K. Komiyama

发表

Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.

M. Hayashi, M. Rho, A. Enomoto, 2004, Journal of natural products.

Biochemical characterization of 60S acidic ribosomal P proteins associated with CK-II from bamboo shoots and potent inhibitors of their phosphorylation in vitro.

K. Komiyama, T. Maekawa, S. Kosuge, 1999, Biological & pharmaceutical bulletin.

Sichuan pepper extracts block the PAK1/Cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice

T. Nheu, L. Kluwe, V. Mautner, 2006, Cancer biology & therapy.

Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent

M. Hayashi, K. Ryoyama, K. Komiyama, 2008 .

Structure-biological activities relationships among the leucomycins and their derivatives.

S. Ōmura, K. Komiyama, M. Katagiri, 1968, The Journal of antibiotics.

A randomized clinical study of tea catechin inhalation effects on methicillin-resistant Staphylococcus aureus in disabled elderly patients.

H. Yamada, Takako Shimizu, Hiroshi Watanabe, 2006, Journal of the American Medical Directors Association.

New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.

Y. Uehara, M. Hayashi, M. Ishibashi, 2005, Bioorganic & medicinal chemistry letters.

Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.

Tatsushi Yoshida, T. Sakai, Yasuaki Yamada, 2006, Blood.

Inhibitory effect of a formulated extract from multiple citrus peels on LPS-induced inflammation in RAW 246.7 macrophages

Chi-Tang Ho, M. Hayashi, K. Komiyama, 2013 .

Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities.

S. Ōmura, M. Hayashi, Y. Takahashi, 1996, The Journal of antibiotics.

Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma.

K. Komiyama, K. Ito, O. Takeichi, 2006, International endodontic journal.

Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells.

S. Ōmura, M. Hayashi, M. Rho, 1998, The Journal of antibiotics.

Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20S,21-Epoxy-resibufogenin-3-formate

M. Hayashi, M. Rho, A. Enomoto, 2002, Journal of Pharmacology and Experimental Therapeutics.

A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production.

M. Tomonaga, Yasuaki Yamada, S. Kamihira, 2007, Blood.

Structure of cypemycin, a new peptide antibiotic

S. Ōmura, Ken‐ichiro Yoshida, T. Otani, 1994 .

Agariblazeispirols A and B, an unprecedented skeleton from the cultured mycelia of the fungus, Agaricus blazei

K. Komiyama, T. Yoshikawa, M. Hirotani, 2003 .

Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.

S. Ōmura, Y. Takahashi, M. Ishibashi, 1990, The Journal of antibiotics.

Biosynthesis of furaquinocins A and B

S. Ōmura, M. Ishibashi, K. Komiyama, 1990 .

Structures of novel antibiotics, furaquinocins A and B

S. Ōmura, M. Ishibashi, K. Komiyama, 1989 .

Antitumor activity of a new antitumor antibiotic, stubomycin.

H. Yamamoto, K. Komiyama, I. Umezawa, 1982, The Journal of antibiotics.

A new antitumor antibiotic, stubomycin.

K. Komiyama, H. Takeshima, I. Umezawa, 1981, The Journal of antibiotics.

Cycloanthranilylproline-derived constituents from a myxomycete Fuligo candida.

M. Hayashi, M. Ishibashi, K. Komiyama, 2004, Chemical & pharmaceutical bulletin.

Collagenase inhibitory quinic acid esters from Ipomoea pes-caprae.

M. Hayashi, T. Koyano, M. Ishibashi, 2005, Journal of natural products.

Chemical modification and antitumor activity of herbimycin A. 8,9-Epoxide, 7,9-cyclic carbamate, and 17 or 19-amino derivatives.

S. Ōmura, H. Sano, A. Nakagawa, 1984, The Journal of antibiotics.

A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics.

S. Ōmura, M. Hayashi, Y. Takahashi, 1993, The Journal of antibiotics.

Suppression of cancer cachexia by 20S,21-epoxy-resibufogenin-3-acetate-a novel nonpeptide IL-6 receptor antagonist.

M. Hayashi, M. Rho, A. Enomoto, 2004, Biochemical and biophysical research communications.

Structures of new Erythrinan alkaloids and nitric oxide production inhibitors from Erythrina crista-galli.

M. Hayashi, K. Komiyama, C. Kuroda, 2010, Chemical & pharmaceutical bulletin.

Antitumor activity of a nitrosourea derivative, CNUA, on murine tumors

K. Komiyama, I. Umezawa, K. Edanami, 2004, Cancer Chemotherapy and Pharmacology.

Sesquiterpenoids and plasmin-inhibitory flavonoids from Blumea balsamifera.

M. Hayashi, T. Koyano, M. Ishibashi, 2005, Journal of natural products.

Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physiochemical properties and structural elucidation.

S. Ōmura, M. Hayashi, S. Takamatsu, 1996, The Journal of antibiotics.

Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba.

K. Komiyama, T. Kam, Yun-Yee Low, 2011, Phytochemistry.

Biologically active aspidofractinine, rhazinilam, akuammiline, and vincorine alkaloids from Kopsia.

M. Hayashi, T. Koyano, K. Komiyama, 2007, Journal of natural products.

Structure of phenazinomycin, a novel antitumor antibiotic

S. Ōmura, T. Tokunaga, K. Komiyama, 1989 .

Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis.

M. Hayashi, K. Komiyama, T. Kam, 2009, Journal of natural products.

Efficient chemical conversion of louisianin A to C and D, the inhibitor of angiogenesis.

S. Ōmura, M. Hayashi, S. Takamatsu, 1997, The Journal of antibiotics.

Louisianins A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. II. Physico-chemical properties and structural elucidation.

H. B. Woodruff, S. Ōmura, M. Hayashi, 1995, The Journal of antibiotics.

Parviflorene A, a novel cytotoxic unsymmetrical sesquiterpene–dimer constituent from Curcuma parviflora

M. Hayashi, Masae Takahashi, T. Koyano, 2003 .

Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130

S. Ōmura, M. Hayashi, M. Rho, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Pauciflorines A and B, novel melanin biosynthesis inhibitors from Kopsia

T. Koyano, K. Komiyama, T. Kam, 1996 .

Lundurines A-D, cytotoxic indole alkaloids incorporating a cyclopropyl moiety from Kopsia tenuis and revision of the structures of tenuisines A-C

M. Hayashi, K. Komiyama, K. Lim, 2004 .

Macrodasines A–G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran–tetrahydrofuran and tetrahydrofuran–tetrahydropyran rings

W. Robinson, K. Komiyama, T. Kam, 2011 .

A new antibiotic, 13-hydroxyglucopiericidin A. Isolation, structure elucidation and biological characteristics.

S. Ōmura, K. Komiyama, S. Funayama, 1990, The Journal of antibiotics.

Physiological Effect of Tocotrienol

Akio Kato, A. Kato, K. Komiyama, 1985 .

Convolutamydine A, a novel bioactive hydroxyoxindole alkaloid from marine bryozoan Amathia convoluta

George R. Pettit, K. Komiyama, Yoshiaki Kamano, 1995 .

Unusual spirocyclic macroline alkaloids, nitrogenous derivatives, and a cytotoxic bisindole from Alstonia

K. Komiyama, T. Kam, Y. Choo, 2004 .

Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp.

S. Ōmura, A. Mita, Y. Takahashi, 1989, The Journal of antibiotics.

Structural study of isoflavonoids possessing antioxidant activity isolated from the fermentation broth of Streptomyces sp.

S. Ōmura, A. Mita, K. Komiyama, 1989, The Journal of antibiotics.

Louisianins A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. I. Taxonomy, fermentation, isolation and biological characteristics.

H. B. Woodruff, S. Ōmura, M. Hayashi, 1995, The Journal of antibiotics.

Studies on a novel antitumor antibiotic, phenazinomycin: taxonomy, fermentation, isolation, and physicochemical and biological characteristics.

H. B. Woodruff, S. Ōmura, Y. Takahashi, 1989, The Journal of antibiotics.

A novel antibiotic, sohbumycin. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.

K. Komiyama, S. Funayama, I. Umezawa, 1985, The Journal of antibiotics.

Studies on a novel cytocidal antibiotic, trienomycin A. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.

K. Komiyama, S. Funayama, I. Umezawa, 1985, The Journal of antibiotics.

A new antitumor antibiotic, kazusamycin.

K. Komiyama, I. Umezawa, T. Miyano, 1984, The Journal of antibiotics.

A new antitumor antibiotic, awamycin.

K. Komiyama, I. Umezawa, T. Miyano, 1983, The Journal of antibiotics.

A new antitumor antibiotic, sporamycin.

K. Komiyama, H. Takeshima, I. Umezawa, 1977, The Journal of antibiotics.

Isolation and structure determination of (+)-trienomycin F. an endgame synthetic strategy for the trienomycin family of antitumor antibiotics

S. Ōmura, A. Gould, K. Komiyama, 1991 .

Structural studies on minor components of trienomycin group antibiotics trienomycins D and E.

S. Ōmura, K. Komiyama, K. Takahashi, 1989, The Journal of antibiotics.

Structure-activity relationship of a novel antitumor ansamycin antibiotic trienomycin A and related compounds.

S. Ōmura, A. Mita, K. Komiyama, 1988, The Journal of antibiotics.

Antitumor activity of trienomycin A on murine tumors.

S. Ōmura, K. Komiyama, S. Funayama, 1987, The Journal of antibiotics.

Structures of trienomycins A, B and C, novel cytocidal ansamycin antibiotics.

K. Komiyama, S. Funayama, I. Umezawa, 1985, The Journal of antibiotics.

Structure of trienomycin A, a novel cytocidal ansamycin antibiotic.

K. Komiyama, S. Funayama, I. Umezawa, 1985, The Journal of antibiotics.

Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa.

K. Komiyama, K. Lim, T. Kam, 2008, Journal of natural products.

Three new alkaloids, convolutamines F and G, and convolutamydine E, from the Floridian marine bryozoan Amathia convoluta

M. Hayashi, K. Komiyama, G. Pettit, 1999 .

ISOLATION AND STRUCTURE OF CONVOLUTAMYDINES B D FROM MARINE BRYOZOAN AMATHIA CONVOLUTA

K. Komiyama, H. Itokawa, G. Pettit, 1995 .

Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids.

M. Hayashi, T. Koyano, K. Komiyama, 2004, Bioorganic & medicinal chemistry letters.

Biologically Active Ibogan and Vallesamine Derivatives from Tabernaemontana divaricata

K. Komiyama, T. Kam, Y. Choo, 2004, Chemistry & biodiversity.

Biologically active indole alkaloids from Kopsia arborea.

M. Hayashi, T. Koyano, K. Komiyama, 2007, Journal of natural products.

Carbazole alkaloids from Murraya koenigii.

K. Komiyama, Y. Harigaya, M. Chakrabarty, 1997, Phytochemistry.

Phenopyrrozin, a new radical scavenger produced by Penicillium sp. FO-2047.

M. Hayashi, K. Komiyama, R. Masuma, 1995, The Journal of antibiotics.

Absolute stereochemistries and total synthesis of (+)/(−)-macrosphelides, potent, orally bioavailable inhibitors of cell–cell adhesion

S. Ōmura, M. Hayashi, K. Komiyama, 2005 .

Macrosphelides C and D, novel inhibitors of cell adhesion.

S. Ōmura, M. Hayashi, S. Takamatsu, 1997, The Journal of antibiotics.

Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities.

S. Ōmura, M. Hayashi, S. Takamatsu, 1995, The Journal of antibiotics.

Total Synthesis of (+)-Madindoline A and (-)-Madindoline B, Potent, Selective Inhibitors of Interleukin 6. Determination of the Relative and Absolute Configurations.

S. Ōmura, M. Hayashi, K. Komiyama, 2000 .

Biologically active aspidofractinine alkaloids from Kopsia singapurensis.

M. Hayashi, T. Koyano, K. Komiyama, 2008, Journal of natural products.

Antitumor activity of leptomycin B.

T. Beppu, K. Komiyama, T. Hamamoto, 1985, The Journal of antibiotics.

Leucophyllidine, a cytotoxic bisindole alkaloid constituted from the union of an eburnan and a new vinylquinoline alkaloid.

M. Hayashi, W. Robinson, K. Komiyama, 2009, Organic letters.

Bipleiophylline, an unprecedented cytotoxic bisindole alkaloid constituted from the bridging of two indole moieties by an aromatic spacer unit.

S. Ng,, K. Komiyama, T. Kam, 2008, Organic letters.

Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia.

M. Hayashi, K. Komiyama, T. Kam, 2007, Journal of natural products.

Leishmanicidal alkaloids from Kopsia griffithii

T. Koyano, K. Komiyama, T. Kam, 1999 .

Reversal of multidrug resistance (MDR) by aspidofractinine-type indole alkaloids.

M. Hayashi, M. Rho, T. Koyano, 1998, Bioorganic & medicinal chemistry letters.

Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii.

M. Hayashi, T. Koyano, K. Komiyama, 1998, Journal of natural products.

The mode of action of a new antitumor antibiotic, sporamycin.

K. Komiyama, H. Takeshima, I. Umezawa, 1979, The Journal of antibiotics.

Dendocarbins A--N, new drimane sesquiterpenes from the nudibranch Dendrodoris carbunculosa.

M. Hayashi, M. Ishibashi, K. Komiyama, 2001, Journal of natural products.

Wrightiamines A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica.

M. Hayashi, T. Koyano, M. Ishibashi, 2003, Chemical & pharmaceutical bulletin.

A new antibiotic, okicenone. II. Physico-chemical properties and structure elucidation.

S. Ōmura, M. Ishibashi, K. Komiyama, 1991, The Journal of antibiotics.

New constituents from the leaves of Morinda citrifolia.

M. Hayashi, K. Komiyama, A. Ohsaki, 2007, Chemical & pharmaceutical bulletin.

Structure, biological activity, and a biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana

M. Hayashi, K. Komiyama, K. Lim, 2010 .

Conolutinine, a hexacyclic indole alkaloid with a novel ring system incorporating a diazaspiro center and fused oxadiazepine–tetrahydrofuran rings

M. Hayashi, K. Komiyama, K. Lim, 2009 .

Parviflorenes B–F, novel cytotoxic unsymmetrical sesquiterpene-dimers with three backbone skeletons from Curcuma parviflora

M. Hayashi, Masae Takahashi, T. Koyano, 2004 .

Antitumor activity of a new antitumor antibiotic, sporamycin.

K. Komiyama, H. Takeshima, I. Umezawa, 1977, Gan.

A new antitumor antibiotic, PO-357.

S. Ōmura, K. Komiyama, J. Awaya, 1976, The Journal of antibiotics.

Immunological studies on sporamycin-treated animals.

T. Hata, K. Komiyama, I. Umezawa, 1979, The Journal of antibiotics.

Mechanism of action of acetyl kidamycin. I. Interaction with DNA.

K. Komiyama, H. Takeshima, I. Umezawa, 1976, Biochimica et biophysica acta.

Dihydrolindbladiones, three new naphthoquinone pigments from a myxomycete Lindbladia tubulina.

M. Hayashi, M. Ishibashi, K. Komiyama, 2003, Journal of natural products.

Studies on the biological activity of stubomycin.

H. Yamamoto, K. Komiyama, I. Umezawa, 1983, The Journal of antibiotics.

Pimaricin potentiation of bleomycin activity against murine tumors.

S. Komiyama, M. Kuwano, K. Komiyama, 1983, Gan.

A new anti-influenza virus antibiotic, 10-norparvulenone from Microsphaeropsis sp. FO-5050.

S. Ōmura, M. Hayashi, H. Yamada, 2000, The Journal of antibiotics.

[Fundamental studies on antibacterial activity of clindamycin against Propionibacterium acnes].

K. Komiyama, Y. Komagata, S. Nomura, 1998, The Japanese Journal of Antibiotics.

New members of the macrosphelides from Microsphaeropsis sp. FO-5050 IV.

S. Ōmura, M. Hayashi, M. Rho, 1999, The Journal of antibiotics.

Relative and Absolute Stereochemistries and Total Synthesis of (+)-Macrosphelides A and B, Potent, Orally Bioavailable Inhibitors of Cell—Cell Adhesion.

S. Ōmura, M. Hayashi, S. Takamatsu, 1998 .

New inhibitors of melanogenesis, OH-3984 K1 and K2. I. Taxonomy, fermentation, isolation and biological characteristics.

S. Ōmura, G. Imokawa, M. Hayashi, 1993, The Journal of antibiotics.

Arboricine and arboricinine, unusual tetracyclic indole regioisomers from Kopsia

K. Komiyama, K. Lim, T. Kam, 2007 .

Amphistin, a new melanogenesis inhibitor, produced by an actinomycete.

S. Ōmura, Y. Takahashi, S. Takamatsu, 1997, The Journal of antibiotics.

New inhibitors of melanogenesis, OH-3984 K1 and K2. II. Physico-chemical properties and structural elucidation.

S. Ōmura, G. Imokawa, M. Hayashi, 1993, The Journal of antibiotics.

A new inhibitor of melanogenesis, albocycline K3, produced by Streptomyces sp. OH-3984.

S. Ōmura, G. Imokawa, M. Hayashi, 1996, The Journal of antibiotics.

Isolation and structure of a new polyether antibiotic, octacyclomycin.

S. Ōmura, K. Komiyama, S. Nozoe, 1992, The Journal of antibiotics.

A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics.

S. Ōmura, Y. Takahashi, M. Ishibashi, 1991, The Journal of antibiotics.

Macrosphelide B suppressed metastasis through inhibition of adhesion of sLe(x)/E-selectin molecules.

S. Ōmura, M. Hayashi, K. Komiyama, 2002, Biochemical and biophysical research communications.

A new antimicrobial antibiotic from Actinoplanes capillaceus sp. K95-5561T.

S. Ōmura, M. Hayashi, M. Rho, 2000, The Journal of antibiotics.

Antitumor activity of a novel nucleotide derivative, 5'-(1,2-dipalmitoyl-sn-glycero-3-phospho)-5-fluorouridine (TJ14026) on murine tumors.

M. Hayashi, K. Komiyama, T. Koshio, 1993, Biological & pharmaceutical bulletin.

Antitumor effect of kazusamycin B on experimental tumors.

K. Komiyama, S. Funayama, I. Umezawa, 1987, The Journal of antibiotics.

One step preparation of 6-demethyl-6-formylmitomycin C and cytotoxicity activity of its derivatives.

K. Komiyama, H. Ogura, K. Takeda, 1992, The Journal of antibiotics.

Pyridindolols Kl and K 2 , New Alkaloids from Streptomyces sp . K 93-0711

M. Hayashi, K. Komiyama, Satoshi, 2006 .

Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711.

S. Ōmura, M. Hayashi, S. Takamatsu, 1997, Journal of antibiotics (Tokyo. 1968).

Antitumour antibiotics and microorganisms their producing

K. Komiyama, 1992 .

A study of immunosuppressive effect of antitumor agents.

T. Hata, K. Komiyama, I. Umezawa, 1972, The Kitasato archives of experimental medicine.

Effect of salivary supernatant on the glycolytic activity of the bacteria in salivary sediment.

I. Kleinberg, K. Komiyama, D. Craw, 1973, Archives of oral biology.

Isolation and characterization of a new antitumor antibiotic OS-3256-B from Streptomyces candidus var. azaticus.

S. Ōmura, K. Komiyama, R. Oiwa, 1974, The Journal of antibiotics.

Structural study of a new antitumor antibiotic, kazusamycin.

K. Komiyama, S. Funayama, I. Umezawa, 1985, The Journal of antibiotics.

Antitumor activity of a new antibiotic, kazusamycin.

K. Komiyama, I. Umezawa, Y. Hirokawa, 1985, The Journal of antibiotics.

OM-4842, a new platelet aggregation inhibitor from Streptomyces.

S. Ōmura, Y. Takahashi, A. Nakagawa, 1988, The Journal of antibiotics.

Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. I. Taxonomy, fermentation, isolation and biological activities.

S. Ōmura, M. Hayashi, S. Takamatsu, 1996, The Journal of antibiotics.

Novel antibiotics, furaquinocins C, D, E, F, G and H.

S. Ōmura, M. Ishibashi, K. Komiyama, 1991, The Journal of antibiotics.

Conodiparines A-D, new bisindoles from Tabernaemontana. Reversal of vincristine-resistance with cultured cells.

M. Hayashi, T. Koyano, K. Komiyama, 1998, Bioorganic & medicinal chemistry letters.

Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C-20 configuration of scholaricine.

Zanariah Abdullah, Yeun-Mun Choo, Masahiko Hayashi, 2010, Journal of natural products.

The effect of dietary or intraperitoneally injected seaweed preparations on the growth of sarcoma-180 cells subcutaneously implanted into mice.

K. Komiyama, H. Maruyama, I. Yamamoto, 1986, Cancer letters.

Conodiparines A—D, New Bisindoles from Tabernaemontana. Reversal of Vincristine-Resistance with Cultured Cells.

M. Hayashi, T. Koyano, K. Komiyama, 1998 .

MECHANISM OF ACTION OF ACETYL KIDAMYCIN

K. Komiyama, H. Takeshima, I. Umezawa, 1976 .

Mechanism of action of acetyl kidamycin. II. Inhibition of RNA synthesis in HeLa cells.

K. Komiyama, H. Takeshima, I. Umezawa, 1976, The Journal of antibiotics.

Constituents of Tritonia crocosmaeflora, I. Tricrozarin A, a novel antimicrobial naphthazarin derivative.

K. Komiyama, S. Funayama, I. Umezawa, 1987, Journal of natural products.

Part 74. "Constituents of marine plants". The structure of brominated diterpene from the marine red alga Laurencia obtusa (Hudson) Lamouroux.

I. Tanaka, K. Komiyama, S. Takeda, 1989 .

Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia.

Yeun-Mun Choo, Masahiko Hayashi, M. Hayashi, 2011, Journal of natural products.

Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol.

S. Ōmura, K. Komiyama, H. Tanaka, 1989, The Journal of antibiotics.

New bisindole alkaloids isolated from Myxomycetes Arcyria cinerea and Lycogala epidendrum.

T. Yamori, M. Hayashi, M. Ishibashi, 2005, Chemical & pharmaceutical bulletin.

Tubiferal A, a backbone-rearranged triterpenoid lactone isolated from the myxomycete tubifera dimorphotheca, Possessing reversal of drug resistance activity

H. Onuki, H. Hirota, M. Hayashi, 2004 .

Unusual indole alkaloid-pyrrole, -pyrone, and -carbamic acid adducts from Alstonia angustifolia.

W. Robinson, K. Komiyama, T. Kam, 2010 .

An In Vitro Cytotoxicity Assay Using Rat Hepatocytes and MTT and Coomassie Blue Dye as Indicators

C. Tyson, K. Komiyama, K. Otoguro, 1991 .

Cytocidal and antimicrobial activities of flavonoids

K. Komiyama, S. Nozoe, S. Funayama, 1995 .

Bisindole alkaloids from myxomycetes Arcyria denudata and Arcyria obvelata.

M. Hayashi, M. Ishibashi, K. Komiyama, 2006, Journal of natural products.

Structural Characterization and Antitumor Activity of a Pectic Polysaccharide from the Roots of Angelica acutiloba 1

J. Cyong, H. Kiyohara, H. Yamada, 1990, Planta medica.

Antioxidative activities of α-tocotrienol and its derivative in the oxidation of dilinoleoylphosphatidylcholine liposomes

K. Komiyama, M. Yamaoka, 1989 .

Studies on the biological activity of tocotrienols.

K. Komiyama, M. Yamaoka, I. Umezawa, 1989, Chemical & pharmaceutical bulletin.

Antioxidative activity of tocotrienol in heterogeneous system: indication of restriction within membrane by fluorescence measurement.

K. Komiyama, M. Yamaoka, 1994, Methods in enzymology.

Antioxidative activities of tocotrienols on phospholipid liposomes

T. Nakahara, K. Komiyama, M. Yamaoka, 1991 .

Chemical modification of herbimycin A. Synthesis and in vivo antitumor activities of halogenated and other related derivatives of herbimycin A.

S. Ōmura, H. Sano, A. Nakagawa, 1986, The Journal of antibiotics.

A Novel Testosterone 5α-Reductase Inhibitor, 8', 9'-Dehydroascochlorin Produced by Verticillium sp. FO-2787

S. Ōmura, M. Hayashi, M. Rho, 1994 .

The Cytotoxic Activity of Diterpenoids from Isodon species

K. Komiyama, A. Ohsaki, Akio Kishida, 2012, Natural product communications.

Madindolines, novel inhibitors of IL-6 activity from streptomyces sp. K93-0711. II. Physico-chemical properties and structural elucidation.

S. Ōmura, M. Hayashi, S. Takamatsu, 1997, Journal of antibiotics (Tokyo. 1968).

Madindolines, Novel Inhibitors of IL-6 Activity from Streptomyces sp. K93-0711. Part 2. Physico-Chemical Properties and Structural Elucidation.

S. Ōmura, S. Takamatsu, A. Enomoto, 1998 .

Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. II. Physicochemical properties and structural elucidation.

S. Ōmura, M. Hayashi, S. Takamatsu, 1996, The Journal of antibiotics.

Antitumor acidic polysaccharide NRP-1 isolated from starfish; Asterias amurensis Lütken.

K. Komiyama, S. Funayama, I. Umezawa, 1987, The Kitasato archives of experimental medicine.

TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.

M. Hayashi, K. Komiyama, A. Ohsaki, 2009, Bioorganic & medicinal chemistry letters.

[The suppressive effect of pyrrole-2-carboxylic acid on platelet aggregation].

K. Komiyama, S. Funayama, I. Umezawa, 1986, The Japanese journal of antibiotics.

Structure of awamycin, a novel antitumor ansamycin antibiotic.

K. Komiyama, S. Funayama, I. Umezawa, 1985, The Journal of antibiotics.

New multiflorane-type triterpenoid acids from Sandoricum indicum.

M. Hayashi, T. Koyano, M. Ishibashi, 2001, Journal of natural products.

Novel cytocidal antibiotics, glucopiericidinols A1 and A2. Taxonomy, fermentation, isolation, structure elucidation and biological characteristics.

S. Ōmura, M. Ishibashi, K. Komiyama, 1989, The Journal of antibiotics.

A NEW ANTIBIOTIC, 1 3-HYDROXYGLUCOPIERICIDIN A ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL CHARACTERISTICS

K. Komiyama, Satoshi, Shinji, 2006 .

Alkenylphenol and alkenylsalicylic acid from Mangifera caesia

M. Hayashi, T. Koyano, M. Ishibashi, 2002 .

Casein kinase II inhibitors isolated from two Brazilian plants Hymenaea parvifolia and Wulffia baccata.

M. Ishibashi, E. Okuyama, K. Komiyama, 1999, Bioorganic & medicinal chemistry letters.

Reversal of P-glycoprotein associated multidrug resistance by new isoprenoid derivatives.

M. Kuwano, M. Hayashi, M. Rho, 2001, Anti-cancer drug design.

Four new triterpenoids from Maytenus ilicifolia.

K. Komiyama, S. Ayabe, A. Ohsaki, 2004, Journal of natural products.

Hand Disinfectant Activities of Two Kind of Electrolyzed Acid Aqueous Solutions by Globe Juice Method

J. Cyong, K. Komiyama, K. Otoguro, 1996 .

The effect of adriamycin against a liver metastatic model by encapsulation in liposomes.

H. Kikuchi, N. Suzuki, K. Komiyama, 1996, Biopharmaceutics & drug disposition.

Constituents of Tritonia crocosmaeflora, II. Tricrozarin B, an antitumor naphthazarin derivative.

K. Komiyama, S. Funayama, I. Umezawa, 1987, Journal of natural products.

Effects of Colforsin Daropate Hydrochloride (Adehl® Inj.), Anti-Acute Heart Failure Agent, on Adenylate Cyclase-Related Hormone Actions

S. Hosoda, H. Yamashita, H. Matsuda, 2004 .

Lindbladione and related naphthoquinone pigments from a myxomycete Lindbladia tubulina.

M. Hayashi, M. Ishibashi, K. Komiyama, 2002, Chemical & pharmaceutical bulletin.

Reversal of multidrug resistance by kopsiflorine isolated from Kopsia dasyrachis.

M. Hayashi, M. Rho, T. Koyano, 1999, Planta medica.

Histopathological studies on antitumor effect of sporamycin

Y. Kawakubo, K. Komiyama, I. Umezawa, 1980, Cancer Chemotherapy and Pharmacology.

Tissue pharmacokinetics and inhibition of DNA synthesis in mice treated with sporamycin.

K. Komiyama, I. Umezawa, 1978, The Journal of antibiotics.

Reversal of multidrug resistance by 7-O-benzoylpyripyropene A in multidrug-resistant tumor cells.

S. Ōmura, M. Hayashi, M. Rho, 2000, The Journal of antibiotics.

Chemical modification of hitachimycin. Synthesis, antibacterial, cytocidal and in vivo antitumor activities of hitachimycin derivatives.

S. Ōmura, H. Sano, A. Nakagawa, 1988, The Journal of antibiotics.

Inhibitory effect of erythraline on Toll-like receptor signaling pathway in RAW264.7 cells.

M. Hayashi, K. Komiyama, A. Ohsaki, 2013, Biological & pharmaceutical bulletin.

The alkaloids of the mersinine group: a new subclass of the monoterpenoid indole alkaloids from Kopsia

K. Komiyama, T. Kam, Y. Choo, 2008 .

Synergism between cellular messengers and agonist combinations in pepsinogen secretion.

K. Dickinson, B. Hirschowitz, K. Komiyama, 1987, The American journal of physiology.

Antitumor activity of polysaccharide fractions from the brown seaweed Sargassum kjellmanianum.

K. Komiyama, I. Umezawa, M. Fujihara, 1985, The Kitasato archives of experimental medicine.

Antitumor and Antioxidant Activity of Tocotrienols

K. Komiyama, M. Yamaoka, M. Hayashi, 1992 .

Patents and literature

E. Balazs, R. Wallace, C. Cooney, 1986 .

Mechanism of action of antitumor antibiotic stubomycin.

K. Komiyama, I. Umezawa, H. Yamamoto, 1985, The Journal of antibiotics.