K. Irie

发表

Photocytotoxicity of water-soluble fullerene derivatives.

H. Ohigashi, E. Nakamura, H. Tokuyama, 1996, Bioscience, biotechnology, and biochemistry.

Stomatal density is controlled by a mesophyll-derived signaling molecule.

T. Kakimoto, Y. Sakagami, K. Irie, 2010, Plant & cell physiology.

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

S. Dan, H. Miyoshi, E. Kodama, 2020, Nature Communications.

Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.

H. Ohigashi, K. Irie, Y. Nakagawa, 2005, Chemical record.

Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry.

H. Ohigashi, K. Irie, M. Shindo, 2003, Bioorganic & medicinal chemistry.

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.

U. Kikkawa, H. Konishi, H. Ohigashi, 2002, Pharmacology & therapeutics.

Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s

H. Ohigashi, A. Masuda, K. Irie, 2002 .

The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.

H. Ohigashi, K. Irie, Y. Nakamura, 2001, Bioorganic & medicinal chemistry letters.

Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding.

U. Kikkawa, H. Konishi, H. Ohigashi, 2001, Bioorganic & medicinal chemistry.

The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.

H. Ohigashi, K. Irie, Y. Nakamura, 2001, Bioorganic & medicinal chemistry letters.

Diacylglycerol Kinase γ Is One of the Specific Receptors of Tumor-Promoting Phorbol Esters

H. Ohigashi, N. Saito, K. Irie, 2001 .

Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.

H. Ohigashi, H. Hayashi, K. Irie, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D.

U. Kikkawa, H. Konishi, H. Ohigashi, 1999, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma.

H. Ohigashi, K. Irie, P. Wender, 1999, Bioorganic & medicinal chemistry.

Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma

H. Ohigashi, K. Irie, P. Wender, 1998 .

Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C

H. Ohigashi, K. Irie, P. Wender, 1997 .

Synthesis and characterization of the second cysteine-rich region of mouse skin PKCGh

H. Ohigashi, B. Miller, K. Irie, 1996 .

Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.

K. Irie, Ryo C. Yanagita, 2014, Chemical record.

Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.

H. Tokuda, K. Suenaga, H. Nagai, 2013, Bioorganic & medicinal chemistry letters.

Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.

A. Murakami, H. Tokuda, H. Nagai, 2010, Bioorganic & medicinal chemistry letters.

Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2005, Journal of the American Chemical Society.

Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice.

A. Murakami, Hirotaka Sekiguchi, K. Irie, 2012, Journal of medicinal food.

Suppression of CD74 Expression and Helicobacter pylori Adhesion by Auraptene Targeting Serum Starvation-Activated ERK1/2 in NCI-N87 Gastric Carcinoma Cells

A. Murakami, Hirotaka Sekiguchi, K. Irie, 2010, Bioscience, biotechnology, and biochemistry.

The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease.

M. Nagao, T. Shirasawa, H. Ohigashi, 2007, Mini reviews in medicinal chemistry.

Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment

N. Colburn, T. Schmid, M. Yasuda, 2010, Molecular carcinogenesis.

Biosynthesis of (−)-indolactam V, the basic ring-structure of tumor promotes teleogidins

S. Kajiyama, H. Hayashi, K. Irie, 1990 .

Isolation and biosynthesis of (−)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins

S. Kajiyama, H. Hayashi, K. Irie, 1990 .

Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase.

D. B. Ball, W. Gerwick, S. Kajiyama, 2010, Journal of natural products.

Identification and Biological Activities of Bryostatins from Japanese Bryozoan

A. Murakami, H. Tokuda, T. Fujiwara, 2012, Bioscience, biotechnology, and biochemistry.

Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid

K. Irie, K. Murakami, Ryotaro Yagita, 2020 .

Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting.

H. Narita, S. Masuda, M. Nagao, 2015, The Biochemical journal.

Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer’s Disease

Takahiko Shimizu, K. Irie, Yayoi Obata, 2020, ACS omega.

New Water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer

K. Irie, T. Ando, S. Nakajima, 1991 .

Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis).

A. Akaike, H. Sugimoto, K. Irie, 2012, Free radical biology & medicine.

Triterpenoids Isolated from Ziziphus jujuba Enhance Glucose Uptake Activity in Skeletal Muscle Cells.

H. Ohigashi, K. Kawabata, Masakazu Takahashi, 2017, Journal of nutritional science and vitaminology.

Potential Role of Vitamin C in the Prevention of Alzheimer’s Disease

Takahiko Shimizu, K. Irie, K. Murakami, 2015 .

Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1.

S. Masuda, M. Nagao, H. Isoda, 2019, Biochemical and biophysical research communications.

Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris

M. Nagao, H. Isoda, M. Neffati, 2021, Chemistry.

Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C.

B. Miller, K. Irie, P. Wender, 1995, Proceedings of the National Academy of Sciences of the United States of America.

A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens

Ryuichi Watanabe, H. Uchida, Toshiyuki Suzuki, 2014, Marine drugs.

Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models.

I. Tooyama, K. Irie, C. Tsukano, 2022, ACS chemical neuroscience.

Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1

A. Murakami, K. Irie, K. Ohnishi, 2016, PloS one.

The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation

H. Akari, K. Irie, Ayaka Washizaki, 2021, Viruses.

Molecular Basis for Protein Kinase C Isozyme-Selective Binding: The Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich Domains of All Protein Kinase C Isozymes

U. Kikkawa, H. Konishi, H. Ohigashi, 1998 .

Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.

A. Akaike, K. Irie, K. Murakami, 2012, ACS chemical neuroscience.

Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases.

H. Isoda, K. Irie, K. Murakami, 2017, Biological & pharmaceutical bulletin.

Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein.

T. Imazawa, T. Doi, K. Irie, 2012, Biochemical and biophysical research communications.

Synthetic and biophysical studies on the toxic conformer in amyloid β with the E22Δ mutation in Alzheimer pathology.

K. Irie, H. Hara, K. Murakami, 2020, ACS chemical neuroscience.

An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease

Takahiko Shimizu, K. Takabe, T. Awano, 2020, The Journal of Biological Chemistry.

Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers.

K. Irie, K. Murakami, K. Hirose, 2018, Chemical communications.

Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals.

T. Shirasawa, Takahiko Shimizu, K. Irie, 2008, Bioorganic & medicinal chemistry letters.

Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38.

I. Tooyama, K. Irie, C. Tsukano, 2022, ACS chemical neuroscience.

Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction.

K. Irie, Koji Itagaki, T. Sugimoto, 2008, Bioorganic & medicinal chemistry.

APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression

D. Uta, K. Irie, Naotaka Izuo, 2022, International journal of molecular sciences.

Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (−)-indolactam-V

H. Ohigashi, K. Irie, Y. Nakagawa, 2004 .

Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine.

K. Irie, K. Murakami, Sumie Katayama, 2018, Bioorganic & medicinal chemistry.

Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/π interaction.

K. Irie, Ryo C. Yanagita, Takumi Kobayashi, 2020, Bioorganic & medicinal chemistry letters.

Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.

M. Imoto, K. Irie, Masayuki Kikumori, 2018, Biochemical and biophysical research communications.

Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens

Ryuichi Watanabe, H. Uchida, Toshiyuki Suzuki, 2014, Marine drugs.

Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP.

M. Imoto, K. Irie, E. Tashiro, 2011, Bioorganic & medicinal chemistry.

Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.

H. Ohigashi, K. Irie, Y. Nakagawa, 2003, Bioorganic & medicinal chemistry letters.

Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum.

H. Ohigashi, H. Hayashi, K. Irie, 1999, Bioscience, biotechnology, and biochemistry.

Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V.

H. Ohigashi, H. Hayashi, K. Irie, 1998, Bioscience, biotechnology, and biochemistry.

Synthesis of 6-substituted indolactams by microbial conversion

H. Ohigashi, H. Nishino, H. Hayashi, 1995 .

Synthesis and biological activities of new conformationally fixed analogues of (−)-indolactam-V, the core structure of tumor-promoting teleocidins

H. Ohigashi, Yoshimasa Nakamura, K. Irie, 1995 .

Photolabile derivatives of indole alkaloid tumor promoter teleocidins: synthesis, biological activities and photoaffinity labeling studies

H. Nishino, K. Irie, K. Koshimįzu, 1993 .

Tumor Promoting Activities of New Synthetic Analogues of Teleocidin

T. Sugimura, K. Shudo, Y. Endo, 1985 .

Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium blastmyceticum

S. Murao, H. Tokuda, H. Hayashi, 1985 .

The epstein-barr virus early antigen inducing indole alkaloids. (-)-Indolactam V and its related compounds, produced by actinomycetes.

S. Murao, H. Tokuda, H. Hayashi, 1984 .

Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist.

S. Masuda, M. Nagao, H. Isoda, 2013, Biochemical and biophysical research communications.

Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 23.

K. Miki, M. Maeda, K. Irie, 2022, Biochemical and biophysical research communications.

Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate

Y. Ikawa, H. Ohigashi, K. Irie, 2000, Bioscience, biotechnology, and biochemistry.

Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin

H. Nishino, H. Tokuda, K. Irie, 1989, International journal of cancer.

Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells.

A. Murakami, K. Irie, K. Ohnishi, 2019, Journal of clinical biochemistry and nutrition.

Modulation of Protein Quality Control Systems as Novel Mechanisms Underlying Functionality of Food Phytochemicals

A. Murakami, K. Irie, K. Ohnishi, 2013 .

Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor

S. Kitamura, Y. Sakagami, K. Irie, 2012, Bioscience, biotechnology, and biochemistry.

Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy.

A. Murakami, K. Irie, K. Ohnishi, 2013, Biochemical and biophysical research communications.

A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities.

K. Irie, Ryo C. Yanagita, Yusuke Hanaki, 2022, Bioorganic & medicinal chemistry.

Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture.

J. Hoseki, Y. Sakai, K. Irie, 2017, Cell structure and function.

Abietane diterpenoids from Salvia officinalis leaves as aryl hydrocarbon receptor ligands

M. Nagao, H. Isoda, R. Ksouri, 2021 .

Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

J. Kira, M. Maeda, K. Irie, 2020, Neurobiology of Disease.

Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region.

K. Irie, K. Murakami, K. Akagi, 2015, Biochemical and biophysical research communications.

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.

H. Isoda, K. Irie, Junkyu Han, 2012, Bioorganic & Medicinal Chemistry.

Synthesis of Stereoisomeric Simplified Analogs of Alotaketals toward the Elucidation of the Structural Requirements of Protein Kinase C Isozyme-Selective Binding.

K. Irie, C. Tsukano, Sogen Okuda, 2023, Organic letters.

Synthesis of Alkyl Bridged‐Tris‐α‐Amino Acids as C 3 ‐Symmetric and Linear Linkers

K. Irie, C. Tsukano, T. Imamoto, 2021, European Journal of Organic Chemistry.

Quantitative structure-activity studies of benzoylphenylurea larvicides: III. Effects of substituents at the benzoyl moiety

T. Fujita, H. Iwamura, Y. Nakagawa, 1987 .

Challenges to the development of bryostatin‐type anticancer drugs based on the activation mechanism of protein kinase Cδ

K. Irie, Y. Nakagawa, Ryo C. Yanagita, 2012, Medicinal research reviews.

Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities.

S. Dan, K. Irie, Ryo C. Yanagita, 2021, Bioscience, biotechnology, and biochemistry.

Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity.

K. Irie, K. Murakami, T. Takai, 2017, ACS chemical neuroscience.

Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator

H. Inoue, T. Kondo, K. Irie, 2020, International journal of molecular sciences.

Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.

H. Ohigashi, K. Irie, P. Wender, 1999, Bioorganic & medicinal chemistry letters.

Structure of β-amyloid fibrils and its relevance to their neurotoxicity: Implications for the pathogenesis of Alzheimer’s disease

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2005 .

Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

H. Isoda, K. Irie, Junkyu Han, 2013, Bioscience, biotechnology, and biochemistry.

Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead

H. Tokuda, K. Suenaga, H. Nagai, 2016, Bioscience, biotechnology, and biochemistry.

Inhibitory Activity of Hispidin Derivatives Isolated from Inonotus obliquus on Amyloid β Aggregation

K. Irie, K. Murakami, H. Shigemori, 2017 .

Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities

S. Dan, N. Saito, H. Tokuda, 2017, Molecules.

Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense

Y. Ikeda, N. Kioka, A. Murakami, 2013, PloS one.

A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.

A. Murakami, N. Saito, H. Nagai, 2009, Journal of the American Chemical Society.

Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type

H. Tokuda, K. Irie, K. Koshimįzu, 2005 .

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.

Katsuhiro Yoshikawa, Takashi Asada, Takashi Aoi, 2013, Cell stem cell.

Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties

K. Irie, K. Murakami, 2019, Molecules.

A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease

M. Maeda, Takahiko Shimizu, K. Yokote, 2017, Scientific Reports.

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques

S. Resnick, Y. An, J. Troncoso, 2018, Scientific Reports.

Indolactam-V Is Involved in the CH/π Interaction with Pro-11 of the PKCδ C1B Domain: Application for the Structural Optimization of the PKCδ Ligand

H. Ohigashi, K. Irie, Y. Nakagawa, 2005 .

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2003, The Journal of biological chemistry.

1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor from Perilla frutescens var. crispa

A. Murakami, H. Ohigashi, K. Kawabata, 2011, Bioscience, biotechnology, and biochemistry.

Identification of Physiological and Toxic Conformations in Aβ42 Aggregates

T. Shirasawa, Takahiko Shimizu, K. Irie, 2009, Chembiochem : a European journal of chemical biology.

Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

T. Shirasawa, Takahiko Shimizu, H. Ohigashi, 2005, Bioorganic & medicinal chemistry.

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

S. Dan, H. Miyoshi, E. Kodama, 2020, Nature Communications.

Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain.

D. Walker, I. Tooyama, H. Sugiyama, 2021, ACS chemical neuroscience.

Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability.

N. Kioka, A. Murakami, K. Irie, 2012, Archives of biochemistry and biophysics.

Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis

S. Masuda, M. Nagao, H. Isoda, 2020, Biochemistry and biophysics reports.

Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.

T. Shirasawa, Takahiko Shimizu, K. Irie, 2011, Biochemical and biophysical research communications.

Searching for Natural Products That Delay Nucleation Phase and Promote Elongation Phase of Amyloid β42 toward Alzheimer's Disease Therapeutics.

K. Irie, K. Murakami, Mizuho Hanaki, 2021, ACS chemical neuroscience.

Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease

Takahiko Shimizu, K. Irie, K. Murakami, 2011, Journal of amino acids.

Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils.

Kazuyuki Takeda, Takayoshi Imazawa, Masashi Fukuchi, 2011, Bioorganic & medicinal chemistry.

New probes for receptor analysis of tumor promoters synthesis of fluorescent derivatives of (-)-indolactam v,the basic ring-structure of teleocidins

K. Irie, K. Koshimįzu, N. Hagiwara, 1987 .

Synthesis and biological activities of fluorine-substituted (−)-indolactam-V, the core structure of tumor promoter teleocidins

H. Nishino, K. Irie, K. Koshimįzu, 1994 .

The Indole Alkaloid Tumor Promoter Teleocidins as Epstein-Barr Virus Inducers: Structure, Biosynthesis and Structure-Activity Relationship

K. Irie, K. Koshimįzu, 1992 .

Biosynthesis of indole alkaloid tumor promoters teleocidins (I) possible biosynthetic pathway of the monoterpenoid moieties of teleocidins

S. Kajiyama, H. Hayashi, K. Irie, 1990 .

Structure of blastmycetin E, a new teleocidin-related compound, from streptoverticillium blastmyceticum

H. Hayashi, K. Irie, K. Koshimįzu, 1989 .

New Probes for Receptor Analysis of Tumor Promoters. Synthesis of Fluorescent Derivatives of (-)-Indolactam V, the Basic Ring-Structure of Teleocidins.

K. Irie, N. Hagiwara, Koichi Koshimizu, 1988 .

Structure-activity studies of the indole alkaloid tumor promoter teleocidins.

H. Tokuda, K. Irie, K. Koshimįzu, 1987, Carcinogenesis.

Synthesis of a biologically active fluorescent indolactam derivative; A method of preparing new probes for receptor analysis of tumor promoters

K. Irie, K. Koshimįzu, N. Hagiwara, 1987 .

Structure‐activity relationship in the induction of Epstein‐Barr virus by teleocidin derivatives

S. Murao, H. Tokuda, H. Hayashi, 1985, International journal of cancer.

Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ

U. Kikkawa, H. Ohigashi, K. Irie, 1997 .

New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β

K. Irie, 2020, Bioscience, biotechnology, and biochemistry.

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

T. Shirasawa, Takahiko Shimizu, K. Irie, 2010, Bioscience, biotechnology, and biochemistry.

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.

T. Shirasawa, Takahiko Shimizu, S. Murayama, 2010, ACS chemical neuroscience.

Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.

T. Tabira, T. Iwaki, J. Kira, 2013, Current Alzheimer research.

An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.

M. Maeda, Takahiko Shimizu, T. Saido, 2019, Biochemical and biophysical research communications.

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis

T. Tokuda, M. Maeda, Takahiko Shimizu, 2016, Scientific Reports.

Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease.

Takahiko Shimizu, A. Akaike, K. Irie, 2013, Biochemical and biophysical research communications.

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues*

K. Irie, Y. Masuda, K. Takegoshi, 2013, Journal of Biological Chemistry.

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

R. Nitsch, T. Welt, L. Kulic, 2012, Translational Psychiatry.

The turn formation at positions 22 and 23 in the 42‐mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimer's disease

T. Shirasawa, Takahiko Shimizu, K. Irie, 2010, Geriatrics & gerontology international.

Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.

H. Ohigashi, K. Irie, Y. Nakagawa, 2004, Current pharmaceutical design.

Synthesis and Phorbol Ester Binding of the Cysteine-rich Domains of Diacylglycerol Kinase (DGK) Isozymes

H. Ohigashi, Y. Shirai, N. Saito, 2003, The Journal of Biological Chemistry.

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2002, Biochemical and biophysical research communications.

Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy.

S. Masuda, M. Nagao, A. Kakizuka, 2015, ACS chemical biology.

Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities

M. Aida, H. Tokuda, K. Irie, 2015, Bioscience, biotechnology, and biochemistry.

Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.

H. Ohigashi, A. Masuda, K. Irie, 2004, Bioorganic & medicinal chemistry.

Structure–activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity

H. Tokuda, K. Irie, N. Suzuki, 2013 .

Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.

A. Murakami, H. Tokuda, K. Irie, 2013, Bioorganic & medicinal chemistry.

Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.

H. Tokuda, K. Suenaga, H. Nagai, 2012, Journal of medicinal chemistry.

Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus

H. Sugano, M. Miyajima, M. Nakajima, 2018, Journal of Alzheimer's disease : JAD.

Toxic Amyloid-β42 Conformer May Accelerate the Onset of Alzheimer's Disease in the Preclinical Stage.

S. Yano, K. Ono, T. Kuroda, 2021, Journal of Alzheimer's disease : JAD.

Title Soybean extracts increase cell surface ZIP 4 abundance and cellular zinc levels : A potential novel strategy to enhance zinc absorption by ZIP 4 targeting

H. Narita, S. Masuda, M. Nagao, 2019 .

Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease.

T. Shirasawa, Takahiko Shimizu, K. Irie, 2011, Journal of Alzheimer's disease : JAD.

Geranyl modification on the tryptophan residue of ComXRO‐E‐2 pheromone by a cell‐free system

S. Kitamura, Y. Sakagami, K. Irie, 2012, FEBS letters.

Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids.

Ken-ichi Akagi, K. Irie, Kazuhiro Irie, 2016, Bioorganic & medicinal chemistry.

Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii.

K. Irie, Kento Tsukada, K. Murakami, 2022, Journal of natural products.

Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation.

K. Irie, Ryo C. Yanagita, Y. Matsushima, 2020, Chemical communications.

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

A. Akaike, T. Nagata, T. Nishizaki, 2010, International journal of Alzheimer's disease.

Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces

H. Ohigashi, K. Irie, Y. Nakagawa, 1998 .

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease*

Takao Kaneko, Shigeo Murayama, Noriaki Kinoshita, 2011, The Journal of Biological Chemistry.

Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation.

K. Irie, Kyohei Ido, K. Murakami, 2016, Journal of natural products.

Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology

K. Irie, K. Murakami, K. Hirose, 2020, RSC advances.

Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model

T. Shirasawa, Takahiko Shimizu, K. Irie, 2012, Bioscience, biotechnology, and biochemistry.

Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro.

T. Shirasawa, Takahiko Shimizu, K. Irie, 2008, Biochemical and biophysical research communications.

Distance Measurement between Tyr10 and Met35 in Amyloid β by Site‐Directed Spin‐Labeling ESR Spectroscopy: Implications for the Stronger Neurotoxicity of Aβ42 than Aβ40

H. Ohigashi, K. Irie, H. Hara, 2007 .

Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation

K. Irie, K. Murakami, Y. Nakagawa, 2013, Bioscience, biotechnology, and biochemistry.

Protein kinase C regulatory domain surrogate peptides : Effects of metal ions on folding, phorbol ester-binding, and selectivity

H. Ohigashi, K. Irie, P. Wender, 1997 .

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.

M. Vendruscolo, H. Hirai, N. Saito, 2015, Human molecular genetics.

Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation.

T. Kawabata, K. Irie, K. Murakami, 2018, Chemical communications.

In Vitro Covalent Binding Proteins of Zerumbone, a Chemopreventive Food Factor

A. Murakami, K. Irie, K. Ohnishi, 2009, Bioscience, biotechnology, and biochemistry.

Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug

K. Irie, Ryo C. Yanagita, Masayuki Kikumori, 2014 .

Neurotoxicity and Physicochemical Properties of Aβ Mutant Peptides from Cerebral Amyloid Angiopathy

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2003, Journal of Biological Chemistry.

Aggregation and neurotoxicity of mutant amyloid β (Aβ) peptides with proline replacement: importance of turn formation at positions 22 and 23

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2002 .

Total Synthesis and Structure Revision of (+)-Lancilactone C.

K. Irie, C. Tsukano, S. Suzuki, 2023, Journal of the American Chemical Society.

Total synthesis and biological evaluation of oscillatoxin D, E, and F.

K. Irie, T. Nishikawa, Atsuo Nakazaki, 2021, Bioscience, biotechnology, and biochemistry.

Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug

K. Irie, Ryo C. Yanagita, Masayuki Kikumori, 2014 .

Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin

A. Murakami, H. Tokuda, H. Nagai, 2011, Bioscience, biotechnology, and biochemistry.

Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2005, Journal of bioscience and bioengineering.

Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain.

K. Irie, Ryo C. Yanagita, Y. Kawanami, 2016, Bioorganic & medicinal chemistry.

Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): The Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers

K. Irie, P. Wender, M. Koehler, 1999 .

Studies Toward the Total Synthesis of Schinortriterpenoids: Diastereoselective Synthesis of the Left‐Hand Fragment

K. Irie, C. Tsukano, Ryotaro Yagita, 2021 .

Analysis of binding mode of vibsanin A with protein kinase C C1 domains: An experimental and molecular dynamics simulation study

K. Irie, Ryo C. Yanagita, S. Miyake, 2022, Journal of Molecular Structure.

[Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].

T. Shirasawa, Takahiko Shimizu, S. Murayama, 2011, Rinsho shinkeigaku = Clinical neurology.

Analysis of the Secondary Structure of β-Amyloid (Aβ42) Fibrils by Systematic Proline Replacement*

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2004, Journal of Biological Chemistry.

Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives

Isao Sakata, Takeshi Takemura, Tomoyuki Ando, 1990 .

Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis.

K. Irie, K. Murakami, H. Gunji, 2022, Bioorganic & medicinal chemistry letters.

aInvivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest.

S. Dan, M. Imoto, K. Irie, 2023, Biochemical and biophysical research communications.

Verification of the Intermolecular Parallel β-Sheet in E22K-Aβ42 Aggregates by Solid-State NMR Using Rotational Resonance: Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42

T. Shirasawa, Takahiko Shimizu, K. Irie, 2008 .

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2004, The Journal of biological chemistry.

The metabolism of indole alkaloid tumor promoter, (-)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes.

H. Tokuda, K. Irie, K. Koshimįzu, 1987, Carcinogenesis.

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques

S. Resnick, Y. An, J. Troncoso, 2018, Scientific Reports.

APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex

Y. An, J. Troncoso, K. Miki, 2021, bioRxiv.

The turn formation at positions 22 and 23 in the 42‐mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimer's disease

T. Shirasawa, Takahiko Shimizu, K. Irie, 2010, Geriatrics & gerontology international.

Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K

M. Nagao, K. Irie, K. Nishino, 2023, Molecules.

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues*

K. Irie, Y. Masuda, K. Takegoshi, 2013, The Journal of Biological Chemistry.

Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers.

K. Irie, K. Murakami, K. Hirose, 2018, Chemical communications.

Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.

H. Tokuda, K. Suenaga, H. Nagai, 2012, Journal of medicinal chemistry.

Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1

A. Murakami, H. Tokuda, K. Suenaga, 2012 .

STRUCTURE-ACTIVITY STUDIES OF INDOLE ALKALOID TUMOR PROMOTERS

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Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy.

A. Murakami, K. Irie, K. Ohnishi, 2013, Biochemical and biophysical research communications.

Epstein-Barr virus early antigen inducing activity of 14-O-derivatives of (−)-indolactam V

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Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist.

S. Masuda, M. Nagao, H. Isoda, 2013, Biochemical and biophysical research communications.

PHOTOCYTOTOXICITY OF WATER‐SOLUBLE METALLOPORPHYRIN DERIVATIVES

H. Nishino, K. Irie, T. Ando, 1993, Photochemistry and photobiology.

Synthesis and Biological Activities of New Conformationally Restricted Analogues of (−)-Indolactam-V: Elucidation of the Biologically Active Conformation of the Tumor-Promoting Teleocidins

H. Ohigashi, Yoshimasa Nakamura, H. Nishino, 1996 .

Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase.

D. B. Ball, W. Gerwick, S. Kajiyama, 2010, Journal of natural products.

Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters.

H. Ohigashi, N. Saito, K. Irie, 2001, Biochemical and biophysical research communications.

Binding Selectivity of Conformationally Restricted Analogues of (−)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes

H. Ohigashi, A. Masuda, K. Irie, 2002, Bioscience, biotechnology, and biochemistry.