Adel A Rashad

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Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins.

Adel A Rashad, P. Keller, 2013, Journal of molecular graphics & modelling.

Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors.

Md. Alamgir Hossain, M. Kutzler, I. Chaiken, 2020, Biochemistry.

Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter.

I. Chaiken, Adel A Rashad, Irwin Chaiken, 2015, Journal of medicinal chemistry.

Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.

I. Chaiken, Huiyuan Li, Adel A Rashad, 2015, Journal of medicinal chemistry.

Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodeling and heart failure.

M. Jackson, P. Lam, B. Polyak, 2021, Cardiovascular research.

Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface.

M. Kutzler, I. Chaiken, Y. Long, 2018, Journal of medicinal chemistry.

FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2

Hisham A. Abbas, Mahmoud M. Shehata, M. Ali, 2020, Pharmaceuticals.

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

I. Chaiken, M. Root, Adel A Rashad, 2021, Retrovirology.

Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.

I. Chaiken, Adel A Rashad, Kriti Acharya, 2017, Organic & biomolecular chemistry.

Click Chemistry for Cyclic Peptide Drug Design.

Adel A Rashad, 2019, Methods in molecular biology.

Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry

M. Kutzler, I. Chaiken, C. Abrams, 2021, Microorganisms.

Pharmacokinetic stability of macrocyclic peptide triazole HIV‐1 inactivators alone and in liposomes

I. Chaiken, S. Wrenn, G. Pasut, 2019, Journal of peptide science : an official publication of the European Peptide Society.

Irreversible HIV-1 Inactivation Employing a Small Molecule Dual-Action Virolytic Entry Inhibitor Strategy

I. Chaiken, C. Abrams, Alamgir Hossain, 2019 .

Impact of HIV-1 Membrane Cholesterol on Cell-Independent Lytic Inactivation and Cellular Infectivity.

I. Chaiken, C. Abrams, S. Wrenn, 2016, Biochemistry.

Chikungunya virus: emerging targets and new opportunities for medicinal chemistry.

Adel A Rashad, P. Keller, S. Mahalingam, 2014, Journal of medicinal chemistry.

Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives

C. Pannecouque, J. Balzarini, G. Andrei, 2010, Medicinal Chemistry Research.

Synthesis and antiviral activity of new pyrazole and thiazole derivatives.

C. Pannecouque, J. Balzarini, G. Andrei, 2009, European journal of medicinal chemistry.

A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication

J. Neyts, P. Leyssen, Adel A Rashad, 2017 .

Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei.

J. Baell, V. Avery, Adel A Rashad, 2014, ACS medicinal chemistry letters.

Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2

M. Ali, G. Kayali, A. Kandeil, 2021, Pathogens.

Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer.

I. Chaiken, C. Abrams, Adel A Rashad, 2016, Biochemistry.

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Jimmy P. Xu, R. Ptak, G. Melikyan, 2018, Journal of drug design and research.

Disulfide Sensitivity in the Env Protein Underlies Lytic Inactivation of HIV-1 by Peptide Triazole Thiols.

I. Chaiken, Huiyuan Li, Adel A Rashad, 2015, ACS chemical biology.

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

A. Ward, G. Ozorowski, Adel A Rashad, 2019, Molecules.

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

Adel A Rashad, Michael B. Murphy, S. Cocklin, 2018, Molecules.

Peptide triazole inactivators of HIV-1: how do they work and what is their potential?

I. Chaiken, Adel A Rashad, 2015, Future medicinal chemistry.

Short Communication: Inhibition of DC-SIGN-Mediated HIV-1 Infection by Complementary Actions of Dendritic Cell Receptor Antagonists and Env-Targeting Virus Inactivators.

I. Chaiken, Adel A Rashad, M. Hutchinson, 2015, AIDS research and human retroviruses.

Recognition of HIV‐inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664

John P. Moore, I. Chaiken, C. Abrams, 2017, Proteins.

Synthesis, molecular modeling and anti-inflammatory screening of new 1,2,3-benzotriazinone derivatives

Adel A Rashad, S. El-feky, T. Ibrahim, 2012, Medicinal Chemistry Research.