H. Buchstaller

发表

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations.

R. Wade, M. Frech, M. Dreyer, 2018, Journal of chemical theory and computation.

Discovery of novel 7-azaindoles as PDK1 inhibitors.

Dirk Finsinger, Margarita Wucherer-Plietker, Hans-Peter Buchstaller, 2016, Bioorganic & medicinal chemistry letters.

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.

Astrid Zimmermann, Djordje Musil, Hans-Michael Eggenweiler, 2012, Bioorganic & medicinal chemistry letters.

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Catherine Jorand Lebrun, Andrea Unzue Lopez, Daniel Kuhn, 2020, J. Chem. Inf. Model..

Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor.

M. Krug, D. Steinhilber, C. Noe, 2006, Journal of medicinal chemistry.

The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.

S. Anzali, T. Knöchel, D. Finsinger, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of Novel 2-Aminothiophene-3-carboxylates by Variations of the Gewald Reaction

C. Noe, H. Buchstaller, R. Gottschlich, 2001 .

Synthesis of Novel 2-Aminothiophene-3-carboxylates by Variations of the Gewald Reaction.

C. Noe, H. Buchstaller, R. Gottschlich, 2001 .

Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors.

M. Grell, D. Finsinger, H. Buchstaller, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of 3-IndazolecarboxylicEsters and Amides via Pd-Catalyzed Carbonylation of 3-Iodoindazoles

H. Buchstaller, K. Wilkinson, K. Burek, 2011 .

Synthesis of 2′,3′‐Dideoxy‐2′‐hydroxymethyl Nucleosides.

C. Noe, A. Holzner, H. Buchstaller, 1997 .

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

R. Wade, M. Frech, J. Bomke, 2017, Nature Communications.

Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates.

F. Rohdich, B. Cezanne, D. Musil, 2017, Bioorganic & medicinal chemistry letters.

A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

A. Ashworth, F. Rohdich, O. Sansom, 2019, Scientific Reports.

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.

Daniel Kuhn, D. Dorsch, F. Rohdich, 2021, Journal of medicinal chemistry.

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

R. Wade, M. Frech, P. Matias, 2017, Nature Communications.

1,3-dihydro-isoindole derivatives

H. Buchstaller, H. Eggenweiler, C. Sirrenberg, 2007 .

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

G. Ecker, M. Frech, D. Musil, 2018, Journal of Medicinal Chemistry.

Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.

M. Lehmann, Daniel Kuhn, D. Dorsch, 2019, Journal of medicinal chemistry.

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

T. Dale, K. Ewan, A. Clarke, 2019, bioRxiv.

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

M. Nowak, D. Musil, Liming Dong, 2023, Journal of medicinal chemistry.

Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.

D. Dorsch, M. Busch, A. Blum, 2023, Journal of medicinal chemistry.

A novel strategy for ADME screening of prodrugs: combined use of serum and hepatocytes to integrate bioactivation and clearance, and predict exposure to both active and prodrug to the systemic circulation.

J. März, N. Hewitt, H. Buchstaller, 2014, Journal of pharmaceutical sciences.