D. Ziegler

发表

Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum.

J. Suh, L. Poulsen, J. Robertus, 1999, Proceedings of the National Academy of Sciences of the United States of America.

FORMATION OF AN INTERMEDIATE N-OXIDE IN THE OXIDATIVE DEMETHYIATION OF N,N-DIMETHYIANILINE CATALYZED BY LIVER MICROSOMES.

F. Pettit, D. Ziegler, 1964, Biochemical and biophysical research communications.

The isolation and properties of a soluble succinic coenzyme Q reductase from reef heart mitochondria

D. Ziegler, K. Doeg, 1959 .

The isolation of a functionally intact succinic dehydrogenase-cytochrome b complex from beef heart mitochondria.

D. Ziegler, K. Doeg, 1959, Archives of biochemistry and biophysics.

Studies on the electron transfer system. XXV. The isolation and properties of a lipoflavoprotein with diaphorase activity from beef heart mitochondria.

D. E. Green, D. Ziegler, K. Doeg, 1959, The Journal of biological chemistry.

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines.

F. Kadlubar, D. Ziegler, K. Morton, 1973, Biochemical and biophysical research communications.

Reduced pyridine nucleotide-dependent N-hydroxy amine oxidase and reductase activities of hepatic microsomes.

F. Kadlubar, D. Ziegler, E. M. McKee, 1973, Archives of biochemistry and biophysics.

Properties of a NADH-dependent N-hydroxy amine reductase isolated from pig liver microsomes.

F. Kadlubar, D. Ziegler, 1974, Archives of biochemistry and biophysics.

Simplified methods for the estimation of iron in mitochondria and submitochondrial fractions.

D. Ziegler, K. Doeg, 1962, Archives of biochemistry and biophysics.

Microsomal flavoprotein-catalyzed N-oxidation of arylamines.

L. Poulsen, D. Ziegler, E. M. McKee, 1973, Drug metabolism and disposition: the biological fate of chemicals.

The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions.

R. Prough, D. Ziegler, 1977, Archives of biochemistry and biophysics.

Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation.

D. Ziegler, 1985, Annual review of biochemistry.

Microsomal oxidase. IV. Properties of a mixed-function amine oxidase isolated from pig liver microsomes.

D. Ziegler, C. Mitchell, 1972, Archives of biochemistry and biophysics.

Microsomal mixed-function oxidase-dependent renaturation of reduced ribonuclease.

L. Poulsen, D. Ziegler, 1977, Archives of biochemistry and biophysics.

N-methylation: potential mechanism for metabolic activation of carcinogenic primary arylamines.

F. Kadlubar, D. Ziegler, W. Jakoby, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Studies on the biliary efflux of GSH from rat liver due to the metabolism of aminopyrine.

D. Ziegler, R. Burk, K. Hill, 1985, Biochemical pharmacology.

THE PROPERTIES OF A PURIFIED HEPATIC MICROSOMAL MIXED FUNCTION AMINE OXIDASE

D. Ziegler, D. Jollow, C. Mitchell, 1969 .

Microsomal oxidases. I. The isolation and dialkylarylamine oxygenase activity of pork liver microsomes.

F. Pettit, D. Ziegler, 1966, Biochemistry.

The requirement for flavin adenine dinucleotide by a liver microsmal oxygenase catalyzing the oxidation of alkylaryl amines.

F. Pettit, W. Orme-Johnson, D. Ziegler, 1964, Biochemical and biophysical research communications.

The catalytic demethylation of N,N-dimethylaniline-N-oxide by liver microsomes☆

F. Pettit, D. Ziegler, 1963 .

Rat liver oxidative N-dealkylase and N-oxidase activities as a function of animal age.

M. L. Das, D. Ziegler, 1970, Archives of biochemistry and biophysics.

Properties and applications of an immobilized mixed-function hepatic drug oxidase.

S. Sofer, L. Poulsen, D. Ziegler, 1976, Methods in enzymology.

Changes in dimethylaniline N-oxidase activity of mouse liver and kidney induced by steroid sex hormones.

J. Graham, M. Duffel, D. Ziegler, 1981, Molecular pharmacology.

Flavin-containing monooxygenases: catalytic mechanism and substrate specificities.

D. Ziegler, Daniel M. Ziegler, 1988, Drug metabolism reviews.

Microsomal mixed-function amine oxidase. Oxidation products of piperazine-substituted phenothiazine drugs.

S. Sofer, D. Ziegler, 1978, Drug metabolism and disposition: the biological fate of chemicals.

[14] Hepatic microsomal mixed-function amine oxidase

L. Poulsen, D. Ziegler, 1978 .

The flavin-containing monooxygenase expressed in pig liver: primary sequence, distribution, and evidence for a single gene.

D. Ziegler, R. Gasser, R. Tynes, 1990, Biochemistry.

Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity.

D. Ziegler, 1990, Trends in pharmacological sciences.

Role of Reversible Oxidation-Reduction of Enzyme Thiols-Dilsulfides in Metabolic Regulation

D. Ziegler, 1985 .

Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).

S. Povey, I. Phillips, D. Ziegler, 1991, The Journal of biological chemistry.

Mechanisms for the generation of oxygen radicals by drugs.

D. Ziegler, 1988, Basic life sciences.

Cytochrome P-450- and Flavin-containing Monooxygenase-catalyzed Formation of the Carcinogen A/-Hydroxy-2-aminofluorene and Its Covalent Binding to Nuclear DMA1

F. Guengerich, F. Kadlubar, D. Ziegler, 2006 .

Cytochrome P-450-and Flavin-containing Monooxygenase-catalyzed Formation of the Carcinogen A /-Hydroxy-2-aminofluorene and Its Covalent Binding to Nuclear DMA 1

F. Guengerich, F. Kadlubar, D. Ziegler, 2006 .

Use of thiocarbamides as selective substrate probes for isoforms of flavin-containing monooxygenases.

L. Poulsen, D. Ziegler, W. Guo, 1992, Biochemical pharmacology.

Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNA.

F. Guengerich, F. Kadlubar, D. Ziegler, 1982, Cancer research.

19 – A BIOCHEMICAL MECHANISM FOR THE OXIDATION OF GLUTATHIONE BY XENOBIOTIC THIOLS

D. Ziegler, 1989 .

Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations.

J. Cashman, D. Ziegler, 1986, Molecular pharmacology.

Properties of an N,N-dimethyl-p-aminoazobenzene oxide reductase purified from rat liver cytosol.

D. Ziegler, P. R. Lashmet Johnson, 1986, Journal of biochemical toxicology.

Chapter 9 – Functional Groups Bearing Sulfur

D. Ziegler, 1982 .

The oxidation of ebselen metabolites to thiol oxidants catalyzed by liver microsomes and perfused rat liver.

H. Sies, D. Ziegler, T. Akerboom, 1995, Archives of Biochemistry and Biophysics.

Interaction of primary amines with a mixed-function amine oxidase isolated from pig liver microsomes.

L. Poulsen, D. Ziegler, E. M. McKee, 1971, Xenobiotica; the fate of foreign compounds in biological systems.

A quantitative micro method for the estimation of amine oxides.

D. Ziegler, C. Mitchell, 1969, Analytical biochemistry.

Studies on the electron transport system. XLIII. The isolation of a succinic-coenzyme Q reductase from beef heart mitochondria

D. Ziegler, K. Doeg, 1962 .

Chapter 9 – Microsomal Flavin-Containing Monooxygenase: Oxygenation of Nucleophilic Nitrogen and Sulfur Compounds

D. Ziegler, 1980 .

[42] Preparation and properties of succinate dehydrogenase-coenzyme Q reductase (complex II)

D. Ziegler, J. S. Rieske, 1967 .

Studies on the electron transfer system. 29. The isolation and properties of a succinic dehydrogenase-cytochrome b complex from beef-heart mitochondria.

D. Ziegler, K. Doeg, S. Krueger, 1960, Biochimica et biophysica acta.

Sequence of components in the succinic chain of the mitochondrial electron transport system.

D. E. Green, D. Ziegler, K. Doeg, 1959, Archives of biochemistry and biophysics.

Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases.

D. Ziegler, 1993, Annual review of pharmacology and toxicology.

The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine.

B Kedzierski, D. Williams, D. Buhler, 1989, Drug metabolism and disposition: the biological fate of chemicals.

S-Oxygenation of N-substituted thioureas catalyzed by the pig liver microsomal FAD-containing monooxygenase.

L. Poulsen, R. Hyslop, D. Ziegler, 1979, Archives of biochemistry and biophysics.

Mechanism, multiple forms and substrate specificities of flavin-containing mono-oxygenases

D. Ziegler, 1991 .

The liver microsomal FAD-containing monooxygenase. Spectral characterization and kinetic studies.

L. Poulsen, D. Ziegler, 1979, The Journal of biological chemistry.

Protein disulfide bond synthesis: a possible intracellular mechanism

L. Poulsen, D. Ziegler, 1977 .

Mechanism of 2-naphthylamine oxidation catalysed by pig liver microsomes.

B. Masters, L. Poulsen, D. Ziegler, 1976, Xenobiotica; the fate of foreign compounds in biological systems.

S-oxidation of thioureylenes catalyzed by a microsomal flavoprotein mixed-function oxidase.

L. Poulsen, R. Hyslop, D. Ziegler, 1974, Biochemical pharmacology.

Role of the microsomal mixed-function amine oxidase in the oxidation of N,N-disubstituted hydroxylamines.

L. Poulsen, F. Kadlubar, D. Ziegler, 1974, Archives of biochemistry and biophysics.

Dimethylaniline N-oxidase and aminopyrine N-demethylase activities of human liver tissue.

D. Ziegler, M. Gold, 1973, Xenobiotica; the fate of foreign compounds in biological systems.

[58] Electron transport particles

D. E. Green, D. Ziegler, 1963 .

Synthesis of N-oxides with a hepatic microsomal drug oxidase insolubilized on artificial matrices.

S. Sofer, D. Ziegler, R. Popovich, 1974, Biochemical and biophysical research communications.

On the reduction of externally added DPN by succinate in submitochondrial particles.

D. Ziegler, H. Low, H. Krueger, 1961, Biochemical and biophysical research communications.

Increased biliary GSSG efflux from rat livers perfused with thiocarbamide substrates for the flavin-containing monooxygenase.

D. Ziegler, R. Burk, K. Hill, 1984, Molecular pharmacology.

Studies on the mechanism of oxidative phosphorylation. I. Preparation and properties of a phosphorylating electron transfer particle from beef heart mitochondria.

D. E. Green, D. Ziegler, R. Lester, 1957, Biochimica et biophysica acta.

Alcohol mixed function. Oxidase activity of mammalian liver microsomes.

W. Orme-Johnson, D. Ziegler, Daniel M. Ziegler, 1965, Biochemical and biophysical research communications.

Microsomal oxidases. II. Properties of a pork liver microsomal N-oxide dealkylase.

W. Orme-Johnson, D. Ziegler, J. Machinist, 1966, Biochemistry.

Studies on substrate specificity of the hog liver flavin-containing monooxygenase. Anionic organic sulfur compounds.

K. L. Taylor, D. Ziegler, 1987, Biochemical pharmacology.

The enzymes of detoxication.

D. Ziegler, W. Jakoby, 1983, The Journal of biological chemistry.

Studies on the electron transport system. XI. Correlation of the morphology and enzymic properties of mitochondrial and sub-mitochondrial particles.

H. Ris, D. E. Green, D. Ziegler, 1958, Biochimica et biophysica acta.

Estimation of lipid concentrations on thin-layer plates by densitometry of transparent copies.

L. Poulsen, D. Ziegler, T. Nagata, 1988, Analytical biochemistry.

Studies on the nature and regulation of the cellular thio:disulphide potential.

M. Duffel, L. Poulsen, D. Ziegler, 1979, Ciba Foundation symposium.

FLAVOENZYMES INHIBITED BY INDOMETHACIN

G. Chen, S. Raybuck, D. Ziegler, 1994, Drug metabolism and drug interactions.

The 1990 Bernard B. Brodie Award Lecture. Unique properties of the enzymes of detoxication.

D. Ziegler, 1991, Drug metabolism and disposition: the biological fate of chemicals.

NADPH-dependent oxidation of reduced ebselen, 2-selenylbenzanilide, and of 2-(methylseleno)benzanilide catalyzed by pig liver flavin-containing monooxygenase.

W. Stahl, L. Poulsen, H. Sies, 1992, Chemical Research in Toxicology.

Effect of SKF 525-A on the excretion of amine oxides by the rat.

D. Ziegler, J. Machinist, E. Dehner, 1968, Life sciences.

Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificity.

L. Poulsen, D. Ziegler, 1995, Chemico-biological interactions.

The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression.

J R Cashman, D. Williams, J. Cashman, 1994, Toxicology and applied pharmacology.

Stereoselectivity in the N'-oxidation of nicotine isomers by flavin-containing monooxygenase.

P. Crooks, D. Ziegler, W. Pool, 1988, Molecular pharmacology.

Studies on the mechanism of oxidative phosphorylation. II. Role of bound pyridine nucleotide in phosphorylation.

D. E. Green, D. Ziegler, R. Lester, 1957, Biochimica et biophysica acta.

Effect of hypoxic perfusion on hepatic concentration and biliary release of glutathione disulfide.

D. Ziegler, R. Burk, S. Cummings, 1988, Biochemical pharmacology.

Estimation of flavin-containing monooxygenase activities in crude tissue preparations by thiourea-dependent oxidation of thiocholine.

D. Ziegler, W. Guo, 1991, Analytical biochemistry.

The distinct nature and function of NADPH-cytochrome c reductase and the NADPH-dependent mixed-function amine oxidase of porcine liver microsomes.

B. Masters, D. Ziegler, 1971, Archives of biochemistry and biophysics.

Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzyme.

D. Williams, B. Masters, D. Ziegler, 1984, Biochemical and biophysical research communications.

Bioactivation of xenobiotics by flavin-containing monooxygenases.

D. Ziegler, 1991, Advances in experimental medicine and biology.

Substrate specificity of the rabbit lung flavin-containing monooxygenase for amines: oxidation products of primary alkylamines.

D. Williams, B. Masters, L. Poulsen, 1986, Molecular pharmacology.

Redox regulation of yeast flavin-containing monooxygenase.

L. Poulsen, J. Robertus, J. K. Suh, 2000, Archives of biochemistry and biophysics.

Molecular cloning and kinetic characterization of a flavin-containing monooxygenase from Saccharomyces cerevisiae.

L. Poulsen, J. Robertus, J. K. Suh, 1996, Archives of biochemistry and biophysics.

Substrate specificities of rabbit lung and porcine liver flavin-containing monooxygenases: differences due to substrate size.

D. Williams, D. Ziegler, T. Nagata, 1990, Chemical research in toxicology.

Lysine 219 participates in NADPH specificity in a flavin-containing monooxygenase from Saccharomyces cerevisiae.

L. Poulsen, J. Robertus, J. K. Suh, 1999, Archives of biochemistry and biophysics.

AN OVERVIEW OF THE MECHANISM, SUBSTRATE SPECIFICITIES, AND STRUCTURE OF FMOs

D. Ziegler, Daniel M Ziegler, 2002, Drug metabolism reviews.

Cellular protein-mixed disulfides.

L. Poulsen, D. Ziegler, M. Lou, 1987, Methods in enzymology.

Studies on the mechanism of oxidative phosphorylation. V. The phosphorylating properties of the electron transport particle.

D. Ziegler, A. Linnane, 1958, Biochimica et biophysica acta.

Nitroglycerin and isosorbide dinitrate stimulation of glutathione disulfide efflux from perfused rat liver.

M. Haap, D. Ziegler, R. Burk, 1989, Biochemical pharmacology.

Oxidative metabolism of tertiary amine drugs by human liver tissue.

D. Ziegler, M. Gold, 1971, Xenobiotica; the fate of foreign compounds in biological systems.

Fractionation of Pituitary Tissue by Differential Centrifugation

D. Ziegler, 1955 .

Estimation of amine oxides in the presence of hepatic microsomes.

D. Ziegler, A. Fok, 1970, Biochemical and biophysical research communications.

Studies on the electron transport system. XIII. Mitochondrial structure and dehydrogenase activity in isolated mitochondria.

D. Ziegler, A. Linnane, 1958, Biochimica et biophysica acta.

[27] Estimation of tissue cysteamine by quantitative thin-layer chromatography

L. Poulsen, D. Ziegler, 1995 .

Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1.

Y. Kim, D. Ziegler, 2000, Drug Metabolism And Disposition.

Lipid Peroxidation: The Role of Hepatic FAD-Monooxygenase

D. Ziegler, J. George, G. Rosen, 1980 .

Hamster hepatic nuclear mixed-function amine oxidase: location and specific activity.

S. E. Patton, D. Ziegler, D. Graham, 1980, Molecular Pharmacology.

Intermediate metabolites of thiocarbamides, thioureylenes and thioamides: mechanism of formation and reactivity.

D. Ziegler, 1978, Biochemical Society transactions.

Microsomal oxidases. 3. Comparison of species and organ distribution of dialkylarylamine N-oxide dealkylase and dialkylarylamine N-oxidase.

D. Ziegler, J. Machinist, E. Dehner, 1968, Archives of biochemistry and biophysics.

Metabolic oxygenation of organic nitrogen and sulfur compounds

D. Ziegler, 1984 .

Oxidative phosphorylation by an electron transport particle from beef heart.

D. E. Green, D. Ziegler, R. Lester, 1956, Biochimica et biophysica acta.

Cysteamine and cystamine.

M. Duffel, D. Ziegler, D. J. Logan, 1987, Methods in enzymology.

S -Oxygenation in Herbicide Metabolism in Mammals

D. Ziegler, M. J. Crawford, D. Hutson, 1978 .