P. Wender

发表

Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells.

H. Dai, Nadine Wong Shi Kam, T. C. Jessop, 2004, Journal of the American Chemical Society.

Function oriented synthesis: the design, synthesis, PKC binding and translocation activity of a new bryostatin analog.

T. Meyer, P. Wender, J. Baryza, 2004, Current drug discovery technologies.

RhI-catalyzed C-C bond activation: seven-membered ring synthesis by a [6+1] carbonylative ring-expansion reaction of allenylcyclobutanes.

P. Wender, N. Deschamps, Robert Sun, 2006, Angewandte Chemie.

Towards the Ideal Synthesis

S. Handy, P. Wender, D. Wright, 1998 .

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

C. Contag, S. Thorne, E. Dubikovskaya, 2008, Proceedings of the National Academy of Sciences.

Molecular understanding of cellular uptake by arginine-rich cell penetrating peptides

J. Rothbard, T. C. Jessop, P. Wender, 2006 .

A Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-resistant E. coli and Targets Cell-Wall Synthesis.

L. Cegelski, P. Wender, Alexandra Antonoplis, 2019, ACS chemical biology.

A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.

L. Cegelski, Kelvin K L Chong, P. Wender, 2018, Journal of the American Chemical Society.

Beyond cell penetrating peptides: designed molecular transporters.

Christina B. Cooley, P. Wender, Erika I. Geihe, 2012, Drug discovery today. Technologies.

Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real‐Time Imaging

J. Rothbard, P. Wender, Thomas H. Pillow, 2006, Chembiochem : a European journal of chemical biology.

A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters

B. Parvin, P. Wender, Joel M. Hyman, 2012, Proceedings of the National Academy of Sciences.

Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.

Michael G. Yang, J. Rothbard, P. Wender, 2003, Organic letters.

Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells.

J. Rothbard, T. C. Jessop, P. Wender, 2005, Advanced drug delivery reviews.

Peptide delivery to tissues via reversibly linked protein transduction sequences.

P. Khavari, P. Wender, P. Robbins, 2002, BioTechniques.

REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment

V. Pande, A. Axtman, L. Cegelski, 2018, ACS central science.

Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

Vijay S. Pande, Paul A. Wender, V. Pande, 2017, Nature Communications.

A Gateway Synthesis, PKC Affinities and Cell Growth Activities of Daphnane Congeners

P. Wender, J. Kowalski, L. R. Jones, 2011, Nature chemistry.

Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities.

P. Wender, J. Kowalski, L. R. Jones, 2011, Nature chemistry.

Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding.

U. Kikkawa, H. Konishi, H. Ohigashi, 2001, Bioorganic & medicinal chemistry.

The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.

H. Ohigashi, K. Irie, Y. Nakamura, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.

H. Ohigashi, H. Hayashi, K. Irie, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D.

U. Kikkawa, H. Konishi, H. Ohigashi, 1999, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma.

H. Ohigashi, K. Irie, P. Wender, 1999, Bioorganic & medicinal chemistry.

Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma

H. Ohigashi, K. Irie, P. Wender, 1998 .

Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C

H. Ohigashi, K. Irie, P. Wender, 1997 .

Synthesis and characterization of the second cysteine-rich region of mouse skin PKCGh

H. Ohigashi, B. Miller, K. Irie, 1996 .

Prodrugs of PKC modulators show enhanced HIV latency reversal and an expanded therapeutic window

T. Chun, M. Marsden, J. Zack, 2020, Proceedings of the National Academy of Sciences.

Carbonyl(chloro)bis(triphenylphosphine)rhodium(I)

T. Williams, P. Wender, Xuefeng Jiang, 2001 .

The Synthesis of Seven‐Membered Rings: General Strategies and the Design and Development of a New Class of Cycloaddition Reactions

P. Wender, J. Love, 1999 .

Metal-catalyzed [2+2+1] cycloadditions of 1,3-dienes, allenes, and CO.

P. Wender, N. Deschamps, Mitchell P. Croatt, 2006, Angewandte Chemie.

Propargyltrimethylsilanes as Allene Equivalents in Transition Metal-Catalyzed [5 + 2] Cycloadditions

F. Inagaki, P. Wender, Magnus Pfaffenbach, 2014, Organic letters.

Total synthesis of bryostatin 9.

P. Wender, Adam J. Schrier, 2011, Journal of the American Chemical Society.

Tetrakis(triphenylphosphine)nickel(0)

Thomas E. Smith, P. Wender, 2001 .

Substituent effects, reactant preorganization, and ligand exchange control the reactivity in Rh(I)-catalyzed (5+2) cycloadditions between vinylcyclopropanes and alkynes.

K. Houk, Peng Liu, P. Wender, 2008, Angewandte Chemie.

Sequence Specific DNA Cleavage by Conjugates of Benzotriazoles and Minor Groove Binders

C. C. Poon, P. Wender, Sofia M. Touami, 1997 .

mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice

R. Levy, R. Waymouth, P. Wender, 2018, Proceedings of the National Academy of Sciences.

The synthesis of highly substituted cyclooctatetraene scaffolds by metal-catalyzed [2+2+2+2] cycloadditions: studies on regioselectivity, dynamic properties, and metal chelation.

P. Wender, J. Christy, Adam B. Lesser, 2009, Angewandte Chemie.

METHODOLOGY FOR THE FACILE AND REGIO-CONTROLLED SYNTHESIS OF INDOLES

P. Wender, A. White, 1983 .

Synthesis and biological evaluation of (-)-laulimalide analogues.

Lei Zhang, Paul A Wender, P. Wender, 2003, Organic letters.

Function-oriented synthesis: biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy.

P. Wender, S. Mooberry, E. Clark, 2008, Molecular pharmaceutics.

Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue.

P. Wender, S. Mooberry, Nicolas Soldermann, 2006, Organic letters.

Microtubule-stabilizing agents based on designed laulimalide analogues.

P. Wender, S. Mooberry, Lei Zhang, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a tunable site in bryostatin analogs: C20 Bryologs through late stage diversification.

Paul A Wender, P. Wender, J. Baryza, 2005, Organic letters.

Rethinking the Role of Natural Products: Function‐Oriented Synthesis, Bryostatin, and Bryologs

P. Wender, Alison C. Donnelly, Daryl Staveness, 2014 .

The Preparation of Cyclohept‐4‐Enones by Rhodium‐Catalyzed Intermolecular [5+2] Cycloaddition

P. Wender, Adam B. Lesser, Lauren E. Sirois, 2012 .

Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogues

P. Wender, M. Koehler, P. Harran, 1998 .

Synthetic bryostatin analogues activate the RasGRP1 signaling pathway.

J. Stone, P. Wender, J. Baryza, 2004, Journal of medicinal chemistry.

Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP.

T. Meyer, P. Wender, J. Baryza, 2004, Chemistry & biology.

Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.

Paul A. Wender, P. Wender, Adam J. Schrier, 2008, Journal of the American Chemical Society.

Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

Jana K. Maclaren, Ryan V. Quiroz, P. Wender, 2017, Science.

Beyond Natural Products: Synthetic Analogues of Bryostatin 1

Vishal A. Verma, P. Wender, J. Baryza, 2006 .

The synthesis and chemistry of a simplified, functional analogue of neocarzinostatin chromophore: identification of an intramolecular 1,5-hydrogen atom

P. Wender, M. Tebbe, 1994 .

1,4‐Dibromobutane

Thomas E. Smith, P. Wender, 2001 .

Structural Complexity Through Multicomponent Cycloaddition Cascades Enabled by Dual-Purpose, Reactivity Regenerating

Ryan V. Quiroz, F. Inagaki, P. Wender, 2014 .

Structural Complexity Through Multicomponent Cycloaddition Cascades Enabled by Dual-Purpose, Reactivity Regenerating 1,2,3-Triene Equivalents

Ryan V. Quiroz, F. Inagaki, P. Wender, 2014, Nature chemistry.

An arene-alkene photocycloaddition-radical cyclization cascade: The first syntheses of cis,cis,cis,trans-[5.5.5.5]-fenestranes

T. M. Dore, P. Wender, M. Delong, 1996 .

Studies on tumor promoters. 9. A second-generation synthesis of phorbol

P. Wender, F. McDonald, 1990 .

Ligand effects on rates and regioselectivities of Rh(I)-catalyzed (5 + 2) cycloadditions: a computational study of cyclooctadiene and dinaphthocyclooctatetraene as ligands.

K. Houk, Peng Liu, P. Wender, 2012, Journal of the American Chemical Society.

Asymmetric catalysis of the [5 + 2] cycloaddition reaction of vinylcyclopropanes and pi-systems.

Jaehong Lim, T. Williams, P. Wender, 2006, Journal of the American Chemical Society.

On the mechanism of [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2) reactions between vinylcyclopropanes and alkynes.

K. Houk, P. Wender, Zhi‐Xiang Yu, 2004, Journal of the American Chemical Society.

Electronic and steric control of regioselectivities in Rh(I)-catalyzed (5 + 2) cycloadditions: experiment and theory.

K. Houk, Peng Liu, P. Wender, 2010, Journal of the American Chemical Society.

Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions.

F. Inagaki, C. Ebner, P. Wender, 2017, Organic letters.

Highly efficient, facile, room temperature intermolecular [5 + 2] cycloadditions catalyzed by cationic rhodium(I): one step to cycloheptenes and their libraries.

T. Williams, P. Wender, Lauren E. Sirois, 2010, Organic letters.

Studies on tumor promoters. 11. A new [5+2] cycloaddition method and its application to the synthesis of BC ring precursors of phorboids

P. Wender, J. Mascareñas, 1991 .

Function-oriented synthesis: studies aimed at the synthesis and mode of action of 1alpha-alkyldaphnane analogues.

P. Wender, J. Kowalski, Noel D'angelo, 2007, Organic letters.

Preparation and cycloadditions of a 4-methoxy-3-oxidopyrylium ylid: a reagent for the synthesis of highly substituted seven-membered rings and tetrahydrofurans

P. Wender, J. Mascareñas, 1992 .

Origins of differences in reactivities of alkenes, alkynes, and allenes in [Rh(CO)2Cl]2-catalyzed (5 + 2) cycloaddition reactions with vinylcyclopropanes.

Claude Y. Legault, K. Houk, Peng Liu, 2008, Journal of the American Chemical Society.

Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapy.

T. Chun, C. Hallahan, J. Justement, 2012, The Journal of infectious diseases.

Translating Nature's Library: The Bryostatins and Function-Oriented Synthesis.

P. Wender, Adam J. Schrier, B. Loy, 2011, Israel journal of chemistry.

Guanidinium-rich, glycerol-derived oligocarbonates: a new class of cell-penetrating molecular transporters that complex, deliver, and release siRNA.

J. R. Vargas, P. Wender, Melanie A Huttner, 2015, Molecular pharmaceutics.

Bryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents

D. Alkon, P. Wender, T. Khan, 2018, Journal of cellular physiology.

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts

D. Alkon, Vishal A. Verma, P. Wender, 2009, Neurobiology of Disease.

Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells

J. Hedrick, R. Hickerson, Christina B. Cooley, 2012, Proceedings of the National Academy of Sciences.

A new and practical approach to the synthesis of taxol and taxol analogs: the pinene path.

P. Wender, T. P. Mucciaro, 1992 .

The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor

K. Tomooka, D. B. Rawlins, M. Natchus, 1997 .

The Pinene Path to Taxanes. 4. Approaches to Taxol and Taxol Analogs through Elaboration of Aromatic C-Ring Precursors.

D. B. Rawlins, P. Wender, T. Glass, 1996, The Journal of organic chemistry.

Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery.

B. L. Wylie, J. Rothbard, T. C. Jessop, 2002, Journal of the American Chemical Society.

Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C.

B. Miller, K. Irie, P. Wender, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Fingolimod-Conjugated Charge-Altering Releasable Transporters Efficiently and Specifically Deliver mRNA to Lymphocytes In Vivo and In Vitro.

D. Czerwinski, R. Waymouth, P. Wender, 2022, Biomacromolecules.

Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs).

C. Contag, M. Bachmann, R. Waymouth, 2018, Biomacromolecules.

Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters

R. Waymouth, P. Wender, O. Haabeth, 2018, Proceedings of the National Academy of Sciences.

Introduction: Frontiers in Organic Synthesis.

P. Wender, 1996, Chemical reviews.

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo

J. R. Vargas, G. Gasser, C. Schultz, 2016, Nature Communications.

Molecular Basis for Protein Kinase C Isozyme-Selective Binding: The Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich Domains of All Protein Kinase C Isozymes

U. Kikkawa, H. Konishi, H. Ohigashi, 1998 .

Beyond Cell Penetrating Peptides: Designed Molecular Transporters.

Christina B. Cooley, P. Wender, Erika I. Geihe, 2012, Drug discovery today. Technologies.

Oligocarbonate molecular transporters: oligomerization-based syntheses and cell-penetrating studies.

J. Hedrick, Christina B. Cooley, R. Waymouth, 2009, Journal of the American Chemical Society.

Fifteen years of cell-penetrating, guanidinium-rich molecular transporters: basic science, research tools, and clinical applications.

J. R. Vargas, P. Wender, Brian M. Trantow, 2013, Accounts of chemical research.

Cyclocarboamination of alkynes with aziridines: synthesis of 2,3-dihydropyrroles by a catalyzed formal [3 + 2] cycloaddition.

P. Wender, D. Strand, 2009, Journal of the American Chemical Society.

Synthesis of novel taxol analogs and evaluation of their biological activities

S. Horwitz, P. Wender, Daesung Lee, 1997 .

Effect of Serum and Antioxidants on the Immunogenicity of Protein Kinase C-Activated Chronic Lymphocytic Leukemia Cells

M. Debenedette, D. Cervi, D. Spaner, 2005, Journal of immunotherapy.

Studies on DNA - active agents: The synthesis of the parent carbocyclic subunit of neocarzinostatin chromophore A

P. Wender, C. Mukai, J. Suffert, 1988 .

Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters

J. R. Vargas, R. Waymouth, P. Wender, 2018, ACS central science.

A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.

P. Blumberg, J. Stone, A. Lopez-Campistrous, 2009, Experimental hematology.

The intramolecular addition of silylated alkynes to aldehydes: Methodology for the construction of cyclic enediynes and its application to dynemicin analogs

D. Mohler, P. Wender, S. Beckham, 1995 .

General methodology for the synthesis of neocarzinostatin chromophore analogues : intramolecular chromium-mediated closures for strained-ring synthesis

P. Wender, J. Mckinney, C. Mukai, 1990 .

Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery.

R. Waymouth, P. Wender, C. McKinlay, 2016, Journal of the American Chemical Society.

The practical synthesis of a novel and highly potent analogue of bryostatin.

P. Wender, J. Baryza, S. E. Brenner, 2002, Journal of the American Chemical Society.

Synthesis and biological evaluation of fully synthetic bryostatin analogues

K. Hinkle, P. Wender, P. Harran, 1998 .

Local Delivery of Ox40l, Cd80, and Cd86 mRNA Kindles Global Anticancer Immunity.

R. Waymouth, P. Wender, O. Haabeth, 2019, Cancer research.

Toward the ideal synthesis. New transition metal-catalyzed reactions inspired by novel medicinal leads

F. Gosselin, T. Williams, P. Wender, 2002 .

Synthesis and biological activities of new conformationally fixed analogues of (−)-indolactam-V, the core structure of tumor-promoting teleocidins

H. Ohigashi, Yoshimasa Nakamura, K. Irie, 1995 .

The rational design of potential chemotherapeutic agents: Synthesis of bryostatin analogues

K. Hinkle, P. Wender, M. Koehler, 1999, Medicinal research reviews.

Engineering circular RNA for enhanced protein production

Howard Y. Chang, P. Wender, Chun-Kan Chen, 2022, Nature Biotechnology.

Photocleavage of DNA by 4′-bromoacetophenone analogs

P. Wender, R. Jeon, Raok Jeon, 2001, Archives of pharmacal research.

Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release.

C. Contag, J. Rothbard, P. Wender, 2006, Journal of the American Chemical Society.

Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation.

B. Franc, C. Contag, P. Wender, 2006, Bioconjugate chemistry.

Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate

Y. Ikawa, H. Ohigashi, K. Irie, 2000, Bioscience, biotechnology, and biochemistry.

Indole synthesis based on triazole photochemistry: Total synthesis of7-methoxymitosene☆

C. Cooper, P. Wender, 1987 .

A general method for -hydroisoquinoline synthesis

D. Torney, P. Wender, J. Schaus, 1979 .

Function-Oriented Synthesis: Design, Synthesis, and Evaluation of Highly Simplified Bryostatin Analogues.

P. Wender, Yasuyuki Ogawa, Steven M. Ryckbosch, 2020, The Journal of organic chemistry.

Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV

P. Wender, Jung-Min Kee, Jeffrey M. Warrington, 2008, Science.

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.

K. Pattabiraman, J. Rothbard, D. Mitchell, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Dendrimeric molecular transporters: synthesis and evaluation of tunable polyguanidino dendrimers that facilitate cellular uptake.

J. Rothbard, P. Wender, E. Pelkey, 2005, Organic letters.

Bis‐(1,5‐cyclooctadiene)nickel(0)

Thomas E. Smith, P. Wender, J. Louie, 2006 .

Toward the synthesis of the taxol C,D, ring system: Photolysis of α-methoxy ketones

D. B. Rawlins, P. Wender, David B Rawlins, 1992 .

Nickel-catalyzed intramolecular [4+4] cycloadditions: 2. Allylic stereoinduction and modelling studies in the preparation of bicyclo[6.4.0]dodecadienes

P. Wender, N. Ihle, 1987 .

Nickel-catalyzed intramolecular [4 + 4]-cycloadditions: a new method for the synthesis of polycycles containing eight-membered rings

P. Wender, N. Ihle, 1986 .

In Vivo Targeting of Escherichia coli with Vancomycin-Arginine

Madeline B. Chosy, L. Cegelski, P. Warn, 2021, Antimicrobial Agents and Chemotherapy.

Actin is the primary cellular receptor of bistramide A

Vishal A. Verma, P. Wender, J. Baryza, 2005, Nature chemical biology.

C–C Bond Formation (Part 1) by Addition Reactions: Higher-order Cycloadditions

P. Wender, N. Deschamps, Mitchell P. Croatt, 2007 .

Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs.

P. Wender, J. Reuber, 2011, Tetrahedron.

An approach to the site-selective diversification of apoptolidin A with peptide-based catalysts.

Scott J. Miller, P. Wender, Kate E. Longcore, 2009, Journal of natural products.

MACROEXPANSION METHODOLOGY: AN EFFICIENT EIGHT UNIT RING EXPANSION

S. Sieburth, P. Wender, 1981 .

Macroexpansion methodology : Medium ring synthesis based on an eight unit ring expansion process

S. Sieburth, Sunil Singh, J. Petraitis, 1981 .

Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.

J. Stone, A. Lopez-Campistrous, P. Wender, 2012, Experimental Hematology.

Improved Protein Kinase C Affinity through Final Step Diversification of a Simplified Salicylate-Derived Bryostatin Analog Scaffold

P. Wender, Daryl Staveness, 2014, Organic letters.

Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs

P. Wender, Daryl Staveness, K. Near, 2014, Organic letters.

The Preparation of Cyclohept‐4‐Enones by Rhodium‐Catalyzed Intermolecular [5+2] Cycloaddition

P. Wender, Adam B. Lesser, Lauren E. Sirois, 2012 .

A new synthetic approach to the C ring of known as well as novel bryostatin analogues.

P. Wender, M. Koehler, Martin Sendzik, 2003, Organic letters.

A concise, selective synthesis of the polyketide spacer domain of a potent bryostatin analogue.

A. Mayweg, P. Wender, C. Vandeusen, 2003, Organic letters.

GENERAL METHODOLOGY FOR CIS‐HYDROISOQUINOLINE SYNTHESIS: SYNTHESIS OF RESERPINE

P. Wender, A. White, J. Schaus, 2002 .

Function-oriented synthesis, step economy, and drug design.

Paul A Wender, Vishal A Verma, Thomas J Paxton, 2008, Accounts of chemical research.

A formal synthesis of crinipellin B based on the arene-alkene meta-photocycloaddition reaction

T. M. Dore, P. Wender, 1998 .

Stereochemistry of dialkylcuprate additions to cyclopropyl acrylic esters. An application to the synthesis of (.+-.)-eremophilone

P. Wender, W. Studt, G. R. Reid, 1977 .

Synthetic studies on arene-olepin cycloadditions-VII:1 a three-step total synthesis of (±)-silphinene

P. Wender, R. Ternansky, 1985 .

Synthetic studies on arene-olefin cycloadditions -III- total synthesis of (±)-hirsutene☆

J. Howbert, P. Wender, 1982 .

Synthetic studies on arene-olefin cycloadditions. ii. total synthesis of (±)-isocomene

G. Dreyer, P. Wender, 1981 .

Taxol®: science and applications.

Michael L. Shuler, Haeil Park, William C. Rose, 1995 .

Nickel-catalyzed intramolecular [4+4] cycloadditions. 4. Enantioselective total synthesis of (+)-asteriscanolide

C. R. Correia, P. Wender, N. Ihle, 1988 .

Studies on tumor promoters. 10. Synthesis of the abc ring system of the tiglianes and daphnanes by a zirconium-mediated intramolecular enyne carbocyclization

P. Wender, F. McDonald, 1990 .

Reaction of allylically substituted enolates with organometallic reagents: a convenient source of enolonium ion equivalents

P. Wender, L. Letendre, Jeanette M. Erhardt, 1981 .

Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System

R. Waymouth, P. Wender, Brian M. Trantow, 2015, Bioconjugate chemistry.

Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.

P. Wender, 2013, Tetrahedron.

[3 + 2] and [5 + 2] Arene–Alkene Photocycloadditions

J. Nuss, P. Wender, L. Siggel, 1991 .

Synthetic studies on arene-olefin cycloadditions-VIII. Total syntheses of (±)-silphiperfol-6-ene, (±)-7 α H-silphiperfol-5-ene and (±)-7 β H-silphiperfol-5-ene☆

Sunil Singh, P. Wender, 1985 .

Synthetic Studies on Arene-Olefin Cycloadditions. Part 3. Total Synthesis of (±)-Hirsutene.

J. Howbert, P. Wender, 1983 .

Synthetic studies on areneolefin cycloadditions -VI- two syntheses of (±)-coriolin.

J. Howbert, P. Wender, 1983 .

Arene-alkene cycloadditions and organic synthesis

P. Wender, R. Ternansky, A. Olivero, 1990 .

Toward the ideal synthesis and molecular function through synthesis-informed design.

Paul A Wender, P. Wender, 2014, Natural product reports.

Studies on oxidopyrylium [5+2] cycloadditions: toward a general synthetic route to the C12-hydroxydaphnetoxins.

F. Gosselin, P. Wender, N. Buschmann, 2006, Organic letters.

New reactions and step economy: the total synthesis of (±)-salsolene oxide based on the type II transition metal-catalyzed intramolecular [4 + 4] cycloaddition

P. Wender, Mitchell P. Croatt, B. Witulski, 2006 .

Synthetic studies on arene-olefin cycloadditions. 11. Total synthesis of (−)-retigeranic acid

Sunil Singh, P. Wender, S. Singh, 1990 .

Seven-membered ring synthesis based on arene olefin cycloadditions: The total synthesis of (±)-Rudmollin

K. Fisher, P. Wender, 1986 .

Synthetic studies on arene-olefin cycloadditions: total synthesis of (.+-.)-.alpha.-cedrene

J. Howbert, P. Wender, 1981 .

Synthesis at the molecular frontier

Benjamin L. Miller, Paul A. Wender, B. Miller, 2009, Nature.

Synthetic studies on arene-olefin cycloadditions. 10. A concise, stereocontrolled total synthesis of (.+-.)-laurenene

B. Levine, P. Wender, T. V. Geldern, 1988 .

Synthetic studies on arene-olefin cycloadditions - V. total synthesis of (±)-isoiridomyrmecin.☆

G. Dreyer, P. Wender, 1983 .

Synthetic studies on arene-olefin cycloadditions. 4. Total synthesis of (.+-.)-modhephene

G. Dreyer, P. Wender, 1982 .

Hetero-atom substituted chromium allyls: Synthetic studies on neocarzinostatin chromophore analogues

P. Wender, R. Mah, U. Hoffmann, 1990 .

Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin.

H. Seto, P. Wender, Orion D Jankowski, 2002, Organic letters.

A metal-catalyzed intermolecular [5+2] cycloaddition/Nazarov cyclization sequence and cascade.

P. Wender, Lauren E. Sirois, R. Stemmler, 2010, Journal of the American Chemical Society.

Transition metal-catalyzed intramolecular [4 + 2] cycloadditions: Mechanistic and synthetic investigations

Thomas E. Smith, P. Wender, 1998 .

Multicomponent cycloadditions: the four-component [5+1+2+1] cycloaddition of vinylcyclopropanes, alkynes, and CO.

P. Wender, Gabriel G. Gamber, Lei Zhang, 2005, Journal of the American Chemical Society.

Three-component cycloadditions: the first transition metal-catalyzed [5+2+1] cycloaddition reactions.

P. Wender, Gabriel G. Gamber, Lei Zhang, 2002, Journal of the American Chemical Society.

A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones.

Lei Jiao, Paul A Wender, Dazhi Yang, 2007, Journal of the American Chemical Society.

Transition Metal Catalyzed [5 + 2] Cycloadditions of Vinylcyclopropanes and Alkynes: A Homolog of the Diels-Alder Reaction for the Synthesis of Seven-Membered Rings

P. Wender, Hisashi Takahashi, B. Witulski, 1995 .

Transition metal-catalyzed intermolecular [5+2] and [5+2+1] cycloadditions of allenes and vinylcyclopropanes.

H. Wegner, A. de Meijere, P. Wender, 2005, Journal of the American Chemical Society.

The Diene Effect: The Design, Development, and Mechanistic Investigation of Metal-Catalyzed Diene-yne, Diene-ene, and Diene-allene [2+2+1] Cycloaddition Reactions

P. Wender, Mitchell P. Croatt, 2010 .

Pharmacophore mapping in the laulimalide series: total synthesis of a vinylogue for a late-stage metathesis diversification strategy.

Paul A Wender, P. Wender, S. Mooberry, 2006, Organic letters.

Transition metal-catalyzed hetero-[5 + 2] cycloadditions of cyclopropyl imines and alkynes: dihydroazepines from simple, readily available starting materials.

P. Wender, T. M. Pedersen, M. Scanio, 2002, Journal of the American Chemical Society.

An approach to the tiglianes, daphnanes, and ingenanes via the divinylcyclopropane rearrangement

P. Wender, M. Szymonifka, C. Hillemann, 1980 .

A general methodology for pseudoguaiane synthesis: total synthesis of (.+-.)-damsinic acid and (.+-.)-confertin

P. Wender, M. Eissenstat, Michael P. Filosa, 1979 .

METHODOLOGY FOR THE FACILE AND REGIO-CONTROLLED SYNTHESIS OF INDOLES

P. Wender, A. White, 1983 .

Total synthesis of (.+-.)-isabelin

P. Wender, J. Lechleiter, 1980 .

Nickel-catalyzed intramolecular [4+2] dienyne cycloadditions: an efficient new method for the synthesis of polycycles containing cyclohexa-1,4-dienes

P. Wender, T. Jenkins, 1989 .

Intramolecular nickel catalyzed cycloadditions of bis-dienes: 3 approaches to the taxane skeleton☆

P. Wender, M. Snapper, 1987 .

Transition Metal-Catalyzed (6+2) Cycloadditions of 2-Vinylcyclobutanones and Alkenes: A New Reaction for the Synthesis of Eight-Membered Rings

A. Corrêa, P. Wender, Robert Sun, 2000 .

Reactivity and Chemoselectivity of Allenes in Rh(I)-Catalyzed Intermolecular (5 + 2) Cycloadditions with Vinylcyclopropanes: Allene-Mediated Rhodacycle Formation Can Poison Rh(I)-Catalyzed Cycloadditions

K. Houk, Peng Liu, P. Wender, 2014, Journal of the American Chemical Society.

Total synthesis of (-)-laulimalide.

P. Wender, Lei Zhang, Sayee G. Hegde, 2000, Journal of the American Chemical Society.

Cyclopentadienone synthesis by rhodium(I)-catalyzed [3 + 2] cycloaddition reactions of cyclopropenones and alkynes.

T. Williams, P. Wender, Thomas J. Paxton, 2006, Journal of the American Chemical Society.

Macroexpansion methodology. 3. Eight-step synthesis of (-)-(3Z)-cembrene A

D. Holt, P. Wender, 1985 .

Rhodium dinaphthocyclooctatetraene complexes: synthesis, characterization and catalytic activity in [5+2] cycloadditions.

P. Wender, Adam B. Lesser, Lauren E. Sirois, 2012, Angewandte Chemie.

The Transition Metal-Catalyzed Intermolecular [5+2] Cycloaddition: The Homologous Diels−Alder Reaction

P. Wender, H. Rieck, M. Fuji, 1998 .

Organobiscuprates. A single-step spiroannelation method

P. Wender, S. Eck, 1977 .

Total synthesis of (-)-laulimalide.

Lei Zhang, Paul A Wender, P. Wender, 2000, Journal of the American Chemical Society.

The First Synthesis of a Daphnane Diterpene: The Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin

A. Tebbe, P. Wender, C. Jesudason, 1997 .

Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.

P. Wender, D. Tantillo, Yasuyuki Ogawa, 2013, The Journal of organic chemistry.

Trimethylene Methane Dianion Equivalent for the Asymmetric Consecutive Allylation of Aldehydes: Applications to Prins-Driven Macrocyclizations for the Synthesis of Bryostatin 1 and Analogues.

P. Wender, Jack L. Sloane, Quang H Luu-Nguyen, 2022, The Journal of organic chemistry.

Studies on tumor promoters: V. Complementary 1,4-stereocontrol in phorboid cycloheptene synthesis via the divinylcyclopropane rearrangement

P. Wender, K. Brighty, 1988 .

Rh(I)-catalyzed cleavage of unactivated CO bonds Carbonylative rearrangement reactions of allenyl ethers to 2-carboalkoxy-1,3-dienes

P. Wender, N. Deschamps, Robert Sun, 2005 .

2‐Alkenyl Carbinols from 2‐Halo Ketones: 2‐E‐Propenylcyclohexanol

D. Holt, S. Sieburth, P. Wender, 2003 .

Asymmetric synthesis of the tricyclic core of NGF-inducing cyathane diterpenes via a transition-metal-catalyzed [5 + 2] cycloaddition.

F. Gosselin, P. Wender, M. Brodney, 2001, Organic letters.

Arene-Alkene Photocycloaddition Reactions

J. Nuss, P. Wender, L. Siggel, 1990 .

The photochemistry of 1-alkenylbenzotriazoles : Methodology for the synthesis of indoles

Christopher B. Cooper, C. Cooper, P. Wender, 1986 .

Intramolecular photoinduced diene-diene cyaloadditions: a selective method for the synthesis of complex eight-membered rings and polyquinanes

C. R. Correia, P. Wender, 1987 .

An enolate-accelerated Cope rearrangement

S. Sieburth, P. Wender, R. Ternansky, 1985 .

General methodology for cis-hydroisoquinoline synthesis. III: A sixteen step synthesis of reserpine

P. Wender, A. White, J. Schaus, 1987 .

General methodology for cis-hydroisoquinoline synthesis: synthesis of reserpine

P. Wender, A. White, J. Schaus, 1980 .

Methods for the preparations of 1,5-dienes. A metathetical route to medium-sized carbocycles

P. Wender, J. Lechleiter, 1977 .

Studies on tumor promoters. 7. The synthesis of a potentially general precursor of the tiglianes, daphnanes, and ingenanes

R. Wilhelm, P. Wender, Hee‐Yoon Lee, 1989 .

Total synthesis of quadrone and terrecyclic acid A

P. Wender, D. Wolanin, 1985 .

Intermolecular dienyl Pauson-Khand reaction.

T. Williams, P. Wender, N. Deschamps, 2004, Angewandte Chemie.

Rhodium(I)-catalyzed [2+2+1] cycloadditions of 1,3-dienes, alkenes, and CO.

P. Wender, N. Deschamps, Mitchell P. Croatt, 2004, Journal of the American Chemical Society.

The dienyl Pauson-Khand reaction.

P. Wender, Gabriel G. Gamber, N. Deschamps, 2003, Angewandte Chemie.

Transition Metal-Catalyzed Intramolecular [4 + 2] Cycloadditions: Initial Studies on Stereochemistry and on Steroid and Vitamin D Analog Syntheses

Thomas E. Smith, P. Wender, 1995 .

Nickel(0)-Catalyzed Intramolecular [4 + 4] Cycloadditions: 5. The Type II Reaction in the Synthesis of Bicyclo[5.3.1]undecadienes

P. Wender, M. Tebbe, 1991 .

Synthetic Studies on Arene‐Olefin Cycloadditions. Part 12. Total Synthesis of (.+‐.)‐Subergorgic Acid (I).

P. Wender, M. Delong, 1991 .

The pinene path to taxol: Readily accessible a-ring building blocks based on novel alkyl- and alkenyllithium reagents with internal carbonyl groups

D. B. Rawlins, L. Wessjohann, P. Wender, 1995 .

Synthetic Studies on Arene-Olefin Cycloadditions. Part 10. A Concise, Stereocontrolled Total Synthesis of (.+-.)-Laurenene.

B. Levine, P. Wender, T. V. Geldern, 1988 .

Synthesis and biological evaluation of bryostatin analogues: the role of the A-ring

P. Wender, B. Lippa, 2000 .

Tris(triphenylphosphine)nickel(0)

Thomas E. Smith, P. Wender, 2001 .

A general methodology for pseudoguaiane synthesis: total synthesis of (.+-.)-damsinic acid and (.+-.)-confertin

P. Wender, M. Eissenstat, Michael P. Filosa, 1979 .

Catalytic Efficiency Is a Function of How Rhodium(I) (5 + 2) Catalysts Accommodate a Conserved Substrate Transition State Geometry: Induced Fit Model for Explaining Transition Metal Catalysis.

P. Wender, P. Cheong, T. Mustard, 2015, ACS catalysis.

Hetero‐Atom Substituted Chromium Allyls: Synthetic Studies on Neocarzinostatin (I) Analogues.

P. Wender, R. Mah, U. Hoffmann, 1992 .

Studies on DNA cleaving agents : synthesis and chemically induced cycloaromatization of a monocyclic neocarzinostatin chromophore analogue

P. Wender, M. Tebbe, 1991 .

Olefin metathesis-transannular ene sequence. A method for the stereocontrolled synthesis of trans-decalin derivatives. 1. Total synthesis of (.+-.)-calameon

P. Wender, J. Hubbs, 1980 .

The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol

M. Natchus, P. Wender, P. Floreancig, 1997 .

Transition Metal-Catalyzed [5 + 2] Cycloadditions of Allenes and Vinylcyclopropanes: First Studies of Endo−Exo Selectivity, Chemoselectivity, Relative Stereochemistry, and Chirality Transfer

F. Glorius, P. Wender, J. Love, 1999 .

A facile route to divinylcyclopropanes. An efficient method for the annelative formation of functionalized cycloheptanes

P. Wender, Michael P. Filosa, 1976 .

Spiroannelation via Organobis(Cuprates): 9,9‐Dimethylspiro[4.5]Decan‐7‐One

P. Wender, A. White, F. McDonald, 2003 .

Organobis(cuprates): a new class of reagents and method for spiroannelation

P. Wender, A. White, 1988 .

Studies on tumor promoters: the first synthesis of the phorbol skeleton

R. Keenan, P. Wender, Hee‐Yoon Lee, 1987 .

An efficient, scalable synthesis of the molecular transporter octaarginine via a segment doubling strategy.

K. Pattabiraman, T. C. Jessop, P. Wender, 2001, Organic letters.

The design of guanidinium-rich transporters and their internalization mechanisms.

P. Wender, Thomas H. Pillow, E. Goun, 2008, Advanced drug delivery reviews.

Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells.

J. Rothbard, Richard S Lewis, T. C. Jessop, 2004, Journal of the American Chemical Society.

Synthesis of modified nucleoside oligophosphates simplified: Fast, pure, and protecting group free.

Thomas M. Haas, K. Baldridge, J. Siegel, 2019, Journal of the American Chemical Society.

The first metal-catalyzed intramolecular [5+2] cycloadditions of vinylcyclopropanes and alkenes: Scope, stereochemistry, and asymmetric catalysis

P. Wender, J. Love, Craig O. Husfeld, 1998 .

Methodology for indole synthesis

P. Wender, A. White, 1981 .

Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures through a PKC-Dependent Mechanism.

D. E. Olson, Whitney C. Duim, P. Wender, 2020, ACS chemical neuroscience.

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

M. Marsden, J. Zack, P. Wender, 2020, Nature Communications.

Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.

H. Ohigashi, K. Irie, P. Wender, 1999, Bioorganic & medicinal chemistry letters.

The First Intermolecular Transition Metal‐Catalyzed [5 + 2] Cycloadditions with Simple, Unactivated, Vinylcyclopropanes.

P. Wender, A. Dyckman, C. M. Barzilay, 2001 .

Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.

L. Delang, J. Neyts, P. Leyssen, 2016, Journal of natural products.

In Situ Detection of Endogenous HIV Activation by Dynamic Nuclear Polarization NMR and Flow Cytometry

Chukun Gao, Lauren E. Price, A. Barnes, 2020, International journal of molecular sciences.

The olefin metathesis/transannular ene sequence: a method for the stereocontrolled synthesis of -decalin derivatives. 3. total synthesis of (±)-warburganal

P. Wender, S. Eck, 1982 .

Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues.

P. Wender, Edward Njoo, Quang H Luu-Nguyen, 2022, Nature chemistry.

The First Formal Asymmetric Synthesis of Phorbol.

M. Schnute, P. Wender, K. Rice, 1997 .

STUDIES ON TUMOR PROMOTERS .8. THE SYNTHESIS OF PHORBOL

H. Kogen, R. Wilhelm, P. Wender, 1989 .

The First Formal Asymmetric Synthesis of Phorbol

M. Schnute, P. Wender, K. Rice, 1997 .

Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues.

Paul A Wender, A. Mayweg, P. Wender, 2005, Organic letters.

A New and Selective Catalyst for the [5 + 2] Cycloaddition of Vinylcyclopropanes and Alkynes

P. Wender, David Sperandio, 1998 .

Latency reversal plus natural killer cells diminish HIV reservoir in vivo

Jocelyn T. Kim, D. Wodarz, N. Komarova, 2022, Nature communications.

Studies on the regio- and diastereo-selective epoxidation of daphnanes and tiglianes.

P. Wender, Pierre-Luc Boudreault, Jennifer K Mattler, 2015, Tetrahedron letters.

Function through Synthesis-Informed Design

Paul A. Wender, Ryan V. Quiroz, Matthew C. Stevens, 2015, Accounts of chemical research.

Tumor Promoters. Part 8. The Synthesis of Phorbol.

H. Kogen, R. Wilhelm, P. Wender, 1990 .

Retrosynthetic Reaction Prediction Using Neural Sequence-to-Sequence Models

Bowen Liu, Vijay S. Pande, Joseph Gomes, 2017, ACS central science.

Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates.

P. Wender, R. Jeon, 1999, Organic letters.

Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates.

P. Wender, R. Jeon, 2003, Bioorganic & medicinal chemistry letters.

Triazole Photonucleases: A New Family of Light Activatable DNA Cleaving Agents

P. Wender, Sofia M. Touami, C. Alayrac, 1996 .

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

J. Rothbard, P. Khavari, P. Wender, 2000, Nature Medicine.

Latency reversal plus natural killer cells diminish HIV reservoir in vivo

Jocelyn T. Kim, D. Wodarz, R. Sun, 2022, Nature Communications.

Tetrakis(trichlorophosphine)nickel(0)

Thomas E. Smith, P. Wender, 2001 .

Practical method for .alpha.-alkenyl ketone synthesis based on a facile reductive rearrangement of alkynyl halohydrins

D. Holt, S. Sieburth, P. Wender, 1983 .

An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory

D. Czerwinski, R. Waymouth, P. Wender, 2021, ACS central science.

An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory

D. Czerwinski, R. Waymouth, P. Wender, 2021, bioRxiv.

Nickel(0)-catalyzed [2 + 2 + 2 + 2] cycloadditions of terminal diynes for the synthesis of substituted cyclooctatetraenes.

P. Wender, J. Christy, 2007, Journal of the American Chemical Society.

PRACTICAL METHOD FOR α‐ALKENYL KETONE SYNTHESIS BASED ON A FACILE REDUCTIVE REARRANGEMENT OF ALKYNYL HALOHYDRINS

D. Holt, S. Sieburth, P. Wender, 1983 .

Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs.

Paul A Wender, Vishal A Verma, Vishal A. Verma, 2006, Organic letters.

Clinical correlates of HIV-1 DNA and inducible HIV-1 RNA reservoirs in peripheral blood in children with perinatally acquired HIV-1 infection with sustained virologic suppression for at least 5 years.

J. Singer, M. Hawkes, J. Brophy, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery.

V. Kickhoefer, L. Rome, P. Wender, 2017, ACS nano.

Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy

B. Franc, C. Contag, Z. Siprashvili, 2003 .

Breaching biological barriers: protein translocation domains as tools for molecular imaging and therapy.

B. Franc, C. Contag, Z. Siprashvili, 2003, Molecular imaging.

Regiospecific generation of lithioenamines from .alpha.,.beta.-unsaturated imines. An alternative method for reduction-alkylation of enones

P. Wender, M. Eissenstat, 1978 .

Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake.

B. L. Wylie, J. Rothbard, P. Wender, 2002, Journal of medicinal chemistry.

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents

M. Marsden, J. Zack, P. Wender, 2018, Virology.

Toward the synthesis of taxol and its analogs: Incorporation of non-aromatic C-rings in the pinene pathway

M. Natchus, P. Wender, P. Floreancig, 1995 .

Cell-Penetrating, Guanidinium-Rich Molecular Transporters for Overcoming Efflux-Mediated Multidrug Resistance

J. R. Vargas, P. Wender, N. Teng, 2014, Molecular pharmaceutics.

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs.

K. Koehler, M. Dell'aquila, P. Blumberg, 1986, Proceedings of the National Academy of Sciences of the United States of America.

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

P. Wender, M. Koehler, P. Harran, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Tracking HIV Rebound following Latency Reversal Using Barcoded HIV

Jocelyn T. Kim, R. Sun, Yushen Du, 2020, Cell reports. Medicine.

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation

G. Marshall, Robert M. Williams, L. Ratner, 2017, Scientific Reports.

Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

T. Chun, M. Marsden, J. Zack, 2013, Proceedings of the National Academy of Sciences.

Designed, Synthetically Accessible Bryostatin Analogues Potently Induce Activation of Latent HIV Reservoirs in vitro

M. Marsden, J. Zack, P. Wender, 2012, Nature chemistry.

Charge-Altering Releasable Transporters Enable Specific Phenotypic Manipulation of Resting Primary Natural Killer Cells

Aaron J. Wilk, C. Blish, R. Waymouth, 2020, bioRxiv.

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

J. R. Vargas, Christopher H. Contag, Robert M. Waymouth, 2017, Proceedings of the National Academy of Sciences.

Comprehensive analysis of HIV reservoirs in elite controllers

T. Chun, J. Justement, P. Wender, 2023, The Journal of clinical investigation.

In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication

T. Chun, M. Marsden, J. Zack, 2017, PLoS pathogens.

Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells

Y. Shi, D. Spaner, J. Tomić, 2009, Clinical and experimental immunology.

Apoptolidins B and C: isolation, structure determination, and biological activity.

P. Wender, Kate E. Longcore, Martin Sukopp, 2005, Organic letters.

The olefin metathesis-transannular ene sequence: a method for the stereocontrolled synthesis of trans-decalin derivatives. 2. Formal eudesmane syntheses

P. Wender, L. Letendre, 1980 .

Studies on DNA-cleaving agents: computer modeling analysis of the mechanism of activation and cleavage of dynemicin-oligonucleotide complexes.

B. Miller, P. Wender, S. Beckham, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Studies on DNA-cleaving agents: synthesis of a functional dynemicin analogue

P. Wender, C. Zercher, 1991 .

Guanidinium rich peptide transporters and drug delivery.

J. Rothbard, P. Wender, L. Wright, 2003, Current protein & peptide science.

Studies on DNA-Cleaving Agents: Synthesis of a Functional Dynemicin Analogue.

P. Wender, C. Zercher, 1991 .

Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ

U. Kikkawa, H. Ohigashi, K. Irie, 1997 .

Synthesis and Biological Evaluation of a New Class of Bryostatin Analogues: The Role of the C20 Substituent in Protein Kinase C Binding.

K. Hinkle, P. Wender, 2000 .

Synthesis and biological evaluation of a new class of bryostatin analogues: the role of the C20 substituent in protein kinase C binding

Paul A. Wender, K. Hinkle, P. Wender, 2000 .

Bioengineered Vaults: Self-Assembling Protein Shell–Lipophilic Core Nanoparticles for Drug Delivery

V. Kickhoefer, L. Rome, Z. Zhou, 2014, ACS nano.

Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.

L. Delang, J. Neyts, P. Leyssen, 2016, Biochemical pharmacology.

“Picolog,” a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo

D. Felsher, P. Wender, A. Fan, 2012, Oncotarget.

Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7).

D. Mochly‐Rosen, Che-Hong Chen, P. Wender, 2001, Chemistry & biology.

A general method for cis-hydroisoquinoline synthesis

D. Torney, P. Wender, J. Schaus, 1979 .

Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy.

L. Cegelski, P. Wender, Daryl Staveness, 2015, Journal of the American Chemical Society.

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

Vishal A. Verma, P. Wender, J. Baryza, 2011, Proceedings of the National Academy of Sciences.

Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin.

Vishal A. Verma, P. Wender, 2006, Organic letters.

Function‐Oriented Synthesis, Step Economy, and Drug Design

Paul A. Wender, Vishal A. Verma, P. Wender, 2008 .

A Phosphoramidite Analogue of Cyclotriphosphate Enables Iterative Polyphosphorylations.

P. Wender, N. Steck, A. Ripp, 2019, Angewandte Chemie.

Design and synthesis of new DNA photocleavers, 4′-bromoacetophenone-pyrrolecarboxamide hybrid compounds

P. Wender, R. Jeon, 2000, Archives of pharmacal research.

Bis(acrylonitrile)nickel(0)

Thomas E. Smith, P. Wender, 2001 .

Dicyanobis(triphenylphosphine)nickel(II)

Thomas E. Smith, P. Wender, 2001 .

Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions

P. Wender, Matthew S. Jeffreys, Andrew G. Raub, 2015, Journal of the American Chemical Society.

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.

K. Koehler, P. Blumberg, P. Wender, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Transition Metal-Catalyzed Intramolecular [4 + 2] Diene-Allene Cycloadditions: A Convenient Synthesis of Angularly Substituted Ring Systems with Provision for Catalyst-Controlled Chemo- and Stereocomplementarity

P. Wender, T. Jenkins, Shigeaki Suzuki, 1995 .

Transition‐Metal‐Catalyzed Intramolecular (4 + 2) Diene‐Allene Cycloadditions: A Convenient Synthesis of Angularly Substituted Ring Systems with Provision for Catalyst‐Controlled Chemo‐ and Stereocomplementarity.

P. Wender, T. Jenkins, Shigeaki Suzuki, 1995 .

Rhodium-Catalyzed [5 + 2] Cycloadditions of Allenes and Vinylcyclopropanes: Asymmetric Total Synthesis of (+)-Dictamnol.

P. Wender, J. Love, Craig O. Husfeld, 1999 .

Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues.

H. Seto, P. Wender, Kate E. Longcore, 2006, Organic letters.

Facile synthetic access to and biological evaluation of the macrocyclic core of apoptolidin.

H. Seto, P. Wender, E. Tabet, 2003, Organic letters.

Toward a structure-activity relationship for apoptolidin: selective functionalization of the hydroxyl group array.

H. Seto, P. Wender, E. Tabet, 2003, Organic letters.

Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation

S. Snyder, L. Hester, P. Wender, 2020, bioRxiv.

Protein kinase C regulatory domain surrogate peptides : Effects of metal ions on folding, phorbol ester-binding, and selectivity

H. Ohigashi, K. Irie, P. Wender, 1997 .

The first intermolecular transition metal-catalyzed [5+2] cycloadditions with simple, unactivated, vinylcyclopropanes.

P. Wender, A. Dyckman, C. M. Barzilay, 2001, Journal of the American Chemical Society.

Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice

C. Contag, J. Rothbard, P. Wender, 2007, Proceedings of the National Academy of Sciences.

Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

L. Delang, J. Neyts, Vishal A. Verma, 2016, Journal of natural products.

A New and Practical Approach to the Synthesis of Taxol and Taxol Analogues: The Pinene Path.

P. Wender, T. P. Mucciaro, 1992 .

Art, architecture, and the molecular frontier.

Paul A Wender, P. Wender, 2015, Accounts of chemical research.

[(arene)Rh(cod)]+ Complexes as catalysts for [5+2] cycloaddition reactions.

T. Williams, P. Wender, 2002, Angewandte Chemie.

The stereospecific generation of the cis-vicinal methyls in eremophilane and valencane sesquiterpenes: The total synthesis of (±) eremophilone and (±) 7-epieremophilone.

P. Wender, F. Ziegler, 1974 .

Base-induced decomposition of methyl dialkylcyanodiazenecarboxylates. Transformation of ketones into nitriles, .alpha.-carbomethoxynitriles, and .alpha.-methylnitriles

P. Wender, F. Ziegler, 1971 .

Nitriles from Ketones: Cyclohexanecarbonitrile

P. Wender, M. Eissenstat, F. Ziegler, 2003 .

BASENINDUZIERTE ZERS. VON DIALKYLCYANDIAZENCARBONSAEUREMETHYLESTERN, UMWANDLUNG VON KETONEN IN NITRILE, ALPHA-METHOXYCARBONYL- UND ALPHA-METHYL-NITRILE

P. Wender, F. Ziegler, 1971 .

Methyldialkylcyanodiazenecarboxylates as intermediates for transforming aliphatic ketones into nitriles

P. Wender, F. Ziegler, 1977 .

Synthesis and mechanistic investigations of pH-responsive cationic poly(aminoester)s

R. Waymouth, P. Wender, Xiaoyu Zang, 2020, Chemical science.

Single-molecule motions of oligoarginine transporter conjugates on the plasma membrane of Chinese hamster ovary cells.

W. Moerner, R. Twieg, A. Semyonov, 2008, Journal of the American Chemical Society.

Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol.

P. Wender, S. Mooberry, E. Clark, 2006, Molecular pharmaceutics.

Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma.

N. Teng, P. Wender, Thomas H. Pillow, 2012, Gynecologic oncology.

The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.

Paul A Wender, Vishal A Verma, Vishal A. Verma, 2008, Organic letters.

Charge-altering releasable transporters enable phenotypic manipulation of natural killer cells for cancer immunotherapy.

Aaron J. Wilk, C. Blish, R. Waymouth, 2020, Blood advances.

Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

V. Pande, P. Wender, Steven M. Ryckbosch, 2017, Nature Communications.

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

M. Marsden, J. Zack, P. Wender, 2020, Nature Communications.

Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery.

Paul A Wender, R. Waymouth, P. Wender, 2019, Journal of the American Chemical Society.

Transition Metal Catalyzed Cycloadditions: An Intramolecular [4 + 4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[a,d]cyclooctene 5−8−5 Ring Systems

J. Nuss, P. Wender, J. Bordner, 1997 .

First Studies of the Transition Metal‐Catalyzed [5+2] Cycloadditions of Alkenes and Vinylcyclopropanes: Scope and Stereochemistry.

P. Wender, J. Love, Craig O. Husfeld, 1998 .

Role of the A-ring of bryostatin analogues in PKC binding: synthesis and initial biological evaluation of new A-ring-modified bryologs.

Paul A Wender, P. Wender, M. Clarke, 2005, Organic letters.

Inspirations from nature. New reactions, new therapeutic leads, and new drug delivery systems

T. C. Jessop, P. Wender, J. Baryza, 2003 .

Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): The Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers

K. Irie, P. Wender, M. Koehler, 1999 .

Delivery of antimicrobials into parasites

D. Rice, S. Prigge, C. Roberts, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides.

C. Contag, Z. Siprashvili, P. Khavari, 2003, Human gene therapy.

Conjugation of Vancomycin with a Single Arginine Improves Efficacy against Mycobacteria by More Effective Peptidoglycan Targeting.

L. Cegelski, P. Wender, J. Brčić, 2023, Journal of medicinal chemistry.

Reversible RNA acylation for control of CRISPR–Cas9 gene editing†

E. Kool, A. Kietrys, R. Waymouth, 2019, Chemical science.

13 – Structural Design in Antitumor Compounds

P. Wender, C. Cribbs, 1991 .

Impact of Treatment Interruption on HIV Reservoirs and Lymphocyte Subsets in Individuals Who Initiated Antiretroviral Therapy During the Early Phase of Infection.

T. Chun, J. Justement, A. Fauci, 2019, The Journal of infectious diseases.

Synthesis of 1-(2-naphthoyl) benzotriazoles as photoactivated DNA cleaving agents

P. Wender, Jae-Wook Yang, 1997, Archives of pharmacal research.

Transition Metal-Catalyzed Intramolecular [4 + 2] Cycloadditions: A Novel Method for the Assembly of Nitrogen Heterocycles and Its Application to Yohimban Alkaloid Synthesis

Thomas E. Smith, P. Wender, 1996 .

Nickel(0)-Catalyzed Intramolecular [4 + 4] Cycloadditions: 5. The Type II Reaction in the Synthesis of Bicyclo[5.3.1]undecadienes

P. Wender, M. Tebbe, 1992 .

Circular RNA vaccine induces potent T cell responses

Howard Y. Chang, B. Pulendran, P. Wender, 2023, Proceedings of the National Academy of Sciences of the United States of America.

A Phosphoramidite Analogue of Cyclotriphosphate Enables Iterative Polyphosphorylations

P. Wender, N. Steck, A. Ripp, 2019, Angewandte Chemie.

Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters

J. R. Vargas, R. Waymouth, P. Wender, 2018, ACS central science.

Local Delivery of Ox40l, Cd80, and Cd86 mRNA Kindles Global Anticancer Immunity.

R. Waymouth, P. Wender, O. Haabeth, 2019, Cancer research.

Oligocarbonate molecular transporters: oligomerization-based syntheses and cell-penetrating studies.

Christina B. Cooley, R. Waymouth, P. Wender, 2009, Journal of the American Chemical Society.

A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.

L. Cegelski, Kelvin K L Chong, P. Wender, 2018, Journal of the American Chemical Society.

Toward the ideal synthesis and molecular function through synthesis-informed design.

P. Wender, 2014, Natural product reports.

Beyond Cell Penetrating Peptides: Designed Molecular Transporters.

Christina B. Cooley, P. Wender, Erika I. Geihe, 2012, Drug discovery today. Technologies.

Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism

C. Blish, R. Waymouth, P. Wender, 2023, Nature communications.

Lysine-Derived Charge-Altering Releasable Transporters: Targeted Delivery of mRNA and siRNA to the Lungs.

R. Waymouth, P. Wender, O. Haabeth, 2023, Bioconjugate chemistry.

Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters

R. Waymouth, P. Wender, O. Haabeth, 2018, Proceedings of the National Academy of Sciences.

Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

Vishal A. Verma, P. Wender, J. Baryza, 2011 .

A metal-catalyzed intermolecular [5+2] cycloaddition/Nazarov cyclization sequence and cascade.

P. Wender, Lauren E. Sirois, R. Stemmler, 2010, Journal of the American Chemical Society.

Substituent effects, reactant preorganization, and ligand exchange control the reactivity in Rh(I)-catalyzed (5+2) cycloadditions between vinylcyclopropanes and alkynes.

K. Houk, Peng Liu, P. Wender, 2008, Angewandte Chemie.

Rhodium(I)‐Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis

T. Williams, P. Wender, Gabriel G. Gamber, 2005 .

Asymmetric total synthesis of (+)-aphanamol I based on the transition metal catalyzed [5 + 2] cycloaddition of allenes and vinylcyclopropanes.

P. Wender, L. Zhang, 2000, Organic letters.

Synthesis and Biological Activities of New Conformationally Restricted Analogues of (−)-Indolactam-V: Elucidation of the Biologically Active Conformation of the Tumor-Promoting Teleocidins

H. Ohigashi, Yoshimasa Nakamura, H. Nishino, 1996 .

Rhodium(I)-Catalyzed [2+2], [2+2+2], and [2+2+2+2] Cycloadditions of Dienes or Alkynes with a Bis-ene

P. Wender, Mitchell P. Croatt, Björn Kühn, 2009 .

Rhodium(I)-catalyzed [4+2+2] cycloadditions of 1,3-dienes, alkenes, and alkynes for the synthesis of cyclooctadienes.

P. Wender, J. Christy, 2006, Journal of the American Chemical Society.

Transition metal-catalyzed intramolecular [4 + 2] cycloadditions: Mechanistic and synthetic investigations

Thomas E. Smith, P. Wender, 1998 .

Transition Metal-Catalyzed Intramolecular [4 + 2] Cycloadditions: A Novel Method for the Assembly of Nitrogen Heterocycles and Its Application to Yohimban Alkaloid Synthesis

Thomas E. Smith, P. Wender, 1996 .

Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.

J. Stone, A. Lopez-Campistrous, P. Wender, 2012, Experimental hematology.

L. Cegelski, P. Wender, Daryl Staveness, 2015, Journal of the American Chemical Society.