H. Kasahara

发表

Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration

D. Torella, M. Rota, P. Anversa, 2003, Cell.

Myocardin Expression Is Regulated by Nkx2.5, and Its Function Is Required for Cardiomyogenesis

Q. Nie, S. Izumo, H. Kasahara, 2003, Molecular and Cellular Biology.

Csm, a Cardiac-specific Isoform of the RNA Helicase Mov10l1, Is Regulated by Nkx2.5 in Embryonic Heart*

S. Izumo, H. Kasahara, N. Yamasaki, 2003, Journal of Biological Chemistry.

Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes.

W. Manning, P. Kang, C. Berul, 2003, Journal of molecular and cellular cardiology.

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein.

W. Manning, C. Berul, H. Wakimoto, 2001, The Journal of clinical investigation.

The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression

Youngsook Lee, S. Izumo, H. Kasahara, 1998, Molecular and Cellular Biology.

Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development.

G. Lyons, I. Komuro, Youngsook Lee, 1998, Developmental genetics.

Heart Failure Induced by Perinatal Ablation of Cardiac Myosin Light Chain Kinase

Robert H. Anderson, H. Kasahara, Y. Islam, 2016, Front. Physiol..

Slow progressive conduction and contraction defects in loss of Nkx2–5 mice after cardiomyocyte terminal differentiation

H. Wakimoto, K. Chien, K. Robertson, 2009, Laboratory Investigation.

Induction of Cytoplasmic Rods and Rings Structures by Inhibition of the CTP and GTP Synthetic Pathway in Mammalian Cells

Naohiro Terada, Minoru Satoh, Bing Yao, 2011, PloS one.

Bone Marrow Cells Differentiate in Cardiac Cell Lineages After Infarction Independently of Cell Fusion

D. Torella, C. Bearzi, M. Rota, 2004, Circulation research.

Defective coronary vessel organization and reduction of VEGF‐A in mouse embryonic hearts with gestational mild hypoxia

H. Kasahara, Lawrence X. Cai, Fariz F. Alkassis, 2020, Developmental dynamics : an official publication of the American Association of Anatomists.

Characterization of Homo- and Heterodimerization of Cardiac Csx/Nkx2.5 Homeoprotein*

A. Usheva, N. Horikoshi, S. Izumo, 2001, The Journal of Biological Chemistry.

Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies

A. Riva, H. Kasahara, O. Moumne, 2018, Front. Cardiovasc. Med..

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis

T. Shiratsuchi, N. Terada, S. P. Oh, 2015, Cell Death and Differentiation.

Gestational intermittent hyperoxia rescues murine genetic congenital heart disease in part

H. Kasahara, Lawrence X. Cai, Fariz F. Alkassis, 2021, Scientific Reports.

Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract

S. Rowan, Junmin Peng, R. Mathias, 2015, Proceedings of the National Academy of Sciences.

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species.

K. Wagner, M. Grant, S. P. Oh, 2011, Cardiovascular research.

Vascular smooth muscle Jak 2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species

K. Wagner, M. Grant, S. P. Oh, 2011 .

Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies.

D. Benson, H. Kasahara, 2004, Cardiovascular research.

A novel variant of cardiac myosin-binding protein-C that is unable to assemble into sarcomeres is expressed in the aged mouse atrium.

N. Sato, T. Obinata, H. Kasahara, 2003, Molecular biology of the cell.

Impaired atrial contraction in patients with atrial flutter and gradual recovery after cardioversion.

T. Yaginuma, H. Kasahara, M. Saito, 1998, Japanese circulation journal.

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

S. P. Oh, K. Wagner, H. Kasahara, 2011, Journal of molecular and cellular cardiology.

Monogenic Causes of Heart Failure

H. Kasahara, 2005 .

Crystallization and preliminary X-ray analysis of the NKX2.5 homeodomain in complex with DNA.

H. Nam, H. Kasahara, C. Genis, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Elevated expression of Nkx‐2.5 in developing myocardial conduction cells

M. Yacoub, S. Izumo, P. Barton, 2001, The Anatomical record.

COUP-TF1 Antagonizes Nkx2.5-mediated Activation of the Calreticulin Gene during Cardiac Development*

Lei Guo, M. Michalak, S. Izumo, 2001, The Journal of Biological Chemistry.

Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations

H. Kasahara, Lawrence X. Cai, Fariz F. Alkassis, 2019, Front. Physiol..

Chibby, an Antagonist of the Wnt/β-Catenin Pathway, Facilitates Cardiomyocyte Differentiation of Murine Embryonic Stem Cells

K. Takemaru, Feng-Qian Li, N. Terada, 2007, Circulation.

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice

C. Berul, H. Wakimoto, S. Izumo, 2003, Genesis.

Developmentally Modulated Cardiac Conduction Failure in Transgenic Mice with Fetal or Postnatal Overexpression of DNA Nonbinding Mutant Nkx2.5

C. Berul, H. Wakimoto, S. Izumo, 2002, Journal of cardiovascular electrophysiology.

Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation

Robert H. Anderson, H. Wakimoto, M. Silberbach, 2015, Circulation. Arrhythmia and electrophysiology.

Bone Marrow Cells Differentiate in Cardiac Cell Lineages After Infarction Independently

C. Bearzi, M. Rota, A. Leri, 2004 .

Comparison of Effects of Nicardipine Hydrochloride Tablets and the Sustained-release Formulation on Essential Hypertension by 24-hour Ambulatory Blood Pressure Monitoring

M. Hirai, H. Hayashi, Y. Inden, 1997 .

AAV‐mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes

B. Byrne, A. Lewin, H. Kasahara, 2008, The journal of gene medicine.

Identification of Cardiac-Specific Myosin Light Chain Kinase

N. Sato, K. Chien, N. Horikoshi, 2008, Circulation research.

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation.

K. Chien, Jonathan T. Lu, H. Kasahara, 2011, Cardiovascular research.

Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5.

H. Nam, H. Kasahara, L. Pradhan, 2016, Biochemistry.

Heart Failure-Inducible Gene Therapy Targeting Protein Phosphatase 1 Prevents Progressive Left Ventricular Remodeling

M. Matsuzaki, Y. Ikeda, H. Kasahara, 2012, PloS one.

Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress

M. Swanson, R. Moss, S. Lecker, 2012, Circulation.

Results Regional Expression of cMLCK Protein and Phosphorylation of MLC 2 v in Mouse and Human Hearts

M. Swanson, R. Moss, S. Lecker, 2012 .

Compound loss of muscleblind-like function in myotonic dystrophy

M. Swanson, L. Ranum, Christopher M. Chamberlain, 2013, EMBO molecular medicine.

Perinatal Loss of Nkx2-5 Results in Rapid Conduction and Contraction Defects

H. Wakimoto, Y. Ikeda, K. Chien, 2008, Circulation research.

Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein.

S. Izumo, S. Bartunkova, H. Kasahara, 1998, Circulation research.

Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors

N. Terada, Shouguang Jin, H. Kasahara, 2015, Scientific Reports.

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

Andrew D McCulloch, Richard L Moss, Ju Chen, 2012, The Journal of clinical investigation.

Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments

E. Chan, L. Morel, H. Kasahara, 2018, Front. Immunol..

A Mouse Model of Human Congenital Heart Disease: High Incidence of Diverse Cardiac Anomalies and Ventricular Noncompaction Produced by Heterozygous Nkx2-5 Homeodomain Missense Mutation

Robert H. Anderson, M. Zarate, H. Nam, 2014, Circulation. Cardiovascular genetics.

Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2

T. Golde, Sixue Chen, H. Kasahara, 2019, Scientific Reports.

Identification of the In Vivo Casein Kinase II Phosphorylation Site within the Homeodomain of the Cardiac Tisue-Specifying Homeobox Gene Product Csx/Nkx2.5

S. Izumo, H. Kasahara, 1999, Molecular and Cellular Biology.

Gene silencing using adenoviral RNAi vector in vascular smooth muscle cells and cardiomyocytes.

H. Kasahara, H. Aoki, 2005, Methods in molecular medicine.

Differential Role of Nkx2-5 in Activation of the Atrial Natriuretic Factor Gene in the Developing versus Failing Heart

Thomas P. Yang, W. Chien, T. Seki, 2011, Molecular and Cellular Biology.

Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor.

S. Izumo, Jerry T. Thompson, D. Menick, 2002, Journal of molecular and cellular cardiology.

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease.

J. Seidman, C. Seidman, S. Izumo, 2000, The Journal of clinical investigation.

A hypoxia-inducible vigilant vector system for activating therapeutic genes in ischemia

A. Agarwal, H. Kasahara, M. Phillips, 2005, Gene Therapy.

Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.

Robert H. Anderson, R. Moss, G. Walter, 2016, Cardiovascular research.

Extracellular Matrix Disparities in an Nkx2-5 Mutant Mouse Model of Congenital Heart Disease

Rebecca A. Wachs, C. Schmidt, H. Kasahara, 2020, Frontiers in Cardiovascular Medicine.

Progressive Anatomical Closure of Foramen Ovale in Normal Neonatal Mouse Hearts

H. Kasahara, A. Wessels, Colleen T. Cole-Jeffrey, 2012, Anatomical record.

Crystal structure of the human NKX2.5 homeodomain in complex with DNA target.

H. Nam, H. Kasahara, L. Pradhan, 2012, Biochemistry.

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

A. McCulloch, Yusu Gu, N. Dalton, 2012, The Journal of clinical investigation.