W. Holleran

发表

Skin Barrier and Transdermal Drug Delivery

M. Prausnitz, P. Elias, K. Feingold, 2012 .

Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.

P. Elias, S. Kim, M. A. Mandal, 2007, Human molecular genetics.

Structural and biochemical basis for the UVB‐induced alterations in epidermal barrier function

P. Elias, W. Holleran, L. Halkier-Sørensen, 1997, Photodermatology, photoimmunology & photomedicine.

Low Molecular Weight Inhibitors in Corneal Ulceration a

M. Schaefer, D. Grobelny, G. Schultz, 1994, Annals of the New York Academy of Sciences.

Water Extract of Gromwell (Lithospermum erythrorhizon) Enhances Migration of Human Keratinocytes and Dermal Fibroblasts with Increased Lipid Synthesis in an in vitro Wound Scratch Model

Y. Cho, W. Holleran, Y. Uchida, 2011, Skin Pharmacology and Physiology.

Infection and inflammation induce LDL oxidation in vivo.

K. Feingold, C. Grunfeld, A. Moser, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin.

K. Feingold, C. Grunfeld, A. Moser, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Evolution of high-dose cisplatin

W. Holleran, M. Degregorio, M. DeGregorio, 1988, Investigational New Drugs.

Glucosylceramide metabolism is regulated during normal and hormonally stimulated epidermal barrier development in the rat.

P. Elias, K. Feingold, M. Williams, 1997, Journal of lipid research.

A Murine Model of Isolated Cardiac Steatosis Leads to Cardiomyopathy

D. Gardner, W. Holleran, Y. Yeghiazarians, 2011, Hypertension.

ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex

H. Ikushiro, P. Elias, Yong-Moon Lee, 2016, Proceedings of the National Academy of Sciences.

De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes.

P. Elias, W. Holleran, A. Nardo, 2003, The Journal of investigative dermatology.

Sphingolipid Activator Proteins Are Required for Epidermal Permeability Barrier Formation*

P. Elias, K. Sandhoff, W. Holleran, 1999, The Journal of Biological Chemistry.

Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis.

P. Elias, K. Feingold, M. Schmuth, 2000, The Journal of investigative dermatology.

Regulation of Cathelicidin Antimicrobial Peptide Expression by an Endoplasmic Reticulum (ER) Stress Signaling, Vitamin D Receptor-independent Pathway*

P. Elias, T. Mauro, W. Holleran, 2011, The Journal of Biological Chemistry.

Ceramide Reduction and Transcriptional Up-Regulation of Glucosylceramide Synthase through Doxorubicin-Activated Sp1 in Drug-Resistant HL-60/ADR Cells

Y. Hirabayashi, S. Ichikawa, H. Umehara, 2004, Cancer Research.

Glucosylceramides stimulate mitogenesis in aged murine epidermis.

P. Elias, B. Brown, W. Holleran, 1998, The Journal of investigative dermatology.

Glucosylceramides stimulate murine epidermal hyperproliferation.

P. Elias, W. Holleran, N. L. Marsh, 1995, The Journal of clinical investigation.

Regulation of Glycosphingolipid Metabolism in Liver during the Acute Phase Response*

K. Feingold, C. Grunfeld, A. Moser, 1999, The Journal of Biological Chemistry.

Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis.

P. Elias, K. Feingold, C. Grunfeld, 1997, The Journal of investigative dermatology.

beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation.

G. Imokawa, P. Elias, W. Holleran, 1992, Journal of lipid research.

Ceramide Stimulates ABCA12 Expression via Peroxisome Proliferator-activated Receptor δ in Human Keratinocytes*

P. Elias, K. Feingold, C. Grunfeld, 2009, The Journal of Biological Chemistry.

Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis.

P. Elias, K. Feingold, C. Grunfeld, 1998, Journal of lipid research.

The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism.

P. Elias, Yong-Moon Lee, W. Holleran, 2014, The Journal of nutritional biochemistry.

EXPRESSION OF EPIDERMAL CAMP CHANGES IN PARALLEL WITH PERMEABILITY BARRIER STATUS

P. Elias, Soyun Cho, M. Man, 2011, The Journal of investigative dermatology.

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis

Weiguo Feng, P. Elias, D. Crumrine, 2016, PloS one.

Topical 11&bgr;-Hydroxysteroid Dehydrogenase Type 1 Inhibition Corrects Cutaneous Features of Systemic Glucocorticoid Excess in Female Mice

P. Elias, W. Holleran, A. Tiganescu, 2018, Endocrinology.

Skin ultrastructural findings in type 2 Gaucher disease: diagnostic implications.

R. Schiffmann, E. Ginns, P. Elias, 2011, Molecular genetics and metabolism.

Type 2 Gaucher disease with hydrops fetalis in an Ashkenazi Jewish family resulting from a novel recombinant allele and a rare splice junction mutation in the glucocerebrosidase locus.

S. Almashanu, T. Cowan, E. Sidransky, 1998, Molecular genetics and metabolism.

Epidermal Abnormalities May Distinguish Type 2 from Type 1 and Type 3 of Gaucher Disease

E. Ginns, P. Elias, E. Sidransky, 1996, Pediatric Research.

A role for ceramide in driving cancer cell resistance to doxorubicin

A. Giuliano, M. Cabot, S. Jazwinski, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

High-dose cisplatin with diethyldithiocarbamate (DDTC) rescue therapy: preliminary pharmacologic observations

T. Montine, E. Perez, D. Gandara, 1989, Cancer Chemotherapy and Pharmacology.

Preliminary observations of intraperitoneal carboplatin pharmacokinetics during a phase I study of the Northern California Oncology Group

B. Sikic, W. Holleran, B. Lum, 2004, Cancer Chemotherapy and Pharmacology.

An Endoplasmic Reticulum Stress-Initiated Sphingolipid Metabolite, Ceramide-1-Phosphate, Regulates Epithelial Innate Immunity by Stimulating β-Defensin Production

P. Elias, Yong-Moon Lee, W. Holleran, 2014, Molecular and Cellular Biology.

An ER Stress-Initiated Sphingolipid Metabolite, Ceramide-1-Phosphate, Regulates 2

P. Elias, Yong-Moon Lee, W. Holleran, 2014 .

Origin of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes.

P. Elias, D. Crumrine, W. Holleran, 2000, The Journal of investigative dermatology.

Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia

P. Elias, W. Holleran, R. Galardy, 1997, Archives of Dermatological Research.

Gaucher disease: A tale of two species

E. Ginns, R. Mulligan, B. Martin, 1995 .

Local blockade of glucocorticoid activation reverses stress‐ and glucocorticoid‐induced delays in cutaneous wound healing

P. Elias, T. Mauro, W. Holleran, 2013, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Empiric amphotericin B therapy in patients with acute leukemia.

W. Holleran, J. Wilbur, M. DeGregorio, 1985, Reviews of infectious diseases.

Permeability barrier requirements regulate epidermal beta-glucocerebrosidase.

P. Elias, K. Feingold, G. Menon, 1994, Journal of lipid research.

A Novel Role of a Lipid Species, Sphingosine-1-Phosphate, in Epithelial Innate Immunity

A. Borkowski, P. Elias, Yong-Moon Lee, 2012, Molecular and Cellular Biology.

Resveratrol Stimulates Sphingosine-1-Phosphate Signaling of Cathelicidin Production

A. Borkowski, P. Elias, Yong-Moon Lee, 2013, The Journal of investigative dermatology.

Both Sphingosine Kinase 1 and 2 Coordinately Regulate Cathelicidin Antimicrobial Peptide Production during Keratinocyte Differentiation.

H. Ikushiro, Young‐Hee Kang, Yong-Moon Lee, 2019, The Journal of investigative dermatology.

UVB induces epidermal 11β‐hydroxysteroid dehydrogenase type 1 activity in vivo

P. Elias, T. Mauro, W. Holleran, 2015, Experimental dermatology.

The Epidermis of Grhl3-Null Mice Displays Altered Lipid Processing and Cellular Hyperproliferation

S. Jane, J. Cunningham, P. Elias, 2005, Organogenesis.

Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin.

K. Feingold, C. Grunfeld, A. Moser, 2001, Journal of lipid research.

Characterization of cellular lipids in doxorubicin-sensitive and -resistant P388 mouse leukemia cells

R. Ganapathi, W. Holleran, B. Macher, 2004, Cancer Chemotherapy and Pharmacology.

Formation and functions of the corneocyte lipid envelope (CLE).

P. Elias, G. Menon, W. Holleran, 2014, Biochimica et biophysica acta.

Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome.

M. Akiyama, H. Shimizu, P. Elias, 2010, The Journal of investigative dermatology.

Kinetics and sensitivity of daunorubicin in patients with acute leukemia

W. Holleran, B. Macher, J. Wilbur, 2004, Cancer Chemotherapy and Pharmacology.

UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes.

P. Elias, W. Holleran, R. C. Dickson, 1998, Journal of lipid research.

UVB-induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response.

R. Yasuda, P. Elias, M. Schmuth, 1997, The Journal of investigative dermatology.

Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.

Y. Hannun, P. Elias, N. Radin, 2010, The Journal of investigative dermatology.

Murine atopic dermatitis responds to peroxisome proliferator-activated receptor α , β / δ (but not γ ), and liver-X-receptor activators

Debra, P. Elias, K. Feingold, 2010 .

Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.

P. Elias, K. Feingold, T. Mauro, 2010, The Journal of allergy and clinical immunology.

Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.

P. Elias, K. Feingold, Seung Ho Lee, 2008, The Journal of investigative dermatology.

Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function.

E. Gratton, P. Elias, T. Mauro, 2003, The Journal of investigative dermatology.

Intrinsically aged epidermis displays diminished UVB-induced alterations in barrier function associated with decreased proliferation.

P. Elias, W. Holleran, Y. Uchida, 1997, The Journal of investigative dermatology.

Barrier function regulates epidermal lipid and DNA synthesis

P. Elias, K. Feingold, G. Menon, 1993, The British journal of dermatology.

Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism.

P. Elias, M. Schmuth, W. Holleran, 2008, Journal of lipid research.

Regulation of epidermal sphingolipid synthesis by permeability barrier function.

P. Elias, K. Feingold, M. Man, 1991, Journal of lipid research.

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

P. Elias, K. Feingold, T. Mauro, 2009, The Journal of investigative dermatology.

Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures.

P. Elias, W. Holleran, M. Behne, 2001, The Journal of investigative dermatology.

A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice

S. Jane, J. Cunningham, P. Elias, 2005, Science.

Beta-glucocerebrosidase activity in mammalian stratum corneum.

G. Imokawa, P. Elias, E. Kriehuber, 1999, Journal of lipid research.

Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease.

E. Ginns, P. Elias, E. Sidransky, 1994, The Journal of clinical investigation.

Serine-palmitoyl transferase activity in cultured human keratinocytes.

P. Elias, M. Williams, W. Holleran, 1990, Journal of lipid research.

Serine-pal mitoy transferase activity in cultured human keratinocytes

P. Elias, M. Williams, W. Holleran, 2002 .

Stratum Corneum Lipid Processing: The Final Steps in Barrier Formation

W. Holleran, Y. Takagi, 2005 .

Localization of epidermal sphingolipid synthesis and serine palmitoyl transferase activity: alterations imposed by permeability barrier requirements

P. Elias, K. Feingold, W. Holleran, 2005, Archives of Dermatological Research.

Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation.

P. Elias, K. Feingold, M. Man, 1991, The Journal of clinical investigation.

Kinetic Characteristics of Acidic and Alkaline Ceramidase in Human Epidermis

T. Vanhaecke, V. Rogiers, W. Holleran, 2007, Skin Pharmacology and Physiology.

Epidermal sphingomyelins are precursors for selected stratum corneum ceramides.

P. Elias, E. Sidransky, F. Otsuka, 2000, Journal of lipid research.

Heparin and its non-anticoagulant analogues inhibit human keratinocyte growth without inducing differentiation.

L. Gilliam, W. Holleran, H. Conrad, 1994, The Journal of investigative dermatology.

Epidermal sphingolipids: Metabolism, function, and roles in skin disorders

W. Holleran, Y. Takagi, Y. Uchida, 2006, FEBS letters.

Omega-O-acylceramide, a lipid essential for mammalian survival.

W. Holleran, Y. Uchida, 2008, Journal of dermatological science.

Basis for the permeability barrier abnormality in lamellar ichthyosis

P. Elias, K. Feingold, R. Rice, 2002, Experimental dermatology.

SERCA2-controlled Ca2+-dependent Keratinocyte Adhesion and Differentiation is Mediated via the Sphingolipid Pathway- a Novel Therapeutic Target for Darier’s Disease

T. Mauro, W. Holleran, D. Bikle, 2011, The Journal of investigative dermatology.

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis Published, JLR Papers in Press, February 13, 2006.

V. Rogiers, P. Elias, L. Obeid, 2006, Journal of Lipid Research.

Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function.

P. Elias, P. R. Montellano, W. Holleran, 2000, The Journal of investigative dermatology.

A critical review of 900 cases of gastroduodenal surgery.

W. Holleran, D. Ross, L. Powsner, 1960, The American journal of gastroenterology.

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis.

Robert H. Brown, S. Yasuda, K. Hanada, 2002, The Journal of clinical investigation.

4.04 – Skin Glycobiology

W. Holleran, Y. Uchida, 2007 .

Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function.

P. Elias, K. Feingold, G. Menon, 1993, The Journal of clinical investigation.

Loss of functional ELOVL4 depletes very long-chain fatty acids (≥C28) and the unique ω-O-acylceramides in skin leading to neonatal death

Radha Ayyagari, Peter M. Elias, P. Elias, 2007 .

Lipid modulators of epidermal proliferation and differentiation.

W. Holleran, 1991, Advances in lipid research.

Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response.

C. Benz, W. Holleran, E. Cadman, 1985, Cancer research.

Quantitation of Toremifene and its Major Metabolites in Human Plasma by High-Performance Liquid Chromatography Following Fluorescent Activation

W. Holleran, M. DeGregorio, S. Gharbo, 1987 .

Quantitative analysis of 5-fluorouracil in human serum by high-performance liquid chromatography

C. Benz, W. Holleran, E. Cadman, 1985 .

Fatty Acid 2-Hydroxylase, Encoded by FA2H, Accounts for Differentiation-associated Increase in 2-OH Ceramides during Keratinocyte Differentiation*

P. Elias, D. Crumrine, N. L. Alderson, 2007, Journal of Biological Chemistry.

Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma.

W. Holleran, E. Cadman, A. Deisseroth, 1985, Cancer treatment reports.

NHE1 Regulates the Stratum Corneum Permeability Barrier Homeostasis

Enrico Gratton, Theodora M Mauro, E. Gratton, 2002, The Journal of Biological Chemistry.

NHE 1 Regulates the Stratum Corneum Permeability Barrier Homeostasis MICROENVIRONMENT ACIDIFICATION ASSESSED WITH FLUORESCENCE LIFETIME IMAGING *

E. Gratton, P. Elias, D. Crumrine, 2002 .

Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress DOI 10.1194/jlr.M100442-JLR200

P. Elias, M. Schmuth, Y. Hirabayashi, 2002, Journal of Lipid Research.

On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides.

P. Elias, W. Holleran, Y. Uchida, 2008, Journal of dermatological science.

Decreased Ceramide Transport Protein (CERT) Function Alters Sphingomyelin Production following UVB Irradiation*

K. Hanada, Keigo Kumagai, M. Kawano, 2008, Journal of Biological Chemistry.

Glucosylceramide synthase activity in murine epidermis: quantitation, localization, regulation, and requirement for barrier homeostasis.

P. Elias, K. Feingold, W. Holleran, 1998, Journal of lipid research.

TUMORS OF THE SMALL BOWEL.

W. Holleran, J. F. Regan, K. Schmutzer, 1964, American journal of surgery.

Increased glucocorticoid activation during mouse skin wound healing.

P. Elias, T. Mauro, W. Holleran, 2014, The Journal of endocrinology.

Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing.

P. Elias, K. Feingold, M. Schmuth, 2006, The Journal of investigative dermatology.

Estrogen Priming in Advanced Breast Cancer

W. Holleran, M. DeGregorio, Maziar Maghsoodnia, 1988, Drug intelligence & clinical pharmacy.

Elevated plasma tamoxifen levels in a patient with liver obstruction

A. Venook, W. Holleran, M. DeGregorio, 2004, Cancer Chemotherapy and Pharmacology.

Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction.

Gabriel Wong, P. Elias, G. Wong, 2013, Journal of dermatological science.

Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis.

P. Elias, Y. Obata, H. Sano, 2013, Journal of dermatological science.

Psychological stress regulates antimicrobial peptide expression by both glucocorticoid and β-adrenergic mechanisms.

P. Elias, M. Man, W. Holleran, 2011, European journal of dermatology : EJD.

Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features.

P. Elias, W. Holleran, J. Takeda, 2004, The Journal of investigative dermatology.

Imaging Mass Spectrometry Visualizes Ceramides and the Pathogenesis of Dorfman-Chanarin Syndrome Due to Ceramide Metabolic Abnormality in the Skin

M. Setou, N. Goto-Inoue, W. Holleran, 2012, PloS one.

Thematic review series: Skin Lipids. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism Published, JLR Papers in Press, February 2, 2008.

P. Elias, M. Schmuth, W. Holleran, 2008, Journal of Lipid Research.

Thematic review series: Skin Lipids. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism Published, JLR Papers in Press, February 2, 2008.

P. Elias, M. Schmuth, W. Holleran, 2008, Journal of Lipid Research.

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin.

K. Feingold, C. Grunfeld, A. Moser, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Increased glucocorticoid activation during mouse skin wound healing.

P. Elias, T. Mauro, W. Holleran, 2014, The Journal of endocrinology.

Local blockade of glucocorticoid activation reverses stress‐ and glucocorticoid‐induced delays in cutaneous wound healing

P. Elias, T. Mauro, W. Holleran, 2013, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

The potential of metabolic interventions to enhance transdermal drug delivery.

Kenneth R Feingold, Gopinathan K Menon, P. Elias, 2002, The journal of investigative dermatology. Symposium proceedings.

Skin abnormalities as an early predictor of neurologic outcome in Gaucher disease

R. Schiffmann, E. Sidransky, O. Goker-Alpan, 2006, Clinical genetics.

Beta-glucocerebrosidase activity in mammalian stratum corneum.

G. Imokawa, P. Elias, E. Kriehuber, 1999, Journal of lipid research.

Sphingosine-1-phosphate-cathelicidin axis plays a pivotal role in the development of cutaneous squamous cell carcinoma.

S. Arron, T. Mauro, W. Holleran, 2024, The Journal of investigative dermatology.

Evolution of high-dose cisplatin

W. Holleran, M. DeGregorio, 1988, Investigational New Drugs.