C. Weyand

发表

Enables T Cell Responses to Self-Antigens Mediated TCR Sensitization - and IL-15 - IL-7

Pratima Deshpande, Mary M. Cavanagh, S. Saux, 2013 .

IL-7– and IL-15–Mediated TCR Sensitization Enables T Cell Responses to Self-Antigens

Pratima Deshpande, Mary M. Cavanagh, Karnail Singh, 2013, The Journal of Immunology.

The influence of sex on the phenotype of rheumatoid arthritis.

U. Wagner, C. Weyand, J. Goronzy, 1998, Arthritis and rheumatism.

Regulation of T-cell function by endogenously produced angiotensin II.

D. Harrison, C. Weyand, Nyssa E. Hoch, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

L. Tian, E. Matteson, C. Weyand, 2016, Science Translational Medicine.

Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis

G. Berry, S. Goodman, C. Weyand, 2021, Frontiers in Immunology.

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging

Ash A. Alizadeh, Aaron M. Newman, C. Garrison Fathman, 2015, PloS one.

Epigenomics of human CD8 T cell differentiation and aging

David M. Moskowitz, Jason D. Buenrostro, J. Buenrostro, 2017, Science Immunology.

Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination

Gary E. Swan, Richard A. Olshen, Qian Qi, 2016, Science Translational Medicine.

Association of MHC and rheumatoid arthritis:HLA polymorphisms in phenotypic variants of rheumatoid arthritis

C. Weyand, J. Goronzy, Jörg J Goronzy, 2000, Arthritis research.

The Influence of Age on T Cell Generation and TCR Diversity1

A. Vallejo, C. Weyand, J. Goronzy, 2005, The Journal of Immunology.

Diversity and clonal selection in the human T-cell repertoire

Richard A. Olshen, Yi Liu, Qian Qi, 2014, Proceedings of the National Academy of Sciences.

Immunometabolism in early and late stages of rheumatoid arthritis

C. Weyand, J. Goronzy, 2017, Nature Reviews Rheumatology.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

K-RAS GTPase- and B-RAF kinase–mediated T-cell tolerance defects in rheumatoid arthritis

Karnail Singh, Mary Cavanagh, Pratima Deshpande, 2012, Proceedings of the National Academy of Sciences.

Immune aging and rheumatoid arthritis.

C. Weyand, J. Goronzy, L. Shao, 2010, Rheumatic diseases clinics of North America.

Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells.

C. Weyand, J. Goronzy, Guangjin Li, 2009, Blood.

Cell-cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis

C. Weyand, J. Goronzy, Paul J. Kurtin, 2000, Arthritis Research & Therapy.

MMP (Matrix Metalloprotease)-9–Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis

L. Tian, G. Berry, C. Weyand, 2018, Circulation research.

Regulatory T Cells and the Immune Aging Process: A Mini-Review

Y. Shimojima, C. Weyand, J. Goronzy, 2013, Gerontology.

Mechanisms underlying T cell ageing

C. Weyand, J. Goronzy, 2019, Nature Reviews Immunology.

Dendritic cells in atherosclerotic disease.

C. Weyand, A. Niessner, 2010, Clinical immunology.

T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells.

A. Weiss, C. Weyand, J. Goronzy, 1985, Journal of immunology.

Metabolic Fitness of T Cells in Autoimmune Disease

C. Weyand, J. Goronzy, Bowen Wu, 2020, Immunometabolism.

Hematopoietic stem cell function in rheumatoid arthritis

C. Weyand, J. Goronzy, I. Colmegna, 2008 .

The Transcription Factor TCF1 in T Cell Differentiation and Aging

C. Weyand, J. Goronzy, Chulwoo Kim, 2020, International journal of molecular sciences.

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

W. Hildebrand, A. Hirsch, C. Weyand, 2019, Cell reports.

Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, Hisashi Oishi, 2012, Clinical immunology.

CD8+CD45RA+CCR7+FOXP3+ T Cells with Immunosuppressive Properties: A Novel Subset of Inducible Human Regulatory T Cells

Y. Shimojima, C. Weyand, J. Goronzy, 2012, The Journal of Immunology.

Immunosuppressive Properties: A Novel Subset of Inducible Human Regulatory T Cells

Y. Shimojima, C. Weyand, Masakatsu Suzuki, 2012 .

Trapping of misdirected dendritic cells in the granulomatous lesions of giant cell arteritis.

Myung-Shin Jeon, C. Weyand, J. Goronzy, 2002, The American journal of pathology.

The immunology of rheumatoid arthritis

C. Weyand, J. Goronzy, 2020, Nature Immunology.

Immunosenescence, autoimmunity, and rheumatoid arthritis

C. Weyand, J. Goronzy, J. Fulbright, 2003, Experimental Gerontology.

Disease-specific metabolic abnormalities in rheumatoid arthritis and systemic lupus erythematosus Rheumatoid arthritis

E. Matteson, C. Weyand, J. Goronzy, 2016 .

Gene Conversion A Mechanism to Explain HLA‐D Region and Disease Association a

C. Fathman, C. Weyand, J. Goronzy, 1986, Annals of the New York Academy of Sciences.

Immune cell repertoires in breast cancer patients after adjuvant chemotherapy.

L. Tian, M. Pegram, C. Weyand, 2020, JCI insight.

Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels upon T Cell Activation

D. Harrison, S. Dikalov, C. Weyand, 2011, The Journal of Biological Chemistry.

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation.

L. Tian, G. Berry, C. Weyand, 2019, Cell metabolism.

Inflammation and cardiac outcome

K. Huber, J. Wojta, P. Hohensinner, 2011, Current opinion in infectious diseases.

T-cell metabolism in autoimmune disease

E. Matteson, C. Weyand, J. Goronzy, 2015, Arthritis Research & Therapy.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

D. Harrison, L. Roberts, K. Bernstein, 2016, The Journal of clinical investigation.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

D. Harrison, L. Roberts, K. Bernstein, 2016, The Journal of clinical investigation.

Immune checkpoint dysfunction in large and medium vessel vasculitis.

G. Berry, C. Weyand, J. Goronzy, 2017, American journal of physiology. Heart and circulatory physiology.

Cytokines, growth factors and proteases in medium and large vessel vasculitis.

G. Berry, M. Akiyama, C. Weyand, 2019, Clinical immunology.

T cell receptor peptide vaccination in rheumatoid arthritis : A placebo-controlled trial using a combination of Vβ3, Vβ14, and Vβ17 peptides

T. C. Adamson, V. Strand, D. Carlo, 1998 .

NOTCH-induced rerouting of endosomal trafficking disables regulatory T-cells in vasculitis.

G. Berry, C. Weyand, J. Goronzy, 2020, The Journal of clinical investigation.

Interleukin 12 Induces T-Cell Recruitment Into the Atherosclerotic Plaque

R. Frye, S. Kopecky, C. Weyand, 2006, Circulation research.

Polymyalgia rheumatica and giant cell arteritis

C. Weyand, J. Goronzy, 2015 .

Sonography in giant-cell arteritis.

G. Hunder, C. Weyand, 1997, The New England journal of medicine.

Large-Vessel Vasculitides

C. Weyand, 2019, Clinical Immunology.

59 – Large-vessel vasculitides

C. Weyand, J. Goronzy, 2008 .

Clinical and Pathological Evolution of Giant Cell Arteritis: A Prospective Study of Follow-Up Temporal Artery Biopsies in 40 Treated Patients

G. Hunder, C. Weyand, J. Goronzy, 2017, Modern Pathology.

Th 17 and Th 1 T-Cell Responses in Giant Cell Arteritis

R. Olshen, Jiusheng Deng, C. Weyand, 2010 .

Th17 and Th1 T-Cell Responses in Giant Cell Arteritis

R. Olshen, Jiusheng Deng, C. Weyand, 2010, Circulation.

The treatment of giant cell arteritis.

N. Newman, G. Hunder, V. Biousse, 2008, Reviews in neurological diseases.

Treatment of giant cell arteritis using induction therapy with high-dose glucocorticoids: a double-blind, placebo-controlled, randomized prospective clinical trial.

G. Hunder, E. Matteson, Kirk A Easley, 2006, Arthritis and rheumatism.

Giant Cell Arteritis: From Pathogenesis to Therapeutic Management

G. Berry, Y. J. Liao, C. Weyand, 2016, Current Treatment Options in Rheumatology.

Clinical practice. Giant-cell arteritis and polymyalgia rheumatica.

C. Weyand, J. Goronzy, 2014, The New England journal of medicine.

Giant Cell Arteritis

C. Weyand, J. Goronzy, 2012 .

IFN-γ and IL-17: the two faces of T-cell pathology in giant cell arteritis

C. Weyand, J. Goronzy, B. Younge, 2011, Current opinion in rheumatology.

Occurrence of giant cell arteritis...suddenly.

C. Weyand, J. Goronzy, B. Younge, 2007, Transactions of the American Ophthalmological Society.

Immunopathways in giant cell arteritis and polymyalgia rheumatica.

C. Weyand, J. Goronzy, Wei Ma-Krupa, 2004, Autoimmunity reviews.

Large-vessel vasculitis

Goel, N. Basu, C. Goodyear, 2021, Nature Reviews Disease Primers.

Clinicopathologic correlations in giant cell arteritis: a retrospective study of 107 cases.

N. Newman, H. Grossniklaus, V. Biousse, 2009, Ophthalmology.

Infliximab for Maintenance of Glucocorticosteroid-Induced Remission of Giant Cell Arteritis

Mahboob Rahman, P. Merkel, J. Stone, 2007, Annals of Internal Medicine.

Therapeutic effects of acetylsalicylic acid in giant cell arteritis.

Hongyu Yang, C. Weyand, J. Goronzy, 2002, Arthritis and rheumatism.

Giant Cell Arteritis: Pathogenesis

C. Weyand, J. Goronzy, 2000 .

Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis.

C. Weyand, J. Goronzy, A. Wagner, 1996, The Journal of clinical investigation.

Pro-inflammatory and anti-inflammatory T cells in giant cell arteritis.

G. Berry, C. Weyand, J. Goronzy, 2017, Joint, bone, spine : revue du rhumatisme.

Visual Manifestations in Giant Cell Arteritis: Trend over 5 Decades in a Population-based Cohort

E. Matteson, C. Crowson, C. Weyand, 2015, The Journal of Rheumatology.

Blocking the NOTCH Pathway Inhibits Vascular Inflammation in Large-Vessel Vasculitis

M. Desai, Jiusheng Deng, C. Weyand, 2011, Circulation.

Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries.

L. Szweda, C. Weyand, J. Goronzy, 2002, The American journal of pathology.

Medium- and large-vessel vasculitis.

C. Weyand, J. Goronzy, 2003, The New England journal of medicine.

CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis.

G. Berry, S. Nadler, C. Weyand, 2019, Journal of the American College of Cardiology.

The immunoinhibitory PD‐1/PD‐L1 pathway in inflammatory blood vessel disease

G. Berry, C. Weyand, J. Goronzy, 2017, Journal of leukocyte biology.

Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis

L. Tian, G. Berry, C. Weyand, 2017, Circulation.

Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis

G. Berry, A. Vaglio, Y. J. Liao, 2017, Proceedings of the National Academy of Sciences.

Serpin Treatment Suppresses Inflammatory Vascular Lesions in Temporal Artery Implants (TAI) from Patients with Giant Cell Arteritis

C. Weyand, A. Lucas, A. Yachnis, 2015, PloS one.

Dendritic Cells and Vascular Inflammation

C. Weyand, 2012 .

The immunopathology of giant cell arteritis: diagnostic and therapeutic implications.

Y. J. Liao, C. Weyand, J. Goronzy, 2012, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

Vascular damage in giant cell arteritis

N. Newman, V. Biousse, C. Weyand, 2009, Autoimmunity.

Toll-Like Receptors 4 and 5 Induce Distinct Types of Vasculitis

Jiusheng Deng, A. Gewirtz, C. Weyand, 2009, Circulation research.

Vessel-Specific Toll-Like Receptor Profiles in Human Medium and Large Arteries

Olga Pryshchep, C. Weyand, J. Goronzy, 2008, Circulation.

T cells in arteritis and atherosclerosis

C. Weyand, J. Goronzy, B. Younge, 2008, Current opinion in lipidology.

Surgical Pathology of Noninfectious Ascending Aortitis: A Study of 45 Cases With Emphasis on an Isolated Variant

W. Edwards, M. Aubry, H. Tazelaar, 2006, The American journal of surgical pathology.

Treatment of chronic inflammatory diseases with biologic agents: Opportunities and risks for the elderly

C. Weyand, J. Goronzy, A. Díaz-Borjón, 2006, Experimental Gerontology.

Vascular Dendritic Cells in Giant Cell Arteritis

S. Gröschel, Olga Pryshchep, C. Weyand, 2005, Annals of the New York Academy of Sciences.

Vasculitis: A Dialogue Between the Artery and the Immune System

G. Hoffman, C. Weyand, 2000 .

Corticosteroid requirements in polymyalgia rheumatica.

J. Evans, G. Hunder, Jonathan M. Evans, 1999, Archives of internal medicine.

Tissue Cytokine Patterns in Patients with Polymyalgia Rheumatica and Giant Cell Arteritis

G. Hunder, C. Weyand, J. Goronzy, 1994, Annals of Internal Medicine.

The Dunlop-Dottridge Lecture: The pathogenesis of giant cell arteritis.

C. Weyand, 2000, The Journal of rheumatology.

Pathogenic mechanisms in giant cell arteritis.

C. Weyand, J. Goronzy, 2002, Cleveland Clinic journal of medicine.

Disease patterns and tissue cytokine profiles in giant cell arteritis.

A. Brack, C. Weyand, J. Goronzy, 1997, Arthritis and rheumatism.

Giant Cell Vasculitis Is a T Cell-Dependent Disease

A. Brack, C. Weyand, J. Goronzy, 1997, Molecular medicine.

AB0598 OSTEOPOROSIS AND RISK OF GIANT CELL ARTERITIS: A COMPARATIVE STUDY

D. Sène, C. Weyand, A. Mahr, 2019, Abstracts Accepted for Publication.

152. OSTEOPOROSIS AND RISK OF GIANT CELL ARTERITIS: A COMPARATIVE STUDY

D. Sène, C. Weyand, A. Mahr, 2019, Rheumatology.

Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity

G. Berry, D. Harrison, J. Tremmel, 2017, The Journal of clinical investigation.

The metabolic signature of T cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, Bowen Wu, 2019, Current opinion in rheumatology.

Innate and Adaptive Immunity in Giant Cell Arteritis

G. Berry, M. Akiyama, C. Weyand, 2021, Frontiers in Immunology.

T-cell aging in rheumatoid arthritis

C. Weyand, J. Goronzy, Zhen Yang, 2014, Current opinion in rheumatology.

Lysosomes in T Cell Immunity and Aging

C. Weyand, J. Goronzy, Jun Jin, 2021, Frontiers in Aging.

Insufficient Deactivation of the Protein Tyrosine Kinase Lck Amplifies T-Cell Responsiveness in Acute Coronary Syndrome

C. Weyand, J. Goronzy, Sergey Pryshchep, 2010, Circulation research.

Genetic risk factors in inflammatory abdominal aortic aneurysms: polymorphic residue 70 in the HLA-DR B1 gene as a key genetic element.

W. Harmsen, T. Rasmussen, J. Hallett, 1997, Journal of vascular surgery.

Immunopathologic aspects of rheumatoid arthritis: who is the conductor and who plays the immunologic instrument?

C. Weyand, 2007, The Journal of rheumatology. Supplement.

Neutrophil Extracellular Traps Induce Tissue-Invasive Monocytes in Granulomatosis With Polyangiitis

G. Berry, M. Akiyama, C. Weyand, 2019, Front. Immunol..

Lymphoma in rheumatoid arthritis: an immune system set up for failure.

C. Weyand, J. Goronzy, Paul J. Kurtin, 2006, Arthritis and rheumatism.

Rheumatoid Arthritis Lowers Threshold for T Cell Activation in Unchecked CD70 Expression on T Cells

C. Weyand, J. Goronzy, Guangjin Li, 2007 .

Unchecked CD70 Expression on T Cells Lowers Threshold for T Cell Activation in Rheumatoid Arthritis1

C. Weyand, J. Goronzy, Guangjin Li, 2007, The Journal of Immunology.

Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages.

C. Weyand, J. Goronzy, David L. Lamar, 2010, Blood.

Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation

Ji-hang Ju, C. Weyand, J. Goronzy, 2015, The Journal of Immunology.

Opposite effects of CX3CR1 receptor polymorphisms V249I and T280M on the development of acute coronary syndrome

O. Wagner, G. Maurer, K. Huber, 2005, Thrombosis and Haemostasis.

Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications.

F. Crea, C. Weyand, G. Liuzzo, 2016, Journal of the American College of Cardiology.

Redox‐sensitive signaling in inflammatory T cells and in autoimmune disease

C. Weyand, J. Goronzy, Yi Shen, 2018, Free radical biology & medicine.

Chronic inflammation and aging: DNA damage tips the balance.

Mary M. Cavanagh, C. Weyand, J. Goronzy, 2012, Current opinion in immunology.

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis.

S. Goodman, Ji-hang Ju, P. Hohensinner, 2016, Immunity.

ActivationReceptor Signaling Thresholds after T Cell Age-Associated Failure To Adjust Type I IFN

Ji-hang Ju, C. Weyand, Goronzy Guangjin Li, 2015 .

Induction of hypertension and peripheral inflammation by deletion of extracellular superoxide dismutase in the central nervous system

C. Weyand, T. Guzik, P. Marvar, 2010, Hypertension.

Regulation of T cell receptor signaling by activation-induced zinc influx

L. Tian, M. Cześnikiewicz-Guzik, Karnail Singh, 2011, The Journal of experimental medicine.

Human leukocyte antigen class II immune response genes, female gender, and cigarette smoking as risk and modulating factors in abdominal aortic aneurysms.

W. O'Fallon, V. Miller, T. Rasmussen, 2002, Journal of vascular surgery.

T-Cell–Mediated Lysis of Endothelial Cells in Acute Coronary Syndromes

R. Frye, S. Kopecky, S. Schulte, 2002, Circulation.

Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.

L. Tian, M. Akiyama, C. Weyand, 2020, Cell metabolism.

T follicular helper cell development and functionality in immune ageing.

C. Weyand, J. Goronzy, C. Gustafson, 2018, Clinical science.

L. Tian, C. Weyand, J. Goronzy, 2020, Frontiers in Immunology.

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation

L. Tian, C. Weyand, J. Goronzy, 2019, Aging cell.

Inflammatory Diseases of Blood Vessels

G. Hoffman, C. Weyand, 2001 .

Metabolic reprogramming in memory CD4 T cell responses of old adults.

C. Weyand, J. Goronzy, Yi Shen, 2019, Clinical immunology.

Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions.

D. Maron, C. Weyand, T. Shirai, 2015, International journal of clinical rheumatology.

Treating autoimmune disease by targeting CD8+ T suppressor cells

C. Weyand, J. Goronzy, Christine Konya, 2009, Expert opinion on biological therapy.

Inhibitory CD8+ T cells in autoimmune disease.

C. Weyand, J. Goronzy, Masakatsu Suzuki, 2008, Human immunology.

Ectopic lymphoid organogenesis: a fast track for autoimmunity.

C. Weyand, J. Goronzy, Paul J. Kurtin, 2001, The American journal of pathology.

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.

Ji-hang Ju, Y. Shimojima, C. Weyand, 2016, The Journal of clinical investigation.

Rheumatoid Synovitis IL-16 as an Anti-Inflammatory Cytokine in

P. Klimiuk, C. Weyand, J. Goronzy, 2013 .

Aging of the Immune System. Mechanisms and Therapeutic Targets.

C. Weyand, J. Goronzy, 2016, Annals of the American Thoracic Society.

T-Cell Aging-Associated Phenotypes in Autoimmune Disease

C. Weyand, J. Goronzy, Tuantuan V. Zhao, 2022, Frontiers in Aging.

The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages

G. Berry, C. Weyand, J. Goronzy, 2022, Nature Metabolism.

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

C. Weyand, J. Goronzy, Tuantuan V. Zhao, 2021, Nature Immunology.

N-myristoyltransferase deficiency impairs AMPK activation and promotes synovial tissue inflammation

L. Tian, S. Shoor, C. Weyand, 2018, Nature Immunology.

Stimulatory Killer Ig-Like Receptors Modulate T Cell Activation through DAP12-Dependent and DAP12-Independent Mechanisms1

P. Leibson, M. Snyder, C. Weyand, 2004, The Journal of Immunology.

CD8 T Cells Are Required for the Formation of Ectopic Germinal Centers in Rheumatoid Synovitis

U. Wagner, R. Beckenbaugh, Y. Kang, 2002, The Journal of experimental medicine.

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages

S. Schönland, C. Weyand, J. Goronzy, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Functional properties of CD4+CD28− T cells in the aging immune system

C. Weyand, J. Goronzy, D. Schmidt, 1998, Mechanisms of Ageing and Development.

The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy

C. Weyand, J. Goronzy, Zhen Yang, 2014, Autophagy.

Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells

É. Vivier, M. Snyder, C. Weyand, 2003, The Journal of experimental medicine.

Immunometabolism in the development of rheumatoid arthritis

C. Weyand, J. Goronzy, 2020, Immunological reviews.

Giant cell arteritis: new concepts in pathogenesis and implications for management.

C. Weyand, G. Bartley, 1997, American journal of ophthalmology.

T-cell-targeted therapies in rheumatoid arthritis

C. Weyand, J. Goronzy, 2006, Nature Clinical Practice Rheumatology.

B cells in rheumatoid synovitis

C. Weyand, J. Goronzy, Thorsten M. Seyler, 2005, Arthritis research & therapy.

The power of the third dimension: tissue architecture and autoimmunity in rheumatoid arthritis.

C. Weyand, J. Goronzy, Paul J. Kurtin, 2003, Current opinion in rheumatology.

Cytokines in giant-cell arteritis.

C. Weyand, J. Goronzy, 2002, Cleveland Clinic journal of medicine.

Pathogenic principles in giant cell arteritis

C. Weyand, J. Goronzy, 2000, International journal of cardiology.

Metabolic signatures of T-cells and macrophages in rheumatoid arthritis.

C. Weyand, J. Goronzy, M. Zeisbrich, 2017, Current opinion in immunology.

Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis1

Y. Kang, E. Davila, C. Weyand, 2005, The Journal of Immunology.

Ectopic Germinal Center Formation in Rheumatoid Synovitis

C. Weyand, J. Goronzy, 2003, Annals of the New York Academy of Sciences.

Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease

G. Berry, R. Frye, C. Weyand, 2022, Nature Cardiovascular Research.

Selective Nitration of Neocapillaries

L. Szweda, C. Weyand, B. Younge, 2002 .

T Cell Recognition and Killing of Vascular Smooth Muscle Cells in Acute Coronary Syndrome

Kayoko Sato, C. Weyand, J. Goronzy, 2006, Circulation research.

De Novo Expression of Killer Immunoglobulin‐Like Receptors and Signaling Proteins Regulates the Cytotoxic Function of CD4 T Cells in Acute Coronary Syndromes

R. Frye, S. Kopecky, C. Weyand, 2003, Circulation research.

Baricitinib for relapsing giant cell arteritis: a prospective open-label 52-week pilot study

E. Matteson, C. Crowson, C. Weyand, 2022, Annals of the Rheumatic Diseases.

Refractory Giant Cell Arteritis Complicated by Vision Loss From Optic Atrophy and Maculopathy Associated With Pachymeningitis

G. Berry, Y. J. Liao, C. Weyand, 2017, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

Global Transcriptomic Profiling Identifies Differential Gene Expression Signatures Between Inflammatory and Noninflammatory Aortic Aneurysms

J. Sung, C. Weyand, M. Koster, 2022, Arthritis & rheumatology.

Targets of immune regeneration in rheumatoid arthritis.

P. Hohensinner, C. Weyand, J. Goronzy, 2014, Mayo Clinic proceedings.

T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis.

T. Imai, C. Weyand, J. Goronzy, 2005, Arthritis and rheumatism.

Costimulatory Pathways in Rheumatoid Synovitis and T‐Cell Senescence

Karnail Singh, C. Weyand, J. Goronzy, 2005, Annals of the New York Academy of Sciences.

T-cell regulation in rheumatoid arthritis

C. Weyand, J. Goronzy, 2004, Current opinion in rheumatology.

A Mitochondrial Checkpoint in Autoimmune Disease.

C. Weyand, J. Goronzy, 2018, Cell metabolism.

Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation

T. Assimes, C. Weyand, J. Goronzy, 2018, Annals of the rheumatic diseases.

Stem cell aging and autoimmunity in rheumatoid arthritis.

C. Weyand, J. Goronzy, 2004, Trends in molecular medicine.

Response to Comment on “Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination”

C. Weyand, J. Goronzy, Qian Qi, 2017, Science Translational Medicine.

T Cell Activation in Rheumatoid Synovium Is B Cell Dependent1

P. Klimiuk, A. Braun, C. Weyand, 2001, The Journal of Immunology.

Molecular Basis for the Loss of CD28 Expression in Senescent T Cells*

Stephen Naylor, A. Vallejo, C. Weyand, 2002, The Journal of Biological Chemistry.

Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis1

J. Yen, P. Leibson, M. Snyder, 2000, The Journal of Immunology.

CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation.

A. Vallejo, C. Weyand, J. Goronzy, 2003, Blood.

Clonality and Longevity of CD4+CD28null T Cells Are Associated with Defects in Apoptotic Pathways1

A. Vallejo, C. Weyand, J. Goronzy, 2000, The Journal of Immunology.

Premature immunosenescence in rheumatoid arthritis.

C. Weyand, J. Goronzy, 2002, The Journal of rheumatology.

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.

Timothy M. Gould, C. Weyand, J. Goronzy, 2020, The Journal of clinical investigation.

Rheumatoid Arthritis: A Polygenic Disease with Multiple Phenotypes

C. Weyand, 1999, Arthritis Research.

Human T-cell clones used to define functional epitopes on HLA class II molecules.

C. Fathman, C. Weyand, J. Goronzy, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Histologic and Cytokine Response to Immunosuppression in Giant-Cell Myocarditis

W. Edwards, H. Tazelaar, S. Hammill, 1998, Annals of Internal Medicine.

Distinct Transcriptional Control Mechanisms of Killer Immunoglobulin-like Receptors in Natural Killer (NK) and in T Cells*

J. Xu, Yong Jiang, A. Vallejo, 2005, Journal of Biological Chemistry.

Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis.

M. Detmar, Y. Kang, J. Butterfield, 2004, The American journal of pathology.

Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis.

A. Vallejo, A. Braun, C. Weyand, 2004, Arthritis and rheumatism.

The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis.

U. Wagner, C. Weyand, J. Goronzy, 1998, Journal of immunology.

B cells as a therapeutic target in autoimmune disease

C. Weyand, J. Goronzy, 2003, Arthritis research & therapy.

Tissue trafficking patterns of effector memory CD4+ T cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, T. Nakajima, 2005, Arthritis and rheumatism.

Restrictions in the repertoire of allospecific T cells. Contribution of the alpha-helical sequence polymorphism of HLA-DR molecules.

C. Weyand, J. Goronzy, S. Lundy, 1993, Journal of immunology.

Systemic monocyte and T-cell activation in a patient with human parvovirus B19 infection.

E. Matteson, C. Weyand, J. Goronzy, 1995, Mayo Clinic proceedings.

Seropositive Rheumatoid Arthritis Is Associated with T-Cell Epitopes Encoded Within the Third Hypervariable Region of the HLA-DR1 and the HLA-DR4 Haplotype

C. Weyand, J. Goronzy, 1989 .

Single Amino Acid Substitutions Within the HLA DR4β1 Chain Create Multiple T-Cell Recognition Sites

C. Weyand, J. Goronzy, 1989 .

The Use of Human T Cell Clones to Dissect HLA and Disease Associations

C. Fathman, C. Weyand, J. Goronzy, 1986 .

Fractalkine mediates T cell-dependent proliferation of synovial fibroblasts in rheumatoid arthritis.

C. Weyand, J. Goronzy, Xiaowen He, 2007, Arthritis and rheumatism.

The double life of NK receptors: stimulation or co-stimulation?

M. Snyder, C. Weyand, J. Goronzy, 2004, Trends in immunology.

CD 4 1 CD 7 2 CD 28 2 T Cells Are Expanded in Rheumatoid Arthritis and Are Characterized by Autoreactivity

C. Weyand, J. Goronzy, D. Schmidt, 2013 .

Calibration in Rheumatoid Arthritis ERK-Dependent T Cell Receptor Threshold

Pratima Deshpande, Karnail Singh, C. Weyand, 2009 .

Cell Recognition and Killing of Vascular Smooth Muscle Cells in Acute Coronary Syndrome

Kayoko Sato, C. Weyand, J. Goronzy, 2006 .

Lymphoid microstructures in rheumatoid synovitis.

A. Braun, C. Weyand, J. Goronzy, 2001, Current directions in autoimmunity.

oligoarthritis : results of a prospective study . Clinically silent infections in patients with

C. Weyand, J. Goronzy, 2022 .

Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute coronary syndrome.

N. Hagiwara, Kayoko Sato, C. Weyand, 2010, Atherosclerosis.

Selective induction of rheumatoid factors by superantigens and human helper T cells.

C. Weyand, J. Goronzy, X. He, 1992, The Journal of clinical investigation.

Synoviocyte Stimulation by the LFA-1–Intercellular Adhesion Molecule-2–Ezrin–Akt Pathway in Rheumatoid Arthritis1

Karnail Singh, C. Weyand, J. Goronzy, 2008, The Journal of Immunology.

Akt Pathway in Rheumatoid Arthritis − Ezrin − Intercellular Adhesion Molecule-2 − Synoviocyte Stimulation by the LFA-1 Weyand and

Karnail Singh, C. Weyand, J. Goronzy, 2008 .

DAP 12-Dependent and DAP 12-Independent Modulate T Cell Activation through Stimulatory Killer Ig-Like Receptors

P. Leibson, M. Snyder, C. Weyand, 2004 .

MechanismsDAP12-Dependent and DAP12-Independent Modulate T Cell Activation through Stimulatory Killer Ig-Like Receptors

P. Leibson, M. Snyder, C. Weyand, 2004 .

IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression

C. Weyand, J. Goronzy, Lingjie Li, 2022, JCI insight.

T Cell Aging in Hypertension.

C. Weyand, J. Goronzy, 2020, Cardiovascular research.

Pathogenic principles in giant cell arteritis.

C. Weyand, J. Goronzy, 2000, International journal of cardiology.

Inﬂuence of antigenic experience on BJ gene segment usage in human CD4 (cid:70) T cells

C. Weyand, J. Goronzy, D. Walser-Kuntz, 1997 .

Rheumatoid Synovitis Formation of Germinal Centers in T Cells in the + CD40L + The Role of CD8

U. Wagner, C. Weyand, J. Goronzy, 1998 .

TEMPORAL ARTERY BIOPSY: A TECHNICAL GUIDE AND REVIEW OF ITS IMPORTANCE & INDICATIONS.

John J. Chen, C. Weyand, A. Fauchais, 2022, Survey of ophthalmology.

Cloning of human alloreactive T cells.

C. Fathman, C. Weyand, J. Goronzy, 1987, Methods in enzymology.

Double blind controlled phase III multicenter clinical trial with interferon gamma in rheumatoid arthritis

V. Diehl, P. Hofschneider, W. Gaus, 1992, Rheumatology International.

PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages.

M. C. Zuniga, Wei Zhou, W. Robinson, 2017, Atherosclerosis.

“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop

Peter Searson, David Kleinfeld, Maiken Nedergaard, 2016, Journal of the American Heart Association.

Modulation of CD4 by antigenic activation.

C. Fathman, C. Weyand, J. Goronzy, 1987, Journal of immunology.

Chronic inflammation in the etiology of disease across the life span

Alejandro Lucia, Eric Verdin, Luigi Ferrucci, 2019, Nature Medicine.

W. O'Fallon, W. Harmsen, T. Rasmussen, 2001, Journal of vascular surgery.

PP13. PHASE II STUDY OF THE SAFETY AND EFFICACY OF INFLIXIMAB IN GIANT CELL ARTERITIS (GCA): 22 WEEK INTERIM ANALYSIS

Mahboob Rahman, P. Merkel, J. Stone, 2005 .

Immune Deficiencies at the Extremes of Age

C. Weyand, J. Goronzy, C. Gustafson, 2018, Clinical Immunology.

T cell receptor peptide vaccination in rheumatoid arthritis: a placebo-controlled trial using a combination of Vbeta3, Vbeta14, and Vbeta17 peptides.

T. C. Adamson, V. Strand, D. Carlo, 1998, Arthritis and rheumatism.

Disease specific patterns of cytokine production by T-lymphocytes in coronary atheroscierosis: evidence for a role of infections agents in the pathogenesis of ustable Angina?

R. Frye, A. Maseri, S. Kopecky, 1998 .

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

T. Assimes, D. Harrison, C. Weyand, 2016 .

Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4

C. Fathman, C. Weyand, J. Goronzy, 1986, The Journal of experimental medicine.

B Cell Dependent T Cell Activation in Rheumatoid Synovium Is

P. Klimiuk, A. Braun, C. Weyand, 2001 .

Human T cell clones express functional homing receptors required for normal lymphocyte trafficking

S. Jalkanen, E. Butcher, A. Krensky, 1985, The Journal of experimental medicine.

The influence of three-dimensional structure on naïve T cell homeostasis and aging

C. Weyand, J. Goronzy, Jie-Yu Liu, 2022, Frontiers in Aging.

T cell aging as a risk factor for autoimmunity.

C. Weyand, J. Goronzy, Yanyan Zheng, 2022, Journal of autoimmunity.

Inflammation, Immunity, and Hypertension

Antony Vinh, C. Weyand, T. Guzik, 2011, Hypertension.

Administration of recombinant interleukin 2 in vivo induces a polyclonal IgM response

M. Dallman, C. Fathman, C. Weyand, 1986, The Journal of experimental medicine.

Successful and Maladaptive T Cell Aging.

C. Weyand, J. Goronzy, 2017, Immunity.

This information is current as Arthritis T Cells Clonally Expanded in Rheumatoid nullCD 28 + Costimulatory Molecules on CD 4 Killer Cell Activating Receptors Function as and

J. Yen, P. Leibson, M. Snyder, 2000 .

General Approach to the Diagnosis of Vasculitis

G. Hoffman, C. Weyand, 2016 .

Antigen recognition by a human T cell clone leads to increases in inositol trisphosphate.

J. Imboden, C. Weyand, J. Goronzy, 1987, Journal of immunology.

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

E. Krishnan, C. Weyand, J. Goronzy, 2012, Nature Medicine.

Geographical variations in ocular and extra-ocular manifestations in Behçet's disease.

F. Shahram, Y. J. Liao, F. Davatchi, 2019, European journal of rheumatology.

Results of a Phase II Rheumatoid Arthritis Clinical Trial Using T-Cell Receptor Peptides

T. C. Adamson, V. Strand, D. Carlo, 1999 .

Editorial: Vascular Inflammation in Systemic Autoimmunity

A. Vaglio, C. Weyand, G. Ramirez, 2016, Front. Immunol..

Rheumatoid vasculitis manifesting as intra-abdominal hemorrhage.

S. Srivatsa, A. Stanson, L. Dale, 1995, Mayo Clinic proceedings.

Toll-like receptors in giant cell arteritis.

Mildred Kwan, C. Weyand, J. Goronzy, 2005, Clinical immunology.

Management of Central Retinal Artery Occlusion: A Scientific Statement From the American Heart Association

K. Furie, L. Sobrin, V. Biousse, 2021, Stroke.

Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction

D. Harrison, S. Dikalov, C. Weyand, 2007, The Journal of experimental medicine.

Giant-Cell Arteritis and Polymyalgia Rheumatica

C. Weyand, J. Goronzy, Jrg Goronzy, 2003, Annals of Internal Medicine.

Major Histocompatibility Complex Class I–Recognizing Receptors Are Disease Risk Genes in Rheumatoid Arthritis

Daniel J. Schaid, D. Schaid, J. Yen, 2001, The Journal of experimental medicine.

Telomeres and Immunological Diseases of Aging

C. Weyand, J. Goronzy, H. Fujii, 2009, Gerontology.

T cell development and receptor diversity during aging.

C. Weyand, J. Goronzy, 2005, Current opinion in immunology.

A. Vallejo, C. Weyand, J. Goronzy, 1998, The Journal of Biological Chemistry.

Immunosuppression by anti-CD4 treatment in vivo. Cellular and humoral responses to alloantigens.

C. Fathman, C. Weyand, J. Goronzy, 1989, Transplantation.

Immune mechanisms in medium and large-vessel vasculitis

C. Weyand, J. Goronzy, 2013, Nature Reviews Rheumatology.

Aging and T-cell diversity

C. Weyand, J. Goronzy, Won-Woo Lee, 2007, Experimental Gerontology.

Down-Regulation of CD28 Expression by TNF-α1

A. Vallejo, C. Weyand, J. Goronzy, 2001, The Journal of Immunology.

Recognition of H–2 domains by cytotoxic T lymphocytes

C. Weyand, J. Goronzy, G. Hämmerling, 1981, Nature.

Naive T Cell Maintenance and Function in Human Aging

Mary M. Cavanagh, C. Weyand, J. Goronzy, 2015, The Journal of Immunology.

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

T. Assimes, D. Harrison, C. Weyand, 2016, The Journal of experimental medicine.

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

C. Weyand, J. Goronzy, Zhen Yang, 2013, The Journal of experimental medicine.

The immunology of rheumatoid arthritis

C. Weyand, J. Goronzy, 2020, Nature Immunology.

The T-cell receptor Vβ6 gene usage in alloreactive T-cell responses

C. Weyand, J. Goronzy, Weining Hu, 1995 .

The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway

G. Berry, F. Shahram, Y. J. Liao, 2017, Science Translational Medicine.

Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes

P. Klimiuk, C. Weyand, J. Goronzy, 2004, Springer Seminars in Immunopathology.

HLA polymorphisms and T cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, 1999, International reviews of immunology.

Current ideas on the role of HLA molecules in human Diseases

C. Weyand, J. Goronzy, V. Martínez-Taboada, 1996 .

Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis1

J. Yen, P. Leibson, M. Snyder, 2000, The Journal of Immunology.

Functional Disruption of the CD28 Gene Transcriptional Initiator in Senescent T Cells*

A. Vallejo, C. Weyand, J. Goronzy, 2001, The Journal of Biological Chemistry.

Age, T-cell Homeostasis, and T-cell Diversity in Humans

C. Weyand, J. Goronzy, Jörg J. Goronzy, 2009 .

Inhibition and Genetic Ablation of the B7/CD28 T-Cell Costimulation Axis Prevents Experimental Hypertension

D. Weiss, Antony Vinh, C. Weyand, 2010, Circulation.

Large and Medium-Vessel Vasculitides

C. Weyand, J. Goronzy, 2020, The Autoimmune Diseases.

Functional profile of activated dendritic cells in unstable atherosclerotic plaque

F. Meyer, R. Frye, S. Kopecky, 2007, Basic Research in Cardiology.

CHAPTER 66 – Large and Medium Vessel Vasculitides

C. Weyand, J. Goronzy, 2006 .

B cells as a therapeutic target in autoimmune diseases

C. Weyand, J. Goronzy, Sergey Pryshchep, 2005, Expert opinion on therapeutic targets.

Age as a risk factor in vasculitis

G. Berry, C. Weyand, J. Goronzy, 2022, Seminars in Immunopathology.

Hallmarks of the aging T‐cell system

C. Weyand, J. Goronzy, Huimin Zhang, 2021, The FEBS journal.

The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age

Yong Wang, D. Farber, C. Weyand, 2021, Cell reports.

Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

C. Weyand, J. Goronzy, Yi Shen, 2021, Nature Communications.

Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

C. Weyand, J. Goronzy, Yi Shen, 2021, Nature communications.

Immune aging and autoimmunity

C. Weyand, J. Goronzy, 2012, Cellular and Molecular Life Sciences.

Telomere dysfunction, autoimmunity and aging.

P. Hohensinner, C. Weyand, J. Goronzy, 2011, Aging and disease.

Bi-directional modulation of T cell-dependent antibody production by prostaglandin E(2).

C. Weyand, J. Goronzy, Jörg J Goronzy, 2002, International immunology.

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

L. Tian, C. Dekker, Mary M. Cavanagh, 2016, Cell reports.

Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age

C. Weyand, J. Goronzy, Guangjin Li, 2012, Proceedings of the National Academy of Sciences.

Resistance to apoptosis and elevated expression of Bcl-2 in clonally expanded CD4+CD28- T cells from rheumatoid arthritis patients.

A. Vallejo, C. Weyand, J. Goronzy, 1998, Journal of immunology.

Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2.

C. Fathman, C. Weyand, J. Goronzy, 1989, Journal of immunology.

Activation of Arterial Wall Dendritic Cells and Breakdown of Self-tolerance in Giant Cell Arteritis

T. Tedder, Myung-Shin Jeon, C. Weyand, 2004, The Journal of experimental medicine.

Synoviocyte-Mediated Expansion of Inflammatory T Cells in Rheumatoid Synovitis Is Dependent on CD47-Thrombospondin 1 Interaction1

A. Vallejo, P. Klimiuk, Hongyu Yang, 2003, The Journal of Immunology.

Administration in vivo of recombinant interleukin 2 protects mice against septic death.

C. Fathman, C. Weyand, J. Goronzy, 1987, The Journal of clinical investigation.

T cell subset-specific susceptibility to aging.

J. Ouslander, Yuko Hiruma, M. Cześnikiewicz-Guzik, 2008, Clinical immunology.

Regulatory T Cells in Autoimmune Vasculitis

G. Berry, C. Weyand, J. Goronzy, 2022, Frontiers in Immunology.

Human T cell clones as diagnostic tools and potential therapeutic reagents.

C. Fathman, C. Weyand, J. Goronzy, 1986, Immunological investigations.

Influence of immune aging on vaccine responses

C. Weyand, J. Goronzy, C. Gustafson, 2020, Journal of Allergy and Clinical Immunology.

Telomeres, immune aging and autoimmunity

C. Weyand, J. Goronzy, H. Fujii, 2006, Experimental Gerontology.

Telomerase insufficiency in rheumatoid arthritis

C. Weyand, J. Goronzy, H. Fujii, 2009, Proceedings of the National Academy of Sciences.

T Cell–Macrophage Interactions and Granuloma Formation in Vasculitis

G. Berry, C. Weyand, J. Goronzy, 2014, Front. Immunol..

Value of Immunological Markers in Predicting Responsiveness to Influenza Vaccination in Elderly Individuals

W. O'Fallon, C. Crowson, G. Poland, 2001, Journal of Virology.

The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency

C. Weyand, J. Goronzy, Zhen Yang, 2013, Front. Immunol..

DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis

C. Weyand, J. Goronzy, L. Shao, 2010, EMBO molecular medicine.

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

C. Weyand, J. Goronzy, Hisashi Oishi, 2009, The Journal of experimental medicine.

Understanding T cell aging to improve anti-viral immunity.

C. Weyand, J. Goronzy, C. Gustafson, 2021, Current opinion in virology.

Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo.

M. Wolzt, G. Maurer, K. Huber, 2006, Atherosclerosis.

VH3-21 B Cells Escape from a State of Tolerance in Rheumatoid Arthritis and Secrete Rheumatoid Factor

C. Weyand, J. Goronzy, Xiaowen He, 1995, Molecular medicine.

Understanding immunosenescence to improve responses to vaccines

C. Weyand, J. Goronzy, 2013, Nature Immunology.

Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, H. Fujii, 2008, Arthritis and rheumatism.

Vessel Wall–Embedded Dendritic Cells Induce T-Cell Autoreactivity and Initiate Vascular Inflammation

R. Nerem, K. Shimada, C. Weyand, 2008, Circulation research.

Lymphoid Neogenesis in Rheumatoid Synovitis1

W. O'Fallon, R. Cofield, C. Crowson, 2001, The Journal of Immunology.

miR-181a-regulated pathways in T-cell differentiation and aging

C. Weyand, J. Goronzy, Zhongde Ye, 2021, Immunity & ageing : I & A.

Regulation of miR-181a expression in T cell aging

C. Weyand, J. Goronzy, Bin Hu, 2018, Nature Communications.

The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a

Timothy M. Gould, C. Weyand, J. Goronzy, 2021, NPJ aging and mechanisms of disease.

Cardiorheumatology: cardiac involvement in systemic rheumatic disease

S. Gabriel, E. Matteson, J. Oh, 2015, Nature Reviews Cardiology.

Genetics of rheumatoid arthritis: Is there a pattern predicting extraarticular manifestations?

C. Turesson, E. Matteson, C. Weyand, 2004, Arthritis and rheumatism.

Cellular immune responses to Borrelia burgdorferi in Lyme disease

C. Weyand, J. Goronzy, 1991 .

Triggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function.

E. Reinherz, M. Kuno, A. Alcover, 1989, The Journal of biological chemistry.

T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection.

A. Vallejo, C. Weyand, J. Goronzy, 2004, Trends in molecular medicine.

Rejuvenating the immune system in rheumatoid arthritis

C. Weyand, J. Goronzy, H. Fujii, 2009, Nature Reviews Rheumatology.

Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis.

C. Fathman, C. Weyand, J. Goronzy, 1986, The Journal of clinical investigation.

FOXO1 deficiency impairs proteostasis in aged T cells

C. Weyand, J. Goronzy, Bin Hu, 2020, Science Advances.

Functional pathways regulated by microRNA networks in CD8 T‐cell aging

Mary M. Cavanagh, C. Weyand, J. Goronzy, 2018, Aging cell.

Recognition of polymorphic H-2 domains by T lymphocytes. I. Functional role of different H-2 domains for the generation of alloreactive cytotoxic T lymphocytes and determination of precursor frequencies

C. Weyand, J. Goronzy, G. Hämmerling, 1981, The Journal of experimental medicine.

Glucose metabolism controls disease-specific signatures of macrophage effector functions.

G. Berry, D. Harrison, C. Weyand, 2018, JCI insight.

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide

D. Harrison, P. Maffia, Roxana Loperena, 2018, Cardiovascular research.

T-cell co-stimulatory pathways in autoimmunity

C. Weyand, J. Goronzy, 2008, Arthritis research & therapy.

DNA damage, metabolism and aging in pro-inflammatory T cells Rheumatoid arthritis as a model system

C. Weyand, J. Goronzy, Yinyin Li, 2017, Experimental Gerontology.

Prognostic markers of radiographic progression in early rheumatoid arthritis.

Cynthia S Crowson, Eric L Matteson, G. Hunder, 2004, Arthritis and rheumatism.

Interferon-alpha treatment of Behçet's disease.

E. Matteson, J. Jorizzo, C. Weyand, 1998, The Journal of rheumatology.

Interferon-α treatment of Behçet's disease

E. Matteson, J. Jorizzo, C. Weyand, 1998 .

Synergistic Proinflammatory Effects of the Antiviral Cytokine Interferon-&agr; and Toll-Like Receptor 4 Ligands in the Atherosclerotic Plaque

M. Shin, E. Chaikof, C. Weyand, 2007, Circulation.

Pathogen-Sensing Plasmacytoid Dendritic Cells Stimulate Cytotoxic T-Cell Function in the Atherosclerotic Plaque Through Interferon-&agr;

E. Chaikof, Kayoko Sato, C. Weyand, 2006, Circulation.

The molecular basis of rheumatoid arthritis

C. Weyand, J. Goronzy, 1997, Journal of Molecular Medicine.

Immunosuppression in atherosclerosis: mobilizing the opposition within.

C. Weyand, J. Goronzy, 2006, Circulation.

Formation of the Killer Ig-Like Receptor Repertoire on CD4+CD28null T Cells1

W. O'Fallon, M. Snyder, C. Weyand, 2002, The Journal of Immunology.

Expansion of unusual CD4+ T cells in severe rheumatoid arthritis.

D. Schaid, C. Weyand, J. Goronzy, 1997, Arthritis and rheumatism.

Ageing, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation

C. Weyand, J. Goronzy, 2003, Arthritis research & therapy.

Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors.

Karnail Singh, C. Weyand, J. Goronzy, 2006, Blood.

TLR-mediated induction of negative regulatory ligands on dendritic cells

S. Gröschel, A. Vaglio, Karnail Singh, 2008, Journal of Molecular Medicine.

Developments in the scientific understanding of rheumatoid arthritis

C. Weyand, J. Goronzy, 2009, Arthritis research & therapy.

Review Developments in the scientific understanding of rheumatoid

C. Weyand, J. Goronzy, 2009 .

Heterogeneity of signal requirements in T cell activation within a panel of human proliferative T cell clones.

J. Imboden, C. Fathman, C. Weyand, 1987, Journal of immunology.

Autophagy in autoimmune disease

C. Weyand, J. Goronzy, Zhen Yang, 2015, Journal of Molecular Medicine.

DNA Methylation, Age-Related Immune Defects, and Autoimmunity

C. Weyand, J. Goronzy, Guangjin Li, 2010 .

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis.

C. Weyand, J. Goronzy, T. Mccarthy, 1995, The Journal of clinical investigation.

Biology of T lymphocytes.

A. Vallejo, E. Davila, C. Weyand, 2004, Rheumatic diseases clinics of North America.

Treatment of giant cell arteritis: interleukin-6 as a biologic marker of disease activity.

J. Evans, G. Hunder, C. Weyand, 2000, Arthritis and rheumatism.

New insights into the pathogenesis of rheumatoid arthritis.

C. Weyand, 2000, Rheumatology.

ERK-Dependent T Cell Receptor Threshold Calibration in Rheumatoid Arthritis1

Pratima Deshpande, Karnail Singh, C. Weyand, 2009, The Journal of Immunology.

Tumor Necrosis Factor-α and CD80 Modulate CD28 Expression through a Similar Mechanism of T-cell Receptor-independent Inhibition of Transcription*

A. Vallejo, C. Weyand, J. Goronzy, 2004, Journal of Biological Chemistry.

Homeostatic control of T-cell generation in neonates.

S. Schönland, C. Weyand, J. Goronzy, 2003, Blood.

Aging-associated HELIOS deficiency in naive CD4^+ T cells alters chromatin remodeling and promotes effector cell responses

W. Greenleaf, C. Weyand, J. Goronzy, 2022, Nature Immunology.

Epigenetics of T cell aging

C. Weyand, J. Goronzy, Bin Hu, 2018, Journal of leukocyte biology.

Haematopoietic stem and progenitor cells in rheumatoid arthritis.

C. Weyand, I. Colmegna, 2011, Rheumatology.

Vasculitis in Systemic Sclerosis

C. Weyand, Lily Kao, 2010, International journal of rheumatology.

Epigenetic mechanisms of age‐dependent KIR2DL4 expression in T cells

C. Weyand, J. Goronzy, Guangjin Li, 2008, Journal of leukocyte biology.

Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins

Russell E. Durrett, George Georgiou, Jonathan R. McDaniel, 2019, Proceedings of the National Academy of Sciences.

Mechanisms of immunosenescence: lessons from models of accelerated immune aging

C. Weyand, J. Goronzy, S. Le Saux, 2012, Annals of the New York Academy of Sciences.

TRIB2 safeguards naive T cell homeostasis during aging

B. Hu, C. Weyand, J. Goronzy, 2023, Cell reports.

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals

A. Sette, D. Weiskopf, Qiong Xia, 2021, Science Immunology.

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

R. Ahmed, Rama S. Akondy, Mary M. Cavanagh, 2018, Cell reports.

Metabolic control of the scaffold protein TKS5 in tissue-invasive, pro-inflammatory T cells

E. Matteson, C. Weyand, J. Goronzy, 2017, Nature Immunology.

Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment.

C. Weyand, J. Goronzy, Guangjin Li, 2012, Seminars in immunology.

[Nodular panniculitis: a manifestation of Lyme borreliosis?].

L. Zöller, C. Weyand, J. Goronzy, 1992, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling.

I. Shmulevich, A. Aderem, R. Z. Vêncio, 2008, Rejuvenation research.

Lymphocyte generation and population homeostasis throughout life.

C. Weyand, J. Goronzy, C. Gustafson, 2017, Seminars in hematology.

Central Role of Thrombospondin-1 in the Activation and Clonal Expansion of Inflammatory T Cells1

A. Vallejo, P. Klimiuk, C. Weyand, 2000, The Journal of Immunology.

Magnetic Resonance Angiography in Extracranial Giant Cell Arteritis

Diego R. Martín, J. Oshinski, Puneet S. Sharma, 2011, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

BLyS and APRIL in rheumatoid arthritis.

R. Bram, C. Weyand, J. Goronzy, 2005, The Journal of clinical investigation.

Finding Balance: T cell Regulatory Receptor Expression during Aging.

Mary M. Cavanagh, C. Weyand, J. Goronzy, 2011, Aging and disease.

Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study

R. Frye, S. Kopecky, C. Weyand, 2005, Arthritis research & therapy.

Molecular Fingerprint of Interferon-&ggr; Signaling in Unstable Angina

R. Frye, D. Holmes, A. Vallejo, 2001, Circulation.

TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque

R. Frye, Kayoko Sato, S. Kopecky, 2006, The Journal of experimental medicine.

Mechanisms shaping the naïve T cell repertoire in the elderly — Thymic involution or peripheral homeostatic proliferation?

C. Weyand, J. Goronzy, David W. Zhang, 2014, Experimental Gerontology.

Understanding immune senescence to improve vaccine responses

C. Weyand, J. Goronzy, 2014 .

Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis.

E. Matteson, C. Weyand, J. Goronzy, 1995, Arthritis and rheumatism.

Inflammatory Diseases of Blood Vessels: Hoffman/Inflammatory Diseases of Blood Vessels

G. Hoffman, C. Weyand, J. Goronzy, 2012 .

The role of T cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, E. Bryl, 2000, Archivum immunologiae et therapiae experimentalis.

Multiple Mechanisms Support Oligoclonal T Cell Expansion in Rheumatoid Synovitis

H. Rittner, A. Zettl, C. Weyand, 1997, Molecular medicine.

Co‐stimulatory pathways controlling activation and peripheral tolerance of human CD4+CD28− T cells

C. Weyand, J. Goronzy, D. Schmidt, 1997, European journal of immunology.

Pathomechanisms in rheumatoid arthritis--time for a string theory?

C. Weyand, J. Goronzy, 2006, The Journal of clinical investigation.

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging

H. Maecker, E. Newell, Jessica A. L. Hutter-Saunders, 2017, Front. Immunol..

44 – The Innate and Adaptive Immune Systems

C. Weyand, J. Goronzy, 2012 .

Reduced chromatin accessibility to CD4 T cell super-enhancers encompassing susceptibility loci of rheumatoid arthritis

W. Greenleaf, C. Weyand, J. Goronzy, 2022, EBioMedicine.

Cellular Signaling Pathways in Medium and Large Vessel Vasculitis

G. Berry, C. Weyand, J. Goronzy, 2020, Frontiers in Immunology.

Macrophages in vascular inflammation – From atherosclerosis to vasculitis

D. Harrison, C. Weyand, J. Goronzy, 2015, Autoimmunity.

Opposite effects of CX3CR1 receptor polymorphismsV249I andT280Mon the development of acute coronary syndrome A possible implication of fractalkine in inflammatory activation

G. Maurer, K. Huber, R. Marculescu, 2017 .

Fractalkine receptor polymorphisms V249I and T280M as genetic risk factors for restenosis

O. Wagner, G. Maurer, K. Huber, 2005, Thrombosis and Haemostasis.

How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to 'non-aggressive' DMARD treatment and perspective from a 2-yr open label trial.

E. Matteson, R. McClelland, T. Christianson, 2004, Rheumatology.

Influence of age on functional memory T cell diversity

B. Hu, Yong Wang, C. Weyand, 2021, bioRxiv.

T-cell immunity in acute coronary syndromes.

R. Frye, D. Holmes, S. Kopecky, 2001, Mayo Clinic proceedings.

INNATE AND ADAPTIVE IMMUNITY: THE FINE LINE

R. Frye, D. Holmes, S. Kopecky, 2001 .

Oligoclonal T-cell proliferation and interferon-gamma production in periprosthetic inflammation.

M. Bolander, A. Brack, C. Weyand, 1998, Laboratory investigation; a journal of technical methods and pathology.

The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis

C. Weyand, J. Goronzy, D. Schmidt, 1996, Molecular medicine.

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals

Lisa E. Wagar, Mark M. Davis, L. Tian, 2016, PLoS pathogens.

Increased CD4+ T cell infiltrates in rheumatoid arthritis-associated interstitial pneumonitis compared with idiopathic interstitial pneumonitis.

C. Turesson, E. Matteson, T. Colby, 2005, Arthritis and rheumatism.

Immunology of Giant Cell Arteritis

C. Weyand, J. Goronzy, 2023, Circulation research.

Is hypertension an immunologic disease?

D. Harrison, C. Weyand, J. Goronzy, 2008, Current cardiology reports.

CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging

C. Weyand, J. Goronzy, Chenyao Wang, 2023, Nature Aging.

The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4+ T cell responses of older adults

W. Greenleaf, C. Weyand, J. Goronzy, 2021, bioRxiv.

Dynamic Immune Cell Accumulation During Flow-Induced Atherogenesis in Mouse Carotid Artery: An Expanded Flow Cytometry Method

Melissa L. Kemp, H. Jo, D. Son, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Histone deficiency and accelerated replication stress in T cell aging.

L. Tian, C. Weyand, J. Goronzy, 2021, The Journal of clinical investigation.

Autophagy in autoimmune disease

C. Weyand, J. Goronzy, Zhen Yang, 2015, Journal of Molecular Medicine.

Giant cell arteritis: immune and vascular aging as disease risk factors

Y. J. Liao, C. Weyand, J. Goronzy, 2011, Arthritis research & therapy.

Erratum: How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to 'non-aggressive' DMARD treatment and perspective from a 2-yr open label trial (Rheumatology (2004) vol. 43 (619-625))

E. Matteson, R. McClelland, T. Christianson, 2004 .

The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis

D. Schaid, C. Turesson, L. Jacobsson, 2005, Arthritis research & therapy.

VEGF gene polymorphisms and susceptibility to rheumatoid arthritis.

J. Y. Park, J. Seo, C. Weyand, 2004, Rheumatology.

Deficiency of the CD155-CD96 immune checkpoint controls IL-9 production in giant cell arteritis

G. Berry, M. Akiyama, C. Weyand, 2023, Cell reports. Medicine.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis.

D. Schaid, C. Turesson, L. Jacobsson, 2006, Arthritis and rheumatism.

Formation of the Killer Ig-Like Receptor Repertoire on CD4 CD28 T Cells

W. O'Fallon, M. Snyder, C. Weyand, 2002 .

Immune And Inflammatory Mechanisms Mediate Cardiovascular Diseases From Head To Toe.

P. Libby, Z. Mallat, C. Weyand, 2021, Cardiovascular research.

Activation of Human T Cells in HypertensionNovelty and Significance

D. Harrison, D. J. Moore, A. Januszewicz, 2016 .

The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis

C. Weyand, J. Goronzy, K. Hicok, 1992, Annals of Internal Medicine.

Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity

Moses Rodriguez, J. Sung, K. Wright, 2022, Scientific Reports.

Lipopolysaccharide, CD14 and Toll-like receptors: an emerging link between innate immunity and atherosclerotic disease.

K. Shimada, H. Daida, C. Weyand, 2005, Future cardiology.

Pathogenesis of Giant Cell Arteritis and Takayasu Arteritis—Similarities and Differences

G. Berry, C. Weyand, J. Goronzy, 2020, Current Rheumatology Reports.

Mitochondria as disease-relevant organelles in rheumatoid arthritis

C. Weyand, J. Goronzy, Tao Huang, 2022, Clinical and experimental immunology.

Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans.

D. Harrison, D. J. Moore, A. Januszewicz, 2016, Hypertension.

markedinhibitionofIFN-γandIgtranscription.Incontrast,inhibitionofAPRILandBLySinaggregateand diffusesynovitisleftIglevelsunaffectedandenhancedIFN-γproduction.Thesedifferentialimmunomodula- toryeffectscorrelatedwiththepresenceofTACI + Tcellsinaggregateanddiffusesynovitisandtheirabsence inGC + synoviti

R. Bram, C. Weyand, J. Goronzy, 2005 .

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

S. Shoor, C. Weyand, J. Goronzy, 2019, Nature Immunology.

The Repertoire of CD 4 + CD 28 T Cells in Rheumatoid Arthritis

C. Weyand, J. Goronzy, D. Schmidt, 2007 .

Modulation of CD28 expression with anti–tumor necrosis factor α therapy in rheumatoid arthritis

E. Matteson, A. Vallejo, C. Weyand, 2005 .

Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis.

E. Matteson, A. Vallejo, C. Weyand, 2005, Arthritis and rheumatism.

Molecular approaches toward pathologic mechanisms in giant cell arteritis and Takayasu's arteritis

C. Weyand, J. Goronzy, C. Weyand, 1995, Current opinion in rheumatology.

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

M. Kuno, C. Weyand, J. Goronzy, 1986, Nature.

The impact of HLA-DRB 1 genes on extra-articular disease manifestations in rheumatoid arthritis

D. Schaid, C. Turesson, L. Jacobsson, 2005 .

T cell fate decisions during memory cell generation with aging.

Abhinav K. Jain, C. Weyand, J. Goronzy, 2023, Seminars in immunology.

Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes.

R. Frye, D. Holmes, S. Kopecky, 2000, Circulation.

Perturbation of the T cell repertoire in rheumatoid arthritis.

U. Wagner, C. Weyand, J. Goronzy, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells.

C. Weyand, J. Goronzy, J. Bjornsson, 1999, The American journal of pathology.

Platelet-derived growth factor, intimal hyperplasia, and ischemic complications in giant cell arteritis.

C. Weyand, J. Goronzy, J. Bjornsson, 1998, Arthritis and rheumatism.

Correlation between HLA‐DR Sequence Polymorphisms and Rheumatoid Factor Production

C. Weyand, J. Goronzy, C. Weyand, 1997, Annals of the New York Academy of Sciences.

Immune aging - A mechanism in autoimmune disease.

C. Weyand, J. Goronzy, Yanyan Zheng, 2023, Seminars in immunology.

The epidemiology of pathologically confirmed clinically isolated aortitis: a North American population-based study.

C. Weyand, M. Koster, K. Warrington, 2023, Clinical and experimental rheumatology.

Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis.

G. Hunder, C. Weyand, J. Goronzy, 1993, Arthritis and rheumatism.

Superantigens, VH Gene Polymorphism, and Rheumatoid Factor (RF) Production

C. Weyand, J. Goronzy, C. Weyand, 1997, Annals of the New York Academy of Sciences.

Disease pattern in cranial and large-vessel giant cell arteritis.

A. Stanson, A. Brack, C. Weyand, 1999, Arthritis and rheumatism.

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

C. Weyand, J. Goronzy, D. Schmidt, 1996, The Journal of clinical investigation.

HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis.

G. Hunder, C. Weyand, J. Goronzy, 1994, Arthritis and rheumatism.

CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems.

C. Weyand, J. Goronzy, K. Warrington, 2001, Arthritis and rheumatism.

Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.

A. Vallejo, C. Weyand, J. Goronzy, 1999, Journal of immunology.

Functional subsets of CD4 T cells in rheumatoid synovitis.

U. Wagner, C. Weyand, J. Goronzy, 1998, Arthritis and rheumatism.

Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis.

W. O'Fallon, C. Weyand, J. Goronzy, 1995, Immunity.

Tissue cytokine patterns distinguish variants of rheumatoid synovitis.

R. Beckenbaugh, P. Klimiuk, C. Weyand, 1997, The American journal of pathology.

T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease.

C. Weyand, J. Goronzy, C. Weyand, 1999, Current opinion in rheumatology.

High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

Richard A. Olshen, Qian Qi, R. Olshen, 2015, Genome Medicine.

Arterial wall injury in giant cell arteritis.

C. Weyand, J. Goronzy, C. Weyand, 1999, Arthritis and rheumatism.

Heterogeneity of memory T cells in aging

Abhinav K. Jain, C. Weyand, J. Goronzy, 2023, Frontiers in immunology.

Large-vessel vasculitis

N. Basu, C. Goodyear, R. Goel, 2021, Nature Reviews Disease Primers.

Perturbation of the T-cell repertoire in patients with unstable angina.

R. Frye, W. O'Fallon, A. Maseri, 1999, Circulation.

Kimberlite genesis from a common carbonate-rich primary melt modified by lithospheric mantle assimilation

Do Hee Keum, Julia Oh, W. Griffin, 2020, Science Advances.

Inherited and noninherited risk factors in rheumatoid arthritis.

C. Weyand, J. Goronzy, C. Weyand, 1995, Current opinion in rheumatology.

The HLA-DRB1 locus as a genetic component in giant cell arteritis. Mapping of a disease-linked sequence motif to the antigen binding site of the HLA-DR molecule.

G. Hunder, C. Weyand, J. Goronzy, 1992, The Journal of clinical investigation.

Stem-like CD4+ T cells in perivascular tertiary lymphoid structures sustain autoimmune vasculitis

C. Weyand, J. Goronzy, K. Warrington, 2023, Science Translational Medicine.

The life cycle of a T cell after vaccination – where does immune ageing strike?

C. Weyand, J. Goronzy, F. Fang, 2017, Clinical and experimental immunology.

Persistent aortic inflammation in patients with giant cell arteritis

A. Hanson, C. Weyand, Nicholas Boire, 2023, Autoimmunity Reviews.

HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis

Y. Toda, R. Ogawa, C. Weyand, 2004, Modern rheumatology.

T cell homeostasis in patients with rheumatoid arthritis.

W. O'Fallon, C. Weyand, J. Goronzy, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Systems analysis of microRNAs reveals a novel link between CD8 T cell dysfunction and TGF-β signaling in immune aging

Mary M. Cavanagh, C. Weyand, J. Goronzy, 2016, The Journal of Immunology.

The diagnosis of giant cell arteritis.

N. Newman, V. Biousse, C. Weyand, 2007, Reviews in neurological diseases.

Interferon-gamma-producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology.

C. Weyand, J. Goronzy, G. Bartley, 1996, The American journal of pathology.

Visual Manifestations in Giant Cell Arteritis: Trend over 5 Decades in a Population-based Cohort

E. Matteson, C. Crowson, C. Weyand, 2015, Journal of Rheumatology.

Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis.

P. Klimiuk, H. Rittner, L. Szweda, 1999, The Journal of clinical investigation.

Giant cell arteritis as an antigen-driven disease.

C. Weyand, J. Goronzy, C. Weyand, 1995, Rheumatic diseases clinics of North America.

Mechanisms underlying T cell ageing

C. Weyand, J. Goronzy, 2019, Nature Reviews Immunology.

Successful and Maladaptive T Cell Aging.

C. Weyand, J. Goronzy, 2017, Immunity.

Glucose metabolism controls disease-specific signatures of macrophage effector functions.

G. Berry, D. Harrison, C. Weyand, 2018, JCI insight.

Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, P. Bartz-Bazzanella, 1994, The Journal of clinical investigation.

Lymphocyte generation and population homeostasis throughout life.

C. Weyand, J. Goronzy, C. Gustafson, 2017, Seminars in hematology.

Insufficient Deactivation of the Protein Tyrosine Kinase Lck Amplifies T-Cell Responsiveness in Acute Coronary Syndrome

C. Weyand, J. Goronzy, Sergey Pryshchep, 2010, Circulation research.

Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras.

C. Kaltschmidt, H. Rittner, A. Brack, 1997, The Journal of clinical investigation.

IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis.

P. Klimiuk, C. Weyand, J. Goronzy, 1999, Journal of immunology.

T cell receptor repertoire in rheumatoid arthritis.

A. Zettl, C. Weyand, J. Goronzy, 1998, International reviews of immunology.

Immunosuppression by anti-CD4 treatment in vivo. Persistence of secondary antiviral immune responses.

C. Fathman, C. Weyand, J. Goronzy, 1989, Transplantation.

CD4 CD7 CD28 T Cells Are Expanded in Rheumatoid Arthritis and Are Characterized by Autoreactivity

C. Weyand, J. Goronzy, Dorle Schmidt, 1996 .

Homeostatic control of T-cell generation in neonates.

S. Schönland, C. Weyand, J. Goronzy, 2003, Blood.

Recognition of tissue residing antigen by T cells in vasculitic lesions of giant cell arteritis

G. Hunder, C. Weyand, J. Goronzy, 1996, Journal of Molecular Medicine.

CellsSubset of Inducible Human Regulatory T Immunosuppressive Properties: A Novel T Cells with + FOXP3+ CCR7+ CD45RA+ CD8

Y. Shimojima, C. Weyand, J. Goronzy, 2012 .

Disease-associated human histocompatibility leukocyte antigen determinants in patients with seropositive rheumatoid arthritis. Functional role in antigen-specific and allogeneic T cell recognition.

C. Weyand, J. Goronzy, C. Weyand, 1990, The Journal of clinical investigation.

Drug-Induced Vasculitis

C. Weyand, 2016 .

Production of cytokines and metalloproteinases in rheumatoid synovitis is T cell dependent.

P. Klimiuk, C. Weyand, J. Goronzy, 1999, Clinical immunology.

Functional domains on HLA-DR molecules: implications for the linkage of HLA-DR genes to different autoimmune diseases.

C. Weyand, J. Goronzy, C. Weyand, 1994, Clinical immunology and immunopathology.

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.

C. Weyand, J. Goronzy, C. Weyand, 1992, The Journal of clinical investigation.

T cell subset-specific susceptibility to aging.

J. Ouslander, Yuko Hiruma, M. Cześnikiewicz-Guzik, 2008, Clinical immunology.

Tissue-destructive macrophages in giant cell arteritis.

H. Rittner, L. Szweda, A. Brack, 1999, Circulation research.

Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes

U. Oppitz, C. Weyand, J. Goronzy, 1994, The Journal of experimental medicine.

Giant-Cell Arteritis and Polymyalgia Rheumatica

C. Weyand, J. Goronzy, Jrg Goronzy, 2003, Annals of Internal Medicine.

Medium- and large-vessel vasculitis.

C. Weyand, J. Goronzy, 2003, The New England journal of medicine.

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.

Ji-hang Ju, Y. Shimojima, C. Weyand, 2016, The Journal of clinical investigation.

Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction

D. Harrison, S. Dikalov, C. Weyand, 2007, The Journal of experimental medicine.

Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.

C. Weyand, J. Goronzy, H. Fujii, 2008, Arthritis and rheumatism.

Metabolic signatures of T-cells and macrophages in rheumatoid arthritis.

C. Weyand, J. Goronzy, M. Zeisbrich, 2017, Current opinion in immunology.

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

C. Weyand, J. Goronzy, L. Shao, 2009, The Journal of experimental medicine.

Lower Frequency of Comorbidities Prior to Onset of Giant Cell Arteritis: A Population-Based Study

C. Turesson, E. Matteson, S. Achenbach, 2022, The Journal of Rheumatology.

Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis.

C. Fathman, C. Weyand, J. Goronzy, 1986, Journal of Clinical Investigation.

Inflammation and cardiac outcome

K. Huber, J. Wojta, P. Hohensinner, 2011, Current opinion in infectious diseases.

Immune checkpoints in autoimmune vasculitis.

C. Weyand, J. Goronzy, Yuki Sato, 2024, Best practice & research. Clinical rheumatology.

Immune responses and disease biomarker long-term changes following COVID-19 mRNA vaccination in a cohort of rheumatic disease patients

K. Knutson, C. Weyand, H. Zeng, 2023, Frontiers in immunology.

Polymyalgia rheumatica and giant cell arteritis

C. Weyand, J. Goronzy, 2015 .

Ectopic Lymphoid Organogenesis A Fast Track for Autoimmunity

C. Weyand, J. Goronzy, Paul J. Kurtin, 2001 .

Immune aging and rheumatoid arthritis.

C. Weyand, J. Goronzy, L. Shao, 2010, Rheumatic diseases clinics of North America.

TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque

R. Frye, Kayoko Sato, S. Kopecky, 2006, The Journal of experimental medicine.

Vasculitides

C. Weyand, Jörg J. Goronzy, 2008, Primer on the Rheumatic Diseases.

PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age

C. Weyand, J. Goronzy, Shozo Ohtsuki, 2024, JCI insight.

Dynamic Immune Cell Accumulation During Flow-Induced Atherogenesis in Mouse Carotid Artery: An Expanded Flow Cytometry Method

Melissa L. Kemp, H. Jo, D. Son, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis.

C. Weyand, J. Goronzy, C. Weyand, 2001, Trends in immunology.