D. Starczynowski

发表

Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations.

W. Lam, M. Marra, M. Hirst, 2009, Blood.

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

N. Salomonis, R. Levine, Yi Zheng, 2018, Cell reports.

High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.

A. Telenius, D. Horsman, W. Lam, 2008, Blood.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Deconstructing innate immune signaling in myelodysplastic syndromes.

D. Starczynowski, Laura Barreyro, M. Varney, 2015, Experimental hematology.

TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease.

Puneet Agarwal, D. Starczynowski, Madeline Niederkorn, 2020, Experimental hematology.

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

K. Pradhan, M. Walter, N. Salomonis, 2019, Nature Cell Biology.

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

K. Komurov, C. Fontanillo, H. Grimes, 2016, Nature Medicine.

Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells

T. Gilmore, D. Starczynowski, J. G. Reynolds, 2003, Oncogene.

TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling

Jianbo He, Puneet Agarwal, D. Starczynowski, 2021, Cell reports.

Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease.

P. Ntziachristos, D. Starczynowski, Radhika Rawat, 2019, Current opinion in cell biology.

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

H. Grimes, Shailaja N Hegde, J. Cancelas, 2021, eLife.

p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.

B. Aronow, A. Durán, J. Moscat, 2014, Cell reports.

Targeting AML-associated FLT3 mutations with a type I kinase inhibitor.

F. Jiang, A. Wang, J. Perentesis, 2020, The Journal of clinical investigation.

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.

M. Weirauch, K. Komurov, J. Maciejewski, 2014, Cell reports.

Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome.

Lesley A. Mathews, M. Ferrer, Noel Southall, 2013, Cancer cell.

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer.

S. Lam, W. Lam, A. Karsan, 2011, The Journal of clinical investigation.

Regulation and Function of TIFAB in Myelodysplastic Syndrome

D. Starczynowski, 2013 .

Implication of microRNAs in the pathogenesis of MDS.

Jing Fang, D. Starczynowski, M. Varney, 2012, Current pharmaceutical design.

Chronic inflammation suppresses del(5q)-like MDS HSCs via p53

D. Starczynowski, T. Muto, Kathleen Hueneman, 2022, bioRxiv.

The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

J. Perentesis, M. Filippi, M. Wunderlich, 2021, Leukemia.

Errant innate immune signaling in del(5q) MDS.

D. Starczynowski, 2014, Blood.

Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer

K. Pradhan, Amit Verma, A. Maitra, 2022, Journal of Hematology & Oncology.

Differential IRAK signaling in hematologic malignancies.

D. Starczynowski, L. Bolanos, G. Rhyasen, 2013, Experimental hematology.

Ubiquitination of the spliceosome auxiliary factor hnRNPA1 by TRAF6 links chronic innate immune signaling with hematopoietic defects and myelodysplasia

M. Weirauch, P. Stoilov, N. Salomonis, 2016, Nature Immunology.

Correction: Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

M. Weirauch, P. Stoilov, N. Salomonis, 2017, Nature Immunology.

Identification of Mir-145 and Mir-146a as Micrornas Involved in the Pathogenesis of 5q- Syndrome

W. Lam, M. Marra, M. Hirst, 2008 .

Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes

Tae Kon Kim, R. Bejar, O. Abdel-Wahab, 2022, Leukemia.

Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes.

W. Lam, A. Brooks-Wilson, A. Karsan, 2009, Leukemia research.

KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice.

K. Do, S. Colla, G. Garcia-Manero, 2018, Blood advances.

Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q

A. Karsan, D. Starczynowski, 2010, Cell cycle.

Momelotinib is a highly potent inhibitor of FLT 3-mutant AML Tracking no : ADV-2021-004611 R 3

Zachary Kincaid, D. Starczynowski, M. Azam, 2021 .

IKAROS and MENIN in synergy in AML

D. Starczynowski, LaQuita M. Jones, 2022, Nature Cancer.

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis

Yi Zheng, J. Cancelas, G. Thomas, 2013, Haematologica.

GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis.

D. Starczynowski, Madeline Niederkorn, 2017, Cell stem cell.

Ubiquitination of the spliceosome auxiliary factor hnRNPA1 by TRAF6 links chronic innate immune signaling with hematopoietic defects and myelodysplasia

M. Weirauch, P. Stoilov, G. Garcia-Manero, 2016, Nature immunology.

T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone

W. Lam, A. Karsan, H. Bruyèrè, 2011, British journal of haematology.

Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia.

T. Haferlach, J. Maciejewski, R. Padgett, 2021, Cell stem cell.

Polymeric FAD used as enzyme-friendly mediator in lactate detection

Mihaela D. Leonida, B. Aurian‐Blajeni, D. Starczynowski, 2003, Analytical and bioanalytical chemistry.

MicroRNA-146a disrupts hematopoietic differentiation and survival.

C. Hansen, A. Karsan, F. Kuchenbauer, 2011, Experimental hematology.

Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells.

Ryan D. Morin, M. Marra, L. Bullinger, 2011, Blood.

TNFAIP3 Plays a Role in Aging of the Hematopoietic System

M. Figueroa, D. Starczynowski, A. Ma, 2020, Frontiers in Immunology.

Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.

A. Iwama, K. Yokote, K. Aoyama, 2016, Leukemia research.

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

Ryan D. Morin, W. Lam, M. Marra, 2010, Nature Medicine.

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

D. Starczynowski, Jennifer J. Trowbridge, 2021, The Journal of experimental medicine.

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.

C. Leslie, L. Zamparo, E. Papapetrou, 2021, Cell stem cell.

FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome

Michael Schieber, D. Starczynowski, L. Bolanos, 2020, Blood Cancer Journal.

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

A. Karsan, J. Maciejewski, J. Gohda, 2015, The Journal of experimental medicine.

EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk

Ian M. Wilson, C. Brown, C. MacAulay, 2013, Oncogene.

Role of microRNA-146a in normal and malignant hematopoietic stem cell function

D. Starczynowski, Jimmy L. Zhao, 2014, Front. Genet..

Toll-like receptor (TLR) signaling regulates myelopoiesis and innate immune responses, but chronic stimulation of TLR can lead to HSPC

M. Weirauch, P. Stoilov, N. Salomonis, 2017 .

Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1.

G. Jansen, Jing Fang, J. Cloos, 2012, Blood.

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis

J. Inoue, D. Starczynowski, Kathleen Hueneman, 2020, Cell reports.

Chronic immune response dysregulation in MDS pathogenesis.

D. Starczynowski, Laura Barreyro, Timothy M. Chlon, 2018, Blood.

Innate immune signaling in the myelodysplastic syndromes.

A. Karsan, D. Starczynowski, 2010, Hematology/oncology clinics of North America.

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

G. Garcia-Manero, Yi Zheng, Y. Zheng, 2020, Nature Immunology.

Overcoming adaptive therapy resistance in AML by targeting immune response pathways

A. Wang, R. Levine, J. Perentesis, 2019, Science Translational Medicine.

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

D. Kalaitzidis, M. Liang, T. Gilmore, 2004, Oncogene.

Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics

H. Grimes, Shailaja N Hegde, J. Cancelas, 2021, bioRxiv.

Rel/NF-κB/IκB signal transduction in the generation and treatment of human cancer

D. Kalaitzidis, T. Gilmore, D. Starczynowski, 2002 .

Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer.

D. Kalaitzidis, T. Gilmore, D. Starczynowski, 2002, Cancer letters.

Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity

R. Siebert, L. Harder, C. Pott, 2007, Oncogene.

Momelotinib is a highly potent inhibitor of FLT3-mutant AML

Zachary Kincaid, M. Wunderlich, D. Starczynowski, 2021, bioRxiv.

Kinase activating mutation in FLT3 is the most frequent genetic lesion associated with poor prognosis in acute myeloid leukemia (AML). Therapeutic response to FLT3 tyrosine kinase

Zachary Kincaid, D. Starczynowski, M. Azam, 2021 .

Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations

T. Bowman, K. Pradhan, Amit Verma, 2022, bioRxiv.

Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia

Francine E. Garrett-Bakelman, M. Weirauch, A. Melnick, 2022, Science Translational Medicine.

IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival

B. Aronow, A. Jegga, K. Komurov, 2015, Oncotarget.

IRAK1: oncotarget in MDS and AML

D. Starczynowski, L. Beverly, 2014, Oncotarget.

Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities.

D. Horsman, W. Lam, A. Karsan, 2010, American journal of clinical pathology.

Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS).

Tae Kon Kim, R. Bejar, O. Abdel-Wahab, 2023, Blood reviews.

The impact of inflammation-induced tumor plasticity during myeloid transformation.

J. Byrd, O. Abdel-Wahab, A. Tsirigos, 2022, Cancer discovery.

Chronic innate immune signaling results in ubiquitination of splicing machinery

D. Starczynowski, Ashley E. Culver-Cochran, 2018, Cell cycle.

Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages

L. Muglia, Zhiwei Liu, Viral G. Jain, 2017, The Journal of Immunology.

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

H. Döhner, C. Buske, F. Camargo, 2015, Experimental hematology.

participant in human DLBCLs with REL gene amplifications.

D. Kalaitzidis, T. Gilmore, D. Starczynowski, 2016 .

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies

D. Starczynowski, J. Bennett, 2021, Current opinion in hematology.

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

G. Garcia-Manero, Yi Zheng, D. Starczynowski, 2020, Nature Immunology.

HHEX expression drives AML development.

D. Starczynowski, 2020, Blood.

Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells

L. Sulak, D. Kalaitzidis, T. Gilmore, 2004, Oncogene.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes

J. Cerhan, G. Abel, H. Deeg, 2019, Leukemia & lymphoma.

RELevant gene amplification in B-cell lymphomas?

D. Kalaitzidis, T. Gilmore, D. Starczynowski, 2004, Blood.

Mutations of tumor necrosis factor α-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability

T. Gilmore, D. Starczynowski, Joseph G. Reynolds, 2005, Oncogene.

An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS

R. Bejar, O. Abdel-Wahab, P. Greenberg, 2022, Blood advances.

Preclinical Activity of the Clinical Stage Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Splicing Mutant Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

A. Verma, P. Scherle, S. Sahu, 2021, Blood.

Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML

Puneet Agarwal, M. Wunderlich, Craig J. Thomas, 2023, Blood.

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

S. Colla, A. Verma, G. Garcia-Manero, 2015, Leukemia.

RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia

B. Ebert, T. Schlaeger, D. E. Bauer, 2023, Leukemia.

Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS).

Tae Kon Kim, R. Bejar, O. Abdel-Wahab, 2023, Blood reviews.

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

T. Bowman, K. Pradhan, A. Verma, 2019, Blood.

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

M. Weirauch, P. Stoilov, G. Garcia-Manero, 2017, Nature Immunology.

Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development

N. Salomonis, M. Wunderlich, D. Starczynowski, 2023, Blood advances.

TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.

E. Nudler, I. Aifantis, Audrey Lasry, 2022, Cell stem cell.

Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q)

Jing Fang, D. Starczynowski, 2015, Molecular & cellular oncology.

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

K. Pradhan, M. Walter, N. Salomonis, 2019, Nature Cell Biology.

Innate immune signaling in the myelodysplastic syndromes.

A. Karsan, D. Starczynowski, 2010, Hematology/oncology clinics of North America.

Deconstructing innate immune signaling in myelodysplastic syndromes.

D. Starczynowski, Laura Barreyro, M. Varney, 2015, Experimental hematology.

Deregulation of microRNAs in myelodysplastic syndrome

D. Starczynowski, G. Rhyasen, D. Starczynowski, 2012, Leukemia.

An MDS xenograft model utilizing a patient-derived cell line

G. Garcia-Manero, M. Wunderlich, J. Mulloy, 2014, Leukemia.

Research and clinical updates on IRAK4 and its roles in inflammation and malignancy: themes and highlights from the 1st symposium on IRAK4 in cancer

K. Lim, D. Starczynowski, Hagop Kantarjian, 2024, Frontiers in Hematology.

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

M. Weirauch, K. Pradhan, N. Salomonis, 2024, bioRxiv.