P. Fedak

B. Griffith, R. Gullapalli, R. Pierson, 2007, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Does Ischemic Preconditioning Afford Clinically Relevant Cardioprotection?

S. Verma, R. Weisel, Ren-Ke Li, 2003, American Journal of Cardiovascular Drugs.

Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives

P. Fedak, H. Mewhort, 2015 .

Commentary: Cell therapy for spinal regeneration—implications for recovery after complex aortic surgery

P. Fedak, V. Vasanthan, A. F. Hassanabad, 2021, JTCVS open.

CorMatrix Cor™ PATCH for epicardial infarct repair.

P. Fedak, R. Matheny, V. Vasanthan, 2021, Future cardiology.

Commentary: Transplanting the powerhouse of the cell to enhance cardiopulmonary repair.

P. Fedak, V. Vasanthan, A. F. Hassanabad, 2020, The Journal of thoracic and cardiovascular surgery.

Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism.

B. Strauss, S. Verma, S. Fazel, 2005, The Journal of thoracic and cardiovascular surgery.

Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor.

S. Fazel, R. Weisel, Ren-Ke Li, 2005, The Journal of thoracic and cardiovascular surgery.

Cell Transplantation for Therapeutic Angiogenesis

Ren-Ke Li, Hao Zhang, P. Fedak, 2003 .

Direct Effects of Empagliflozin on Extracellular Matrix Remodelling in Human Cardiac Myofibroblasts: Novel Translational Clues to Explain EMPA-REG OUTCOME Results.

S. Verma, J. Dyck, H. Duff, 2019, The Canadian journal of cardiology.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

M. Hollenberg, K. Mihara, C. Triggle, 2018, Vascular pharmacology.

Human pericardial proteoglycan 4 (lubricin): Implications for postcardiotomy intrathoracic adhesion formation

M. Cowman, T. Schmidt, P. Fedak, 2018, The Journal of thoracic and cardiovascular surgery.

Restoration and regeneration of failing myocardium with cell transplantation and tissue engineering.

S. Verma, R. Weisel, Ren-Ke Li, 2003, Seminars in thoracic and cardiovascular surgery.

Ischemic heart disease: Cellular and molecular immune contributions of the pericardium.

J. Deniset, P. Fedak, A. F. Hassanabad, 2021, The international journal of biochemistry & cell biology.

Glitazones and heart failure: critical appraisal for the clinician.

S. Verma, R. Weisel, Peter P. Liu, 2003, Circulation.

Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?

M. Borger, S. Armstrong, T. David, 2004, The Journal of thoracic and cardiovascular surgery.

SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging.

H. Wulff, Vikrant Singh, A. Braun, 2019, Pharmacological research.

Tissue-Engineered Grafts Matured in the Right Ventricular Outflow Tract

Y. Ikada, R. Weisel, Ren-Ke Li, 2004, Cell transplantation.

Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation.

R. Weisel, Ren-Ke Li, D. Mickle, 2004, American journal of physiology. Heart and circulatory physiology.

Altered Expression of Disintegrin Metalloproteinases and Their Inhibitor in Human Dilated Cardiomyopathy

S. Verma, P. McCarthy, R. Weisel, 2006, Circulation.

An Overview of Human Pericardial Space and Pericardial Fluid.

J. Deniset, P. Fedak, A. Fatehi Hassanabad, 2021, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

malformations: implications for aortic dilatation Vascular matrix remodeling in patients with bicuspid aortic valve

B. Strauss, T. David, R. Weisel, 2013 .

Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation.

B. Strauss, S. Verma, T. David, 2003, The Journal of thoracic and cardiovascular surgery.

Applications of a Specialty Bicuspid Aortic Valve Program: Clinical Continuity and Translational Collaboration

M. Markl, P. McCarthy, J. Kruse, 2019, Journal of clinical medicine.

Is Concomitant Aortopathy Unique With Bicuspid Aortic Valve Stenosis?

A. Barker, P. Fedak, 2016, Journal of the American College of Cardiology.

Statin Use and Aneurysm Risk in Patients With Bicuspid Aortic Valve Disease

R. Bonow, James D. Thomas, P. McCarthy, 2014, Clinical cardiology.

The molecular fingerprint of bicuspid aortopathy.

S. Verma, P. Fedak, 2013, The Journal of thoracic and cardiovascular surgery.

Bicuspid aortic valve syndrome: heterogeneous but predictable?

P. Fedak, 2008, European heart journal.

International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes.

Jeroen J. Bax, J. Bavaria, W. Edwards, 2021, The Annals of thoracic surgery.

Evolving Surgical Approaches to Bicuspid Aortic Valve Associated Aortopathy

S. Verma, C. Feindel, P. Fedak, 2019, Front. Cardiovasc. Med..

Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm

G. Oudit, Z. Kassiri, P. Fedak, 2018, Circulation research.

Caveolin: A key target for modulating nitric oxide availability in health and disease

S. Verma, V. Rao, Shu‐hong Li, 2003, Molecular and Cellular Biochemistry.

Commentary: A picture is worth a thousand words: Improving surgical approaches using advanced multimodal cardiac imaging.

P. Fedak, V. Vasanthan, A. F. Hassanabad, 2021, The Journal of thoracic and cardiovascular surgery.

Angiogenesis: protein, gene, or cell therapy?

R. Weisel, P. Fedak, D. Mickle, 2001, The heart surgery forum.

Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: reversal by means of endothelin antagonism.

S. Verma, V. Rao, A. Maitland, 2002, The Journal of thoracic and cardiovascular surgery.

Resistin Promotes Endothelial Cell Activation: Further Evidence of Adipokine-Endothelial Interaction

S. Verma, Shu‐hong Li, R. Weisel, 2003, Circulation.

Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice.

S. Fazel, R. Weisel, Ren-Ke Li, 2009, The Journal of thoracic and cardiovascular surgery.

Cardiac remodeling and failure From molecules to man (Part II).

S. Verma, R. Weisel, Ren-Ke Li, 2005, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure

S. Verma, J. Dyck, J. Levasseur, 2017, JACC. Basic to translational science.

L-arginine protects human heart cells from low-volume anoxia and reoxygenation.

S. Verma, V. Rao, R. Weisel, 2002, American journal of physiology. Heart and circulatory physiology.

Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells.

S. Verma, V. Rao, Shu‐hong Li, 2004, The Journal of surgical research.

Evaluation of a novel sutureless anastomotic connector: from endothelial function to mid-term clinical and angiographic follow-up.

S. Verma, N. Walton, T. Yau, 2003, The Journal of thoracic and cardiovascular surgery.

Stem Cell Factor Deficiency Is Vasculoprotective: Unraveling a New Therapeutic Potential of Imatinib Mesylate

S. Verma, W. Stanford, S. Fazel, 2006, Circulation research.

Coronary Bypass Surgery for Diabetes and Multivessel Disease: Forget the SYNTAX.

Deepak L. Bhatt, S. Verma, P. Fedak, 2018, Journal of the American College of Cardiology.

Rosiglitazone Facilitates Angiogenic Progenitor Cell Differentiation Toward Endothelial Lineage: A New Paradigm in Glitazone Pleiotropy

M. Al-Omran, S. Verma, W. Stanford, 2004, Circulation.

Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3.

B. Strauss, S. Verma, R. Weisel, 2003, American journal of physiology. Heart and circulatory physiology.

Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis.

P. Kubes, J. O’Shea, Y. Kanno, 2019, Immunity.

DIRECT EFFECTS OF EMPAGLIFLOZIN ON EXTRACELLULAR MATRIX REMODELING IN HUMAN CARDIAC FIBROBLASTS: NOVEL TRANSLATIONAL CLUES TO EMPA-REG OUTCOME

S. Verma, P. Fedak, D. Svystonyuk, 2017 .

Off-Pump Coronary Artery Bypass Surgery Fundamentals for the Clinical Cardiologist

S. Verma, R. Weisel, P. Szmitko, 2004 .

On the 'cusp' of clinical feasibility: aortic wall shear stress derived non-invasively with 4D flow MRI.

M. Markl, A. Barker, E. Bollache, 2019, Journal of thoracic disease.

Post-Operative Adhesions: A Comprehensive Review of Mechanisms

J. Deniset, P. Fedak, A. Fatehi Hassanabad, 2021, Biomedicines.

KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca2+ mobilization.

T. Kieser, H. Wulff, A. Braun, 2020, Metabolism: clinical and experimental.

Commentary: The 4AT score-Reducing confusion about delirium diagnosis after cardiac surgery.

P. Fedak, K. Parhar, 2021, The Journal of thoracic and cardiovascular surgery.

saphenous veins Endothelin blockade potentiates endothelial protective effects of ace inhibitors in

V. Rao, A. Maitland, A. Dumont, 2013 .

Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins.

S. Verma, V. Rao, A. Maitland, 2002, The Annals of thoracic surgery.

Global Aortic Pulse Wave Velocity is Unchanged in Bicuspid Aortopathy With Normal Valve Function but Elevated in Patients With Aortic Valve Stenosis: Insights From a 4D Flow MRI Study of 597 Subjects

Michael B. Scott, M. Markl, A. Barker, 2022, Journal of magnetic resonance imaging : JMRI.

Biomechanics in ascending aortic aneurysms correlate with tissue composition and strength

Elena S. Di Martino, G. Dobson, P. Fedak, 2021, JTCVS open.

The role of the plasma from platelet concentrates in transfusion reactions.

J. Kelton, N. Heddle, P. Fedak, 1994, The New England journal of medicine.

Paracrine effects of cell transplantation: modifying ventricular remodeling in the failing heart.

P. Fedak, 2008, Seminars in thoracic and cardiovascular surgery.

C-Reactive Protein Attenuates Endothelial Progenitor Cell Survival, Differentiation, and Function Further Evidence of a Mechanistic Link Between C-Reactive Protein and Cardiovascular Disease Clinical Investigation and Reports

M. Kutryk, S. Verma, D. Stewart, 2004 .

Commentary: Cell therapy goes subcellular.

P. Fedak, Vaibhav B. Patel, 2021, The Journal of thoracic and cardiovascular surgery.

Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation.

S. Verma, V. Rao, A. Maitland, 2002, The Journal of thoracic and cardiovascular surgery.

Precision and targeted therapy in cardiac surgery.

P. Fedak, A. Fatehi Hassanabad, 2018, Journal of thoracic disease.

Validating innovations to improve recovery after heart surgery.

P. Fedak, A. Fatehi Hassanabad, 2018, Annals of translational medicine.

Elastin integrity in bicuspid valve-associated aortopathy is associated with altered biomechanical properties and influenced by age

Elena S. Di Martino, M. Markl, A. Barker, 2021, Annals of cardiothoracic surgery.

The need for comprehensive multidisciplinary programs, complex interventions, and precision medicine for bicuspid aortic valve disease

M. Markl, R. Bonow, P. McCarthy, 2021, Annals of cardiothoracic surgery.

C-Reactive Protein Alters Antioxidant Defenses and Promotes Apoptosis in Endothelial Progenitor Cells

S. Verma, Shu‐hong Li, P. Szmitko, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Endothelial Progenitor Cells New Hope for a Broken Heart Brief Review: From Bench to Bedside

M. Kutryk, S. Verma, D. Stewart, 2003 .

Role of Mutation and Pharmacologic Block of Human KCNH2 in Vasculogenesis and Fetal Mortality: Partial Rescue by Transforming Growth Factor-&bgr;

J. Cross, H. Duff, J. Lees-Miller, 2015, Circulation. Arrhythmia and electrophysiology.

Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism.

S. Verma, V. Rao, A. Maitland, 2002, The Journal of thoracic and cardiovascular surgery.

Commentary: Using ex vivo modeling to validate technical innovations in cardiac surgery.

P. Fedak, R. McClure, 2019, The Journal of thoracic and cardiovascular surgery.

Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines.

S. Verma, S. Fazel, Shu‐hong Li, 2006, The Journal of clinical investigation.

Cell transplantation in non-ischemic dilated cardiomyopathy. A novel biological approach for ventricular restoration.

M. Komeda, R. Weisel, Ren-Ke Li, 2002, The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi.

Cardiac restoration by cell transplantation.

S. Fazel, R. Weisel, Ren-Ke Li, 2004, International journal of cardiology.

Commentary: Cause or consequence? The influence of mitral regurgitation on post-myocardial infarction structural remodeling is better defined using a new rodent model.

J. Deniset, P. Fedak, 2019, The Journal of thoracic and cardiovascular surgery.

Comprehensive characterization of the postoperative pericardial inflammatory response: Potential implications for clinical outcomes

R. Novick, W. Kidd, T. Kieser, 2022, JTCVS open.

Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation.

S. Verma, V. Rao, R. Weisel, 2005, The Journal of thoracic and cardiovascular surgery.

Aortic Biomechanics and Clinical Applications

Elena S. Di Martino, G. Dobson, P. Fedak, 2022, Anesthesiology.

Commentary: The mutation matters: Improving precision for surgical management of hereditary aortic syndromes.

P. Fedak, Holly N. Smith, 2020, The Journal of thoracic and cardiovascular surgery.

Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional, and research purposes.

Jeroen J. Bax, J. Bavaria, W. Edwards, 2021, The Journal of thoracic and cardiovascular surgery.

Bicuspid aortic valve aortopathy: mechanistic and clinical insights from recent studies

S. Verma, P. Fedak, David G. Guzzardi, 2016, Current opinion in cardiology.

Recovery: A Pilot, Randomized Controlled Trial Adhesive-Enhanced Sternal Closure to Improve Postoperative Functional

T. Kieser, A. Maitland, P. Fedak, 2011 .

Catalyzing capital for Canada's life sciences industry

J. Chakma, P. Fedak, M. Cimini, 2011 .

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

J. Deniset, P. Fedak, A. Fatehi Hassanabad, 2021, Biomolecules.

Open hearts. The origins of direct-vision intracardiac surgery.

P. Fedak, 1998, Texas Heart Institute journal.

Determinants of health-related quality of life in adults with congenital heart disease.

S. Siu, D. Harrison, P. Fedak, 2007, Congenital heart disease.

Kryptonite bone cement prevents pathologic sternal displacement.

Kishan Narine, P. Fedak, K. King, 2010, The Annals of thoracic surgery.

Enhancing Sternal Closure Using Kryptonite Bone Adhesive

P. Fedak, Paul W M Fedak, Aleksey Kasatkin, 2011, Surgical innovation.

International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.

Jeroen J. Bax, J. Bavaria, W. Edwards, 2021, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Adhesive-Enhanced Sternal Closure: Feasibility and Safety of Late Sternal Reentry

L. Difrancesco, P. Fedak, H. Mewhort, 2017, Case Reports in Surgery.

Adhesive-enhanced sternal closure to improve postoperative functional recovery: a pilot, randomized controlled trial.

T. Kieser, A. Maitland, P. Fedak, 2011, The Annals of thoracic surgery.

Fundamentals of reperfusion injury for the clinical cardiologist.

S. Verma, V. Rao, A. Maitland, 2002, Circulation.

Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis.

H. Duff, P. Fedak, H. Mewhort, 2015, American journal of physiology. Heart and circulatory physiology.

Using Acellular Bioactive Extracellular Matrix Scaffolds to Enhance Endogenous Cardiac Repair

P. Fedak, H. Mewhort, Daniyil A. Svystonyuk, 2018, Front. Cardiovasc. Med..

Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1.

V. Yong, P. Fedak, H. Mewhort, 2016, American journal of physiology. Heart and circulatory physiology.

Mind the Gap: Current Challenges and Future State of Heart Failure Care.

E. Ashley, J. McMurray, N. Hawkins, 2017, The Canadian journal of cardiology.

Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome*

H. Duff, P. Fedak, J. Chun, 2014, The Journal of Biological Chemistry.

Acellular bioscaffolds redirect cardiac fibroblasts and promote functional tissue repair in rodents and humans with myocardial injury

James A. White, J. White, Y. Mikami, 2020, Scientific Reports.

Promoting Cardiac Regeneration and Repair Using Acellular Biomaterials

P. Fedak, A. Fatehi Hassanabad, P. Niklewski, 2020, Frontiers in Bioengineering and Biotechnology.

Improved Left Ventricular Aneurysm Repair With Bioengineered Vascular Smooth Muscle Grafts

Ren-Ke Li, R. Weisel, Ren-Ke Li, 2003, Circulation.

Predictors of operative risk for coronary bypass operations in patients with left ventricular dysfunction.

R. Weisel, T. Yau, J. Ivanov, 1999, The Journal of thoracic and cardiovascular surgery.

Autoimmune diseases and HIV infection A cross-sectional study

James A. White, J. White, C. Lydell, 2018 .

Endothelial progenitor cells: new hope for a broken heart.

M. Kutryk, S. Verma, D. Stewart, 2003, Circulation.

Research Training in Residency: Making the Most of It

P. Fedak, W. Kent, Jacinthe Leclerc, 2020 .

A Self-Fulfilling Prophecy: C-Reactive Protein Attenuates Nitric Oxide Production and Inhibits Angiogenesis

Ren-Ke Li, S. Verma, D. Stewart, 2002, Circulation.

Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effects of C-Reactive Protein

S. Verma, Shu‐hong Li, R. Weisel, 2002, Circulation.

C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis.

S. Verma, Shu‐hong Li, R. Weisel, 2003, The Journal of thoracic and cardiovascular surgery.

Potential role of epicardial adipose tissue in coronary artery endothelial cell dysfunction in type 2 diabetes

A. Jadli, P. Fedak, Vaibhav B. Patel, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Aorta-specific DNA methylation patterns in cell-free DNA from patients with bicuspid aortic valve-associated aortopathy

A. Barker, P. McCarthy, S. Greenway, 2021, Clinical Epigenetics.

Identification of Aorta-Specific DNA Methylation Patterns in Cell-Free DNA from Patients with Bicuspid Aortic Valve-Associated Aortopathy and Correlation with Aortic Wall Cell Death

A. Barker, P. McCarthy, S. Greenway, 2020, bioRxiv.

Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology/Canadian Society of Cardiac Surgery position statement on revascularization--multivessel coronary artery disease.

G. Dagenais, H. Ly, J. Cox, 2014, The Canadian journal of cardiology.

CCS Guidelines and Position Statements Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology/Canadian Society of Cardiac Surgery Position Statement on RevascularizationdMultivessel Coronary Artery Disease

G. Dagenais, H. Ly, J. Cox, 2014 .

Bicuspid aortic valve disease: recent insights in pathophysiology and treatment

S. Verma, M. Borger, T. David, 2005, Expert review of cardiovascular therapy.

Acellular Extracellular Matrix Bioscaffolds for Cardiac Repair and Regeneration

P. Fedak, A. Fatehi Hassanabad, Simranjit S Pattar, 2019, Front. Cell Dev. Biol..

C-Reactive Protein Attenuates Endothelial Progenitor Cell Survival, Differentiation, and Function: Further Evidence of a Mechanistic Link Between C-Reactive Protein and Cardiovascular Disease

M. Kutryk, S. Verma, D. Stewart, 2004, Circulation.

Integrin-Linked Kinase Expression Is Elevated in Human Cardiac Hypertrophy and Induces Hypertrophy in Transgenic Mice

J. Coles, M. Henkelman, Yu-Qing Zhou, 2006, Circulation.

Transplantation of cryopreserved muscle cells in dilated cardiomyopathy: effects on left ventricular geometry and function.

R. Weisel, Ren-Ke Li, P. Fedak, 2003, The Journal of thoracic and cardiovascular surgery.

Application of Bioengineered Materials in the Surgical Management of Heart Failure

P. Fedak, A. Fatehi Hassanabad, Simranjit S Pattar, 2019, Front. Cardiovasc. Med..

Heparin Augmentation Enhances Bioactive Properties of Acellular Extracellular Matrix Scaffold.

P. Fedak, H. Mewhort, J. Turnbull, 2017, Tissue engineering. Part A.

Cardiac remodeling and failure: from molecules to man (Part III).

S. Verma, R. Weisel, Ren-Ke Li, 2005, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction.

Hai Tian, Ren-Ke Li, S. Fazel, 2007, Journal of molecular and cellular cardiology.

C-Reactive Protein Upregulates Complement-Inhibitory Factors in Endothelial Cells

Richard D. Weisel, Ren-Ke Li, Donald A.G. Mickle, 2004, Circulation.

Cell transplantation to improve ventricular function in the failing heart.

R. Weisel, Ren-Ke Li, T. Yau, 2003, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Mechanical Stretch Regimen Enhances the Formation of Bioengineered Autologous Cardiac Muscle Grafts

Payam Akhyari, Ren-Ke Li, S. Verma, 2002, Circulation.

Surgical management of the aorta in BAV patients.

T. Sundt, H. Schäfers, C. Etz, 2020, Progress in cardiovascular diseases.

Cardiac progenitor cell sheet regenerates myocardium and renews hope for translation.

P. Fedak, 2010, Cardiovascular research.

Effect of aortic aneurysm replacement on outcomes after bicuspid aortic valve surgery: validation of contemporary guidelines.

R. Bonow, P. McCarthy, P. Fedak, 2014, The Journal of thoracic and cardiovascular surgery.

Association of Regional Wall Shear Stress and Progressive Ascending Aorta Dilation in Bicuspid Aortic Valve.

Michael B. Scott, M. Markl, R. Bonow, 2021, JACC. Cardiovascular imaging.

Comparison of coronary artery bypass surgery and percutaneous coronary intervention in patients with diabetes: a meta-analysis of randomised controlled trials.

V. Fuster, Lawrence A Leiter, S. Verma, 2013, The lancet. Diabetes & endocrinology.

Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4‐Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects

M. Markl, R. Bonow, A. Barker, 2017, Journal of the American Heart Association.

Abstract 12518: Bicuspid Aortic Valve Disease Increases Viscous Energy Loss, Circumferential Wall Shear Stress, and Pressure Drop in the Ascending Aorta

J. White, C. Lydell, A. Howarth, 2019 .

Pressure drop mapping using 4D flow MRI in patients with bicuspid aortic valve disease: A novel marker of valvular obstruction.

James A White, Xuexin Gao, Andrew G Howarth, 2019, Magnetic resonance imaging.

The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve–related aortopathy: Full online‐only version

J. Coselli, T. Sundt, M. Markl, 2018, The Journal of thoracic and cardiovascular surgery.

Michael Markl, M. Markl, R. Bonow, 2015, Journal of the American College of Cardiology.

Impact of age, sex, and global function on normal aortic hemodynamics

Michael B. Scott, M. Markl, A. Barker, 2020, Magnetic resonance in medicine.

Bicuspid aortic valve disease is associated with abnormal wall shear stress, viscous energy loss, and pressure drop within the ascending thoracic aorta

James A. White, J. White, C. Lydell, 2021, Medicine.

Evolution of Precision Medicine and Surgical Strategies for Bicuspid Aortic Valve-Associated Aortopathy

M. Markl, A. Barker, P. McCarthy, 2017, Front. Physiol..

C-Reactive Protein Upregulates Angiotensin Type 1 Receptors in Vascular Smooth Muscle

S. Verma, Shu‐hong Li, R. Weisel, 2003, Circulation.

Epicardial infarct repair with basic fibroblast growth factor-enhanced CorMatrix-ECM biomaterial attenuates postischemic cardiac remodeling.

P. Fedak, H. C. Meijndert, J. Ngu, 2014, The Journal of thoracic and cardiovascular surgery.

Year in review: bicuspid aortopathy

A. Barker, S. Verma, P. Fedak, 2016, Current opinion in cardiology.

Epicardial infarct repair with bioinductive extracellular matrix promotes vasculogenesis and myocardial recovery.

James A. White, K. Chow, J. White, 2016, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Reactive Protein Upregulates Angiotensin Type 1 Receptors in Vascular Smooth Muscle

S. Verma, Shu‐hong Li, R. Weisel, 2003 .

The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve–related aortopathy: Executive summary

J. Coselli, T. Sundt, M. Markl, 2018, The Journal of thoracic and cardiovascular surgery.

Perioperative evaluation of regional aortic wall shear stress patterns in patients undergoing aortic valve and/or proximal thoracic aortic replacement

M. Markl, A. Barker, P. McCarthy, 2017, The Journal of thoracic and cardiovascular surgery.

Bicuspid aortic valve-associated aortopathy: update on biomarkers

S. Verma, S. Greenway, P. Fedak, 2017, Current opinion in cardiology.

Human cardiac fibroblast extracellular matrix remodeling: dual effects of tissue inhibitor of metalloproteinase-2.

W. Stetler-Stevenson, P. Fedak, H. C. Meijndert, 2014, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Micronized Acellular Matrix Biomaterial Leverages Eosinophils for Postinfarct Cardiac Repair

J. Deniset, P. Fedak, J. Turnbull, 2023, JACC. Basic to translational science.

Targeting selected extracellular matrix components to attenuate cardiac fibrosis.

P. Fedak, A. Fatehi Hassanabad, Simranjit S Pattar, 2018, Annals of translational medicine.

Hyperglycemia potentiates the proatherogenic effects of C-reactive protein: reversal with rosiglitazone.

S. Verma, Shu‐hong Li, R. Weisel, 2003, Journal of molecular and cellular cardiology.

C-Reactive Protein Upregulates Receptor for Advanced Glycation End Products Expression in Human Endothelial Cells

S. Verma, Shu‐hong Li, Shi-ming Liu, 2006, Hypertension.

Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons.

S. Verma, B. Yanagawa, M. Ruel, 2013, The Journal of thoracic and cardiovascular surgery.

Modify, simplify, apply: Do we need preclinical models for surgical innovation?

P. Fedak, A. F. Hassanabad, 2018, The Journal of thoracic and cardiovascular surgery.

Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling

P. Fedak, J. Ngu, H. Mewhort, 2015, Journal of Translational Medicine.

Acute Ischemia Alters Human Pericardial Fluid Immune Cell Composition

J. Deniset, P. Fedak, A. Fatehi Hassanabad, 2021, JACC. Basic to translational science.

Cell Therapy Limits Myofibroblast Differentiation and Structural Cardiac Remodeling: Basic Fibroblast Growth Factor-Mediated Paracrine Mechanism

H. Duff, P. Fedak, K. Narine, 2012, Circulation. Heart failure.

Cell transplantation, ventricular remodeling, and the extracellular matrix

R. Weisel, Ren-Ke Li, T. Yau, 2002 .

International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.

Jeroen J. Bax, J. Bavaria, W. Edwards, 2021, The Journal of thoracic and cardiovascular surgery.

Hemodynamic Assessment in Bicuspid Aortic Valve Disease and Aortic Dilation: New Insights From Voxel-By-Voxel Analysis of Reverse Flow, Stasis, and Energetics

James A. White, J. White, C. Lydell, 2022, Frontiers in Bioengineering and Biotechnology.

Safety and efficacy of prophylactic negative pressure wound therapy following open saphenous vein harvest in cardiac surgery: a feasibility study.

K. Sikdar, P. Fedak, W. Kent, 2016, Interactive cardiovascular and thoracic surgery.

Summary: international consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.

Jeroen J. Bax, J. Bavaria, W. Edwards, 2021, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Minimally invasive cardiac surgery and the importance of qualitative patient-centered metrics to guide innovations.

P. Fedak, W. Kent, 2019, The Journal of thoracic and cardiovascular surgery.

Induction of human aortic myofibroblast‐mediated extracellular matrix dysregulation: A potential mechanism of fluoroquinolone‐associated aortopathy

P. Fedak, G. Teng, D. Belke, 2019, The Journal of thoracic and cardiovascular surgery.

Commentary: Past is Prologue - Leveraging Big Data to Optimize Future Operative Risk Prediction.

P. Fedak, V. Vasanthan, A. F. Hassanabad, 2021, Seminars in thoracic and cardiovascular surgery.

Mechanical and Structural Remodeling of Cardiac Muscle after Aerobic and Resistance Exercise Training in Rats

W. Herzog, V. Joumaa, P. Fedak, 2020, Medicine and science in sports and exercise.

Aortic valve‐mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve‐associated aortopathy

Elena S. Di Martino, M. Markl, A. Barker, 2018, The Journal of thoracic and cardiovascular surgery.

Clinical guidelines and the evolving approaches to bicuspid aortopathy

A. Barker, S. Verma, P. Fedak, 2016 .

Cardiac remodeling and failure: from molecules to man (Part I).

S. Verma, R. Weisel, Ren-Ke Li, 2005, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Cardiothoracic surgeons in pandemics: Ethical considerations

Douglas D. Wood, R. Whyte, J. Mayer, 2020, The Journal of Thoracic and Cardiovascular Surgery.

Lack of Equity in the Cardiology Physician Workforce: A Narrative Review and Analysis of the Literature

C. Morillo, P. Fedak, M. Slawnych, 2021, CJC Open.

Utilizing wall shear stress as a clinical biomarker for bicuspid valve-associated aortopathy

James A. White, S. Verma, J. White, 2019, Current opinion in cardiology.

Interval changes in aortic peak velocity and wall shear stress in patients with bicuspid aortic valve disease

Michael B. Scott, M. Markl, A. Barker, 2019, The International Journal of Cardiovascular Imaging.

Aortic Valve Replacement in an Era of Rapid Innovation: Better the Devil You Know.

Deepak L. Bhatt, S. Verma, P. Fedak, 2018, Journal of the American College of Cardiology.

Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.

S. Verma, V. Rao, Shu‐hong Li, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Bridging to heart transplant with extracorporeal membrane oxygenation: Good or VAD?

P. Fedak, K. Parhar, 2017, The Journal of thoracic and cardiovascular surgery.

Corticosteroids and cardiopulmonary bypass: Empiricism or science?

P. Fedak, A. F. Hassanabad, 2019, Journal of Thoracic and Cardiovascular Surgery.

Comparison of outcomes and presentation in men-versus-women with bicuspid aortic valves undergoing aortic valve replacement.

R. Bonow, James D. Thomas, P. McCarthy, 2015, The American journal of cardiology.

Na+ current expression in human atrial myofibroblasts: identity and functional roles

Wayne R. Giles, Jussi T. Koivumäki, M. Maleckar, 2014, Front. Physiol..

Dye-Mediated Photo-Oxidation Biomaterial Fixation: Analysis of Bioinductivity and Mechanical Properties of Bovine Pericardium for Use in Cardiac Surgery

P. Fedak, A. Fatehi Hassanabad, G. Teng, 2021, International journal of molecular sciences.

Bicuspid aortopathy and the development of individualized resection strategies.

S. Verma, P. Fedak, 2014, The Journal of thoracic and cardiovascular surgery.

Cardiac Surgery Elicits Pericardial Inflammatory Responses That Are Distinct Compared To Post-Cardiopulmonary Bypass Systemic Inflammation

R. Novick, W. Kidd, T. Kieser, 2023, JTCVS Open.

Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling

P. Fedak, J. Ngu, H. Mewhort, 2015, Journal of Translational Medicine.

Bicuspid aortic valve and the specialty clinic: are your patients at risk?

P. Fedak, 2017, Cardiology in the Young.

FLUOROQUINOLONE INDUCES HUMAN AORTIC FIBROBLAST-MEDIATED EXTRACELLULAR MATRIX DYSREGULATION

P. Fedak, J. Turnbull, G. Teng, 2017 .

Off-pump coronary artery bypass surgery: fundamentals for the clinical cardiologist.

R. Weisel, P. Szmitko, P. Fedak, 2004 .

Off-pump coronary artery bypass surgery: fundamentals for the clinical cardiologist.

R. Weisel, P. Szmitko, P. Fedak, 2004, Circulation.

International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes.

Jeroen J. Bax, J. Bavaria, W. Edwards, 2021, Radiology. Cardiothoracic imaging.

The Role of Plasma from Platelet Concentrates in Transfusion Reactions

J. Kelton, N. Heddle, P. Fedak, 1995 .

Bioactive Extracellular Matrix Scaffold Promotes Adaptive Cardiac Remodeling and Repair

M. Hollenberg, P. Fedak, H. Mewhort, 2017, JACC. Basic to translational science.

Clinician Update Clinical and Pathophysiological Implications of a Bicuspid Aortic Valve What Causes Bicuspid Aortic Valves?

R. Weisel, R. Leask, P. Fedak, 2022 .

Mechanical and Structural Remodeling of Cardiac Muscle after Aerobic and Resistance Exercise Training in Rats

W. Herzog, V. Joumaa, P. Fedak, 2021, Medicine and science in sports and exercise.

Effect of aortic aneurysm replacement on outcomes after bicuspid aortic valve surgery: validation of contemporary guidelines.

R. Bonow, P. McCarthy, P. Fedak, 2014, The Journal of thoracic and cardiovascular surgery.

Role of Mutation and Pharmacologic Block of Human KCNH2 in Vasculogenesis and Fetal Mortality: Partial Rescue by Transforming Growth Factor-&bgr;

J. Cross, H. Duff, J. Lees-Miller, 2015, Circulation. Arrhythmia and electrophysiology.

Human cardiac fibroblast extracellular matrix remodeling: dual effects of tissue inhibitor of metalloproteinase-2.

W. Stetler-Stevenson, P. Fedak, H. C. Meijndert, 2014, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Expression in Human Endothelial Cells C-Reactive Protein Upregulates Receptor for Advanced Glycation End Products

P. Szmitko, P. Fedak, Xiao-qing He, 2006 .

Make sternotomy great again.

P. Fedak, 2018, The Journal of thoracic and cardiovascular surgery.

Interval changes in aortic peak velocity and wall shear stress in patients with bicuspid aortic valve disease

Michael B. Scott, M. Markl, A. Barker, 2019, The International Journal of Cardiovascular Imaging.

Commentary: Use the force: Gaining mechanistic insights on aortic valve calcification using magnetic twisting cytometry.

P. Fedak, Daniyil A. Svystonyuk, 2021, The Journal of thoracic and cardiovascular surgery.

Commentary: Blame the sculptors for the heart of stone-Uncovering cellular mechanisms of aortic valve calcification.

P. Fedak, Daniyil A. Svystonyuk, 2020, The Journal of thoracic and cardiovascular surgery.

Bicuspid aortopathy and the development of individualized resection strategies.

P. Fedak, S. Verma, 2014, The Journal of thoracic and cardiovascular surgery.

Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology/Canadian Society of Cardiac Surgery position statement on revascularization--multivessel coronary artery disease.

G. Dagenais, H. Ly, J. Cox, 2014, The Canadian journal of cardiology.

Tissue-Engineered Grafts Matured in the Right Ventricular Outflow Tract

Y. Ikada, R. Weisel, Ren-Ke Li, 2004, Cell transplantation.

Cellular and Molecular Mechanisms Driving Cardiac Tissue Fibrosis: On the Precipice of Personalized and Precision Medicine.

P. Fedak, A. F. Hassanabad, A. Zarzycki, 2024, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Unveiling the Spectrum of Pericardial Diseases: Insights, Novelties, and Future Directions.

V. Mardigyan, P. Fedak, A. Brucato, 2023, Canadian Journal of Cardiology.

Pericardial Inflammatory Mediators That Can Drive Post-Operative Atrial Fibrillation in Cardiac Surgery Patients.

J. Deniset, P. Fedak, A. Fatehi Hassanabad, 2023, The Canadian journal of cardiology.

Cardiothoracic Surgeons in Pandemics: Ethical Considerations

Douglas D. Wood, R. Whyte, J. Mayer, 2020, The Annals of Thoracic Surgery.