T. Jonckers

发表

Molecular mechanism of respiratory syncytial virus fusion inhibitors.

L. Kwanten, J. McLellan, D. Roymans, 2016, Nature chemical biology.

Design, synthesis, and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids.

N. de Kimpe, T. Jonckers, M. D’hooghe, 2012, Journal of medicinal chemistry.

Dog model with implanted pump to test boosters for antiretroviral medication.

L. Baert, T. Jonckers, G. Van den Mooter, 2008, International journal of pharmaceutics.

2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.

V. Pande, F. Pauwels, T. Jonckers, 2018, Journal of medicinal chemistry.

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

B. Samuelsson, S. Eriksson, L. Leclercq, 2011, Antimicrobial Agents and Chemotherapy.

Discovery of 3 ({5 Chloro-1 [3 (methylsulfonyl)propyl]-1H indol-2 yl}methyl)-1 (2,2,2 trifluoroethyl)-1,3 dihydro-2H imidazo[4,5-c]pyridin-2 one (JNJ-53718678), a potent and orally bioavailable fusion inhibitor of respiratory syncytial virus.

L. Kwanten, J. McLellan, D. Roymans, 2020, Journal of medicinal chemistry.

Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

B. Samuelsson, Lili Hu, L. Leclercq, 2014, Journal of medicinal chemistry.

AMINOPHENYLSULFONAMIDE COMPOUNDS AS HIV PROTEASE INHIBITOR

T. Jonckers, 2017 .

Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.

L. Vrang, B. Samuelsson, Magnus Nilsson, 2012, Bioorganic & medicinal chemistry letters.

Practical synthesis of (2'R)-2'-deoxy-2'-C-methyluridine by highly diastereoselective homogeneous hydrogenation.

T. Jonckers, R. Wechselberger, I. Houpis, 2011, The Journal of organic chemistry.

Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.

F. Pauwels, T. Jonckers, E. Arnoult, 2017, Journal of medicinal chemistry.

Selective Palladium-Catalyzed Aminations on 2-Chloro-3-iodo- and 2-Chloro-5-iodopyridine

R. Dommisse, B. Maes, T. Jonckers, 2002 .

Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.

R. Dommisse, T. Jonckers, G. Lemiére, 2002, European journal of medicinal chemistry.

Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors.

T. Jonckers, J. Sasaki, M. Rouan, 2012, Bioorganic & medicinal chemistry letters.

SYNTHESIS, CYTOTOXICITY AND ANTIPLASMODIAL ACTIVITY OF NEOCRYPTOLEPINE DERIVATIVES

L. Maes, A. Vlietinck, T. Jonckers, 2005 .

In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives.

L. Maes, R. Dommisse, B. Maes, 2004, Experimental parasitology.

Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.

J. Rozenski, C. Bailly, P. Colson, 2002, Journal of medicinal chemistry.

Synthesis of 4-O-Methylcedrusin. Selective Protection of Catechols with Diphenyl Carbonate

R. Dommisse, T. Jonckers, G. Lemiére, 2000 .

2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.

B. Samuelsson, M. Cummings, Christophe Buyck, 2010, Journal of Medicinal Chemistry.

Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes.

K. Hertogs, R. Clayton, M. Van Loock, 2009, Antiviral research.

From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.

J. Neefs, E. Jacoby, Peggy Geluykens, 2022, ACS medicinal chemistry letters.

Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.

L. Leclercq, T. Jonckers, J. Snoeys, 2016, Journal of medicinal chemistry.

Differentiation between isomeric phenylglycidyl ether adducts of 2'-deoxyguanosine and 2'-deoxyguanosine-5'-monophosphate using liquid chromatography/electrospray tandem mass spectrometry.

M. Claeys, T. Jonckers, E. Esmans, 1999, Journal of mass spectrometry : JMS.

A small-molecule fusion inhibitor of influenza virus is orally active in mice

I. Wilson, Divita Garg, D. Roymans, 2019, Science.

Antiviral activity and mode of action of TMC 647078 , a novel 1 nucleoside inhibitor of the HCV NS 5 B polymerase 2 Running title : Characterization of HCV nucleoside inhibitor TMC 647078 3 4

B. Samuelsson, S. Eriksson, L. Leclercq, 2011 .

Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists.

F. Pauwels, T. Jonckers, E. Arnoult, 2018, Bioorganic & medicinal chemistry letters.

Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in Human Immunodeficiency Virus Type 1 Protease

Celia A. Schiffer, Inge Dierynck, C. Schiffer, 2007, Journal of Virology.

Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.

Celia A Schiffer, Hilde Azijn, Rudi Pauwels, 2005, Journal of medicinal chemistry.

Selective Optimization of Side Activities (SOSA) in Drug Discovery

T. Jonckers, 2015 .

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Peggy Geluykens, R. Bartenschlager, A. Marchand, 2021, Nature.

Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists.

V. Pande, F. Pauwels, T. Jonckers, 2018, Bioorganic & medicinal chemistry letters.

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Gregory D. Gromowski, A. Barrett, D. Beasley, 2023, Nature.

TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors

C. Schiffer, M.N.L. Nalam, T. Jonckers, 2011, Antimicrobial Agents and Chemotherapy.

Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region.

Christophe Buyck, J. Grimes, J. Keown, 2019, Journal of medicinal chemistry.

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

B. Samuelsson, S. Eriksson, L. Leclercq, 2011, Antimicrobial Agents and Chemotherapy.

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.

A. Marchand, T. Jonckers, D. Bardiot, 2024, Journal of medicinal chemistry.