J. Brien

发表

Resistance of the hamster to amiodarone-induced pulmonary toxicity following repeated intraperitoneal administration.

T. Massey, R. Leeder, C. Evans, 1994, Toxicology letters.

Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues.

P. Armstrong, J. Brien, S. Jimmo, 1987, Canadian journal of physiology and pharmacology.

Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.

R. Kinobe, J. Brien, G. Roman, 2007, Bioorganic & medicinal chemistry.

Sensitivity of modified Biel-maze task, compared with Y-maze task, to measure spatial learning and memory deficits of ethanol teratogenicity in the guinea pig

J. Reynolds, A. Winterborn, J. Brien, 2012, Behavioural Brain Research.

Quantitation of nitric oxide formation from nitrovasodilator drugs by chemiluminescence analysis of headspace gas.

J. Brien, K. Nakatsu, B. McLaughlin, 1991, Journal of pharmacological methods.

Amiodarone-induced disruption of hamster lung and liver mitochondrial function: lack of association with thiobarbituric acid-reactive substance production.

T. Massey, A. S. Tam, J. Brien, 1998, Toxicology letters.

Amiodarone hepatotoxicity simulating alcoholic liver disease.

P. Armstrong, J. Brien, J. B. Simon, 1984, The New England journal of medicine.

Mechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Nontransformed Human Peripheral Lung Epithelial Cells

Takashi Takahashi, T. Massey, J. Mulder, 2011, Journal of Pharmacology and Experimental Therapeutics.

Does carbon monoxide have a physiological function?

K Nakatsu, J. Brien, K. Nakatsu, 1991, Trends in pharmacological sciences.

Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones.

Takashi Takahashi, T. Massey, L. Bedard, 2007, Toxicology and applied pharmacology.

Chronic prenatal ethanol exposure alters the proportion of GABAergic neurons in layers II/III of the adult guinea pig somatosensory cortex.

J. Reynolds, J. Brien, C. Bailey, 2004, Neurotoxicology and teratology.

Gas-liquid chromatographic analysis of ethanol and acetaldehyde in blood with minimal artifactual acetaldehyde formation.

J. Brien, N. Steenaart, D. Clarke, 1985, Journal of pharmacological methods.

Nitric oxide formation from glyceryl trinitrate by rabbit aortic strip: detection by rabbit taenia coli concurrent with vasorelaxation

J. Brien, K. Nakatsu, M. Poklewska-Koziell, 1994, British journal of pharmacology.

A novel method for detection of nitric oxide binding sites by using a chemiluminescence-headspace gas technique.

J. Brien, K. Nakatsu, B. McLaughlin, 1993, Journal of pharmacological and toxicological methods.

Differential biotransformation of glyceryl trinitrate by red blood cell-supernatant fraction and pulmonary vein homogenate.

J. Brien, K. Nakatsu, B. McLaughlin, 1989, Canadian journal of physiology and pharmacology.

Effect of maternal ethanol ingestion on fetal breathing movements, gross body movements, and heart rate at 37 to 40 weeks' gestational age.

C. Loomis, J. Brien, J. Patrick, 1983, American journal of obstetrics and gynecology.

Disposition of ethanol in human maternal venous blood and amniotic fluid.

J. Tranmer, J. Brien, M. Mcgrath, 1983, American journal of obstetrics and gynecology.

Elimination kinetics of ethanol in pregnant women.

G. Koren, J. Brien, A. Nava-Ocampo, 2004, Reproductive toxicology.

Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta.

J. Brien, B. Bennett, K. Nakatsu, 1986, The Journal of pharmacology and experimental therapeutics.

Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1988, The Journal of pharmacology and experimental therapeutics.

Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates.

J. Brien, K. Nakatsu, B. McLaughlin, 1989, Canadian journal of physiology and pharmacology.

Calcium carbimide–ethanol interaction

J. Brien, C. Loomis, J. Peachey, 1980, Clinical pharmacology and therapeutics.

Alcohol exposure during late gestation adversely affects myocardial development with implications for postnatal cardiac function.

R. Harding, A. Bocking, M. Black, 2011, American journal of physiology. Heart and circulatory physiology.

Heme oxygenase activity in fetal and adult sheep is not altered by acclimatization to high altitude hypoxia.

R. Kinobe, J. Brien, L. Longo, 2006, Canadian journal of physiology and pharmacology.

The role of adenosine A1 receptor activation in ethanol-induced inhibition of stimulated glutamate release in the hippocampus of the fetal and adult guinea pig.

J. Brien, J. Reynolds, James F. Brien, 1995, Alcohol.

Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring

J. Reynolds, D. Brien, A. Winterborn, 2012, Nutrition & Diabetes.

Repeated amiodarone exposure in the rat: toxicity and effects on hepatic and extrahepatic monooxygenase activities.

T. Massey, R. Leeder, J. Brien, 1990, Canadian journal of physiology and pharmacology.

No effect of chronic ethanol administration on the activity of alcohol dehydrogenase and aldehyde dehydrogenases in the near-term pregnant guinea pig.

S. Card, J. Brien, 1989, Canadian journal of physiology and pharmacology.

In vitro Activation of heme oxygenase-2 by menadione and its analogs

Z. Jia, J. Brien, K. Nakatsu, 2014, Medical gas research.

Effect of hypoxia on glutamate efflux and synaptic transmission in the guinea pig hippocampus

J. W. Goh, D. Penning, J. Brien, 1993, Brain Research.

Release of glutamate and gamma-aminobutyric acid in the ovine fetal hippocampus: ontogeny and effect of hypoxia.

D. Penning, J. Brien, J. Patrick, 1991, Journal of developmental physiology.

The adenosine A(1)-receptor antagonist 8-CPT reverses ethanol-induced inhibition of fetal breathing movements.

A. Bocking, J. Brien, S. White, 1999, Journal of applied physiology.

Chronic prenatal ethanol exposure alters expression of central and peripheral insulin signaling molecules in adult guinea pig offspring.

J. Reynolds, A. Winterborn, J. Brien, 2014, Alcohol.

Does carbon monoxide play a role in cigarette smoke dependence?

L. Forkert, J. Brien, B. Milne, 2012 .

Effects of multiple-dose maternal ethanol infusion on fetal cardiovascular and brain activity in lambs.

B. Richardson, J. Brien, J. Patrick, 1988, American journal of obstetrics and gynecology.

Pharmacology of acetaldehyde.

J. Brien, C. Loomis, 1983, Canadian journal of physiology and pharmacology.

Glyceryl trinitrate-induced vasodilation is inhibited by ultraviolet irradiation despite enhanced nitric oxide generation: evidence for formation of a nitric oxide conjugate.

J. Brien, K. Nakatsu, B. McLaughlin, 1999, The Journal of pharmacology and experimental therapeutics.

YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.

J. Brien, K. Nakatsu, B. McLaughlin, 2001, Canadian journal of physiology and pharmacology.

Aldehyde dehydrogenase inhibitors as alcohol-sensitizing drugs: a pharmacological perspective

J. Brien, C. Loomis, 1985 .

The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.

J. Brien, K. Nakatsu, G. S. Marks, 1997, Canadian journal of physiology and pharmacology.

Heme oxygenase activity in the adult rat aorta and liver as measured by carbon monoxide formation.

D K Stevenson, K Nakatsu, D. Stevenson, 1995, Canadian journal of physiology and pharmacology.

The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta.

L. Bui, J. Brien, K. Nakatsu, 2004, Canadian journal of physiology and pharmacology.

Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole].

J. Brien, K. Nakatsu, B. McLaughlin, 2000, Canadian journal of physiology and pharmacology.

Lack of evidence for the involvement of cytochrome P-450 or other hemoproteins in metabolic activation of glyceryl trinitrate in rabbit aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1993, The Journal of pharmacology and experimental therapeutics.

Carbon monoxide does not inhibit glyceryl trinitrate biotransformation by or relaxation of aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1992, European journal of pharmacology.

What role does the heme-- heme oxygenase--carbon monoxide system play in vasoregulation?

J. Brien, K. Nakatsu, G. S. Marks, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

Effectiveness of Novel Imidazole-Dioxolane Heme Oxygenase Inhibitors in Renal Proximal Tubule Epithelial Cells

R. Motterlini, R. Kinobe, J. Brien, 2007, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of the action of nitric oxide prodrugs by pyocyanin: mechanistic studies.

J. Brien, D. Maurice, K. Nakatsu, 1997, Canadian journal of physiology and pharmacology.

Electrospray mass-spectrometric, spectrophotometric and electrochemical methods do not provide evidence for the binding of nitric oxide by pyocyanine at pH 7.

D. Zoutman, J. Brien, K. Nakatsu, 1997, The Biochemical journal.

Heme Oxygenase Expression in Selected Regions of Term Human Placenta

C. Graham, Graeme N. Smith, J. Brien, 2003, Experimental biology and medicine.

Requirement for reduced, unliganded hemoprotein for the hemoglobin- and myoglobin-mediated biotransformation of glyceryl trinitrate.

J. Brien, B. Bennett, K. Nakatsu, 1986, The Journal of pharmacology and experimental therapeutics.

Alcohol exposure during late ovine gestation alters fetal liver iron homeostasis without apparent dysmorphology.

R. Harding, J. Brien, R. De Matteo, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep.

E. Yan, W. Hoy, J. Bertram, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Carbon monoxide decreases perfusion pressure in isolated human placenta.

C. Graham, G. N. Smith, S. Bainbridge, 2002, Placenta.

Chronic ethanol exposure increases the non-dominant glucocorticoid, corticosterone, in the near-term pregnant guinea pig.

J. Reynolds, K. Wynne-Edwards, J. Brien, 2014, Alcohol.

Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 1988, Canadian journal of physiology and pharmacology.

Pulmonary fibrosis induced in the hamster by amiodarone and desethylamiodarone.

T. Massey, J. Brien, J. M. Daniels, 1989, Toxicology and applied pharmacology.

Thiol agents separate nitric oxide formation from vasodilation induced by glyceryl trinitrate.

J. Brien, K. Nakatsu, G. S. Marks, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Activity of alcohol dehydrogenase and aldehyde dehydrogenase in maternal liver, fetal liver and placenta of the near-term pregnant ewe.

Graeme N. Smith, B. Richardson, J. Brien, 1989, Developmental pharmacology and therapeutics.

Disposition of ethanol and its proximate metabolite, acetaldehyde, in the near-term pregnant ewe for short term maternal administration of moderate-dose ethanol.

B. Richardson, G. N. Smith, J. Brien, 1988, Drug metabolism and disposition: the biological fate of chemicals.

Disposition of ethanol and activity of hepatic and placental alcohol dehydrogenase and aldehyde dehydrogenases in the third-trimester pregnant guinea pig for single and short-term oral ethanol administration.

J. Brien, N. Steenaart, D. Clarke, 1986, Alcoholism, clinical and experimental research.

Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells.

F. C. Roth, Takashi Takahashi, T. Massey, 2013, Chemico-biological interactions.

Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro.

T. Massey, R. Leeder, J. Brien, 1996, Journal of biochemical toxicology.

Comparison of the in vivo pulmonary toxicity of amiodarone and des-oxo-amiodarone in the hamster.

T. Massey, G. Kabalka, R. Leeder, 1994, Toxicology and applied pharmacology.

Acetaldehyde concentration in rat blood and brain during the calcium carbimide--ethanol interaction.

J. Brien, D. Hoover, 1981, Canadian journal of physiology and pharmacology.

Effects of maternal ethanol infusion on fetal cardiovascular and brain activity in lambs.

B. Richardson, J. Brien, J. Patrick, 1985, American journal of obstetrics and gynecology.

Maternal glucose injections do not alter the suppression of fetal breathing following maternal ethanol ingestion.

J. Brien, J. Patrick, L. Carmichael, 1984, American journal of obstetrics and gynecology.

Differential susceptibilities of isolated hamster lung cell types to amiodarone toxicity.

T. Massey, J. Brien, W. J. Racz, 1998, Canadian journal of physiology and pharmacology.

Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.

R. Kinobe, J. Brien, J. Vlahakis, 2006, Journal of medicinal chemistry.

Interaction of glyceryl trinitrate and sodium nitroprusside with bovine pulmonary vein homogenate and 10,000 x g supernatant: biotransformation and nitric oxide formation.

J. Brien, K. Nakatsu, B. McLaughlin, 1991, Canadian journal of physiology and pharmacology.

Differential effects of chronic ethanol exposure on cytochrome P450 2E1 and the hypothalamic-pituitary-adrenal axis in the maternal-fetal unit of the guinea pig.

J. Reynolds, J. Brien, M. Poklewska-Koziell, 2010, Neurotoxicology and teratology.

The source of heme for vascular heme oxygenase I: heme uptake in rat aorta.

Ann Smith, L. Bui, J. Brien, 2004, Canadian journal of physiology and pharmacology.

Signal Transduction Pathways Involved in CO-Induced Vasodilation: The Role of Cyclic GMP/SolubleG uanylyl Cyclase

J. Brien, K. Nakatsu, B. McLaughlin, 2001 .

Effects of chronic prenatal ethanol exposure on mitochondrial glutathione and 8-iso-prostaglandin F2alpha concentrations in the hippocampus of the perinatal guinea pig.

J. Reynolds, G. Henderson, J. Brien, 2006, Reproduction, fertility, and development.

Fetal guinea pig brain 15-hydroxyprostaglandin dehydrogenase: ontogeny and effect of ethanol.

J. Brien, D. Treissman, 1991, Alcohol.

Sequestration of Glyceryl Trinitrate (Nitroglycerin) by Cardiopulmonary Bypass Oxygenators

J. Brien, B. Milne, K. Nakatsu, 1991, Anesthesia and Analgesia.

The calcium cyanamide--ethanol interaction in man. Effects of repeated ethanol administration.

J. Brien, C. Loomis, J. Peachey, 1981, Journal of Studies on Alcohol.

Effect of chronic prenatal ethanol exposure on nitric oxide synthase I and III proteins in the hippocampus of the near-term fetal guinea pig.

J. Reynolds, J. Brien, K. Kimura, 1999, Neurotoxicology and teratology.

Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex.

J. Reynolds, J. Brien, C. Bailey, 1999, Brain research. Developmental brain research.

Chronic Prenatal Ethanol Exposure Increases Glucocorticoid‐Induced Glutamate Release in the Hippocampus of the Near‐Term Foetal Guinea Pig

J. Reynolds, J. Brien, S. Matthews, 2006, Journal of neuroendocrinology.

Chronic prenatal ethanol exposure alters ionotropic glutamate receptor subunit protein levels in the adult guinea pig cerebral cortex.

J. Reynolds, C. Valenzuela, J. Brien, 2003, Alcoholism, clinical and experimental research.

Impaired acquisition in the water maze and hippocampal long‐term potentiation after chronic prenatal ethanol exposure in the guinea‐pig

J. Reynolds, M. Byrnes, H. Dringenberg, 2002, The European journal of neuroscience.

Chronic Prenatal Ethanol Exposure Increases GABAAReceptor Subunit Protein Expression in the Adult Guinea Pig Cerebral Cortex

J. Reynolds, J. Brien, C. Bailey, 2001, The Journal of Neuroscience.

Effect of chronic maternal ethanol administration on glutamate and N-methyl-D-aspartate binding sites in the hippocampus of the near-term fetal guinea pig.

J. Brien, S. Abdollah, 1995, Alcohol.

Heme oxygenase activity and immunohistochemical localization in bovine pulmonary artery and vein.

D. Stevenson, J. Brien, K. Nakatsu, 1997, Journal of cardiovascular pharmacology.

Use of nitroglycerin for uterine relaxation.

J. Brien, G. Smith, Graeme N. Smith, 1998, Obstetrical & gynecological survey.

Ethanol neurobehavioral teratogenesis and the role of the hippocampal glutamate-N-methyl-D-aspartate receptor-nitric oxide synthase system.

J. Reynolds, J. Brien, K. Kimura, 2000, Neurotoxicology and teratology.

Nitric oxide formation from glyceryl trinitrate in the developing guinea-pig hippocampus.

J. Brien, B. McLaughlin, M. Chang, 2000, Reproduction, fertility, and development.

Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations.

D. Stevenson, J. Brien, D. Maurice, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Effect of chronic maternal ethanol administration on nitric oxide synthase activity in the hippocampus of the mature fetal guinea pig.

J. Brien, K. Kimura, A. Parr, 1996, Alcoholism, clinical and experimental research.

Ontogeny of heme oxygenase activity in the hippocampus, frontal cerebral cortex, and cerebellum of the guinea pig.

D K Stevenson, K Nakatsu, D. Stevenson, 1996, Brain research. Developmental brain research.

Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function.

J. Brien, K. Nakatsu, G. S. Marks, 1993, Canadian journal of physiology and pharmacology.

The Physiological Role of Carbon Monoxide Derived from Heme Oxidation Catalyzed by Heme Oxygenase

J. Brien, K. Nakatsu, B. McLaughlin, 2001 .

Carbon monoxide formation in the guinea pig hippocampus: ontogeny and effect of in vitro ethanol exposure.

D. Stevenson, J. Brien, K. Nakatsu, 1997, Brain research. Developmental brain research.

Specificity of hepatic aldehyde dehydrogenase inhibition by calcium carbimide (calcium cyanamide) in the rat.

J. Brien, C. Loomis, 1983, Canadian journal of physiology and pharmacology.

Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

R. Kinobe, J. Brien, J. Vlahakis, 2005, Bioorganic & medicinal chemistry letters.

The calcium carbimide‐ethanol interaction: Effects of ethanol dose

J. Brien, C. Loomis, J. Peachey, 1979, Clinical pharmacology and therapeutics.

The Effects of Alcohol Exposure on Fetal Development

Parker J. Holman, J. Reynolds, J. Weinberg, 2016 .

Effect of ethanol on the release of prostaglandins from ovine fetal brain stem during gestation.

A. Bocking, G. N. Smith, J. Brien, 1992, Alcoholism, clinical and experimental research.

Effects of ethanol exposure on the embryo-fetus: experimental considerations, mechanisms, and the role of prostaglandins.

G. N. Smith, J. Brien, J. Patrick, 1991, Canadian journal of physiology and pharmacology.

Inhibition of the Enzymatic Activity of Heme Oxygenases by Azole-Based Antifungal Drugs

R. Kinobe, J. Brien, J. Vlahakis, 2006, Journal of Pharmacology and Experimental Therapeutics.

Heme oxygenase activity in placenta: direct dependence on oxygen availability.

C. Graham, Graeme N. Smith, J. Brien, 2002, American journal of physiology. Heart and circulatory physiology.

Disposition and pharmacokinetics of disulfiram and calcium carbimide (calcium cyanamide).

J. Brien, C. Loomis, 1983, Drug metabolism reviews.

Chemical assays for disulfiram and carbimide (cyanamide) in biological fluids.

J. Brien, C. Loomis, 1983, Alcoholism, clinical and experimental research.

Determination of disopyramide and mono-N-desisopropyl-disopyramide in serum by gas-liquid chromatography with nitrogen-selective detection.

P. Armstrong, J. Brien, K. Nakatsu, 1983, Journal of pharmacological methods.

Determination of carbimide in plasma by gas-liquid chromatography.

J. Brien, C. Loomis, 1981, Journal of chromatography.

A study of the calcium carbimide-ethanol interaction in man: symptom responses.

J. Brien, C. Loomis, J. Peachey, 1980, Alcoholism, clinical and experimental research.

Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells.

C. Graham, G. N. Smith, J. Brien, 2003, American journal of physiology. Heart and circulatory physiology.

Spatial acquisition in the Morris water maze and hippocampal long-term potentiation in the adult guinea pig following brain growth spurt--prenatal ethanol exposure.

J. Reynolds, M. Byrnes, H. Dringenberg, 2004, Neurotoxicology and teratology.

Chronic prenatal ethanol exposure alters hippocampal GABAA receptors and impairs spatial learning in the guinea pig

J. Reynolds, H. Dringenberg, J. Brien, 2004, Behavioural Brain Research.

Gas-liquid chromatographic determination of ethanol and acetaldehyde in blood.

J. Brien, C. Loomis, J. Brien, 1978, Clinica chimica acta; international journal of clinical chemistry.

Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells.

Takashi Takahashi, T. Massey, J. Brien, 2008, Toxicology and applied pharmacology.

Relationship between myocardial amiodarone concentration and antiarrhythmic effect in dogs with myocardial infarction and electrically induced ventricular arrhythmias.

H. Abdollah, J. Brien, S. Jimmo, 1991, Canadian journal of physiology and pharmacology.

A comparative study of the inhibition of hepatic aldehyde dehydrogenases in the rat by methyltetrazolethiol, calcium carbimide, and disulfiram.

J. Brien, C. Loomis, N. Steenaart, 1985, Canadian journal of physiology and pharmacology.

Ethanol neurobehavioural teratogenesis and the role of L-glutamate in the fetal hippocampus.

J. Brien, J. Reynolds, 1995, Canadian journal of physiology and pharmacology.

Ethanol increases uterine blood flow and fetal arterial blood oxygen tension in the near-term pregnant ewe.

F. Dexter, D. Penning, J. Brien, 1996, Alcohol.

Disposition of ethanol in maternal blood, fetal blood, and amniotic fluid of third-trimester pregnant ewes.

B. Richardson, J. Brien, J. Patrick, 1985, American journal of obstetrics and gynecology.

Fetal breathing is not inhibited by ethanol exposure during prolonged reduced uterine blood flow.

A. Bocking, J. Brien, J. Challis, 1996, Canadian journal of physiology and pharmacology.

Effects of alcohol (ethanol) on the fetus.

G. N. Smith, J. Brien, 1991, Journal of developmental physiology.

Effect of ethanol on ovine fetal and maternal plasma prostaglandin E2 concentrations and fetal breathing movements.

G. N. Smith, J. Brien, J. Patrick, 1990, Journal of developmental physiology.

Analysis of nanomolar S-nitrosothiol concentrations in physiological media.

K Nakatsu, D. Zoutman, J. Brien, 1998, Journal of pharmacological and toxicological methods.

Analysis of pyocyanin from Pseudomonas aeruginosa by adsorptive stripping voltammetry.

K Nakatsu, D. Zoutman, J. Brien, 1996, Journal of pharmacological and toxicological methods.

Dose-dependent effects of acute in vivo ethanol exposure on extracellular glutamate concentration in the cerebral cortex of the near-term fetal sheep.

F. Dexter, D. Penning, D. Chestnut, 1995, Alcoholism, clinical and experimental research.

Nitrate and nitrite anion concentration in the intact cerebral cortex of preterm and nearterm fetal sheep: indirect index of in vivo nitric oxide formation.

D. Penning, J. Brien, J. Reynolds, 1998, Journal of pharmacological and toxicological methods.

Ethanol-induced changes in prostaglandin E concentration in the intact cerebral cortex of preterm and near-term fetal sheep.

F. Dexter, D. Penning, J. Brien, 1997, Alcoholism, clinical and experimental research.

Effects of acute ethanol exposure on glutamate release in the hippocampus of the fetal and adult guinea pig.

J. Brien, J. Reynolds, 1994, Alcohol.

Ethanol neuro-behavioural teratogenesis in the guinea pig: behavioural dysfunction and hippocampal morphologic change.

J. Brien, M. Catlin, S. Abdollah, 1993, Canadian journal of physiology and pharmacology.

Dose-dependent effects of prenatal ethanol exposure in the guinea pig.

J. Brien, M. Catlin, S. Abdollah, 1993, Alcohol.

Effect of acute, multiple-dose ethanol on maternal and fetal blood gases and acid-base balance in the near-term pregnant ewe.

G. N. Smith, J. Brien, J. Patrick, 1989, Canadian journal of physiology and pharmacology.

Cerebral oxidative metabolism in fetal sheep with multiple-dose ethanol infusion.

B. Richardson, J. Brien, J. Patrick, 1987, American journal of obstetrics and gynecology.

Chronic Prenatal Ethanol Exposure Impairs Conditioned Responding and Enhances GABA Release in the Hippocampus of the Adult Guinea Pig

J. Reynolds, M. Olmstead, H. Dringenberg, 2004, Journal of Pharmacology and Experimental Therapeutics.

Chronic ethanol exposure and folic acid supplementation: fetal growth and folate status in the maternal and fetal guinea pig.

J. Reynolds, C. Collier, J. Brien, 2011, Reproductive toxicology.

Disposition of amiodarone and its proximate metabolite, desethylamiodarone, in the dog for oral administration of single-dose and short-term drug regimens.

P. Armstrong, H. Abdollah, J. Brien, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone- and vehicle-treated hamsters.

T. Massey, R. Leeder, J. Brien, 1999, Toxicology.

Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.

T. Massey, J. Brien, J. Card, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Measurement of acute and chronic behavioural effects of methamphetamine in the mouse

J. Brien, J. Peachey, A. MacLean, 1976, Psychopharmacology.

Plasma disposition and hemo‐dynamic effects of a single oral dose of isosorbide dinitrate in human males and females

G. Savard, E. Toffelmire, H. Abdollah, 1992, Biopharmaceutics & drug disposition.

The effects of hypothermic and normothermic cardiopulmonary bypass on glyceryl trinitrate activity.

J. Brien, B. Milne, F. Cervenko, 1994, Anesthesia and analgesia.

An extracellular source of heme can induce a significant heme oxygenase mediated relaxation in the rat aorta.

J. Brien, K. Nakatsu, B. McLaughlin, 2002, Canadian journal of physiology and pharmacology.

Determination of the major urinary metabolite of diphenylhydantoin by high-performance liquid chromatography

J. Brien, T. Inaba, 1973 .

Comparative drug elimination in man — Diphenylhydantoin and amobarbital

W. Kalow, J. Brien, T. Inaba, 1975, European Journal of Clinical Pharmacology.

Determination of low levels of 5,5-diphenylhydantoin in serum by gas-liquid chromatography.

J. Brien, T. Inaba, 1974, Journal of chromatography.

Sequestration of Glyceryl Cardiopulmonary Bypass Trinitrate (Nitroglycerin) by Oxygenators

J. Brien, B. Milne, K. Nakatsu, 2006 .

Assay of glyceryl trinitrate, isosorbide dinitrate, and their metabolites in plasma by large‐bore capillary column gas‐liquid chromatography

J. Mccans, J. Brien, B. Bennett, 1990, Biopharmaceutics & drug disposition.

Chronic Prenatal Ethanol Exposure Alters Glucocorticoid Signalling in the Hippocampus of the Postnatal Guinea Pig

J. Reynolds, J. Brien, S. Matthews, 2005, Journal of neuroendocrinology.

Determination of isosorbide dinitrate biotransformation in various tissues of the rabbit by capillary column gas-liquid chromatography.

J. Brien, K. Nakatsu, G. S. Marks, 1987, Biopharmaceutics & drug disposition.

Differential pharmacokinetics for oral and intraperitoneal administration of ethanol to the pregnant guinea pig.

J. Brien, N. Steenaart, D. Clarke, 1985, Canadian journal of physiology and pharmacology.

Binding of acetaldehyde to human and Guinea pig placentae in vitro.

G. Koren, M. Hard, J. Brien, 2003, Placenta.

Ontogeny of the activity of alcohol dehydrogenase and aldehyde dehydrogenases in the liver and placenta of the guinea pig.

S. Card, J. Brien, S. Tompkins, 1989, Biochemical pharmacology.

Disposition of acute, multiple-dose ethanol in the near-term pregnant ewe.

B. Richardson, G. N. Smith, J. Brien, 1987, American journal of obstetrics and gynecology.

Pharmacokinetics of ethanol and its metabolite, acetaldehyde, and fetolethality in the third-trimester pregnant guinea pig for oral administration of acute, multiple-dose ethanol.

J. Brien, N. Steenaart, D. Clarke, 1986, Canadian journal of physiology and pharmacology.

The role of fetal urinary excretion in the transfer of ethanol into amniotic fluid after maternal administration of ethanol to the near-term pregnant ewe.

B. Richardson, G. N. Smith, J. Brien, 1987, Canadian journal of physiology and pharmacology.

Nitric oxide synthase activity in the hippocampus, frontal cerebral cortex, and cerebellum of the guinea pig: ontogeny and in vitro ethanol exposure.

J. Brien, J. Reynolds, B. Kalisch, 1995, Alcohol.

Gas-liquid chromatographic determination of ethanol and acetaldehyde in tissues.

J. Brien, D. Hoover, J. Brien, 1980, Journal of pharmacological methods.

Increased cerebral extracellular adenosine and decreased PGE2 during ethanol-induced inhibition of FBM.

A. Bocking, J. Brien, J. Challis, 1999, Journal of applied physiology.

Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis.

T. Massey, J. Brien, W. Chung, 2001, American journal of physiology. Lung cellular and molecular physiology.

Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells.

T. Massey, J. Brien, W. J. Racz, 2001, Toxicology.

Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity.

T. Massey, J. Brien, J. Card, 2001, The Journal of pharmacology and experimental therapeutics.

Alcohol exposure during late gestation: multiple developmental outcomes in sheep.

J. Bertram, H. Parkington, R. Harding, 2012, Journal of developmental origins of health and disease.

Potential Role of the Placenta in Fetal Alcohol Spectrum Disorder

J. Reynolds, G. Koren, J. Brien, 2009, Paediatric drugs.

Chronic Prenatal Ethanol Exposure and Increased Concentration of Fatty Acid Ethyl Esters in Meconium of Term Fetal Guinea Pig

J. Reynolds, G. Koren, A. Bocking, 2006, Therapeutic drug monitoring.

In vitro hepatic, renal, and pulmonary N-dealkylation of amiodarone.

T. Massey, R. Leeder, J. Brien, 1990, Biochemical pharmacology.

Maternal alcohol consumption in pregnancy enhances arterial stiffness and alters vasodilator function that varies between vascular beds in fetal sheep

D. Walker, H. Coleman, H. Parkington, 2014, The Journal of physiology.

Spatial learning in the guinea pig: cued versus non-cued learning, sex differences, and comparison with rats

J. Reynolds, H. Dringenberg, J. Brien, 2001, Behavioural Brain Research.

Thiol agents potentiate glyceryl trinitrate mediated relaxation of rabbit taenia coli: evidence for thiol-dependent biotransformation.

J. Brien, K. Nakatsu, G. S. Marks, 1997, Canadian journal of physiology and pharmacology.

Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.

J. Brien, S. Jimmo, K. Nakatsu, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Mechanism of glyceryl trinitrate-induced vasodilation. II. Lack of evidence for specific binding of GTN to bovine pulmonary vein.

J. Brien, K. Nakatsu, G. S. Marks, 1988, The Journal of pharmacology and experimental therapeutics.

Meconium Fatty Acid Ethyl Esters as Biomarkers of Late Gestational Ethanol Exposure and Indicator of Ethanol-Induced Multi-Organ Injury in Fetal Sheep

G. Koren, R. Harding, A. Bocking, 2013, PloS one.

Fatty acid ethyl esters (FAEE); comparative accumulation in human and guinea pig hair as a biomarker for prenatal alcohol exposure.

J. Reynolds, G. Koren, B. Kapur, 2006, Alcohol and alcoholism.

A Guinea Pig Model for the Identification of In Utero Alcohol Exposure Using Fatty Acid Ethyl Esters in Neonatal Hair

J. Reynolds, G. Koren, J. Brien, 2005, Pediatric Research.

Biotransformation of Glyceryl Trinitrate and Elevation of Cyclic GMP Precede Glyceryl Trinitrate‐Induced Vasodilation

J. Brien, K. Nakatsu, B. McLaughlin, 1990, Journal of cardiovascular pharmacology.

Inhibition of hepatic aldehyde dehydrogenases in the rat by calcium carbimide (calcium cyanamide).

J. Brien, C. Loomis, 1983, Canadian journal of physiology and pharmacology.

Selectivity of imidazole–dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms

R. Kinobe, J. Brien, J. Vlahakis, 2006, British journal of pharmacology.

Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells.

C. Graham, G. N. Smith, J. Brien, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta.

S. Macdonald-Goodfellow, C. Graham, G. N. Smith, 2003, American journal of physiology. Heart and circulatory physiology.

Measurement of endogenous carbon monoxide formation in biological systems.

J. Brien, K. Nakatsu, B. McLaughlin, 2002, Antioxidants & redox signaling.

Endogenous carbon monoxide formation by chorionic villi of term human placenta.

D. Stevenson, C. Graham, G. N. Smith, 2001, Placenta.

Heme oxygenase activity in term human placenta.

C. Graham, G. N. Smith, J. Brien, 2000, Placenta.

Heme oxygenase and nitric oxide synthase in the placenta of the guinea-pig during gestation.

C. Graham, J. Brien, K. Nakatsu, 1998, Placenta.

Effects of prenatal ethanol exposure on the lungs of postnatal lambs.

P. Meikle, R. Harding, A. Bocking, 2011, American journal of physiology. Lung cellular and molecular physiology.

Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung.

R. Harding, A. Bocking, J. Brien, 2009, American journal of physiology. Lung cellular and molecular physiology.

Relaxation of Vascular Smooth Muscle by Organic Nitrates: Ideas and Hypotheses on a Still Unsolved Problem

J. Brien, B. Bennett, K. Nakatsu, 1986 .

A comparative study of glyceryl trinitrate biotransformation and glyceryl trinitrate induced relaxation in bovine pulmonary artery and vein.

J. Brien, K. Nakatsu, G. S. Marks, 1987, Canadian journal of physiology and pharmacology.

Ontogeny of nitric oxide synthase I and III protein expression and enzymatic activity in the guinea pig hippocampus.

J. Reynolds, J. Brien, K. Kimura, 1999, Brain research. Developmental brain research.

Biotransformation of glyceryl trinitrate to glyceryl dinitrate by human hemoglobin.

J. Brien, B. Bennett, K. Nakatsu, 1984, Canadian journal of physiology and pharmacology.

Chemiluminescence headspace-gas analysis for determination of nitric oxide formation in biological systems.

J. Brien, K. Nakatsu, B. McLaughlin, 1996, Methods in enzymology.

Rapid high-performance liquid chromatographic analysis of amiodarone and N-desethyl-amiodarone in serum.

P. Armstrong, J. Brien, S. Jimmo, 1983, Canadian journal of physiology and pharmacology.

Increased uteroplacental production of prostaglandin E2 during ethanol infusion.

A. Bocking, G. N. Smith, J. Brien, 1993, The American journal of physiology.

Heme oxygenase activity and acute and chronic ethanol exposure in the hippocampus, frontal cerebral cortex, and cerebellum of the near-term fetal guinea pig.

D. Stevenson, J. Brien, K. Nakatsu, 1997, Alcohol.

Investigation of the role of oxidative stress in amiodarone-induced pulmonary toxicity in the hamster.

T. Massey, R. Leeder, J. Brien, 1994, Canadian Journal of Physiology and Pharmacology.

Attenuation of Amiodarone-Induced Pulmonary Fibrosis by Vitamin E Is Associated with Suppression of Transforming Growth Factor-β1 Gene Expression but Not Prevention of Mitochondrial Dysfunction

T. Massey, J. Brien, J. Card, 2003, Journal of Pharmacology and Experimental Therapeutics.

Hippocampal nitric oxide synthase in the fetal guinea pig: effects of chronic prenatal ethanol exposure.

J. Brien, K. Kimura, 1998, Brain research. Developmental brain research.

A comparative study of the behavioural responses induced by chronic administration of methamphetamine and amphetamine in mice

J. Brien, J. Peachey, B. Rogers, 1977, Psychopharmacology.

In vitro ethanol exposure decreases potassium-stimulated, but not veratridine-stimulated, glutamate release in the guinea pig hippocampus.

J. Reynolds, J. Brien, N. Butters, 2001, Alcohol.

Gram quantity synthesis and chromatographic assessment of 3,3′,4,4′-tetrachlorobiphenyl

J. Brien, K. Nakatsu, G. S. Marks, 1982 .

Hippocampal hyperexcitability in fetal alcohol spectrum disorder: Pathological sharp waves and excitatory/inhibitory synaptic imbalance

J. Reynolds, P. Carlen, M. Krawczyk, 2016, Experimental Neurology.

Maternal ethanol consumption by pregnant guinea pigs causes neurobehavioral deficits and increases ethanol preference in offspring

J. Reynolds, M. Olmstead, J. Brien, 2012, Behavioural pharmacology.

Selective activation of heme oxygenase-2 by menadione.

Z. Jia, J. Brien, K. Nakatsu, 2011, Canadian journal of physiology and pharmacology.

RAPID COMMUNICATION / COMMUNICATION RAPIDE

Z. Jia, J. Brien, K. Nakatsu, 2011 .

Altered water–maze search behavior in adult guinea pigs following chronic prenatal ethanol exposure: Lack of mitigation by postnatal fluoxetine treatment

Teresa D. McAdam, J. Reynolds, H. Dringenberg, 2008, Behavioural Brain Research.

Effects of maternal administration of vitamins C and E on ethanol neurobehavioral teratogenicity in the guinea pig.

J. Reynolds, H. Dringenberg, J. Brien, 2007, Alcohol.

Chronic prenatal ethanol exposure-induced decrease of guinea pig hippocampal CA1 pyramidal cell and cerebellar Purkinje cell density.

J. Reynolds, J. Brien, Tara N McGoey, 2003, Canadian journal of physiology and pharmacology.

Effect of prenatal ethanol exposure during the brain growth spurt of the guinea pig.

J. Reynolds, M. Byrnes, J. Brien, 2001, Neurotoxicology and teratology.

Chronic prenatal ethanol exposure increases apoptosis in the hippocampus of the term fetal guinea pig.

J. Reynolds, J. Brien, B. Bennett, 2005, Neurotoxicology and teratology.

Effects of chronic prenatal ethanol exposure on locomotor activity, and hippocampal weight, neurons, and nitric oxide synthase activity of the young postnatal guinea pig.

J. Reynolds, J. Brien, N. Butters, 2000, Neurotoxicology and teratology.

Altered GABA(A)-benzodiazepine receptor number and pharmacology in the adult guinea pig cerebral cortex after chronic prenatal ethanol exposure.

J. Reynolds, J. Brien, C. Bailey, 1999, Alcoholism, clinical and experimental research.

Effects of chronic prenatal ethanol exposure on cGMP content and glutamate release in the hippocampus of the neonatal guinea pig.

J. Reynolds, J. Brien, N. Butters, 2003, Neurotoxicology and teratology.

Gas-liquid chromatographic determination of salsolinol in the striatum of rat brain during the calcium carbimide--ethanol interaction.

J. A. Page, J. Brien, P. Andrews, 1983, Canadian Journal of Physiology and Pharmacology.

A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide.

J. Brien, C. Loomis, J. Peachey, 1981, Journal of clinical psychopharmacology.

A facile, reliable method for staining blood vessel endothelium.

J. Brien, K. Nakatsu, G. S. Marks, 1988, Journal of pharmacological methods.

Methamphetamine-induced behavioural effects and brain concentrations of methamphetamine and its metabolite amphetamine in mice.

J. Brien, J. Peachey, B. Rogers, 1978, Research communications in chemical pathology and pharmacology.

Effects of chronic prenatal ethanol exposure on hippocampal glutamate release in the postnatal guinea pig.

J. Reynolds, J. Brien, N. Butters, 2000, Alcohol.

Comparative study of sodium nitroprusside induced vasodilation of human placental veins from premature and full-term normotensive and preeclamptic pregnancy.

G. N. Smith, J. Brien, S. Pancham, 1995, Canadian journal of physiology and pharmacology.

Endothelium-dependent relaxation of rabbit aorta by acetylcholine requires ethylenediaminetetraacetic acid.

J. Brien, K. Nakatsu, G. S. Marks, 1986, Canadian journal of physiology and pharmacology.

THE BASIC SCIENCE OF FETAL ALCOHOL SPECTRUM DISORDER : NOVEL MOLECULAR MECHANISMS AND POTENTIAL TARGETS FOR THERAPEUTIC INTERVENTION

J. Reynolds, C. Valenzuela, J. Brien, 2007 .

Direct evidence for nitric oxide formation from glyceryl trinitrate during incubation with intact bovine pulmonary artery.

J. Brien, K. Nakatsu, B. McLaughlin, 1992, Canadian journal of physiology and pharmacology.

Ontogeny of glutamate and gamma-aminobutyric acid release in the hippocampus of the guinea pig.

J. Brien, J. Reynolds, 1992, Journal of developmental physiology.

Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors.

Z. Jia, R. Kinobe, J. Brien, 2010, Canadian journal of physiology and pharmacology.

Differential expression of astrocytic connexins in a mouse model of prenatal alcohol exposure

J. Reynolds, P. Carlen, M. Krawczyk, 2016, Neurobiology of Disease.

A study of the calcium carbimide-ethanol interaction in man

J. Brien, C. Loomis, J. Peachey, 1978, European Journal of Clinical Pharmacology.

Amphetamine‐induced stereotyped behaviour and brain concentrations of amphetamine and its hydroxylated metabolites in mice

J. Brien, J. Peachey, B. Rogers, 1977, The Journal of pharmacy and pharmacology.

Chronic ethanol exposure alters MK-801 binding sites in the cerebral cortex of the near-term fetal guinea pig.

J. Reynolds, J. Eubanks, J. Brien, 1999, Alcohol.

Sulfhydryl involvement in nitric oxide sequestration and nitric oxide induced guanylyl cyclase activation in vascular smooth muscle.

J. Brien, K. Nakatsu, B. McLaughlin, 1995, Canadian journal of physiology and pharmacology.

Effects of chronic prenatal ethanol exposure on NMDA receptor number and affinity for [3H]MK-801 in the cerebral cortex of the young postnatal and adult guinea-pig.

J. Reynolds, J. Brien, Rajan K Puri, 2003, Reproduction, fertility, and development.

Brain growth spurt-prenatal ethanol exposure and the guinea pig hippocampal glutamate signaling system.

J. Reynolds, M. Byrnes, J. Brien, 2003, Neurotoxicology and teratology.

Differential expression of astrocytic connexins in a mouse model of prenatal alcohol exposure

J. Reynolds, P. Carlen, M. Krawczyk, 2016, Neurobiology of Disease.

Chronic ethanol exposure during late gestation produces behavioral anomalies in neonatal lambs.

R. Allrich, J. Brien, J. Reynolds, 2000, Neurotoxicology and teratology.

Alcohol exposure during late gestation: multiple developmental outcomes in sheep.

J. Bertram, H. Parkington, R. Harding, 2012, Journal of developmental origins of health and disease.

Glutamate and N-methyl-D-aspartate binding sites in the guinea pig hippocampus: ontogeny and effect of acute in vitro ethanol exposure.

J. Brien, S. Abdollah, 1995, Alcohol.

Antiarrhythmic Effect of Chronic Oral Amiodarone Treatment in Dogs with Myocardial Infarction and Reproducibly Inducible Sustained Ventricular Arrhythmias

H. Abdollah, J. Brien, F. Brennan, 1990, Journal of cardiovascular pharmacology.

Antiarrhythmic effects of desethylamiodarone in dogs with subacute myocardial infarction and inducible ventricular arrhythmias.

H. Abdollah, J. Brien, F. Brennan, 1989, Journal of cardiovascular pharmacology.

Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.

T. Massey, J. Brien, J. Card, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Selective sequestration of nitric oxide by subcellular components of vascular smooth muscle and platelets: relationship to nitric oxide stimulation of the soluble guanylyl cyclase.

J. Brien, D. Maurice, K. Nakatsu, 1993, Canadian journal of physiology and pharmacology.

Cardiovascular changes during the calcium carbimide–ethanol interaction

G. M. Robinson, J. Brien, J. Peachey, 1981, Clinical pharmacology and therapeutics.

Spatial learning deficits induced by chronic prenatal ethanol exposure can be overcome by non-spatial pre-training.

J. Reynolds, J. Brien, U. Iqbal, 2006, Neurotoxicology and teratology.