Pauline Bourbon

发表

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

P. Meikle, P. Helquist, N. Mellett, 2013, Diabetologia.

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

Paul Helquist, Olaf Wiest, Frederick R Maxfield, 2011, Proceedings of the National Academy of Sciences.

Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

Sean Ekins, Malabika Sarker, Carolyn Talcott, 2015, PloS one.

Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics.

O. Wiest, F. Maxfield, P. Helquist, 2009, Journal of medicinal chemistry.

Development of carbamate-tethered coumarins as phototriggers for caged nicotinamide.

O. Wiest, P. Helquist, Q. Peng, 2013, Bioorganic & medicinal chemistry letters.

Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.

Adam Siddiqui-Jain, J. Bliesath, M. Omori, 2011, Journal of medicinal chemistry.

Synthesis and photochemical behavior of coumarin-caged cholesterol.

O. Wiest, P. Helquist, Q. Peng, 2013, Bioorganic & medicinal chemistry letters.

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

Adam Siddiqui-Jain, J. Bliesath, M. Omori, 2011, Molecular and Cellular Biochemistry.

Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties.

Adam Siddiqui-Jain, Nicole Streiner, Caroline B. Ho, 2011, Bioorganic & medicinal chemistry letters.

Complementary Site-Selective Sulfonylation of Aromatic Amines by Superacid Activation.

Pauline Bourbon, A. Martin-Mingot, S. Thibaudeau, 2021, Organic letters.

Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis

S. Ekins, V. Mizrahi, S. Hearnshaw, 2016, Scientific Reports.

Development of potential Niemann-Pick C therapeutics and the synthesis of caged nicotinamide and cholesterol to gain a better understanding of cholesterol biosynthesis and trafficking

Pauline Bourbon, 2013 .

Synthesis, photophysical, photochemical, and computational studies of coumarin-labeled nicotinamide derivatives.

O. Wiest, P. Helquist, Q. Peng, 2012, The Journal of organic chemistry.

Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers

T. Shaler, Pauline Bourbon, L. Sambucetti, 2020, ACS central science.