J. Cantley

发表

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

P. Meikle, P. Helquist, N. Mellett, 2013, Diabetologia.

Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

R. Stocker, M. Ng, J. Cantley, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Steven J. Lingard, M. Duchen, R. Batterham, 2008, The Journal of clinical investigation.

The prolyl hydroxylase PHD 3 maintains β-cell glucose metabolism during fatty 3 acid excess 4 5

Ildem Akerman, D. Tennant, D. Hodson, 2020 .

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

Ildem Akerman, D. Tennant, D. Hodson, 2020, bioRxiv.

The hypoxia response pathway and β‐cell function

S. Grey, D. Withers, P. Maxwell, 2010, Diabetes, obesity & metabolism.

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells*

P. Meikle, J. Weir, J. Cantley, 2013, The Journal of Biological Chemistry.

Sweet and Sour β-Cells: ROS and Hif1α Induce Warburg-Like Lactate Production During Type 2 Diabetes

J. Cantley, T. Biden, 2013, Diabetes.

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis

J. Cantley, 2014, Mammalian Genome.

Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

J. Burchfield, M. Leitges, C. Schmitz‐Peiffer, 2009, Diabetes.

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice

C. Knauf, D. Withers, Patrice D Cani, 2006, Diabetologia.

The diverse roles of protein kinase C in pancreatic beta-cell function.

J. Burchfield, L. Carpenter, C. Schmitz‐Peiffer, 2008, Biochemical Society transactions.

Targeting triglyceride/fatty acid cycling in β-cells as a therapy for augmenting glucose-stimulated insulin secretion

J. Cantley, T. Biden, 2010, Islets.

The radical‐SAM enzyme Viperin catalyzes reductive addition of a 5′‐deoxyadenosyl radical to UDP‐glucose in vitro

F. Armstrong, S. Carr, J. McCullagh, 2017, FEBS letters.

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

D. James, P. Meikle, K. Hoehn, 2018, Diabetologia.

Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation

D. James, K. Hoehn, J. Cantley, 2013 .

Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity

K. Hoehn, J. Cantley, Martina Beretta, 2022, International journal of molecular sciences.

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent

R. Graham, G. Cooney, J. Burchfield, 2013, PloS one.

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis

J. Cantley, 2014, Mammalian Genome.

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

Steven J. Lingard, D. Withers, P. Herrera, 2007, Diabetologia.

The molecular control of beta cell function by insulin and hypoxia cellular signalling pathways

J. Cantley, 2007 .

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

F. Ashcroft, J. Cantley, 2015, BMC Biology.

Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance

D. James, R. Stocker, J. Cantley, 2021, Redox biology.

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

D. James, N. Turner, D. Fazakerley, 2014, Molecular metabolism.

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

M. Raftery, N. Turner, M. Raftery, 2011, Diabetologia.

Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity

S. Grey, R. Brink, T. Loudovaris, 2015, The Journal of experimental medicine.

Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

L. Hodson, D. Tennant, D. Hodson, 2021, JCI insight.

Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid 1 excess in mice 2 3

Leanne, Hodson, D. Tennant, 2021 .

University of Dundee Nuclear factor B-inducing kinase activation as a mechanism of pancreatic cell failure in obesity Malle,

S. Grey, R. Brink, T. Loudovaris, 2015 .

Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP‐1

R. Cox, F. Reimann, F. Gribble, 2019, Obesity.

Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice

Eduardo D. Martín, S. Cragg, R. Moratalla, 2020, Movement disorders : official journal of the Movement Disorder Society.

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion

J. Ahnfelt-Rønne, P. Rorsman, F. Reimann, 2022, Communications Biology.

Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice

W. Santos, K. Hoehn, K. Rye, 2023, Molecular metabolism.

Continuous and non-invasive thermography of mouse skin accurately describes core body temperature patterns, but not absolute core temperature

V. Vyazovskiy, S. Peirson, V. van der Vinne, 2020, Scientific Reports.

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

F. Ashcroft, J. Cantley, 2015, BMC Biology.

Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice

T. Iseli, Xiao-Yi Zeng, E. Kraegen, 2012, PloS one.

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo

D. R. Laybutt, M. Leitges, L. Carpenter, 2011, Diabetologia.

The Human Diabetes Proteome Project (HDPP): The 2014 update

Ioannis Xenarios, Loïc Dayon, Young Ah Goo, 2015 .

A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis

M. Cowley, S. Grey, G. Weir, 2013, Cell Transplantation.

High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Nolan J. Hoffman, B. Vissel, D. James, 2018, The Journal of Biological Chemistry.

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice.

D. R. Laybutt, J. Lau, H. Herzog, 2015, Endocrinology.

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

P. MacDonald, M. Prentki, E. Olson, 2012, Diabetologia.

Inhibition of Y1 receptor signaling improves islet transplant outcome

S. Grey, C. Ip, D. R. Laybutt, 2017, Nature Communications.

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake

D. James, M. Verhage, J. Burchfield, 2014, Diabetologia.

XBP1 expression in pancreatic islet cells is associated with poor glycaemic control across ancestries especially in young non-obese onset diabetes

A. Brown, A. Viñuela, C. Palmer, 2023, medRxiv.

Metabolic regulation of glucagon secretion.

J. Cantley, E. D. Dean, Jade E. Stanley, 2023, The Journal of endocrinology.

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Steven J. Lingard, M. Duchen, R. Batterham, 2008, The Journal of clinical investigation.

Islet cells in human type 1 diabetes: from recent advances to novel therapies – a symposium-based roadmap for future research

D. Eizirik, J. Cantley, E. Latres, 2023, The Journal of endocrinology.