Yukako Ito

T. Sakaeda, Yukako Ito, S. Kobuchi, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Insulin micropiles comprising biodegradable polymers for production of a long-term hypoglycemic effect

Yukako Ito, K. Takada, K. Fukushima, 2011, Journal of drug targeting.

Population Pharmacokinetic–Pharmacodynamic Modeling of 5-Fluorouracil for Toxicities in Rats

T. Sakaeda, Yukako Ito, S. Kobuchi, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats

T. Sakaeda, Yukako Ito, S. Kobuchi, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy

Yukako Ito, S. Kobuchi, Risa Shimizu, 2020, Pharmaceutics.

Assessment of Oxaliplatin-induced Chronic Neuropathy and Anticancer Efficacy Through Pharmacokinetic and Toxicodynamic Evaluation of a Rat Model of Colorectal Cancer

Yukako Ito, S. Kobuchi, Waki Takesada, 2019, AntiCancer Research.

Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats

Yukako Ito, S. Kobuchi, Y. Katsuyama, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Effect of intact oxaliplatin in plasma on a cold allodynia after multiple administrations in colorectal cancer model rats.

Yukako Ito, S. Kobuchi, Mako Takesada, 2020, Annals of palliative medicine.

A predictive biomarker for altered 5‐fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer

Asako Nishimura, N. Shibata, Yukako Ito, 2013, Biopharmaceutics & drug disposition.

Circadian variations in the pharmacokinetics of the oral anticancer agent tegafur‐uracil (UFT) and its metabolites in rats

T. Sakaeda, Yukako Ito, S. Kobuchi, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.

Yukako Ito, K. Takada, S. Kobuchi, 2013, Biological & pharmaceutical bulletin.

Effects of obesity induced by high-fat diet on the pharmacokinetics of cyclosporine A in rats

Yukako Ito, K. Takada, K. Fukushima, 2011 .

A validated LC-MS/MS method for the low-level determination of pemafibrate, a novel SPPARMα, in plasma.

T. Sakaeda, Yukako Ito, S. Kobuchi, 2020, Bioanalysis.

A simple and rapid LC-MS/MS method for quantitation of luseogliflozin in rat plasma and its application to a PK study.

T. Sakaeda, Yukako Ito, M. Yamashita, 2017, Bioanalysis.

Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers.

Asako Nishimura, N. Shibata, Yukako Ito, 2006, Biological & pharmaceutical bulletin.

Development and validation of an LC-MS/MS method for the determination of tofogliflozin in plasma and its application to a pharmacokinetic study in rats.

T. Sakaeda, Yukako Ito, S. Kobuchi, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Population Pharmacokinetic Model-Based Evaluation of Intact Oxaliplatin in Rats with Acute Kidney Injury

Yukako Ito, S. Kobuchi, Miyu Kai, 2021, Cancers.

Pharmacokinetic and toxicodynamic evaluation of oxaliplatin-induced neuropathy and hematological toxicity in rats

Yukako Ito, S. Kobuchi, Risa Shimizu, 2017, Cancer Chemotherapy and Pharmacology.

Self-dissolving micropile array chip as percutaneous delivery system of protein drug.

Yukako Ito, K. Takada, K. Fukushima, 2010, Biological & pharmaceutical bulletin.

Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats

Yukako Ito, K. Takada, S. Kobuchi, 2012, European Journal of Drug Metabolism and Pharmacokinetics.

A validated LC-MS/MS method for the determination of canagliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, in a lower volume of rat plasma: application to pharmacokinetic studies in rats.

T. Sakaeda, Yukako Ito, S. Kobuchi, 2016, Biomedical chromatography : BMC.

Application of dissolving microneedles to glucose monitoring through dermal interstitial fluid.

T. Sakaeda, S. Morita, Yukako Ito, 2014, Biological & pharmaceutical bulletin.

Application of Pharmacometrics of 5-Fluorouracil to Personalized Medicine: A Tool for Predicting Pharmacokinetic–Pharmacodynamic/Toxicodynamic Responses

Yukako Ito, S. Kobuchi, Shinji Kobuchi, 2020, AntiCancer Research.

Pharmacokinetics and distribution of fluvoxamine to the brain in rats under oxidative stress

Yukako Ito, K. Takada, K. Fukushima, 2012, Free radical research.

Effect of water intake on pharmacokinetics of lansoprazole from fast disintegrating tablet in human subjects.

N. Shibata, Yukako Ito, K. Takada, 2004, Drug metabolism and pharmacokinetics.

Percutaneous absorption of interferon-α by self-dissolving micropiles

Yukako Ito, K. Takada, Atsushi Saeki, 2008 .

Effect of streptozotocin‐induced diabetes mellitus on the pharmacokinetics of nelfinavir in rats

Yukako Ito, K. Takada, K. Fukushima, 2008, Biopharmaceutics & drug disposition.

Estimation of minimum whole-blood tacrolimus concentration for therapeutic drug monitoring with plasma prednisolone concentration: A retrospective cohort study in Japanese kidney transplant recipients.

N. Shibata, Yukako Ito, K. Takada, 2006, Current therapeutic research, clinical and experimental.

Comparison of In Vivo Transportability of Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents Into Intracellular and Extracellular Tissue Spaces in Rats.

T. Sakaeda, Yukako Ito, Y. Hiramatsu, 2020, Journal of pharmaceutical sciences.

Semi-physiological pharmacokinetic–pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats

Asako Nishimura, N. Shibata, T. Hayakawa, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Pharmacokinetic/pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer.

Yukako Ito, K. Takada, S. Kobuchi, 2013, Journal of pharmaceutical sciences.

Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats

Keizo Fukushima, Kanji Takada, Hiromi Morita, 2010, Pharmaceutical Research.

Pharmaceutical approach to HIV protease inhibitor atazanavir for bioavailability enhancement based on solid dispersion system.

N. Shibata, Yukako Ito, K. Takada, 2007, Biological & pharmaceutical bulletin.

Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles.

Yukako Ito, K. Takada, K. Fukushima, 2011, International journal of pharmaceutics.

Long-term pharmacokinetic efficacy and safety of low-dose ritonavir as a booster and atazanavir pharmaceutical formulation based on solid dispersion system in rats.

Yukako Ito, K. Takada, K. Fukushima, 2008, Biological & pharmaceutical bulletin.

Enhancing mechanism of Labrasol on intestinal membrane permeability of the hydrophilic drug gentamicin sulfate.

N. Shibata, Yukako Ito, K. Takada, 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Therapeutic Drug Monitoring of Vancomycin in Dermal Interstitial Fluid Using Dissolving Microneedles

T. Sakaeda, Yukako Ito, K. Takada, 2016, International journal of medical sciences.

Self-dissolving micropile array tips for percutaneous administration of insulin

Yukako Ito, K. Takada, N. Sugioka, 2010, Journal of materials science. Materials in medicine.

Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis

T. Sakaeda, Yukako Ito, S. Kobuchi, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin

T. Sakaeda, Yukako Ito, K. Maeda, 2020, Antibiotics.

Transport of Azithromycin into Extravascular Space in Rats

A. Kuwahara, T. Sakaeda, Yukako Ito, 2016, Antimicrobial Agents and Chemotherapy.

Recovery Rate of Rat Skin Micropores Made by Dissolving Microneedles

N. Miyamoto, Yukako Ito, K. Takada, 2013 .

Two- and Three-Layered Dissolving Microneedles for Transcutaneous Delivery of Model Vaccine Antigen in Rats

Yukako Ito, K. Takada, S. Naito, 2012 .

Evaluation of self-dissolving needles containing low molecular weight heparin (LMWH) in rats.

Yukako Ito, K. Takada, N. Sugioka, 2008, International journal of pharmaceutics.

Feasibility of microneedles for percutaneous absorption of insulin.

Kanji Takada, Atsushi Saeki, Yukako Ito, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Self-dissolving microneedles for the percutaneous absorption of EPO in mice

J. Yoshimitsu, Yukako Ito, K. Takada, 2006, Journal of drug targeting.

Pharmacokinetics and lung distribution of macrolide antibiotics in sepsis model rats

T. Sakaeda, Yukako Ito, S. Kobuchi, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Effect of adsorbents on the absorption of lansoprazole with surfactant.

N. Shibata, Yukako Ito, K. Takada, 2005, International journal of pharmaceutics.

Dissolving microneedles to obtain rapid local anesthetic effect of lidocaine at skin tissue

Yukako Ito, K. Takada, Kazuki Imada, 2013, Journal of drug targeting.

Two-layered dissolving microneedles for percutaneous delivery of sumatriptan in rats

Yukako Ito, K. Takada, K. Fukushima, 2011, Drug development and industrial pharmacy.

Permeation enhancement of ascorbic acid by self-dissolving micropile array tip through rat skin.

Yukako Ito, K. Takada, K. Fukushima, 2010, Chemical & pharmaceutical bulletin.

Absorption of interferon alpha from patches in rats

N. Shibata, T. Kishida, T. Kishida, 2005, Journal of drug targeting.

Preparation and evaluation of oral solid heparin using emulsifier and adsorbent for in vitro and in vivo studies.

N. Shibata, Yukako Ito, K. Takada, 2006, International journal of pharmaceutics.

Method to increase the systemically delivered amount of drug from dissolving microneedles.

N. Miyamoto, Yukako Ito, K. Takada, 2013, Chemical & pharmaceutical bulletin.

Effect of chronic administration of ritonavir on function of cytochrome P450 3A and P-glycoprotein in rats.

N. Shibata, Yukako Ito, K. Takada, 2005, Biological & pharmaceutical bulletin.

Oral solid gentamicin preparation using emulsifier and adsorbent.

Kanji Takada, Makoto Ishida, N. Shibata, 2005, Journal of controlled release : official journal of the Controlled Release Society.

A Pharmacokinetic-Pharmacodynamic Model Predicts Uracil-tegafur Effect on Tumor Shrinkage and Myelosuppression in a Colorectal Cancer Rat Model

Yukako Ito, S. Kobuchi, Motoi Tsuda, 2023, AntiCancer Research.

A quantitative LC-MS/MS method for determining ipragliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, and its application to a pharmacokinetic study in rats.

T. Sakaeda, Yukako Ito, S. Kobuchi, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetic and pharmacodynamic evaluation of insulin dissolving microneedles in dogs.

Yukako Ito, K. Takada, K. Fukushima, 2010, Diabetes technology & therapeutics.

Evaluation of insulin self-dissolving micropiles by PK/PD analysis

H. Nakane, Yukako Ito, K. Takada, 2010 .

Self-dissolving micropiles for the percutaneous absorption of recombinant human growth hormone in rats.

Yukako Ito, K. Takada, N. Sugioka, 2008, Biological & pharmaceutical bulletin.

Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs.

Yukako Ito, K. Takada, Atsushi Saeki, 2008, Chemical & pharmaceutical bulletin.

Cytology-based Detection of Circulating Tumour Cells in Human Pancreatic Cancer Xenograft Models With KRAS Mutation

Susumu Nakata, H. Nakanishi, Y. Ikehara, 2020, AntiCancer Research.

Usefulness of Basic Fibroblast Growth Factor (bFGF) Loaded Dissolving Microneedles for Local Therapy of Skin Wounds

I. Ono, Y. Akasaka, Yukako Ito, 2013 .

Effect of oxidative stress on the pharmacokinetics of clomipramine in rats treated with ferric-nitrilotriacetate.

Yukako Ito, K. Takada, H. Aoyama, 2011, Drug metabolism letters.

Population pharmacokinetic model-based evaluation of circadian variations in plasma 5-fluorouracil concentrations during long-term infusion in rats: a comparison with oral anticancer prodrugs.

T. Sakaeda, Yukako Ito, S. Kobuchi, 2020, Journal of pharmaceutical sciences.

Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats

Yukako Ito, K. Takada, S. Kobuchi, 2013, European Journal of Drug Metabolism and Pharmacokinetics.

Assessment of drug-drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model.

T. Sakaeda, Yukako Ito, S. Kobuchi, 2021, Journal of pharmaceutical sciences.

A Physiologically Based Pharmacokinetic–Pharmacodynamic Model for Capecitabine in Colorectal Cancer Rats: Simulation of Antitumor Efficacy at Various Administration Schedules

T. Sakaeda, Yukako Ito, S. Kobuchi, 2021, European Journal of Drug Metabolism and Pharmacokinetics.

Assessment of pharmacokinetic variations of capecitabine after multiple administration in rats: a physiologically based pharmacokinetic model

T. Sakaeda, Yukako Ito, S. Kobuchi, 2020, Cancer Chemotherapy and Pharmacology.

Effect of fiber length of carbon nanotubes on the absorption of erythropoietin from rat small intestine.

N. Venkatesan, Yukako Ito, K. Takada, 2007, International journal of pharmaceutics.

Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity

T. Sakaeda, Yukako Ito, S. Kobuchi, 2019, Biopharmaceutics & drug disposition.

Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles.

Yukako Ito, K. Takada, Tsutomu Tanaka, 2012, Journal of pharmaceutical sciences.

Prolonged hypoglycemic effects obtained by two-layered dissolving microneedles containing insulin glargine

T. Sakaeda, Yukako Ito, K. Takada, 2014 .

Percutaneous absorption of interferon-alpha by self-dissolving micropiles.

Yukako Ito, K. Takada, Atsushi Saeki, 2008, Journal of drug targeting.

Transdermal insulin application system with dissolving microneedles.

Yukako Ito, K. Takada, N. Yoshimoto, 2012, Diabetes technology & therapeutics.

Molecular weight dependence on bioavailability of FITC-dextran after administration of self-dissolving micropile to rat skin

Yukako Ito, K. Takada, N. Sugioka, 2010, Drug development and industrial pharmacy.

High percutaneous bioavailability of granisetron by dissolving microneedleswe

Yukako Ito, K. Takada, A. Ikejiri, 2012 .

Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors

M. Tohkin, T. Sakaeda, T. Hayakawa, 2018, International journal of medical sciences.

Effect of plasma lipid on pharmacokinetics of ciclosporin and its relationship with plasma prednisolone level in renal transplant patients

N. Shibata, Yukako Ito, K. Takada, 2006, The Journal of pharmacy and pharmacology.

Effects of oxidative stress on the pharmacokinetics and hepatic metabolism of atazanavir in rats

Yukako Ito, K. Takada, H. Aoyama, 2013, Free radical research.

Pharmacokinetic and pharmacodynamic studies following oral administration of erythropoietin mucoadhesive tablets to beagle dogs.

N. Shibata, N. Venkatesan, J. Yoshimitsu, 2006, International journal of pharmaceutics.

Pharmacokinetic evaluation of oxaliplatin combined with S-1 (SOX) chemotherapy in a rat model of colorectal cancer with acute kidney injury: predictive renal biomarkers for dose optimisation

Yukako Ito, Shinji Kobuchi, Takumi Tanaka, 2023, Xenobiotica; the fate of foreign compounds in biological systems.

Polymeric three-layered particles for the delivery of prednisolone to the lower gastrointestinal tract in rats

Yukako Ito, K. Takada, K. Fukushima, 2011, Drug development and industrial pharmacy.