S. Kourembanas

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Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype.

T. Wyatt, A. Fernandez-Gonzalez, S. Kourembanas, 2009, American journal of respiratory cell and molecular biology.

B. Thébaud, S. Kourembanas, 2017, The Journal of pediatrics.

Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation

M. Ericsson, Jamie N. Anastas, A. Fernandez-Gonzalez, 2018, American journal of respiratory and critical care medicine.

Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease.

O. Liang, A. Fernandez-Gonzalez, S. Kourembanas, 2009, American journal of respiratory and critical care medicine.

Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia.

Carla F. Kim, Allison N. Lau, S. Kourembanas, 2012, American journal of physiology. Lung cellular and molecular physiology.

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

D. Faller, P. Marsden, S. Kourembanas, 1991, The Journal of clinical investigation.

Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.

S. Kourembanas, S. A. Mitsialis, Sally H Vitali, 2012, American journal of physiology. Lung cellular and molecular physiology.

Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental BPD.

C. White, S. Kourembanas, S. Abman, 2020, American journal of respiratory and critical care medicine.

Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice

I. Rosas, J. Lederer, S. Kourembanas, 2021, Stem cell research & therapy.

Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension?

A. Fernandez-Gonzalez, S. Kourembanas, S. A. Mitsialis, 2018, International journal of molecular sciences.

Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells.

S. Kourembanas, S. A. Mitsialis, H. Christou, 2005, American journal of physiology. Heart and circulatory physiology.

Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency

S. Kourembanas, S. A. Mitsialis, G. Willis, 2017, Front. Cardiovasc. Med..

Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.

L. Kobzik, C. Hsieh, K. Maemura, 1999, The Journal of clinical investigation.

Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure

S. Kourembanas, 2011 .

Endothelin-1 production during the acute chest syndrome in sickle cell disease.

H. Farber, S. Kourembanas, M. Tucci, 1997, American journal of respiratory and critical care medicine.

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer*

G. Semenza, E. Laughner, S. Kourembanas, 1998, The Journal of Biological Chemistry.

Divergent Cardiopulmonary Actions of Heme Oxygenase Enzymatic Products in Chronic Hypoxia

F. McGowan, O. Liang, A. Fernandez-Gonzalez, 2009, PloS one.

Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.

H. Ott, C. Blaisdell, P. Anversa, 2013, American journal of respiratory and critical care medicine.

Immortalization of human endothelial cells by murine sarcoma viruses, without morphologic transformation

D. Faller, J. Pober, T. Collins, 1988, Journal of cellular physiology.

Perinatal stress, brain inflammation and risk of autism-Review and proposal

K. Alysandratos, S. Kourembanas, S. Asadi, 2012, BMC Pediatrics.

Newborn Chest

S. Kourembanas, R. Cleveland, J. Levin, 2019, Imaging in Pediatric Pulmonology.

Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension

B. Kalish, S. Kourembanas, Sally H Vitali, 2021, Frontiers in Cardiovascular Medicine.

Hypoxia and endothelial-smooth muscle cell interactions in the lung.

M. Bernfield, S. Kourembanas, 1994, American journal of respiratory cell and molecular biology.

Basic fibroblast growth factor increases nitric oxide synthase production in bovine endothelial cells.

S. Kostyk, S. Kourembanas, E. L. Wheeler, 1995, The American journal of physiology.

Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension.

G. Visner, Hanzhong Liu, S. Kourembanas, 2013, American journal of respiratory and critical care medicine.

Increases in the 35kDa surfactant‐associated protein and its mRNA following in vivo dexamethasone treatment of fetal and neonatal rats

J. Floros, S. Kourembanas, H. Taeusch, 1987 .

Systemic Administration of Human Bone Marrow‐Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract‐Induced Allergic Airway Inflammation in Immunocompetent Mice

D. McKenna, S. Kourembanas, S. A. Mitsialis, 2015, Stem cells translational medicine.

Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells.

T. Quertermous, M. Yoshizumi, S. Kourembanas, 1992, The Journal of biological chemistry.

Targeted Expression of Heme Oxygenase-1 and Pulmonary Responses to Hypoxia

T. Minamino, N. Abraham, C. Hsieh, 2002 .

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia

T. Minamino, N. Abraham, C. Hsieh, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model

H. Hudalla, Jun Li, S. Kourembanas, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Mesenchymal Stromal Cells Expressing Heme Oxygenase‐1 Reverse Pulmonary Hypertension

O. Liang, Eleni Vergadi, A. Fernandez-Gonzalez, 2011, Stem cells.

The Sugen 5416/Hypoxia Mouse Model of Pulmonary Hypertension Revisited: Long-Term Follow-Up

G. Hansmann, A. Fernandez-Gonzalez, S. Kourembanas, 2014, Pulmonary circulation.

Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension

O. Liang, Eleni Vergadi, A. Fernandez-Gonzalez, 2011, Circulation.

Effect of Heme Oxygenase-1 Overexpression in Two Models of Lung Inflammation

A. Zampetaki, T. Minamino, S. Kourembanas, 2003, Experimental biology and medicine.

Expanding the pool of stem cell therapy for lung growth and repair.

S. Kourembanas, 2014, Circulation.

Pulmonary Circulation | April-june 2012 | Vol 2 | No 2 170 Mesenchymal Stem Cell-mediated Reversal of Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension

G. Hansmann, A. Fernandez-Gonzalez, S. Kourembanas, 2022 .

Erratum: Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental Bronchopulmonary Dysplasia

S. Kourembanas, S. Abman, E. Mandell, 2023, American journal of respiratory and critical care medicine.

Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia.

A. Fernandez-Gonzalez, S. Kourembanas, Xianlan Liu, 2012, American journal of physiology. Lung cellular and molecular physiology.

Endothelial cells synthesize basic fibroblast growth factor and transforming growth factor beta.

K. Flanders, A. Roberts, D. Faller, 1988, Growth factors.

In-house neonatology: what are we waiting for?

S. Kourembanas, R. Steinhorn, 2010, American journal of respiratory and critical care medicine.

Gene and Stem Cell Therapies for Fetal Care: A Review.

L. Wilkins-Haug, J. Chan, G. Almeida-Porada, 2020, JAMA pediatrics.

Stem cell-based therapy for newborn lung and brain injury: feasible, safe, and the next therapeutic breakthrough?

S. Kourembanas, 2014, The Journal of pediatrics.

Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn

A. Stark, D. Wessel, E. Allred, 2000, Critical care medicine.

Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.

J. Tsai, C. Hsieh, M. Yoshizumi, 1994, The Journal of biological chemistry.

Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells*

S. Kourembanas, S. A. Mitsialis, T. Morita, 1997, The Journal of Biological Chemistry.

Prevention of Hypoxia-Induced Pulmonary Hypertension by Enhancement of Endogenous Heme Oxygenase-1 in the Rat. • 238

C. Hsieh, S. Kourembanas, H. Christou, 1997, Pediatric Research.

Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice

I. Rosas, J. Lederer, S. Kourembanas, 2020, Stem Cell Research & Therapy.

Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors.

J. Brody, S. Kourembanas, T. Morita, 1995, Cellular & molecular biology research.

Pulmonary Hypertension and Right Ventricular Dysfunction in Growth-Restricted, Extremely Low Birth Weight Neonates

T. Geva, S. Kourembanas, R. Margossian, 2005, Journal of Perinatology.

Child health status, neurodevelopmental outcome, and parental satisfaction in a randomized, controlled trial of nitric oxide for persistent pulmonary hypertension of the newborn.

M. McCormick, D. Wessel, E. Allred, 2001, Pediatrics.

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.

D. Faller, S. Kourembanas, R. Hannan, 1990, The Journal of clinical investigation.

Fetal rat lung fibroblasts produce a TGF beta homolog that blocks alveolar type II cell maturation.

J. Torday, S. Kourembanas, 1990, Developmental biology.

Hypoxia Extends the Life Span of Vascular Smooth Muscle Cells through Telomerase Activation

T. Minamino, S. Kourembanas, S. A. Mitsialis, 2001, Molecular and Cellular Biology.

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

S. Kourembanas, M. Perrella, M. -. Lee, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy.

S. Kourembanas, 2015, Annual review of physiology.

‘Good things come in small packages’: Application of exosome-based therapeutics in neonatal lung injury

S. Kourembanas, S. A. Mitsialis, G. Willis, 2017, Pediatric Research.

Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer.

S. Kourembanas, T. Morita, Yuxiang Liu, 1995, Circulation research.

Mesenchymal stromal cell‐derived syndecan‐2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation

K. Tsoyi, I. Rosas, S. Kourembanas, 2021, The FEBS journal.

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia

R. Maehr, A. Derr, A. Fernandez-Gonzalez, 2021, Frontiers in Immunology.

Therapeutic Effects of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Oxygen-Induced Multi-Organ Disease: A Developmental Perspective

A. Fernandez-Gonzalez, S. Kourembanas, S. A. Mitsialis, 2021, Frontiers in Cell and Developmental Biology.

Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung injury

M. Ericsson, Nick A. Andrews, A. Fernandez-Gonzalez, 2020, Journal of extracellular vesicles.

Regenerative pulmonary medicine: potential and promise, pitfalls and challenges

J. Loscalzo, A. Choi, P. Anversa, 2012, European journal of clinical investigation.

Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.

D. Faller, S. Kourembanas, L. McQuillan, 1993, The Journal of clinical investigation.

Generation of a Dominant-negative Mutant of Endothelial PAS Domain Protein 1 by Deletion of a Potent C-terminal Transactivation Domain*

C. Hsieh, K. Maemura, M. Layne, 1999, The Journal of Biological Chemistry.

Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension.

S. Kourembanas, H. Christou, A. Yoshida, 1998, American journal of respiratory cell and molecular biology.

Pulmonary hypertension in bronchopulmonary dysplasia

G. Hansmann, E. Austin, S. Kourembanas, 2020, Pediatric Research.

PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

G. Hansmann, M. Meier, D. Jonigk, 2018, Science Translational Medicine.

Diffuse lung disease in children: Summary of a scientific conference

A. Hamvas, J. Whitsett, W. Balch, 2014, Pediatric pulmonology.

Mechanisms of Telomerase Induction During Vascular Smooth Muscle Cell Proliferation

T. Minamino, S. Kourembanas, Tohru Minamino, 2001, Circulation research.

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

S. Kourembanas, T. Morita, 1995, The Journal of clinical investigation.

Heme Oxygenase 1 dampens the macrophage sterile inflammasome response and regulates its components in the hypoxic lung.

A. Fernandez-Gonzalez, S. Kourembanas, S. A. Mitsialis, 2019, American journal of physiology. Lung cellular and molecular physiology.

Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms.

S. Kostyk, P. Marsden, S. Kourembanas, 1994, The American journal of physiology.

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

Changjin Lee, Eleni Vergadi, A. Fernandez-Gonzalez, 2012, Circulation.

Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes.

A. Fernandez-Gonzalez, S. Kourembanas, S. A. Mitsialis, 2019, JCI insight.

Extracellular Vesicles Protect the Neonatal Lung from Hyperoxic Injury Through the Epigenetic and Transcriptomic Reprogramming of Myeloid Cells.

M. Ericsson, A. H. Gheinani, A. Fernandez-Gonzalez, 2021, American journal of respiratory and critical care medicine.

Mesenchymal stromal cell-derived extracellular vesicle therapy prevents preeclamptic physiology through intrauterine immunomodulation†

A. Fernandez-Gonzalez, S. Kourembanas, S. A. Mitsialis, 2020, Biology of Reproduction.

Absence of Cyclooxygenase-2 Exacerbates Hypoxia-Induced Pulmonary Hypertension and Enhances Contractility of Vascular Smooth Muscle Cells

D. Ingber, Tom Polte, O. Liang, 2008, Circulation.

Hypoxia Regulates Bone Morphogenetic Protein Signaling Through C-Terminal–Binding Protein 1

S. Kourembanas, S. A. Mitsialis, M. Chang, 2006, Circulation research.

Hypoxia and carbon monoxide in the vasculature.

S. Kourembanas, 2002, Antioxidants & redox signaling.

Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension The first two authors contributed equally to this manuscript.

F. Spyropoulos, C. Petty, S. Kourembanas, 2020, Pulmonary circulation.

Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension.

H. Hudalla, M. Geraci, A. Fernandez-Gonzalez, 2019, American journal of respiratory cell and molecular biology.

Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn.

A. Stark, D. Wessel, S. Kourembanas, 1997, Pediatrics.

Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension.

A. Stark, D. Wessel, S. Kourembanas, 1997, The Journal of pediatrics.

Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature.

S. Kourembanas, H. Christou, T. Morita, 1997, Kidney international.

Hypoxia induces macrophage inflammatory protein‐2 (MIP‐2) gene expression in murine macrophages via NF‐κB: the prominent role of p42/ p44 and PI3 kinase pathways

A. Zampetaki, J. Pfeilschifter, S. Kourembanas, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Extracellular Acidosis Alters the Metabolic Phenotype and Susceptibility to Apoptosis of Pulmonary Artery Smooth Muscle Cells

J. Fessenden, S. Kourembanas, S. A. Mitsialis, 2013 .

Harnessing the therapeutic potential of the stem cell secretome in neonatal diseases.

A. Fernandez-Gonzalez, S. Kourembanas, S. A. Mitsialis, 2023, Seminars in perinatology.

Persistent Pulmonary Hypertension of the Newborn: Role of Nitric Oxide

S. Kourembanas, 1995 .

Platelet-derived growth factor production by human umbilical vein endothelial cells is regulated by basic fibroblast growth factor.

D. Faller, S. Kourembanas, 1989, The Journal of biological chemistry.

An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells.

L. Moore, R. Pande, M. Creager, 2014, Biochimica et biophysica acta.

Therapeutic Applications of Extracellular Vesicles: Perspectives from Newborn Medicine.

S. Kourembanas, S. A. Mitsialis, G. Willis, 2017, Methods in molecular biology.

Stem cell-based therapies for the newborn lung and brain: Possibilities and challenges.

S. Kourembanas, S. A. Mitsialis, S. Mitsialis, 2016, Seminars in perinatology.

MSC microvesicles for the treatment of lung disease: a new paradigm for cell-free therapy.

S. Kourembanas, Konstantinos Sdrimas, 2014, Antioxidants & redox signaling.

Paving the Road for Mesenchymal Stem Cell-Derived Exosome Therapy in Bronchopulmonary Dysplasia and Pulmonary Hypertension

S. Kourembanas, S. A. Mitsialis, G. Willis, 2019, Stem Cell-Based Therapy for Lung Disease.

Diagnosis and management of pulmonary hypertension in infants with bronchopulmonary dysplasia.

G. Hansmann, S. Kourembanas, K. Leeman, 2022, Seminars in fetal & neonatal medicine.

Urine Proteomics for Noninvasive Monitoring of Biomarkers in Bronchopulmonary Dysplasia

J. Steen, H. Steen, R. Parad, 2022, Neonatology.

Pericytes Contribute to Flow-induced Pulmonary Hypertension.

A. Fernandez-Gonzalez, S. Kourembanas, M. Puder, 2023, American journal of respiratory cell and molecular biology.

Antenatal Mesenchymal Stromal Cell Extracellular Vesicle Therapy Prevents Preeclamptic Lung Injury in Mice.

A. Fernandez-Gonzalez, S. Kourembanas, S. A. Mitsialis, 2021, American journal of respiratory cell and molecular biology.

Hypoxic responses of vascular cells.

S. Kourembanas, D. Brodsky, H. Christou, 1998, Chest.

IMPROVED OXYGENATION IN A RANDOMIZED TRIAL OF INHALED NITRIC OXIDE FOR PPHN.• 1498

A. Stark, D. Wessel, L. V. Marter, 1996, Pediatric Research.

Hypoxic responses of the neonatal endothelium.

S. Kourembanas, 1992, Seminars in perinatology.

Inhaled nitric oxide does not affect adenosine 5'-diphosphate-dependent platelet activation in infants with persistent pulmonary hypertension of the newborn.

D. Wessel, E. Allred, S. Kourembanas, 1998, Pediatrics.