D. Hadsell

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Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging

S. Ellis, M. Fiorotto, A. Capuco, 2006, Experimental Gerontology.

Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome.

Monique Rijnkels, M. Rijnkels, P. Sen, 2009, Physiological genomics.

Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions

Danielle G. Lemay, J. Neu, M. Rijnkels, 2012, Journal of Mammary Gland Biology and Neoplasia.

Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.

Adrian V. Lee, D. Hadsell, D. Torres, 2007, The Journal of endocrinology.

The insulin-like growth factor system in normal mammary gland function.

D. Hadsell, 2003, Breast disease.

Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.

X. Wehrens, J. Marini, Y. Qu, 2017, American journal of physiology. Endocrinology and metabolism.

Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis

B. Foster, N. Greenberg, R. Barrios, 2008, Oncogene.

Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein.

Victor V. Keasler, S. Lemon, S. Forbes, 2006, Virology.

Genetic manipulation of the IGF-I axis to regulate mammary gland development and function.

D. Hadsell, A. V. Lee, S. Bonnette, 2002, Journal of dairy science.

Advances in Brief Estrogen-mediated Down-Regulation of E-cadherin in Breast Cancer Cells 1

Adrian V. Lee, R. Schiff, S. Oesterreich, 2003 .

HIF 1 α is a critical regulator of secretory differentiation and activation , but not vascular expansion , in the mouse mammary gland

J. McManaman, M. Neville, B. Welm, 2003 .

In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1

M. Rijnkels, M. Grusak, P. Williamson, 2018, Mammalian Genome.

In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci

C. Creighton, M. Rijnkels, T. Cox, 2015, Mammalian Genome.

Technical note: assessing the functional capacity of mitochondria isolated from lactating mammary tissue: choose your chelating agent wisely.

B. Lambert, R. Collier, D. Hadsell, 2009, Journal of dairy science.

Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds.

D. Hadsell, S. Bonnette, 2001, Endocrinology.

Perinatal expression of type I IGF receptors in porcine small intestine.

D. Hadsell, F. Simmen, D. Schober, 1990, Endocrinology.

Maternal Adipocyte Connexin43 Gap Junctions Affect Breastmilk Lactose Levels and Neonate Growth in Mice

Xi Chen, D. Hadsell, Chunmei Wang, 2022, Biology.

Overexpression of Des(1–3) Insulin-Like Growth Factor 1 in the Mammary Glands of Transgenic Mice Delays the Loss of Milk Production with Prolonged Lactation1

Adrian V. Lee, M. Fiorotto, D. Hadsell, 2005, Biology of Reproduction.

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

J. Rosen, N. Greenberg, D. Hadsell, 1996, Endocrinology.

GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.

J. Holst, B. Stoll, D. Burrin, 2006, Gastroenterology.

Regulation of cell apoptosis by insulin-like growth factor I.

D. Hadsell, G. Abdel-Fattah, 2001, Advances in experimental medicine and biology.

Effects of dietary insulin-like growth factor I on growth and insulin-like growth factor receptors in neonatal calf intestine.

D. Hadsell, J. Blum, C. Baumrucker, 1994, Journal of animal science.

Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs.

B. Stoll, D. Burrin, A. Suryawan, 2010, The Journal of nutrition.

and proliferation in neonatal piglets signaling pathways involved in intestinal cell survival GLP-2 rapidly activates divergent intracellular

B. Stoll, D. Burrin, X. Guan, 2007 .

GLP-2 rapidly activates divergent intracellular signaling pathways involved in intestinal cell survival and proliferation in neonatal piglets.

B. Stoll, D. Burrin, X. Guan, 2007, American journal of physiology. Endocrinology and metabolism.

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

J. Rosen, N. Greenberg, D. Hadsell, 1996, Endocrinology.

Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression.

D. Hadsell, D. Torres, J. George, 2008, The Journal of endocrinology.

Inability of Overexpressed des(1-3)Human Insulin-Like Growth Factor I (IGF-I) to Inhibit Forced Mammary Gland Involution Is Associated with Decreased Expression of IGF Signaling Molecules.

Adrian V. Lee, D. Hadsell, D. Torres, 2001, Endocrinology.

Characterization of the change in type I and II insulin-like growth factor receptors of bovine mammary tissue during the pre- and postpartum periods.

P. Campbell, D. Hadsell, C. Baumrucker, 1990, Endocrinology.

In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci

C. Creighton, M. Rijnkels, T. Cox, 2014, Mammalian Genome.

Constitutively Active Insulin-Like Growth Factor I Receptor Tumor Development by Transgenic Expression of a

Adrian V. Lee, F. Lee, D. Bol, 2005 .

Oncogenic Transformation by the Signaling Adaptor Proteins Insulin Receptor Substrate (IRS)-1 and IRS-2

Adrian V. Lee, Adrian V Lee, X. Cui, 2007, Cell cycle.

Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice.

M. Fiorotto, J. Mills, D. Hadsell, 2003, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Inability of overexpressed des(1-3)human insulin-like growth factor I (IGF-I) to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling molecules.

Y. Klimentidis, D. Hadsell, D. Torres, 2001, Endocrinology.

The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes.

B. Raught, J. Rosen, D. Hadsell, 1996, The American journal of clinical nutrition.

Milk glucosidase activity enables suckled pup starch digestion

B. Hamaker, S. Baker, B. Nichols, 2016, Molecular and Cellular Pediatrics.

Mammary Tumorigenesis and Metastasis Caused by Overexpression of Insulin Receptor Substrate 1 (IRS-1) or IRS-2

Adrian V. Lee, X. Cui, S. Mohsin, 2006, Molecular and Cellular Biology.

Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.

C. Kahn, S. Oesterreich, J. Rosen, 2003, Endocrinology.

Regulation of milk protein gene expression.

J. Rosen, S. Wyszomierski, D. Hadsell, 1999, Annual review of nutrition.

Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G.

Y. Klimentidis, J. Summy-Long, D. Hadsell, 2003, Molecular endocrinology.

Estrogen-mediated down-regulation of E-cadherin in breast cancer cells.

Adrian V. Lee, R. Schiff, S. Oesterreich, 2003, Cancer research.

Engineering transgenes for use in the mammary gland.

J. Rosen, D. Hadsell, S. Yarus, 1996, Genetic engineering.

Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups.

D. Burrin, M. Fiorotto, D. Hadsell, 1999, The Journal of nutrition.

p190-B RhoGAP regulates mammary ductal morphogenesis.

J. Settleman, J. Rosen, G. Chakravarty, 2003, Molecular Endocrinology.

Insulin‐like growth factor (IGF) binding to a murine mammary epithelial cell line

D. Hadsell, C. A. Gibson, C. Baumrucker, 1994, Journal of cellular physiology.

Genetic manipulation of mammary gland development and lactation.

D. Hadsell, 2004, Advances in experimental medicine and biology.

New Mechanisms of Signal Transduction Inhibitor Action

Steffi Oesterreich, Adrian V. Lee, Rachel Schiff, 2003 .

New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation.

Steffi Oesterreich, Adrian V. Lee, Adrian V Lee, 2003, Clinical Cancer Research.

IGF and Insulin Action in the Mammary Gland: Lessons from Transgenic and Knockout Models

D. Hadsell, S. Bonnette, 2004, Journal of Mammary Gland Biology and Neoplasia.

Insulin-like growth factor (IGF)-I and -II and IGF binding proteins in serum and mammary secretions during the dry period and early lactation in dairy cows.

T. Skaar, D. Hadsell, C. A. Gibson, 1991, Journal of animal science.

Milk yield differences between 1× and 4× milking are associated with changes in mammary mitochondrial number and milk protein gene expression, but not mammary cell apoptosis or SOCS gene expression.

R. Collier, D. Hadsell, J. Collier, 2015, Journal of dairy science.

Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women.

M. Rijnkels, P. Sen, M. Haymond, 2011, Physiological genomics.

In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1

M. Rijnkels, M. Grusak, P. Williamson, 2018, Mammalian Genome.

The Declining Phase of Lactation: Peripheral or Central, Programmed or Pathological?

D. Hadsell, D. Torres, J. George, 2007, Journal of Mammary Gland Biology and Neoplasia.

Genetic variation in sensitivity to estrogens and breast cancer risk

M. Rijnkels, A. Trentham-Dietz, J. Shull, 2018, Mammalian Genome.

Local insulin-like growth factor-II mediates prolactin-induced mammary gland development.

Adrian V. Lee, Adrian V Lee, Christopher J Ormandy, 2003, Molecular endocrinology.

Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis

Kristen L Murphy, R. Laucirica, J. Rosen, 2000, Oncogene.

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.

Adrian V. Lee, Brandy M Heckman, J. Settleman, 2007, Developmental biology.

In silico QTL mapping of maternal nurturing ability with the mouse diversity panel.

P. Williamson, P. Thomson, D. Hadsell, 2012, Physiological genomics.

The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth

Adrian V. Lee, R. Schiff, C. Osborne, 2006, Breast Cancer Research and Treatment.

HIF1α is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

Margaret C. Neville, J. McManaman, M. Neville, 2003 .

Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans.

Mahmoud A. Mohammad, M. Haymond, D. Hadsell, 2012, American journal of physiology. Endocrinology and metabolism.

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.

Adrian V. Lee, F. Lee, D. Bol, 2005, Cancer research.

Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle.

Robert J Collier, M. Fiorotto, R. Collier, 2011, Physiological genomics.

Regulation of gene expression in human mammary epithelium: effect of breast pumping.

P. Sen, M. Haymond, A. Sunehag, 2007, The Journal of endocrinology.

Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions[S]

B. Stoll, D. Burrin, C. Newgard, 2016, Journal of Lipid Research.

Diet-Induced Inflammation and Mammary Ductal Development: Alternative Activation of Estrogen-Dependent Stromal-Epithelial Signaling.

D. Hadsell, 2017, Endocrinology.