C. Karle

发表

Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone

H. Katus, Dierk Thomas, E. Zitron, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone

H. Katus, Dierk Thomas, E. Ficker, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine

H. Katus, Dierk Thomas, E. Ficker, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin

H. Katus, Dierk Thomas, A. Bauer, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656

G. Seemann, H. Katus, F. Konrad, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels

H. Katus, Dierk Thomas, A. Bauer, 2006, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation

H. Katus, Dierk Thomas, E. Zitron, 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action

Hugo A. Katus, Eberhard P. Scholz, Edgar Zitron, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of human ether-a-go-go-related gene potassium channels by α1-adrenoceptor antagonists prazosin, doxazosin, and terazosin

Hugo A. Katus, Y. Kuryshev, H. Katus, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.

H. Katus, Dierk Thomas, J. Kiehn, 2003, Cardiovascular research.

Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine

H. Katus, Dierk Thomas, E. Zitron, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Regulation of two‐pore‐domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein

E. Ficker, A. Bauer, J. Gierten, 2008, British journal of pharmacology.

A multiplex PCR strategy to screen for known mutations in families with sudden cardiac death burden

T. Helms, C. Karle, G. Duong, 2017, Journal of biological methods.

Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels.

M. Völkers, H. Katus, Dierk Thomas, 2011, Journal of molecular and cellular cardiology.

Cardiovascular ion channels as a molecular target of flavonoids.

H. Katus, E. Zitron, E. Scholz, 2010, Cardiovascular therapeutics.

Deletion of Protein Kinase A Phosphorylation Sites in the HERG Potassium Channel Inhibits Activation Shift by Protein Kinase A*

W. Kübler, Dierk Thomas, W. Schöls, 1999, The Journal of Biological Chemistry.

Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Cardiovascular research.

Dual regulation of renal Kir7.1 potassium channels by protein Kinase A and protein Kinase C.

H. Katus, M. Zeier, E. Zitron, 2008, Biochemical and biophysical research communications.

Human Cardiac Inwardly-Rectifying K+ Channel Kir2.1b Is Inhibited by Direct Protein Kinase C-Dependent Regulation in Human Isolated Cardiomyocytes and in an Expression System

C. Vahl, H. Katus, Dierk Thomas, 2002, Circulation.

Far‐Field R Wave Oversensing in a Dual Chamber Arrhythmia Management Device: Predisposing Factors and Practical Implications

R. Becker, W. Schoels, C. Karle, 2001, Pacing and clinical electrophysiology : PACE.

Activation of inwardly rectifying Kir2.x potassium channels by β3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2

H. Katus, Dierk Thomas, A. Bauer, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1

H. Katus, Dierk Thomas, E. Zitron, 2005, Journal of Molecular Medicine.

Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.

H. Katus, Dierk Thomas, E. Zitron, 2004, Cardiovascular research.

Atp-Dependent K+Channels in Vascular Smooth Muscle

V. Kreye, C. Karle, S. Kajioka, 1995 .

Inhibition of hK2P3.1 (TASK-1) Potassium Channels by the Tyrosine Kinase Inhibitor Genistein

H. Katus, Dierk Thomas, E. Ficker, 2009 .

Dynamical disorder in glasses studied by 2H and 1H NMR

M. Taupitz, C. Karle, E. Rössler, 1996 .

Antiarrhythmic drug carvedilol inhibits HERG potassium channels.

S. Kathöfer, J. Kiehn, V. Kreye, 2001, Cardiovascular research.

QTc Prolongation by Grapefruit Juice and Its Potential Pharmacological Basis: HERG Channel Blockade by Flavonoids

R. Owen, H. Katus, F. Niroomand, 2005, Circulation.

Bertosamil blocks HERG potassium channels in their open and inactivated states

Dierk Thomas, E. Zitron, S. Kathöfer, 2002, British journal of pharmacology.

Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels

H. Katus, Dierk Thomas, E. Zitron, 2003, British journal of pharmacology.

Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome.

H. Katus, K. Brockmeier, J. Kiehn, 2004, Biochimica et biophysica acta.

Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.

H. Katus, Dierk Thomas, E. Zitron, 2012, Biochemical and biophysical research communications.

Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents

W. Rottbauer, G. Seemann, H. Katus, 2009, British journal of pharmacology.

Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels.

A. Remppis, H. Katus, J. Greten, 2007, Biochemical and biophysical research communications.

In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.

H. Katus, J. Greten, Dierk Thomas, 2006, Toxicology letters.

[Molecular basis of primary electrical heart diseases].

E. Zitron, C. Kiesecker, E. Scholz, 2005, Herzschrittmachertherapie & Elektrophysiologie.

Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways.

E. Zitron, S. Kathöfer, J. Kiehn, 2002, Cardiovascular research.

Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, IKr, and the underlying hERG ion channel

H. Katus, Dierk Thomas, J. Kiehn, 2004, Basic Research in Cardiology.

Relativistic laser pulse focusing and self-compression in stratified plasma-vacuum systems

K. Spatschek, C. Karle, 2008 .

Human β3-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Doxazosin induces apoptosis of cells expressing hERG K+ channels.

H. Katus, Dierk Thomas, E. Ficker, 2008, European journal of pharmacology.

HERG Potassium Channel Activation Is Shifted by Phorbol Esters via Protein Kinase A-dependent Pathways*

W. Kübler, Dierk Thomas, J. Kiehn, 1998, The Journal of Biological Chemistry.

The novel antiarrhythmic drug dronedarone: comparison with amiodarone.

Dierk Thomas, C. Karle, S. Kathofer, 2006, Cardiovascular drug reviews.

Functional coupling of human beta 3-adrenoreceptors to the KvLQT1/MinK potassium channel.

S. Kathöfer, J. Kiehn, W. Schoels, 2000, The Journal of biological chemistry.

Ventricular Oversensing:

M. Bahner, R. Becker, J. Senges, 2003, Pacing and clinical electrophysiology : PACE.

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by α1A-adrenoceptors

H. Katus, Dierk Thomas, E. Zitron, 2004, Journal of Molecular Medicine.

The antiarrhythmic drug BRL-32872.

Dierk Thomas, J. Kiehn, C. Karle, 2006, Cardiovascular drug reviews.

An ion channel 'addicted' to ether, alcohol and cocaine: the HERG potassium channel.

J. Kiehn, C. Karle, 2002, Cardiovascular research.

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen

H. Katus, Dierk Thomas, S. Kathöfer, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Vascular effects of class-III antiarrhythmic drugs: chromanol 293B, but not dofetilide blocks the smooth muscle delayed rectifier K+ channel

A. Bauer, E. Zitron, V. Kreye, 2002, Basic Research in Cardiology.

Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.

H. Katus, Dierk Thomas, S. Kathöfer, 2005, Cardiovascular research.

The antipsychotic drug chlorpromazine inhibits HERG potassium channels

Hugo A Katus, H. Katus, Dierk Thomas, 2003, British journal of pharmacology.

Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action

B. Wible, H. Katus, Dierk Thomas, 2004, British Journal of Pharmacology.

The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.

J. Kiehn, C. Karle, D. Thomas, 2006, Current pharmaceutical design.

Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish.

W. Rottbauer, H. Katus, B. Meder, 2011, Biochemical and biophysical research communications.

Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells.

H. Katus, P. Bärtsch, T. Gehrig, 2004, American journal of physiology. Lung cellular and molecular physiology.

Atrial septal aneurysm mimicking ECG signs of enlarged right atrium.

H. Katus, D. Mereles, E. Zitron, 2007, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

K+ channel activation with minoxidil stimulates nasal-epithelial ion transport and blunts exaggerated hypoxic pulmonary hypertension.

C. Dehnert, P. Bärtsch, C. Karle, 2006, High altitude medicine & biology.

Photodermatitis caused by torasemide

C. Karle, M. Haeberle, 2020, Contact dermatitis.

MOLECULAR DYNAMICS IN BINARY ORGANIC GLASS FORMERS

J. Wolber, J. Senker, M. Vogel, 1999 .

Prediction and personalised treatment of atrial fibrillation—stroke prevention: consolidated position paper of CVD professionals

K. Kuck, T. Helms, R. Tilz, 2014, EPMA Journal.

Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors.

H. Katus, Dierk Thomas, A. Bauer, 2008, Journal of molecular and cellular cardiology.

Aquaporin-1 Channel Function Is Positively Regulated by Protein Kinase C*

H. Katus, M. Zeier, Dierk Thomas, 2007, Journal of Biological Chemistry.

Perspectives on Europe’s health care systems: meeting future challenges through innovative health care strategies

T. Helms, K. Budych, C. Karle, 2014, EPMA Journal.

Effect of pre-treatment with catecholamines on cold preservation and ischemia/reperfusion-injury in rats.

B. Yard, M. Schaub, C. Karle, 2006, Kidney international.

Deficient Zebrafish Ether-à-Go-Go-Related Gene Channel Gating Causes Short-QT Syndrome in Zebrafish Reggae Mutants

Benjamin Meder, Gunnar Seemann, Oliver Friedrich, 2008, Circulation.

A parallel implementation of a two-dimensional fluid laser-plasma integrator for stratified plasma-vacuum systems

Marlis Hochbruck, Christoph Karle, Julia Schweitzer, 2008, J. Comput. Phys..

Radiation therapy-induced electrical reset of an implantable cardioverter defibrillator device located outside the irradiation field.

Hugo A Katus, H. Katus, Dierk Thomas, 2004, Journal of electrocardiology.

Numerical solution of nonlinear wave equations in stratified dispersive media

Marlis Hochbruck, Christoph Karle, Julia Schweitzer, 2006, J. Comput. Phys..

Effects of the IKr-Blocking Agent Dofetilide and of the IKs-Blocking Agent Chromanol 293b on Regional Disparity of Left Ventricular Repolarization in the Intact Canine Heart

Ruediger Becker, Alexander Bauer, A. Bauer, 2002, Journal of cardiovascular pharmacology.

Relativistic laser pulse compression and focusing in stratified plasma-vacuum systems

C. Karle, 2008 .

Biophysical properties of zebrafish ether-à-go-go related gene potassium channels.

Daniel Scherer, Hugo A Katus, Edgar Zitron, 2009, Biochemical and biophysical research communications.

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

W. Kübler, Dierk Thomas, W. Schöls, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A

H. Katus, J. Backs, Dierk Thomas, 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

[The Wearable Cardioverter-Defibrillator (WCD)].

T. Helms, C. Karle, A. Müller, 2015, Herzschrittmachertherapie & Elektrophysiologie.

Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1.

H. Katus, Dierk Thomas, C. Karle, 2010, Journal of molecular and cellular cardiology.

Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

M. Andrassy, M. Völkers, H. Katus, 2016, PloS one.

A K+ single channel and whole-cell clamp study on the effects of levcromakalim in guinea pig portal vein cells

V. Kreye, C. Karle, X. Yao, 1998, Naunyn-Schmiedeberg's Archives of Pharmacology.

Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.

A. Remppis, H. Katus, J. Greten, 2007, Nutrition, metabolism, and cardiovascular diseases : NMCD.

Retinal Arterio-Venule-Ratio (AVR) in the cardiovascular risk management of hypertension

Hugo A. Katus, Daniel Scherer, Eberhard P. Scholz, 2013 .

Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).

Daniel Scherer, Hugo A Katus, Y. Kuryshev, 2004, Cardiovascular research.

Modulation of HERG potassium channel function by drug action

Dierk Thomas, J. Kiehn, C. Karle, 2004, Annals of medicine.