Margarita Gutiérrez

发表

Bennett acceptance ratio method to calculate the binding free energy of BACE1 inhibitors: Theoretical model and design of new ligands of the enzyme

Carlos Bustos, Margarita Gutiérrez, G. Vallejos, 2019, Chemical biology & drug design.

Synthesis and in silico analysis of the quantitative structure–activity relationship of heteroaryl–acrylonitriles as AChE inhibitors ☆

Jans H. Alzate-Morales, Julio Caballero, Margarita Gutiérrez, 2016 .

Tetrahydroquinoline-Isoxazole/Isoxazoline Hybrid Compounds as Potential Cholinesterases Inhibitors: Synthesis, Enzyme Inhibition Assays, and Molecular Modeling Studies

Jans H. Alzate-Morales, Margarita Gutiérrez, Yeray A. Rodríguez Núñez, 2019, International journal of molecular sciences.

Spirocyclic derivatives as antioxidants: a review

Margarita Gutiérrez, L. S. Nerio, Karen Acosta-Quiroga, 2021, RSC advances.

Synthesis of diN-Substituted Glycyl-Phenylalanine Derivatives by Using Ugi Four Component Reaction and Their Potential as Acetylcholinesterase Inhibitors

Julio Caballero, Margarita Gutiérrez, Luis Prent-Peñaloza, 2019, Molecules.

Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced Platelet Activation: Role of sCD40L

I. Palomo, Margarita Gutiérrez, E. Fuentes, 2013, Molecules.

Study of the Copper, Chromium, Manganese and Zinc Contents in the Species Azorella spinosa (Apiaceae), Collected in the Maule Region, Chile

Margarita Gutiérrez, L. Vargas-Chacoff, R. Baettig, 2019, Journal of Environmental Protection.

Effect of tomato industrial processing (different hybrids, paste, and pomace) on inhibition of platelet function in vitro, ex vivo, and in vivo.

I. Palomo, Margarita Gutiérrez, Adriana V Treuer, 2014, Journal of medicinal food.

Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold

L. Santana, E. Uriarte, Margarita Gutiérrez, 2016 .

Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors.

Margarita Gutiérrez, A. Galdámez, J. Henao, 2019, Bioorganic chemistry.

Isoxazoles: synthesis, evaluation and bioinformatic design as acetylcholinesterase inhibitors

Margarita Gutiérrez, T. Poblete, Luís Astudillo, 2013, The Journal of pharmacy and pharmacology.

Synthesis of novel 7-aryl and 7-spiropyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors

Margarita Gutiérrez, B. Insuasty, J. Quiroga, 2017, Molecular Diversity.

Dyhidro-β-agarofurans natural and synthetic as acetylcholinesterase and COX inhibitors: interaction with the peripheral anionic site (AChE-PAS), and anti-inflammatory potentials

Margarita Gutiérrez, J. Alarcón-Enos, Edgar Pastene-Navarrete, 2022, Journal of enzyme inhibition and medicinal chemistry.

Molecular Docking Studies of the Antitumoral Activity and Characterization of New Chalcone.

A. San-Martín, M. Cazar, Margarita Gutiérrez, 2015, Current topics in medicinal chemistry.

Experimental and Theoretical Approaches in the Study of Phenanthroline‐Tetrahydroquinolines for Alzheimer's Disease

Jans H. Alzate-Morales, Jorge Soto-Delgado, Margarita Gutiérrez, 2019, ChemistryOpen.

Eugenol Supplementation as an Additive to Improve the Thermal Stability of Hedychium coronarium Koening Essential Oil

Margarita Gutiérrez, C. Vergara, O. Forero-Doria, 2020, The Natural Products Journal.

Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives

Margarita Gutiérrez, J. Quiroga, Jorge Trilleras, 2016, Molecules.

Ultrasound-assisted phase-transfer catalysis method in an aqueous medium to promote the Knoevenagel reaction: advantages over the conventional and microwave-assisted solvent-free/catalyst-free method.

Jans H. Alzate-Morales, Julio Caballero, Margarita Gutiérrez, 2014, Ultrasonics sonochemistry.

Synthetic isoxazole as antiplatelet agent

E. Fuentes, I. Palomo, Margarita Gutiérrez, 2014, Platelets.

CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY OF ESSENTIAL OILS FROM AZORELLA SPINOSA (APIACEAE) AGAINST WILD PHYTOPATHOGENIC BACTERIA

Margarita Gutiérrez, G. Gilardoni, O. Malagón, 2016 .

Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives

F. González-Nilo, Margarita Gutiérrez, Leonardo S. Santos, 2015 .

Synthesis and Biotransformation of Tetrahydroquinoline by Mortierella isabelina

Margarita Gutiérrez, Luís Astudillo, A. San‐Martín, 2009, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Crystal structure and theoretical studies of 2-bromo-N-(2,4-difluorobenzyl)benzamide; intermediate for the synthesis of phenanthridinone

Margarita Gutiérrez, A. Galdámez, J. Henao, 2019, Chemical Data Collections.

1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one

Margarita Gutiérrez, I. Brito, M. López-Rodríguez, 2011, Acta crystallographica. Section E, Structure reports online.

1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one monohydrate

Carlos Segovia Fernández, Margarita Gutiérrez, I. Brito, 2010, Acta crystallographica. Section E, Structure reports online.

Microwave-assisted one-pot synthesis in water of carbonylpyrazolo[3,4-b]pyridine derivatives catalyzed by InCl3 and sonochemical assisted condensation with aldehydes to obtain new chalcone derivatives containing the pyrazolopyridinic moiety

Margarita Gutiérrez, J. Quiroga, Jorge Trilleras, 2017 .

Design, facile synthesis, and evaluation of novel spiro- and pyrazolo[1, 5-c]quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies

Margarita Gutiérrez, Jaime Gálvez, Jans H. Alzate-Morales, 2018, Comput. Biol. Chem..

Synthesis of Pyrazolo-Fused 4-Azafluorenones in an Ionic Liquid. Mechanistic Insights by Joint Studies Using DFT Analysis and Mass Spectrometry

Xaviera A. López-Cortés, Margarita Gutiérrez, O. Forero-Doria, 2019, Catalysts.

Efficient synthesis and antioxidant activity of novel N-propargyl tetrahydroquinoline derivatives through the cationic Povarov reaction

Margarita Gutiérrez, Yeray A. Rodríguez Núñez, Arnold R. Romero Bohórquez, 2019, Heliyon.

Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation

Margarita Gutiérrez, P. De-la-Torre, Adriana V Treuer, 2017 .

Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections

David Ramírez, Margarita Gutiérrez, Leonardo S. Santos, 2018, Molecules.

Synthesis of new 3-(2-chloroquinolin-3-yl)-5-phenylisoxazole derivatives via click-chemistry approach

Margarita Gutiérrez, Carlos Fernández-Galleguillos, Luis Astudillo Saavedra, 2014 .

Novel N‐allyl/propargyl tetrahydroquinolines: Synthesis via Three‐component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors

Jans H. Alzate-Morales, David Ramírez, Margarita Gutiérrez, 2016, Chemical biology & drug design.

Crystal structure of 1,3-bis(6-methoxyquinolin-2-yl)benzene, C26H20N2O2

Margarita Gutiérrez, M. Bolte, Yorley Duarte, 2013 .

Synthesis of Bistetrahydroquinolines as Potential Anticholinesterasic Agents by Double Diels-Alder Reactions

Jans H. Alzate-Morales, N. Valdés, Margarita Gutiérrez, 2013, Molecules.

Bioactive metabolites from the fungus Nectria galligena, the main apple canker agent in Chile.

G. Schmeda-Hirschmann, C. Theoduloz, Margarita Gutiérrez, 2005, Journal of agricultural and food chemistry.

Microwave-assisted synthesis, biological assessment, and molecular modeling of aza-heterocycles: Potential inhibitory capacity of cholinergic enzymes to Alzheimer's disease

Yeray A. Rodríguez Núñez, Margarita Gutiérrez, Jorge Trilleras, 2021 .

Antioxidant and Antiplatelet Activities in Extracts from Green and Fully Ripe Tomato Fruits (Solanum lycopersicum) and Pomace from Industrial Tomato Processing

R. Carle, I. Palomo, Margarita Gutiérrez, 2013, Evidence-based complementary and alternative medicine : eCAM.

Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum

I. Palomo, Margarita Gutiérrez, E. Fuentes, 2012, Evidence-based complementary and alternative medicine : eCAM.

Furanyl chalcone derivatives as efficient singlet oxygen quenchers. An experimental and DFT/MRCI study

W. Vallejo, E. Schott, X. Zarate, 2020 .

Novel Coumarin‐Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease

Jans H. Alzate-Morales, L. Santana, E. Uriarte, 2019, ChemistrySelect.

SHORT COMMUNICATION Biological Activity and Xanthine Oxidase Inhibitors from Scirpus caffirnicus (C. A. Mey.)

G. Schmeda-Hirschmann, Margarita Gutiérrez, J. I. Loyola, 1996 .

Biological Activity and Food Analysis ofCyttaria spp. (Discomycetes)

G. Schmeda-Hirschmann, I. Razmilic, Margarita Gutiérrez, 2008, Economic Botany.

Biological Activity of Isoflavonoids from Azorella madreporica

Margarita Gutiérrez, L. Astudillo, C. Areche, 2012, Natural product communications.

Synthesis, characterization, crystal and molecular structure and theoretical study of N-(naphthalen-1-yl)-2-(piperidin-1-yl) acetamide, a selective butyrylcholinesterase inhibitor

Edison Osorio, Margarita Gutiérrez, J. Cisterna, 2022, Journal of Molecular Structure.

Proximate composition and biological activity of food plants gathered by chilean Amerindians

G. Schmeda-Hirschmann, I. Razmilic, Margarita Gutiérrez, 1999, Economic Botany.

A New Isoxazolic Compound Acts as α7 Nicotinic Receptor Agonist in Human Umbilical Vein Endothelial Cells

F. Jiménez-Aspee, Margarita Gutiérrez, Magdalena P. Cortés, 2014, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables

G. Schmeda-Hirschmann, Margarita Gutiérrez, J. A. Yuri, 2011, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity

M. A. Alarcón, Margarita Gutiérrez, Luis Bustamante, 2012, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Antifungal Activity of Tetrahydroquinolines against Some Phytopathogenic Fungi

U. Carmona, Margarita Gutiérrez, Luís Astudillo, 2012, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Antioxidant activity of bioactive extracts obtained from rhizomes of Cyperus digitatus Roxb.

Margarita Gutiérrez, O. Forero-Doria, R. Castro, 2014 .

New Diterpenes from Azorella spinosa

L. Espinoza, Margarita Gutiérrez, L. Astudillo, 2014, Natural product communications.

Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)

I. Palomo, Margarita Gutiérrez, E. Fuentes, 2013 .

Adenosine Derivates as Antioxidant Agents: Synthesis, Characterization, in Vitro Activity, and Theoretical Insights

Margarita Gutiérrez, Luis Prent-Peñaloza, Francisco Z. Valdés, 2019, Antioxidants.

Synthesis and Study of a Selected Series of Amides with the Coumarin Scaffold for the Treatment of Alzheimer's Disease

L. Santana, E. Uriarte, Margarita Gutiérrez, 2013 .

1-(3-Phenylisoxazol-5-yl)cyclohexane-1,2-diol

Luis Astudillo, Iván Brito, Gabriel Vallejos, 2009, Acta crystallographica. Section E, Structure reports online.

Crystal structure, Hirshfeld surface analysis and DFT studies of N-(4-acetylphenyl)quinoline-3-carboxamide

Margarita Gutiérrez, J. Cisterna, I. Brito, 2021 .

SYNTHESIS AND AChE INHIBITING ACTIVITY OF 2, 4 SUBSTITUTED 6-PHENYL PYRIMIDINES

J. Becerra, Margarita Gutiérrez, M. Peter, 2012 .