Susan E. Knudson

发表

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.

P. Tonge, C. Kisker, R. Slayden, 2017, Journal of the American Chemical Society.

Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity.

P. Tonge, C. Kisker, R. Slayden, 2009, ACS chemical biology.

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor*

C. Sotriffer, P. Tonge, C. Kisker, 2014, The Journal of Biological Chemistry.

Modulating the Spectrum of FabI Inhibition by Pyridones 1 Rational Design of Broad-Spectrum Antibacterial Activity based on a Clinically Relevant Enoyl-ACP Reductase Inhibitor *

C. Sotriffer, P. Tonge, C. Kisker, 2014 .

SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents.

Kunal Kumar, R. Slayden, Susan E. Knudson, 2013, Journal of medicinal chemistry.

Time‐Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

M. García-Díaz, P. Tonge, C. Simmerling, 2014, ChemMedChem.

A Trisubstituted Benzimidazole Cell Division Inhibitor with Efficacy against Mycobacterium tuberculosis

Kunal Kumar, R. Slayden, Susan E. Knudson, 2014, PloS one.

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.

Peter J Tonge, P. Tonge, F. Johnson, 2008, Bioorganic & medicinal chemistry letters.

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Journal of medicinal chemistry.

Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.

Kunal Kumar, R. Slayden, Susan E. Knudson, 2015, The Journal of antimicrobial chemotherapy.

Thermal and Photoinduced Copper-Promoted C-Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis.

C. Goins, Sandeep Thanna, S. J. Sucheck, 2017, The Journal of organic chemistry.

The putative secreted serine protease Chp-7 is required for full virulence and induction of a nonhost hypersensitive response by Clavibacter michiganensis subsp. sepedonicus.

L. Mattinen, M. Pirhonen, C. Ishimaru, 2009, Molecular plant-microbe interactions : MPMI.

Substituted Diphenyl Ethers as a Novel Chemotherapeutic Platform against Burkholderia pseudomallei

P. Tonge, H. Schweizer, R. Slayden, 2013, Antimicrobial Agents and Chemotherapy.

Benzimidazole-based antibacterial agents against Francisella tularensis.

Kunal Kumar, R. Slayden, Susan E. Knudson, 2013, Bioorganic & medicinal chemistry.

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

P. Tonge, R. Slayden, Susan E. Knudson, 2010, Bioorganic & medicinal chemistry letters.

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

P. Tonge, Kunal Kumar, R. Slayden, 2011, Journal of medicinal chemistry.

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia.

Peter J Tonge, P. Tonge, R. Slayden, 2009, The Journal of antimicrobial chemotherapy.

Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Tuberculosis.

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

R. Slayden, A. Lenaerts, M. McNeil, 2009, Bioorganic & medicinal chemistry.

Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.

C. Goins, Sandeep Thanna, D. Ronning, 2016, Organic & biomolecular chemistry.

Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.

Kunal Kumar, Eduard Melief, R. Slayden, 2014, Bioorganic & medicinal chemistry.

CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.

Carlos Simmerling, Peter J Tonge, Nina Liu, 2011, ACS medicinal chemistry letters.

Time‐Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

M. García-Díaz, P. Tonge, C. Simmerling, 2014, ChemMedChem.

Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.

C. Goins, Sandeep Thanna, D. Ronning, 2016, Organic & biomolecular chemistry.