S. Morley

发表

Differential requirements for caspase‐8 activity in the mechanism of phosphorylation of eIF2α, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells

M. Clemens, M. Bushell, V. M. Pain, 2000, FEBS letters.

The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells*

C. Fraser, V. M. Pain, S. Morley, 1999, The Journal of Biological Chemistry.

Cleavage of translation initiation factor 4G (eIF4G) during anti‐Fas IgM‐induced apoptosis does not require signalling through the p38 mitogen‐activated protein (MAP) kinase

L. McKendrick, M. Bushell, S. Morley, 1998, FEBS letters.

Degradation of eukaryotic polypeptide chain initiation factor (eIF) 4G in response to induction of apoptosis in human lymphoma cell lines

M. Clemens, M. Bushell, S. Morley, 1998, Oncogene.

The translation initiation factor ( eIF ) 4 F complex is compartmentalised in normally growing fibroblasts , but is not directly localised to either the actin or tubulin cytoskeleton

S. Morley, M. Willett, S. Flint, 2007 .

Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts.

V. M. Pain, S. Morley, M. Willett, 2006, Experimental cell research.

Shortfalls in the peptidyl-prolyl cis–trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias

N. Cairns, S. Morley, J. Kay, 2004, Neurobiology of Disease.

Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6.

S. Morley, J. A. Traugh, J. Traugh, 1993, Biochimie.

Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG

V. M. Pain, S. Morley, T. Hinton, 2004, Journal of Cell Science.

Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation

Robert A. Baldock, F. Z. Watts, S. Morley, 2014, Translation.

Analysis of translational activity of extracts derived from oocytes and eggs of Xenopus laevis.

R. Cox, V. M. Pain, S. Morley, 1998, Methods in molecular biology.

The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex.

S. Morley, Joanne L. Cowan, J. L. Cowan, 2004, European journal of biochemistry.

The proteasome inhibitor , MG 132 , promotes the reprogramming of translation in C 2 C 12 myoblasts and facilitates the association of hsp 25 with the eIF 4 F complex

S. Morley, Joanne L. Cowan, J. L. Cowan, 2004 .

Disruption of the Interaction of Mammalian Protein Synthesis Eukaryotic Initiation Factor 4B with the Poly(A)-binding Protein by Caspase- and Viral Protease-mediated Cleavages*

M. Clemens, M. Bushell, V. M. Pain, 2001, The Journal of Biological Chemistry.

Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis.

M. Clemens, M. Bushell, S. Morley, 2000, European journal of biochemistry.

Utilizing the Peptidyl-Prolyl Cis-Trans Isomerase Pin1 as a Probe of Its Phosphorylated Target Proteins: Examples of Binding to Nuclear Proteins in a Human Kidney Cell Line and to Tau in Alzheimer's Diseased Brain

S. Morley, S. Rulten, J. Thorpe, 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death

F. Zhang, N. Sonenberg, M. Bennett, 2011, Proceedings of the National Academy of Sciences.

Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation

R. Jackson, L. McKendrick, S. Morley, 2001, The EMBO journal.

CHAPTER 17 – INTRACELLULAR MESSENGERS AND THE CONTROL OF PROTEIN SYNTHESIS

S. Morley, G. Thomas, 1993 .

Intracellular messengers and the control of protein synthesis.

G. Thomas, S. Morley, 1991, Pharmacology & therapeutics.

Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase.

M. Clemens, M. Bushell, S. Morley, 2002, Cancer research.

RNA-dependent Protein Kinase DNA-damaging Agent for Caspases and the Double-stranded Family and a α Requirements by the Tumor Necrosis Factor Inhibition of Protein Synthesis in Apoptosis : Differential Updated

M. Clemens, M. Bushell, S. Morley, 2002 .

Inhibition of Protein Synthesis in Apoptosis: Differential Requirements by the Tumor Necrosis Factor Family and a DNA-damaging Agent for Caspases and the Double-stranded RNA-dependent Protein Kinase

M. Clemens, M. Bushell, S. Morley, 2002 .

Inhibition of Protein Synthesis in Apoptosis : Differential Requirements by the Tumor Necrosis Factor Family and a DNA-damaging Agent for Caspases and the Double-stranded RNA-dependent Protein Kinase 1

M. Clemens, M. Bushell, S. Morley, 2002 .

Translation initiation factor 4E.

L. McKendrick, V. M. Pain, S. Morley, 1999, The international journal of biochemistry & cell biology.

Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines.

D. Walsh, P. Meleady, M. Clynes, 2003, Differentiation; research in biological diversity.

Involvement of Stress-activated Protein Kinase and p38/RK Mitogen-activated Protein Kinase Signaling Pathways in the Enhanced Phosphorylation of Initiation Factor 4E in NIH 3T3 Cells*

L. McKendrick, S. Morley, 1997, The Journal of Biological Chemistry.

Molecular Cross-talk between MEK1/2 and mTOR Signaling during Recovery of 293 Cells from Hypertonic Stress*

S. Morley, S. Naegele, 2004, Journal of Biological Chemistry.

Requirement for the eIF4E Binding Proteins for the Synergistic Down-Regulation of Protein Synthesis by Hypertonic Conditions and mTOR Inhibition

M. Clemens, S. Morley, A. Elia, 2013, PloS one.

Signalling through either the p38 or ERK mitogen‐activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR‐CD3)‐stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells

S. Morley, 1997, FEBS letters.

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Hannah J. Maple, T. Chevassut, O. Fedorov, 2019, Organometallics.

Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1

Hannah J. Maple, T. Chevassut, G. Gasser, 2021, Helvetica Chimica Acta.

Nutrient-responsive mTOR signalling grows on Sterile ground.

S. Cook, S. Morley, 2007, The Biochemical journal.

The Histone 3′-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3

W. Marzluff, V. M. Pain, D. Gallie, 2002, Molecular and Cellular Biology.

Proteolytic cleavage of initiation factor eIF-4 gamma in the reticulocyte lysate inhibits translation of capped mRNAs but enhances that of uncapped mRNAs.

V. M. Pain, T. Ohlmann, S. Morley, 1995, Nucleic acids research.

Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase‐8‐independent mechanisms in Jurkat T cell lines

V. M. Pain, S. Morley, 2001, FEBS letters.

The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS‐I; 4E‐BP1) in the reticulocyte lysate

V. M. Pain, T. Ohlmann, S. Morley, 1997, The EMBO journal.

A genomic approach to overcoming temozolomide resistance in glioblastoma multiforme

J. L. Smalley, T. Gant, Shu-Dong Zhang, 2011 .

Caspase‐3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis

M. Clemens, L. McKendrick, R. Jänicke, 1999, FEBS letters.

Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38.

S. Morley, S. Naegele, 2003, Cellular signalling.

Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo.

L. McKendrick, R. Jagus, V. M. Pain, 2001, European journal of biochemistry.

Identification and early activation of a Xenopus laevis p70s6k following progesterone‐induced meiotic maturation.

M. Dorée, G. Thomas, S. Kozma, 1992, The EMBO journal.

Phosphorylation of Eukaryotic Initiation Factor (eIF) 4E Is Not Required for de Novo Protein Synthesis following Recovery from Hypertonic Stress in Human Kidney Cells*

S. Morley, S. Naegele, 2002, The Journal of Biological Chemistry.

Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1.

S. Morley, M. Willett, Joanne L. Cowan, 2009, Cellular signalling.

Role of p70 S6 kinase in lymphocyte activation.

S. Morley, J. Kay, V. Frost, 1996, Biochemical Society transactions.

The mitogen activated S6 kinase; sites of phosphorylation which lead to activation and identification of a putative kinase kinase.

S. Ferrari, G. Thomas, S. Morley, 1993, Biochemical Society transactions.

Phosphorylation by Aurora-B Negatively Regulates Survivin Function During Mitosis

J. Swedlow, R. Medema, S. Lens, 2007, Cell cycle.

Sumoylation of eIF4A2 affects stress granule formation

Robert A. Baldock, F. Z. Watts, S. Morley, 2016, Journal of Cell Science.

Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability*

S. Desrivières, Y. Nagamine, S. Hashemolhosseini, 1998, The Journal of Biological Chemistry.

Signaling pathways open the GAITway to translational control.

S. Morley, M. Willett, 2008, Developmental cell.

Cellular stress in xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein.

C. Fraser, V. M. Pain, S. Morley, 1999, The Biochemical journal.

Cellular stress in xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein.

C. Fraser, V. M. Pain, S. Morley, 1999, The Biochemical journal.

A fractionated reticulocyte lysate system for studies on protein synthesis initiation factors.

V. M. Pain, T. Ohlmann, S. Morley, 1998, Methods in molecular biology.

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

S. Morley, J. Traugh, 1990, The Journal of biological chemistry.

Preparation and properties of an improved cell-free protein synthesis system from mammalian liver.

R. Jackson, S. Morley, 1985, Biochimica et biophysica acta.

Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F.

S. Morley, J. Traugh, 1989, The Journal of biological chemistry.

A fractionated reticulocyte lysate retains high efficiency for protein synthesis.

J. Hershey, S. Morley, 1990, Biochimie.

eIF4G: translation's mystery factor begins to yield its secrets.

V. M. Pain, S. Morley, P. S. Curtis, 1997, RNA.

The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading

S. Cooper, S. Sweet, S. Morley, 2017, The Biochemical journal.

Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F‐actin and the organization of microtubules

V. M. Pain, S. Morley, J. Thorpe, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

Multiple isoforms of the translation initiation factor eIF4GII are generated via use of alternative promoters, splice sites and a non-canonical initiation codon.

S. Morley, R. Barrett, Joanne L. Cowan, 2012, The Biochemical journal.

Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells

M J Clemens, M. Clemens, M. Bushell, 2000, Cell Death and Differentiation.

Localization of ribosomes and translation initiation factors to talin/β3‐integrin‐enriched adhesion complexes in spreading and migrating mammalian cells

S. Morley, M. Willett, Hilary J Pollard, 2010, Biology of the cell.

mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells

S. Morley, A. Chalmers, S. Smalley, 2014, Molecular Cancer.

The regulation of eIF4F during cell growth and cell death.

S. Morley, 2001, Progress in molecular and subcellular biology.

Systems Biology of Cancer: Regulation and dysregulation of protein synthesis in cancer cells

M. Clemens, S. Morley, A. Elia, 2015 .

Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers.

J. Spencer, S. Morley, Ella Lineham, 2017, Future medicinal chemistry.

Translational Activity Factor 4GI Show Differences in Specific Isoforms of Translation Initiation

S. Morley, M. Coldwell, 2014 .

Specific Isoforms of Translation Initiation Factor 4GI Show Differences in Translational Activity

S. Morley, M. Coldwell, 2006, Molecular and Cellular Biology.

Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism

Benjamin P Towler, S. C. Viegas, C. Arraiano, 2020, PLoS genetics.

The role of 5'-leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes.

M. Niepel, V. M. Pain, D. Gallie, 2000, Nucleic acids research.

Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection

E. Emmott, I. Goodfellow, S. Morley, 2015, The Journal of Biological Chemistry.

Activity During Infection.

E. Emmott, S. Morley, Nicolas Locker, 2015 .

mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration.

S. Morley, M. Willett, Michèle Brocard, 2013, The Biochemical journal.

Canonical Initiation Factor Requirements of the Myc Family of Internal Ribosome Entry Segments

M. Bushell, C. Jopling, A. Willis, 2009, Molecular and Cellular Biology.

Activity of the Hepatitis A Virus IRES Requires Association between the Cap-Binding Translation Initiation Factor (eIF4E) and eIF4G

R. Jackson, L. McKendrick, S. Morley, 2001, Journal of Virology.

Hormone-induced meiotic maturation in Xenopus oocytes occurs independently of p70s6k activation and is associated with enhanced initiation factor (eIF)-4F phosphorylation and complex formation.

V. M. Pain, S. Morley, 1995, Journal of cell science.

Dis3L2 regulates cellular proliferation through a PI3-Kinase dependent signalling pathway

Benjamin P Towler, S. C. Viegas, C. Arraiano, 2019, bioRxiv.

Kinky binding and SECsy insertions.

S. Morley, M. Willett, 2009, Molecular cell.

In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system.

J. Garin, J. Darlix, T. Ohlmann, 2002, Journal of molecular biology.

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing

Tyson V. Sharp, T. Rana, G. Longmore, 2010, Proceedings of the National Academy of Sciences.

mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation

S. Morley, M. Willett, Hilary J Pollard, 2014, Cell cycle.

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells

S. Coles, G. Tizzard, J. Spencer, 2018, Oncotarget.

SMG-1 and mTORC1 Act Antagonistically to Regulate Response to Injury and Growth in Planarians

Simon J. Morley, Matthew D. Smith, Tyson V. Sharp, 2012, PLoS genetics.

The S. pombe Translation Initiation Factor eIF4G Is Sumoylated and Associates with the SUMO Protease Ulp2

Robert A. Baldock, F. Z. Watts, Duncan L Smith, 2014, PloS one.

Paxillin Associates with Poly(A)-binding Protein 1 at the Dense Endoplasmic Reticulum and the Leading Edge of Migrating Cells*

M. Roberts, S. Barry, A. Woods, 2002, The Journal of Biological Chemistry.

Initiation factor modifications in the preapoptotic phase

M. Clemens, S. Morley, M. Coldwell, 2005, Cell Death and Differentiation.

Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage

M. Clemens, R. Lloyd, M. Bushell, 2000, Cell Death and Differentiation.

KIPase activity is a novel caspase-like activity associated with cell proliferation.

A. Sinclair, S. Morley, Cahora Medina-Palazon, 2004, European journal of biochemistry.

Interaction of Eukaryotic Translation Initiation Factor 4G with the Nuclear Cap-Binding Complex Provides a Link between Nuclear and Cytoplasmic Functions of the m7Guanosine Cap

Joe D. Lewis, L. McKendrick, S. Morley, 2001, Molecular and Cellular Biology.

The C‐terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap‐independent translation in the absence of eIF4E.

V. M. Pain, T. Ohlmann, S. Morley, 1996, The EMBO journal.

Increased phosphorylation of eukaryotic initiation factor 4 alpha during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation.

V. M. Pain, S. Morley, J. Kay, 1993, European journal of biochemistry.

A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate (*)

V. M. Pain, T. Ohlmann, S. Morley, 1996, The Journal of Biological Chemistry.

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.

S. Ferrari, G. Thomas, S. Morley, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Functional Analysis of Individual Binding Activities of the Scaffold Protein eIF4G*

V. M. Pain, S. Morley, T. Hinton, 2007, Journal of Biological Chemistry.

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: A reappraisal of translation initiation during mitosis

S. Morley, M. Willett, Joanne L. Cowan, 2013, Cell cycle.

Signal transduction mechanisms in the regulation of protein synthesis

S. Morley, 1994, Molecular Biology Reports.

The Phosphodiesterase Inhibitor SQ 20006 Selectively Blocks Mitogen Activation of p70S6k and Transition to S Phase of the Cell Division Cycle without Affecting the Steady State Phosphorylation of eIF-4E (*)

D. Fabbro, T. Meyer, S. Morley, 1995, The Journal of Biological Chemistry.

Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors

J. Spencer, S. Coles, G. Tizzard, 2018, Molecules.

Inhibition of Protein Synthesis by the Heme-Controlled Eif-2α kinase Leads to the Appearance of mRNA-Containing 48S Complexes that Contain eIF-4E but Lack Methionyl-tRNAf

R. Rhoads, V. M. Pain, S. Morley, 1995 .

Segments the Myc Family of Internal Ribosome Entry Canonical Initiation Factor Requirements of

M. Bushell, C. Jopling, A. Willis, 2017 .

Inhibition of protein synthesis by the heme-controlled eIF-2 alpha kinase leads to the appearance of mRNA-containing 48S complexes that contain eIF-4E but lack methionyl-tRNA(f).

R. Rhoads, V. M. Pain, S. Morley, 1995, European journal of biochemistry.

A rabbit reticulocyte factor which stimulates protein synthesis in several mammalian cell-free systems.

R. Jackson, S. Morley, W. Buhl, 1985, Biochimica et biophysica acta.

A Cunning Stunt: An Alternative Mechanism of Eukaryotic Translation Initiation

S. Morley, M. Coldwell, 2008, Science Signaling.

Inhibition of cap‐dependent translation via phosphorylation of eIF4G by protein kinase Pak2

S. Morley, J. Ling, J. Traugh, 2005, The EMBO journal.

Translational regulation during activation of porcine peripheral blood lymphocytes: association and phosphorylation of the alpha and gamma subunits of the initiation factor complex eIF-4F.

V. M. Pain, S. Morley, 1995, The Biochemical journal.

Mitotic DNA damage targets the Aurora A/TPX2 complex

S. Ferrari, M. Menigatti, S. Morley, 2010, Cell cycle.

Association of initiation factor eIF-4E in a cap binding protein complex (eIF-4F) is critical for and enhances phosphorylation by protein kinase C.

R. Rhoads, W. Merrick, S. Morley, 1990, The Journal of biological chemistry.

Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.

D. Etchison, S. Morley, J. Traugh, 1991, The Journal of biological chemistry.

Rapamycin‐sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver

S. Kimball, L. Jefferson, J. Albrecht, 2004, Hepatology.

Translation initiation factors and active sites of protein synthesis co-localize at the leading edge of migrating fibroblasts.

S. Morley, M. Willett, Michèle Brocard, 2011, The Biochemical journal.

Immunohistochemical mapping of total and phosphorylated eukaryotic initiation factor 4G in rat hippocampus following global brain ischemia and reperfusion

J. Rafols, D. DeGracia, F. Kayali, 2006, Neuroscience.

Systems Biology of Cancer: Regulation and dysregulation of protein synthesis in cancer cells

M. Clemens, S. Morley, A. Elia, 2015 .

Canonical Initiation Factor Requirements of the Myc Family of Internal Ribosome Entry Segments

M. Bushell, C. Jopling, A. Willis, 2009, Molecular and Cellular Biology.

Intracellular signalling pathways regulating initiation factor eIF4E phosphorylation during the activation of cell growth.

S. Morley, 1997, Biochemical Society transactions.