J. Kiehn

发表

Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone

H. Katus, Dierk Thomas, E. Zitron, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Molecular determinants of dofetilide block of HERG K+ channels.

A. Brown, A. Baumann, E. Ficker, 1998, Circulation research.

A. Brown, A. E. Lacerda, J. Kiehn, 1999, American journal of physiology. Heart and circulatory physiology.

Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation

H. Katus, Dierk Thomas, E. Zitron, 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action

Hugo A. Katus, Eberhard P. Scholz, Edgar Zitron, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of human ether-a-go-go-related gene potassium channels by α1-adrenoceptor antagonists prazosin, doxazosin, and terazosin

Hugo A. Katus, Y. Kuryshev, H. Katus, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.

H. Katus, Dierk Thomas, J. Kiehn, 2003, Cardiovascular research.

Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine

H. Katus, Dierk Thomas, E. Zitron, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Deletion of Protein Kinase A Phosphorylation Sites in the HERG Potassium Channel Inhibits Activation Shift by Protein Kinase A*

W. Kübler, Dierk Thomas, W. Schöls, 1999, The Journal of Biological Chemistry.

Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Cardiovascular research.

Human Cardiac Inwardly-Rectifying K+ Channel Kir2.1b Is Inhibited by Direct Protein Kinase C-Dependent Regulation in Human Isolated Cardiomyocytes and in an Expression System

C. Vahl, H. Katus, Dierk Thomas, 2002, Circulation.

Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1

H. Katus, Dierk Thomas, E. Zitron, 2005, Journal of Molecular Medicine.

Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.

H. Katus, Dierk Thomas, E. Zitron, 2004, Cardiovascular research.

Antiarrhythmic drug carvedilol inhibits HERG potassium channels.

S. Kathöfer, J. Kiehn, V. Kreye, 2001, Cardiovascular research.

QTc Prolongation by Grapefruit Juice and Its Potential Pharmacological Basis: HERG Channel Blockade by Flavonoids

R. Owen, H. Katus, F. Niroomand, 2005, Circulation.

Bertosamil blocks HERG potassium channels in their open and inactivated states

Dierk Thomas, E. Zitron, S. Kathöfer, 2002, British journal of pharmacology.

Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels

H. Katus, Dierk Thomas, E. Zitron, 2003, British journal of pharmacology.

Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome.

H. Katus, K. Brockmeier, J. Kiehn, 2004, Biochimica et biophysica acta.

[Molecular basis of primary electrical heart diseases].

E. Zitron, C. Kiesecker, E. Scholz, 2005, Herzschrittmachertherapie & Elektrophysiologie.

Differential Effects of the New Class III Agent Dofetilide on Potassium Currents in Guinea Pig Cardiomyocytes

J. Brachmann, J. Kiehn, T. Beyer, 1994, Journal of cardiovascular pharmacology.

Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways.

E. Zitron, S. Kathöfer, J. Kiehn, 2002, Cardiovascular research.

Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, IKr, and the underlying hERG ion channel

H. Katus, Dierk Thomas, J. Kiehn, 2004, Basic Research in Cardiology.

Human β3-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Doxazosin induces apoptosis of cells expressing hERG K+ channels.

H. Katus, Dierk Thomas, E. Ficker, 2008, European journal of pharmacology.

HERG Potassium Channel Activation Is Shifted by Phorbol Esters via Protein Kinase A-dependent Pathways*

W. Kübler, Dierk Thomas, J. Kiehn, 1998, The Journal of Biological Chemistry.

Separable Kvβ Subunit Domains Alter Expression and Gating of Potassium Channels*

A. Brown, B. Wible, E. Accili, 1997, The Journal of Biological Chemistry.

Interactions among Inactivating and Noninactivating Kvβ Subunits, and Kvα1.2, Produce Potassium Currents with Intermediate Inactivation*

A. Brown, B. Wible, E. Accili, 1997, The Journal of Biological Chemistry.

Interactions among inactivating and noninactivating Kvbeta subunits, and Kvalpha1.2, produce potassium currents with intermediate inactivation.

A. Brown, B. Wible, E. Accili, 1997, The Journal of biological chemistry.

Functional coupling of human beta 3-adrenoreceptors to the KvLQT1/MinK potassium channel.

S. Kathöfer, J. Kiehn, W. Schoels, 2000, The Journal of biological chemistry.

Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A.

J. Kiehn, 2000, Trends in cardiovascular medicine.

Cloned human inward rectifier K+ channel as a target for class III methanesulfonanilides.

A. Brown, B. Wible, E. Ficker, 1995, Circulation research.

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by α1A-adrenoceptors

H. Katus, Dierk Thomas, E. Zitron, 2004, Journal of Molecular Medicine.

The antiarrhythmic drug BRL-32872.

Dierk Thomas, J. Kiehn, C. Karle, 2006, Cardiovascular drug reviews.

An ion channel 'addicted' to ether, alcohol and cocaine: the HERG potassium channel.

J. Kiehn, C. Karle, 2002, Cardiovascular research.

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.

H. Katus, Dierk Thomas, S. Kathöfer, 2005, Cardiovascular research.

The antipsychotic drug chlorpromazine inhibits HERG potassium channels

Hugo A Katus, H. Katus, Dierk Thomas, 2003, British journal of pharmacology.

Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action

B. Wible, H. Katus, Dierk Thomas, 2004, British Journal of Pharmacology.

The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.

J. Kiehn, C. Karle, D. Thomas, 2006, Current pharmaceutical design.

Adrenergic regulation of an ion channel in the heart — inhibition of 3 the slow delayed rectifier potassium current I in guinea pigKs ventricular myocytes

J. Kiehn, Wei Zhang, L. Seipel, 2002 .

High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872.

A. Brown, E. Ficker, J. Kiehn, 2001, The Journal of pharmacology and experimental therapeutics.

Comparison of Binding and Block Produced by Alternatively Spliced Kvβ1 Subunits*

A. Brown, B. Wible, Zhiguo Wang, 1996, The Journal of Biological Chemistry.

β3-Adrenergic regulation of an ion channel in the heart—inhibition of the slow delayed rectifier potassium current IKs in guinea pig ventricular myocytes

J. Kiehn, Wei Zhang, C. Mewis, 2002 .

The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels.

Dierk Thomas, J. Kiehn, G. Wendt-Nordahl, 2002, The Journal of pharmacology and experimental therapeutics.

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

W. Kübler, Dierk Thomas, W. Schöls, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide.

A. Brown, A. Brown, B. Wible, 1996, Circulation.

Differential effects ofd, l-Sotalol andd-Sotalol on isoproterenol-increased delayed rectifier outward potassium current in guinea pig single ventricular myocytes

J. Brachmann, J. Kiehn, N. Yannoulis, 2008, Journal of Tongji Medical University.

Mapping the block of a cloned human inward rectifier potassium channel by dofetilide.

A. Brown, B. Wible, A. E. Lacerda, 1996, Molecular pharmacology.

Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).

Daniel Scherer, Hugo A Katus, Y. Kuryshev, 2004, Cardiovascular research.

Pathways of HERG inactivation.

A. Brown, A. E. Lacerda, J. Kiehn, 1999, The American journal of physiology.

Modulation of HERG potassium channel function by drug action

Dierk Thomas, J. Kiehn, C. Karle, 2004, Annals of medicine.