A. Speers

发表

Proteomics of integral membrane proteins--theory and application.

Christine C. Wu, A. Speers, 2007, Chemical reviews.

Impacts of climate change and ocean acidification on coral reef fisheries: An integrated ecological–economic model

Elena Y. Besedin, A. Speers, C. Moore, 2016 .

A Meta-Analysis of Hedonic Studies to Assess the Property Value Effects of Low Impact Development

Elena Y. Besedin, A. Speers, M. Mazzotta, 2014 .

Shotgun analysis of integral membrane proteins facilitated by elevated temperature.

Christine C. Wu, A. Blackler, A. Speers, 2007, Analytical chemistry.

Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling.

B. Cravatt, A. Speers, Kay Ahn, 2013, Biochemistry.

A shotgun proteomic method for the identification of membrane-embedded proteins and peptides.

Christine C. Wu, A. Blackler, M. Ladinsky, 2008, Journal of proteome research.

Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

Jennifer L. Small, D. Boger, T. Spicer, 2014, ACS chemical biology.

Proteomics of Integral Membrane Proteins — Theory and Application

Christine C. Wu, A. Speers, 2007 .

Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.

Landon R. Whitby, B. Cravatt, A. Speers, 2013, Journal of medicinal chemistry.

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).

Landon R. Whitby, J. Chang, B. Cravatt, 2013, Journal of medicinal chemistry.

Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.

Melinda M. Mulvihill, Steven J Brown, J. Chang, 2015, ACS chemical biology.

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition.

Anna E Speers, B. Cravatt, A. Speers, 2003, Journal of the American Chemical Society.

Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.

Steven J Brown, B. Cravatt, H. Rosen, 2011, Journal of medicinal chemistry.

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

T. Spicer, D. Nomura, B. Cravatt, 2011, Proceedings of the National Academy of Sciences.

Activity‐Based Protein Profiling (ABPP) and Click Chemistry (CC)–ABPP by MudPIT Mass Spectrometry

Anna E Speers, B. Cravatt, A. Speers, 2009, Current protocols in chemical biology.

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)—a general method for mapping sites of probe modification in proteomes

B. Cravatt, E. Weerapana, A. Speers, 2007, Nature Protocols.

A tandem orthogonal proteolysis strategy for high-content chemical proteomics.

B. Cravatt, A. Speers, 2005, Journal of the American Chemical Society.

Profiling enzyme activities in vivo using click chemistry methods.

Anna E Speers, B. Cravatt, A. Speers, 2004, Chemistry & biology.

Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

H. Bostic, B. Cravatt, W. Cho, 2011, Biochemistry.

Chapter 10 Bottom-Up Mass Spectrometry Analysis of Integral Membrane Protein Structure and Topology

Christine C. Wu, A. Speers, 2008 .

Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance.

T. Spicer, B. Cravatt, H. Rosen, 2011, Journal of the American Chemical Society.

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().

B. Cravatt, A. Speers, S. Saario, 2012, Chemical science.

Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2)

Steven J Brown, T. Spicer, B. Cravatt, 2013 .

Chemical Strategies for Activity‐Based Proteomics

Anna E Speers, B. Cravatt, A. Speers, 2004, Chembiochem : a European journal of chemical biology.

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).

Steven J Brown, Joseph M G Nagano, Landon R. Whitby, 2013, Bioorganic & medicinal chemistry letters.

Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)

Fernandez-Vega, Steven J Brown, T. Spicer, 2011 .

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes.

Steven J Brown, Brent R. Martin, J. Chang, 2012, Journal of the American Chemical Society.

Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)

Steven J Brown, Brent R. Martin, T. Spicer, 2013 .

Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2)

Steven J Brown, Brent R. Martin, J. Chang, 2014 .

Chromatographic benefits of elevated temperature for the proteomic analysis of membrane proteins

Christine C. Wu, A. Blackler, A. Speers, 2008, Proteomics.

Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6)

Steven J Brown, T. Spicer, B. Cravatt, 2013 .

Creating opportunities for improving lake-focused stakeholder engagement: knowledge–action systems, pro-environment behaviour and sustainable lake management

K. Bell, M. Teisl, Laura Lindenfeld, 2013 .

A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.

A. Saghatelian, T. Spicer, B. Cravatt, 2011, Journal of the American Chemical Society.

Figure 9, Structures of existing LYPLA1-inhibitors

Peter Hodder, Hugh Rosen, Jill Ferguson, 2013 .

Ligands in crystal structures that aid in functional characterization

B. Cravatt, A. Speers, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.