Y. Hiraku

发表

Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer

Raynoo Thanan, S. Oikawa, Y. Hiraku, 2014, International journal of molecular sciences.

Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions

S. Oikawa, Y. Hiraku, N. Ma, 2020, Scientific Reports.

Nitrative DNA damage in cultured macrophages exposed to indium oxide

S. Oikawa, Y. Hiraku, N. Ma, 2017, Journal of occupational health.

Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation

Tatsuhiko Yamada, Tatsuhiko Yamada, Y. Hiraku, 2016, Particle and Fibre Toxicology.

Urinary 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine in Patients with Parasite Infection and Effect of Antiparasitic Drug in Relation to Cholangiocarcinogenesis

N. Khuntikeo, Raynoo Thanan, S. Oikawa, 2008, Cancer Epidemiology Biomarkers & Prevention.

Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: an indirect effect after praziquantel treatment.

T. Boonmars, Y. Hiraku, N. Ma, 2008, The American journal of tropical medicine and hygiene.

iNOS‐dependent DNA damage via NF‐κB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel

S. Oikawa, Y. Hiraku, N. Ma, 2006, International journal of cancer.

Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH

Y. Hiraku, S. Kawanishi, Y. Ohkuma, 2001, Free radical research.

8-Nitroguanine, a Potential Biomarker to Evaluate the Risk of Inflammation-Related Carcinogenesis

Raynoo Thanan, Y. Hiraku, S. Ohnishi, 2012 .

Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2005, Free radical biology & medicine.

Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma.

T. Boonmars, C. Wongkham, C. Pairojkul, 2012, Cancer biomarkers : section A of Disease markers.

The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson’s disease

Y. Yada, S. Oikawa, Y. Hiraku, 2009, Journal of neurochemistry.

Oxidative DNA damage by hyperglycemia‐related aldehydes and its marked enhancement by hydrogen peroxide

S. Oikawa, Y. Hiraku, S. Kawanishi, 2003, FEBS letters.

Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2001, Biochemical and biophysical research communications.

Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma.

C. Wongkham, C. Pairojkul, N. Khuntikeo, 2012, Free radical biology & medicine.

Zhe Zhang, S. Oikawa, Y. Hiraku, 2016, Mediators of inflammation.

[Environmental Factors and MicroRNA: Application for DOHaD Research and Future Perspectives].

Y. Hiraku, 2018, Nihon eiseigaku zasshi. Japanese journal of hygiene.

Formation of the Nitrative DNA Lesion 8‐Nitroguanine is Associated with Asbestos Contents in Human Lung Tissues: A Pilot Study

N. Hisanaga, M. Kamijima, Y. Hiraku, 2014, Journal of occupational health.

Reactive nitrogen species‐dependent DNA damage in EBV‐associated nasopharyngeal carcinoma: The relation to STAT3 activation and EGFR expression

Y. Fukui, Y. Hiraku, N. Ma, 2008, International journal of cancer.

Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53+/- mice.

L. Donehower, H. Ohgaki, H. Tazawa, 2007, Carcinogenesis.

iNOS‐dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis

A. Uchida, A. Matsumine, Ken Shintani, 2007, Cancer science.

Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis

S. Oikawa, Y. Hiraku, N. Ma, 2005, Cancer science.

Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line.

Y. Hiraku, N. Ma, S. Pinlaor, 2005, International journal for parasitology.

Inducible nitric oxide synthase‐dependent DNA damage in mouse model of inflammatory bowel disease

Kanako Saito, R. Semba, Y. Hiraku, 2005, Cancer science.

Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis.

R. Semba, S. Oikawa, Y. Hiraku, 2004, Nitric oxide : biology and chemistry.

Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase.

R. Semba, S. Oikawa, Y. Hiraku, 2004, Carcinogenesis.

Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II).

J. Kawamura, S. Oikawa, Y. Hiraku, 2003, Mutation research.

Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2003, Chemical research in toxicology.

Involvement of MMP‐9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1‐dependent DNA damage in a hamster model

C. Pairojkul, Y. Hiraku, S. Pinlaor, 2010, International journal of cancer.

Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage.

Y. Hiraku, S. Kawanishi, M. Murata, 2004, Chemico-biological interactions.

Photosensitized DNA damage induced by NADH: Site specificity and mechanism

Y. Hiraku, S. Kawanishi, Kimiko Ito, 2007, Free radical research.

Photohydrolysis of Methotrexate Produces Pteridine, Which Induces Poly-G–specific DNA Damage Through Photoinduced Electron Transfer¶

Y. Hiraku, S. Kawanishi, K. Hirakawa, 2002, Photochemistry and photobiology.

Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation

Y. Hiraku, S. Kawanishi, M. Nishiguchi, 2001, International journal of cancer.

Mechanism of metal-mediated DNA damage induced by metabolites of carcinogenic 2-nitropropane.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2001, Mutation research.

Sequence-specific DNA damage induced by UVA radiation in the presence of endogenous and exogenous photosensitizers.

Y. Hiraku, S. Kawanishi, 2001, Current problems in dermatology.

Distinct mechanisms of guanine-specific DNA photodamage induced by nalidixic acid and fluoroquinolone antibacterials.

Y. Hiraku, S. Kawanishi, 2000, Archives of biochemistry and biophysics.

Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells

S. Oikawa, Y. Hiraku, S. Ohnishi, 2017, Genes and Environment.

Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation

Raynoo Thanan, S. Oikawa, Y. Hiraku, 2018, Mediators of inflammation.

Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells

S. Oikawa, Y. Hiraku, S. Ohnishi, 2016, Genes and Environment.

Proteomic identification of peroxiredoxin 6 for host defence against Opisthorchis viverrini infection

T. Boonmars, C. Wongkham, Y. Hiraku, 2010, Parasite immunology.

Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway.

S. Oikawa, Y. Hiraku, S. Pinlaor, 2015, Oncology reports.

Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay.

Y. Hiraku, S. Kawanishi, M. Murata, 2002, Biochimica et biophysica acta.

Involvement of oxidative DNA damage and apoptosis in antitumor actions of aminosugars.

Y. Hiraku, S. Kawanishi, 1999, Free radical research.

Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2004, Biochemical pharmacology.

2,4,6-Trinitrotoluene-induced Reproductive Toxicity via Oxidative DNA Damage by its Metabolite

S. Oikawa, Y. Hiraku, S. Kawanishi, 2002, Free radical research.

Oxidative DNA damage and apoptosis induced by benzene metabolites.

Y. Hiraku, S. Kawanishi, Shosuke Kawanishi, 1996, Cancer research.

Copper-dependent DNA damage induced by hydrazobenzene, an azobenzene metabolite

S. Oikawa, Y. Hiraku, S. Ohnishi, 2000, Free radical research.

NADH‐mediated DNA damage induced by a new coenzyme, pyrroloquinoline quinone, in the presence of copper(II) ion

Y. Hiraku, S. Kawanishi, 1996, FEBS letters.

Copper-mediated oxidative DNA damage induced by eugenol: possible involvement of O-demethylation.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2004, Mutation research.

Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide

Y. Kagawa, M. Okuda, Y. Hiraku, 2010, Cancer science.

Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2002, Free radical biology & medicine.

Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.

T. Shimosegawa, T. Koike, Raynoo Thanan, 2012, Biochemical and biophysical research communications.

Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation

S. Oikawa, Y. Hiraku, S. Ohnishi, 2019, Free radical research.

Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment.

Y. Hiraku, S. Pinlaor, P. Yongvanit, 2010, European journal of pharmacology.

The liver fluke Opisthorchis viverrini expresses nitric oxide synthase but not gelatinases.

Y. Hiraku, S. Pinlaor, P. Yongvanit, 2012, Parasitology international.

Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells.

Yingxi Mo, K. Takeuchi, S. Oikawa, 2019, Advances in experimental medicine and biology.

DNA damage induced by m-phenylenediamine and its derivative in the presence of copper ion.

S. Oikawa, Y. Hiraku, S. Kawanishi, 1998, Free radical research.

Mechanism of oxidative DNA damage induced by metabolites of carcinogenic naphthalene.

S. Oikawa, Y. Hiraku, S. Ohnishi, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole.

A. Furukawa, A. Shimada, S. Oikawa, 2010, Mutation research.

Oxidative DNA Damage and Apoptosis Induced by Benzene Metabolites 1

Y. Hiraku, S. Kawanishi, 2022 .

Guanine-specific DNA damage induced by γ-irradiated histone

M. Davies, A. Furukawa, S. Oikawa, 2005 .

Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines.

Y. Hiraku, S. Kawanishi, T. Iwamoto, 2005, Archives of biochemistry and biophysics.

Photohydrolysis of Methotrexate Produces Pteridine, Which Induces Poly‐G–specific DNA Damage Through Photoinduced Electron Transfer ¶

Y. Hiraku, S. Kawanishi, K. Hirakawa, 2002 .

Amplification of bleomycin-induced DNA cleavage at cytosine residues 3' to GGG sequences by pyrrole triamide.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2001, Biochemical pharmacology.

Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine.

S. Oikawa, Y. Hiraku, S. Kawanishi, 1999, Archives of biochemistry and biophysics.

Site-specific hydroxylation at polyguanosine in double-stranded DNA by UVA radiation with nalidixic acid.

H. Ito, Y. Hiraku, S. Kawanishi, 1998, Biochemical and biophysical research communications.

Metal-mediated oxidative DNA damage induced by nitro-2-aminophenols.

S. Oikawa, Y. Hiraku, S. Kawanishi, 1998, Cancer letters.

Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.

Zhe Zhang, Yingxi Mo, S. Oikawa, 2012, Cancer letters.

Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B

S. Kaneko, H. Marusawa, M. Ohtani, 2017, PloS one.

The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L

Zhe Zhang, Yingxi Mo, S. Oikawa, 2015, Oncotarget.

Catechol and hydroquinone have different redox properties responsible for their differential DNA-damaging ability.

Kazutaka Hirakawa, S. Oikawa, Y. Hiraku, 2002, Chemical research in toxicology.

Metal-mediated oxidative DNA damage induced by methylene blue.

Y. Hiraku, S. Kawanishi, M. Murata, 2014, Biochimica et biophysica acta.

The role of metals in site-specific DNA damage with reference to carcinogenesis.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2002, Free radical biology & medicine.

Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2001, Mutation research.

Oxidative DNA damage induced by homogentisic acid, a tyrosine metabolite

Y. Hiraku, S. Kawanishi, M. Yamasaki, 1998, FEBS letters.

Superoxide formation and DNA damage induced by a fragrant furanone in the presence of copper(II).

Y. Hiraku, S. Kawanishi, M. Murata, 1998, Mutation research.

Let-7c inhibits migration and epithelial–mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2

H. Ishinaga, K. Takeuchi, S. Oikawa, 2018, Oncotarget.

Oxidative DNA Damage in Relation to Neurotoxicity in the Brain of Mice Exposed to Arsenic at Environmentally Relevant Levels

L. Zhong, S. Oikawa, Y. Hiraku, 2005, Journal of occupational health.

Mechanism of UVA-dependent DNA Damage Induced by An Antitumor Drug Dacarbazine in Relation to its Photogenotoxicity

M. Okuda, Y. Hiraku, S. Kawanishi, 2008, Pharmaceutical Research.

Photosensitized DNA Damage and its Protection via a Novel Mechanism †

Kazutaka Hirakawa, Y. Hiraku, S. Kawanishi, 2007, Photochemistry and photobiology.

Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.

B. Aggarwal, J. Kim, Subash C. Gupta, 2011, Carcinogenesis.

DNA intrastrand cross‐link at the 5′‐GA‐3′ sequence formed by busulfan and its role in the cytotoxic effect

S. Oikawa, Y. Hiraku, S. Kawanishi, 2004, Cancer science.

Metal-mediated oxidative damage to cellular and isolated DNA by certain tryptophan metabolites.

S. Oikawa, Y. Hiraku, S. Kawanishi, 1995, Carcinogenesis.

Role of Oxidative DNA Damage in Dietary Carcinogenesis

Y. Hiraku, S. Kawanishi, M. Murata, 2006 .

Oxidative DNA damage induced by aminoacetone, an amino acid metabolite.

T. Yamaguchi, Y. Hiraku, S. Kawanishi, 1999, Archives of biochemistry and biophysics.

DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (review).

Y. Hiraku, S. Kawanishi, S. Inoue, 1999, International Journal of Molecular Medicine.

8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini.

R. Semba, S. Oikawa, Y. Hiraku, 2003, Biochemical and biophysical research communications.

Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation.

Y. Hiraku, S. Kawanishi, Yusuke Hiraku, 2006, Antioxidants & redox signaling.

DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite

S. Oikawa, Y. Hiraku, S. Kawanishi, 2010, Environmental health and preventive medicine.

Oxidative DNA damage induced by photodegradation products of 3(')-azido-3(')-deoxythymidine.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2003, Archives of biochemistry and biophysics.

Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds.

Y. Hiraku, S. Kawanishi, 2004, Current medicinal chemistry. Anti-cancer agents.

Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2002, Nucleic acids research. Supplement.

Distinct mechanisms of site‐specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH‐cytochrome P450 reductase

S. Oikawa, Y. Hiraku, S. Kawanishi, 2003, Cancer science.

Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation.

Y. Hiraku, S. Kawanishi, M. Murata, 2004, Cancer letters.

Mechanism of site-specific DNA damage induced by ozone.

Y. Hiraku, S. Kawanishi, S. Inoue, 2005, Mutation research.

Oxidative DNA Damage and Apoptosis Induced by Aclarubicin, an Anthracycline: Role of Hydrogen Peroxide and Copper

Y. Kitamura, Tohru Maeda, Y. Hiraku, 2019, AntiCancer Research.

Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide.

Y. Hiraku, S. Kawanishi, Yusuke Hiraku, 2005, Life sciences.

8-Nitroguanine formation in oral leukoplakia, a premalignant lesion.

Xiaohui Ding, T. Tagawa, Y. Hiraku, 2006, Nitric oxide : biology and chemistry.

Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis

Y. Hiraku, S. Ohnishi, N. Ma, 2017, International journal of molecular sciences.

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation‐mediated molecular events related to multistep carcinogenesis

B. Aggarwal, C. Pairojkul, Y. Hiraku, 2011, International journal of cancer.

Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini.

Y. Hiraku, S. Pinlaor, P. Yongvanit, 2009, Molecular nutrition & food research.

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

Y. Hiraku, N. Ma, S. Pinlaor, 2006, Biological chemistry.

Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion.

C. Pairojkul, S. Wongkham, R. Semba, 2005, World journal of gastroenterology.

Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer

O. Hammam, Raynoo Thanan, S. Oikawa, 2012, Mediators of inflammation.

Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma

H. Ishinaga, K. Takeuchi, S. Oikawa, 2015, Cancer biology & therapy.

MicroRNA expression in lung tissues of asbestos‐exposed mice: Upregulation of miR‐21 and downregulation of tumor suppressor genes Pdcd4 and Reck

A. Kaneko, Y. Hiraku, M. Murata, 2021, Journal of occupational health.

DNA damage by ethylbenzenehydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation.

Y. Hiraku, S. Kawanishi, M. Murata, 2003, Biochemical and biophysical research communications.

Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C.

R. Semba, S. Oikawa, Y. Hiraku, 2005, Journal of hepatology.

Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma

Zhe Zhang, S. Oikawa, Y. Hiraku, 2014, BioMed research international.

DNA Damage in CD133-Positive Cells in Barrett's Esophagus and Esophageal Adenocarcinoma

T. Shimosegawa, T. Koike, Raynoo Thanan, 2016, Mediators of inflammation.

C. Wongkham, C. Pairojkul, K. Vaeteewoottacharn, 2013, Free radical biology & medicine.

Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection.

O. Hammam, Raynoo Thanan, S. Oikawa, 2011, Biochemical and biophysical research communications.

Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury.

C. Pairojkul, Y. Hiraku, S. Pinlaor, 2009, International journal for parasitology.

Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters.

Y. Hiraku, S. Pinlaor, P. Yongvanit, 2011, International journal for parasitology.

RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma

Zhe Zhang, Yingxi Mo, K. Takeuchi, 2017, Journal of Experimental & Clinical Cancer Research.

Quantitation of DNA methylation in Epstein-Barr virus–associated nasopharyngeal carcinoma by bisulfite amplicon sequencing

Zhe Zhang, Yingxi Mo, K. Takeuchi, 2017, BMC Cancer.

Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection.

T. Boonmars, C. Wongkham, Y. Hiraku, 2009, Acta tropica.

Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro

Zhe Zhang, K. Takeuchi, S. Oikawa, 2018, Amino Acids.

Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds: comparison with singlet oxygen-induced DNA damage.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2002, Chemical research in toxicology.

Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection.

R. Semba, Y. Hiraku, N. Ma, 2004, Biochemical and biophysical research communications.

α-Tocopherol and lipid profiles in plasma and the expression of α-tocopherol-related molecules in the liver of Opisthorchis viverrini-infected hamsters.

Y. Hiraku, S. Pinlaor, P. Pinlaor, 2013, Parasitology international.

Protective effect of melatonin against Opisthorchis viverrini‐induced oxidative and nitrosative DNA damage and liver injury in hamsters

Patcharee Boonsiri, Y. Hiraku, S. Pinlaor, 2010, Journal of pineal research.

Plasma hydroxyproline, MMP‐7 and collagen I as novel predictive risk markers of hepatobiliary disease‐associated cholangiocarcinoma

C. Pairojkul, N. Khuntikeo, Y. Hiraku, 2012, International journal of cancer.

Quantitation of DNA methylation in Epstein-Barr virus–associated nasopharyngeal carcinoma by bisulfite amplicon sequencing

Zhe Zhang, Yingxi Mo, K. Takeuchi, 2017, BMC Cancer.

(-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA.

A. Furukawa, S. Oikawa, Y. Hiraku, 2003, Biochemical pharmacology.

Role of Chronic Inflammation and Resulting DNA Damage in Cervical Carcinogenesis Induced by Human Papillomavirus

Y. Hiraku, 2012 .

Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance

Y. Hiraku, Yusuke Hiraku, 2010, Environmental health and preventive medicine.

Prognostic Significance of Nitrative DNA Damage in Infection- and Inflammation-Related Carcinogenesis

Y. Hiraku, S. Kawanishi, 2010 .

Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection

Y. Hiraku, N. Ma, S. Kawanishi, 2007, Cancer science.

Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease

Y. Kitamura, S. Oikawa, Y. Hiraku, 2018, Neuroscience.

Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion.

T. Yamashima, A. Furukawa, S. Oikawa, 2009, Free radical biology & medicine.

The role of iNOS‐mediated DNA damage in infection‐ and asbestos‐induced carcinogenesis

Takamichi Ichinose, Y. Hiraku, S. Kawanishi, 2010, Annals of the New York Academy of Sciences.

Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.

Shigenori Tamaki, E. Gabazza, Y. Hiraku, 2003, Journal of biochemistry.

Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis.

Y. Hiraku, S. Kawanishi, Yusuke Hiraku, 2003, Life sciences.

Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells.

Y. Hiraku, N. Ma, S. Kawanishi, 2017, Mutation research.

Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells.

Y. Hiraku, N. Ma, S. Kawanishi, 2012, Toxicology and applied pharmacology.

Oxidative DNA Damage Induced by Pirarubicin, an Anthracycline Anticancer Agent, in the Presence of Copper(II).

Tohru Maeda, Y. Hiraku, S. Kawanishi, 2018, Anticancer research.

Mechanism of metal-mediated DNA damage induced by a metabolite of carcinogenic acetamide.

S. Oikawa, Y. Hiraku, S. Kawanishi, 2004, Chemico-biological interactions.

Pirarubicin, an Anthracycline Anticancer Agent, Induces Apoptosis Through Generation of Hydrogen Peroxide.

Tohru Maeda, Y. Hiraku, S. Kawanishi, 2017, Anticancer research.

Mechanism of Apoptosis Induced by a New Topoisomerase Inhibitor through the Generation of Hydrogen Peroxide*

S. Oikawa, Y. Hiraku, S. Kawanishi, 2002, The Journal of Biological Chemistry.

Role of Nitrative DNA Damage in Inflammation‐Related Carcinogenesis

Y. Hiraku, S. Kawanishi, 2014 .

Social and Family Factors as Determinants of Exercise Habits in Japanese Elementary School Children: The Super Shokuiku School Project

Y. Hiraku, M. Sekine, Y. Fukazawa, 2019 .

Mechanism of Metal-Mediated Oxidative DNA Damage.

Y. Hiraku, S. Kawanishi, 1995 .

9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy.

N. Miyata, S. Oikawa, Y. Hiraku, 2007, Bioorganic & medicinal chemistry.

RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma

Zhe Zhang, Yingxi Mo, K. Takeuchi, 2017, Journal of experimental & clinical cancer research : CR.

Nitrative and oxidative DNA damage caused by K-ras mutation in mice.

Y. Hiraku, S. Ohnishi, N. Ma, 2011, Biochemical and biophysical research communications.

Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis.

Y. Hiraku, S. Kawanishi, 2009, Methods in molecular biology.

Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation

Y. Hiraku, N. Ma, S. Kawanishi, 2015, Particle and Fibre Toxicology.

Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells

S. Oikawa, Y. Hiraku, S. Ohnishi, 2016, Genes and Environment.

Mechanism of Oxidative DNA Damage Induced by δ-Aminolevulinic Acid in the Presence of Copper Ion

Y. Hiraku, S. Kawanishi, Yusuke Hiraku, 1996 .

Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion.

Y. Hiraku, S. Kawanishi, 1996, Cancer Research.

Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters.

Y. Hiraku, S. Pinlaor, P. Yongvanit, 2011, International journal for parasitology.

Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro

Zhe Zhang, K. Takeuchi, S. Oikawa, 2018, Amino Acids.

Involvement of MMP‐9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1‐dependent DNA damage in a hamster model

C. Pairojkul, Y. Hiraku, S. Pinlaor, 2010, International journal of cancer.

Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide

Y. Kagawa, M. Okuda, Y. Hiraku, 2010, Cancer science.

The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L

Zhe Zhang, Yingxi Mo, S. Oikawa, 2015, Oncotarget.

Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2

S. Oikawa, Y. Hiraku, M. Murata, 2024, Scientific reports.