacterial Protein Synthesis

Daniel N. Wilson, M. Krokidis, G. Dinos, 2013, Antimicrobial Agents and Chemotherapy.

Distinct Mode of Interaction of a Novel Ketolide Antibiotic That Displays Enhanced Antimicrobial Activity

Daniel N. Wilson, G. Dinos, D. Kalpaxis, 2009, Antimicrobial Agents and Chemotherapy.