K. Leenhouts

W. Hinrichs, H. Frijlink, A. Huckriede, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

University of Groningen Lactococcus lactis GEM particles displaying pneumococcal antigens induce local and systemic immune responses following intranasal immunization Audouy,

G. Robillard, K. Leenhouts, P. Hermans, 2018 .

Lactococcus lactis GEM particles displaying pneumococcal antigens induce local and systemic immune responses following intranasal immunization.

G. Robillard, K. Leenhouts, P. Hermans, 2006, Vaccine.

A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice

Yongge Wu, W. Kong, Chunlai Jiang, 2018, Immunological investigations.

Exploiting the peptidoglycan-binding motif, LysM, for medical and industrial applications

J. Kok, G. Buist, K. Leenhouts, 2014, Applied Microbiology and Biotechnology.

Expression of a chitinase gene from Serratia marcescens in Lactococcus lactis and Lactobacillus plantarum

G. Venemâ, I. Nes, K. Leenhouts, 1994, Applied Microbiology and Biotechnology.

Mode of action of LciA, the lactococcin A immunity protein

T. Abee, G. Venema, J. Kok, 1994, Molecular microbiology.

Integration of Heterologous Plasmid DNA into the Chromosome of Lactococcus

K. Leenhouts, 2018 .

Production of secreted guar α-galactosidase by Lactococcus lactis

G. Venema, J. Kok, K. Leenhouts, 1995, Applied Microbiology and Biotechnology.

Construction of a food-grade multiple-copy integration system for Lactococcus lactis

G. Venema, G. Venemâ, J. Kok, 1998, Applied Microbiology and Biotechnology.

Effect of X-Prolyl Dipeptidyl Aminopeptidase Deficiency on Lactococcus lactis

W. Bockelmann, G. Venemâ, J. Kok, 1993, Applied and environmental microbiology.

Lactococcal plasmid pWV01 as an integration vector for lactococci

G. Venema, J. Kok, K. Leenhouts, 1991, Applied and environmental microbiology.

AcmD, a Homolog of the Major Autolysin AcmA of Lactococcus lactis, Binds to the Cell Wall and Contributes to Cell Separation and Autolysis

B. Dijkstra, O. Kuipers, J. Kok, 2013, PloS one.

Lactococcus lactis as expression host for the biosynthetic incorporation of tryptophan analogues into recombinant proteins.

H. Permentier, K. Leenhouts, M. El Khattabi, 2008, The Biochemical journal.

Novel Surface Display System for Proteins on Non-Genetically Modified Gram-Positive Bacteria

G. Robillard, O. Kuipers, J. Kok, 2006, Applied and Environmental Microbiology.

Integration strategies and vectors.

K. Leenhouts, 1995, Developments in biological standardization.

A lactococcal pWV 01-based integration toolbox for bacteria

G. Venemâ, J. Kok, K. Leenhouts, 2017 .

Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice

G. van Gemert, R. Sauerwein, K. Leenhouts, 2012, Malaria Journal.

Campbell-like integration of heterologous plasmid DNA into the chromosome of Lactococcus lactis subsp. lactis

G. Venema, G. Venemâ, J. Kok, 1989, Applied and environmental microbiology.

Replacement recombination in Lactococcus lactis

G. Venema, G. Venemâ, J. Kok, 1991, Journal of bacteriology.

Influenza antigen-sparing by immune stimulation with Gram-positive enhancer matrix (GEM) particles.

W. Hinrichs, H. Frijlink, A. Huckriede, 2010, Vaccine.

Short‐course sublingual immunotherapy by mucoadhesive patch and tolerogenic particle enhanced allergen presentation

D. Lubasová, M. Raška, J. Turánek, 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The di- and tripeptide transport protein of Lactococcus lactis. A new type of bacterial peptide transporter.

A. Hagting, Edmund R. S. Kunji, B. Poolman, 1994, The Journal of biological chemistry.

Rapid and Efficient Purification Method for Small, Hydrophobic, Cationic Bacteriocins: Purification of Lactococcin B and Pediocin PA-1

J. Seegers, G. Venema, J. Kok, 1997, Applied and environmental microbiology.

An expression system for the efficient incorporation of an expanded set of tryptophan analogues

D. Petrović, K. Leenhouts, J. Broos, 2013, Amino Acids.

NisT, the Transporter of the Lantibiotic Nisin, Can Transport Fully Modified, Dehydrated, and Unmodified Prenisin and Fusions of the Leader Peptide with Non-lantibiotic Peptides*

O. Kuipers, A. Driessen, R. Rink, 2004, Journal of Biological Chemistry.

Immunogenicity of a malaria parasite antigen displayed by Lactococcus lactis in oral

Ramasamy, G. Venema, J. Kok, 2006 .

Stability of Integrated Plasmids in the Chromosome of Lactococcus lactis

Jan Kok, G. Venemâ, J. Kok, 1990, Applied and environmental microbiology.

Active Lipoprotein Precursors in the Gram-positive EubacteriumLactococcus lactis *

J. V. van Dijl, H. Tjalsma, G. Venemâ, 2003, The Journal of Biological Chemistry.

Nucleotide sequence and characterization of the broad-host-range lactococcal plasmid pWVO1.

S. Bron, G. Venemâ, J. Kok, 1991, Plasmid.

Stress response in Lactococcus lactis: cloning, expression analysis, and mutation of the lactococcal superoxide dismutase gene

G. Venemâ, J. Kok, K. Leenhouts, 1995, Journal of bacteriology.

Nucleotide sequence and characterization of the broad-host-range lactococcal plasmid pWVO1.

S. Bron, J. Seegers, G. Venema, 1991, Plasmid.

A general system for generating unlabelled gene replacements in bacterial chromosomes

G. Venema, G. Venemâ, J. Kok, 1996, Molecular and General Genetics MGG.

Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications

B. Haijema, K. Leenhouts, Natalija Van Braeckel‐Budimir, 2013, Front. Immunol..

Bacterium-like particles supplemented with inactivated influenza antigen induce cross-protective influenza-specific antibody responses through intranasal administration.

B. Haijema, T. Meijerhof, K. Leenhouts, 2012, Vaccine.

Neonatal mucosal immunization with a non-living, non-genetically modified Lactococcus lactis vaccine carrier induces systemic and local Th1-type immunity and protects against lethal bacterial infection

W. Picking, K. Leenhouts, M. Pasetti, 2009, Mucosal Immunology.

Cell Wall Attachment of a Widely Distributed Peptidoglycan Binding Domain Is Hindered by Cell Wall Constituents*

Aldert L. Zomer, O. Kuipers, G. Venemâ, 2003, Journal of Biological Chemistry.

Multiple-peptidase mutants of Lactococcus lactis are severely impaired in their ability to grow in milk

B. Poolman, G. Venema, J. Kok, 1996, Journal of bacteriology.

Shigella IpaB and IpaD displayed on L. lactis bacterium-like particles induce protective immunity in adult and infant mice

W. Blackwelder, W. Picking, K. Leenhouts, 2015, Immunology and cell biology.

Molecular cloning and nucleotide sequence of the gene encoding the major peptidoglycan hydrolase of Lactococcus lactis, a muramidase needed for cell separation

G. Venema, G. Venemâ, J. Kok, 1995, Journal of bacteriology.

Cloning and sequencing of the gene for a lactococcal endopeptidase, an enzyme with sequence similarity to mammalian enkephalinase

G. Venemâ, B. Mayo, J. Kok, 1993, Journal of bacteriology.

A Protective and Safe Intranasal RSV Vaccine Based on a Recombinant Prefusion-Like Form of the F Protein Bound to Bacterium-Like Particles

P. Rottier, C. D. de Haan, B. Haijema, 2013, PloS one.

A system to generate chromosomal mutations in Lactococcus lactis which allows fast analysis of targeted genes

G. Venema, J. Kok, G. Buist, 1995, Journal of bacteriology.

Photodynamic Inactivation of L929 Cells after Treatment with Hematoporphyrin Derivative

T. Dubbelman, K. Leenhouts, J. Steveninck, 1984 .

Systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant Plym2.

Yongge Wu, W. Kong, Chunlai Jiang, 2017, Immunology letters.

GENETICS OF STREPTOCOCCI, ENTEROCOCCI AND LACTOCOCCI

G. Venema, J. Kok, K. Leenhouts, 1995 .

Regulation of Gene Expression in Lactococcus lactis

O. Kuipers, K. Leenhouts, 2003 .

Mode of Action of Lactococcin B, a Thiol-Activated Bacteriocin from Lactococcus lactis

T. Abee, G. Venema, J. Kok, 1993, Applied and environmental microbiology.

Detection and Localization of Single LysM-Peptidoglycan Interactions

Y. Dufrêne, P. Hols, K. Leenhouts, 2008, Journal of bacteriology.

Inactivated influenza vaccine adjuvanted with bacterium-like particles induce systemic and mucosal influenza A virus specific T-cell and B-cell responses after nasal administration in a TLR2 dependent fashion.

W. van Eden, B. Haijema, C. Keijzer, 2014, Vaccine.

Exploiting the peptidoglycan-binding motif, LysM, for medical and industrial applications

J. Kok, G. Buist, K. Leenhouts, 2014, Applied Microbiology and Biotechnology.

Local and Systemic Immunity Against RSV Induced by a Novel Intranasal Vaccine: A Randomised, Double- Blind, Placebo-Controlled Trial.

B. Haijema, C. Chiu, P. Openshaw, 2019, American journal of respiratory and critical care medicine.

Local and Systemic Immunity against Respiratory Syncytial Virus Induced by a Novel Intranasal Vaccine A Randomized, Double-Blind, Placebo-controlled Clinical Trial Induces Durable

B. Haijema, C. Chiu, P. Openshaw, 2019 .

Biophysical characterization of the type III secretion tip proteins and the tip proteins attached to bacterium-like particles.

S. Joshi, W. Picking, W. Picking, 2015, Journal of pharmaceutical sciences.

A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity against Yersinia Infection in Adult and Infant Mice

C. Drachenberg, W. Picking, K. Leenhouts, 2019, The Journal of Immunology.

Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles.

W. Picking, W. Picking, K. Leenhouts, 2015, Journal of Pharmacy and Science.

Mimopath™-Based Vaccine Delivery

K. Leenhouts, 2013 .

A lactococcal pWV01-based integration toolbox for bacteria

G. Venemâ, J. Kok, K. Leenhouts, 1998 .

Monitoring lysin motif-ligand interactions via tryptophan analog fluorescence spectroscopy.

D. Petrović, K. Leenhouts, M. V. van Roosmalen, 2012, Analytical biochemistry.

University of Groningen Nucleotide Sequence of the Cell Wall Proteinase Gene of Streptococcus cremoris Wg 2

K. Leenhouts, A. Haandrikman, '. A. M. Ledeboer, 2022 .

Novel Surface Display System for Proteins on Non-Genetically Modified Gram-Positive Bacteria

G. Robillard, O. Kuipers, J. Kok, 2006, Applied and Environmental Microbiology.

Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles.

W. Picking, W. Picking, K. Leenhouts, 2015, Journal of pharmaceutical sciences.

Immunogenicity of a malaria parasite antigen displayed by Lactococcus lactis in oral immunisations

Aldert L. Zomer, G. Venema, J. Kok, 2006, Vaccine.

NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated and unmodified prenisin and Fusions of the leader peptide with non-lantibiotic peptides

O. Kuipers, A. Driessen, R. Rink, 2004 .

Heterologous Processing and Export of the Bacteriocins Pediocin PA-1 and Lactococcin A in Lactococcus Lactis: A Study with Leader Exchange

K. Venema, K. Leenhouts, S. Pandian, 2010, Probiotics and antimicrobial proteins.

University of Groningen Heterologous Processing and Export of the Bacteriocins Pediocin PA-1 and Lactococcin A in Lactococcus Lactis Chikindas,

M. Emond, G. Venema, J. Kok, 2010 .

Mode of Action of Lactococcin B, a Thiol-Activated Bacteriocin from Lactococcus lactis

T. Abee, G. Venema, J. Kok, 1993, Applied and environmental microbiology.

Topology of LcnD, a protein implicated in the transport of bacteriocins from Lactococcus lactis

G. Venemâ, J. Kok, K. Leenhouts, 1996, Journal of bacteriology.