T. O’Toole

发表

Acrolein decreases endothelial cell migration and insulin sensitivity through induction of let-7a.

N. Cooper, A. Bhatnagar, D. Conklin, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

A comparison of per sample global scaling and per gene normalization methods for differential expression analysis of RNA-seq data

S. Rai, A. Eteleeb, E. Rouchka, 2017, PloS one.

Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial

P. Lorkiewicz, S. Rai, A. Bhatnagar, 2020, BMJ Open.

Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation.

S. Rai, D. Riggs, A. Bhatnagar, 2019, Environmental research.

Environmental Risk Factors for Heart Disease

Aruni Bhatnagar, A. Bhatnagar, D. Conklin, 2008, Reviews on environmental health.

Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3.

M. Ginsberg, T. O’Toole, Y. Chen, 1995, Blood.

Episodic Exposure to Fine Particulate Air Pollution Decreases Circulating Levels of Endothelial Progenitor Cells

C. A. Pope, A. Bhatnagar, D. Conklin, 2010, Circulation research.

The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity (*)

M. Ginsberg, J. Ylänne, T. O’Toole, 1995, The Journal of Biological Chemistry.

Benzene Exposure Induces Insulin Resistance in Mice

A. Bhatnagar, D. Conklin, S. Srivastava, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells.

M. Hensler, B. Faha, B. Felding-Habermann, 2002, Clinical & experimental metastasis.

Involvement of tumor cell integrin αvβ3 in hematogenous metastasis of human melanoma cells

M. Hensler, B. Faha, B. Felding-Habermann, 2004, Clinical & Experimental Metastasis.

Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides

J. Hatzfeld, A. Hatzfeld, E. Brown, 1991, The Journal of experimental medicine.

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions

Y. Takada, M. Ginsberg, J. Loftus, 1993, The Journal of cell biology.

Integrin cytoplasmic domains mediate inside-out signal transduction

V. Quaranta, M. Ginsberg, J. Loftus, 1994, The Journal of cell biology.

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

M. Ginsberg, T. O’Toole, J. McDonald, 1995, Cell.

Benzene exposure is associated with cardiovascular disease risk

S. Rai, D. Riggs, A. Bhatnagar, 2017, PloS one.

Platelet Integrins

M. Ginsberg, J. Loftus, T. O’Toole, 1993, Thrombosis and Haemostasis.

Carnosine Supplementation Mitigates the Deleterious Effects of Particulate Matter Exposure in Mice

A. Bhatnagar, D. Conklin, T. O’Toole, 2019, Journal of the American Heart Association.

Ligands “activate” integrin α IIb β 3 (platelet GPIIb-IIIa)

Xiaoping Du, A. Frelinger, J. Loftus, 1991, Cell.

Protocol to assess the impact of tobacco-induced volatile organic compounds on cardiovascular risk in a cross- sectional cohort: Cardiovascular Injury due to Tobacco Use study

P. Lorkiewicz, D. Riggs, A. Bhatnagar, 2018, BMJ Open.

Lipid Peroxidation Product 4-Hydroxy-trans-2-nonenal Causes Endothelial Activation by Inducing Endoplasmic Reticulum Stress*

S. Srivastava, M. Merchant, A. Bhatnagar, 2012, The Journal of Biological Chemistry.

Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity

P. Lorkiewicz, S. Rai, T. Das, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants

P. Lorkiewicz, D. Riggs, N. Cooper, 2020, Inhalation toxicology.

Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress

A. Bhatnagar, D. Conklin, T. O’Toole, 2016, Environmental health perspectives.

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb.

D. Mandelman, M. Ginsberg, T. O’Toole, 1991, Science.

Fine particulate matter air pollution and aortic perivascular adipose tissue: Oxidative stress, leptin, and vascular dysfunction

D. Riggs, D. Conklin, T. O’Toole, 2021, Physiological reports.

Activation-enhanced αIIbβ3-Integrin–Cytoskeleton Interactions Outside of Focal Contacts Require the α-Subunit

E. Brown, T. O’Toole, D. Kucik, 2001 .

Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue

A. Bhatnagar, S. Baba, O. Barski, 2009, Diabetes.

Glucocorticoid receptor activation and inactivation in cultured human lymphocytes.

K. Leach, W. Pratt, R. Wheeler, 1981, The Journal of biological chemistry.

Systemic Toxicity of Smokeless Tobacco Products in Mice

P. Lorkiewicz, S. Rai, A. Bhatnagar, 2019, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

The Association of CRKII with C3G Can be Regulated by Integrins and Defines a Novel Means to Regulate the Mitogen-activated Protein Kinases*

T. O’Toole, C. Buensuceso, 2000, The Journal of Biological Chemistry.

Polystyrene bead ingestion promotes adiposity and cardiometabolic disease in mice.

E. Rouchka, D. Conklin, Xiaohong Li, 2022, Ecotoxicology and environmental safety.

Hematopoietic potential of cryopreserved and ex vivo manipulated umbilical cord blood progenitor cells evaluated in vitro and in vivo.

Thomas O. Toole, J. Mulé, T. O’Toole, 1996, Blood.

Regulation of integrin function and cellular adhesion

T. O’Toole, I. Stuiver, 1995, Stem cells.

Exposure to Ambient Air Fine Particulate Matter Prevents VEGF-Induced Mobilization of Endothelial Progenitor Cells from the Bone Marrow

A. Bhatnagar, D. Conklin, T. O’Toole, 2012, Environmental health perspectives.

Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk

D. Riggs, A. Bhatnagar, S. Baba, 2021, International journal of molecular sciences.

RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site.

A. Huttenlocher, T. O’Toole, David A Bennin, 2003, Molecular biology of the cell.

A Single Immunoglobulin-like Domain of the Human Neural Cell Adhesion Molecule L1 Supports Adhesion by Multiple Vascular and Platelet Integrins

D. Cheresh, P. Brooks, M. Ginsberg, 1997, The Journal of cell biology.

Regulation of Integrin Affinity States through an NP XY Motif in the β Subunit Cytoplasmic Domain (*)

T. O’Toole, B. M. Culley, J. Ylanne, 1995, The Journal of Biological Chemistry.

Human adenine phosphoribosyltransferase. Identification of allelic mutations at the nucleotide level as a cause of complete deficiency of the enzyme.

T. O’Toole, T. Palella, W. N. Kelley, 1987, The Journal of clinical investigation.

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

M. Ginsberg, J. Loftus, T. O’Toole, 1990, Cell regulation.

Efficient surface expression of platelet GPIIb-IIIa requires both subunits.

M. Ginsberg, J. Loftus, T. O’Toole, 1989, Blood.

Affinity modulation of the allbl33 integrin (platelet GPIlb-lila) is an intrinsic property of the receptor*

J. Loftus, T. O’Toole, Z. Ruggeri, 2022 .

Adhesion-induced unclasping of cytoplasmic tails of integrin alpha(IIb)beta3.

J. Fox, T. Ugarova, S. Lam, 2009, Biochemistry.

Integrin signaling: building connections beyond the focal contact?

T. O’Toole, Timothy E. O'Toole, 1997, Matrix biology : journal of the International Society for Matrix Biology.

Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis.

C. Gahmberg, J. Huuskonen, M. Ginsberg, 1995, The Journal of biological chemistry.

Distinct Functions of Integrin ct and/3 Subunit Cytoplasmic Domains in Cell Spreading and Formation of Focal Adhesions

Y. Takada, M. Ginsberg, J. Loftus, 1993 .

A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa).

J. Rosa, M. Ginsberg, J. Ylänne, 1994, Blood.

Human adenine phosphoribosyltransferase: Characterization from subjects with a deficiency of enzyme activity

M. H. Gault, T. O’Toole, W. N. Kelley, 1983, Biochemical Genetics.

Mutation of the Cytoplasmic Domain of the Integrin Subunit

C. Gahmberg, J. Huuskonen, M. Ginsberg, 1995, The Journal of Biological Chemistry.

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

Xiaoping Du, A. Frelinger, M. Ginsberg, 1991, Cell.

VEGF-integrin interplay controls tumor growth and vascularization.

J. Qin, O. Razorenova, T. Byzova, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit

M. Ginsberg, B. Babior, T. O’Toole, 1995, The Journal of cell biology.

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction

T. O’Toole, K. Peter, 1995, The Journal of experimental medicine.

The inner world of cell adhesion: integrin cytoplasmic domains.

M. Ginsberg, T. O’Toole, M. Ginsberg, 1994, Trends in cell biology.

Different specificities of platelet-associated and plasma autoantibodies to platelet GPIIb-IIIa in patients with chronic immune thrombocytopenic purpura.

M. Ginsberg, P. Tani, T. O’Toole, 1992, Blood.

Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura.

M. Ginsberg, J. Loftus, P. Tani, 1991, Blood.

"Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains.

K. Yamada, M. Ginsberg, T. O’Toole, 1994, The Journal of biological chemistry.

Integrin activation controls metastasis in human breast cancer.

J W Smith, Jeffrey W. Smith, A. Saven, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Tiam1 is recruited to β1‐integrin complexes by 14‐3‐3ζ where it mediates integrin‐induced Rac1 activation and motility

Xiaohong Li, J. Fox, T. O’Toole, 2011, Journal of cellular physiology.

The WD protein Rack1 mediates protein kinase C and integrin-dependent cell migration.

G. Plopper, T. O’Toole, J. Huff, 2001, Journal of cell science.

Exposure to acrolein by inhalation causes platelet activation.

D. Riggs, A. Bhatnagar, D. Conklin, 2010, Toxicology and applied pharmacology.

Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction

S. Rai, D. Riggs, A. Bhatnagar, 2018, PloS one.

Enhanced Integrin α4β1–Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes

A. Bhatnagar, M. Ginsberg, D. Conklin, 2016, Diabetes.

Choice of library size normalization and statistical methods for differential gene expression analysis in balanced two-group comparisons for RNA-seq studies

Eric C. Rouchka, Nigel G. F. Cooper, E. Rouchka, 2020, BMC Genomics.

A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.

A. Frelinger, M. Ginsberg, J. Loftus, 1990, Science.

Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation.

Michael E. Hall, M. Blaha, P. Ganz, 2019, American journal of physiology. Heart and circulatory physiology.

Digestive Enzymes of Fungus-Feeding Beetles

J. Kukor, T. O’Toole, MICHAEL M. Martin, 1981, Physiological Zoology.

Endothelial Progenitor Cells: Properties, Function, and Response to Toxicological Stimuli

D. Conklin, T. O’Toole, P. Haberzettl, 2018 .

Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages.

Yuting Zheng, A. Bhatnagar, O. Barski, 2009, Toxicology and applied pharmacology.

Acute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults

C. Pope, D. Riggs, A. Bhatnagar, 2019, AIMS environmental science.

Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera.

J. Lindstrom, M. Ginsberg, J. Loftus, 1992, The Journal of clinical investigation.

Platelet lntegrins

Xiaoping Du, M. Ginsberg, J. Loftus, 1995, Thrombosis and Haemostasis.

Determination of adhesion force between single cell pairs generated by activated GpIIb-IIIa receptors.

S Chien, K. Sung, S. Chien, 1993, Blood.

Modulation of Cell Adhesion by Changes in O ~ L ~ 2 ( LFA-1 , CD 11 a / CD 18 ) Cytoplasmic Domain / Cytoskeleton Interaction By

T. O’Toole, K. Peter, 2003 .

Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress

A. Bhatnagar, D. Conklin, T. O’Toole, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Endothelial Progenitor Cells as Critical Mediators of Environmental Air Pollution-Induced Cardiovascular Toxicity.

D. Conklin, B. Hill, T. O’Toole, 2021, American journal of physiology. Heart and circulatory physiology.

Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic Inflammation.

C. Pope, A. Bhatnagar, D. Conklin, 2016, Circulation research.

Acrolein Exposure Is Associated With Increased Cardiovascular Disease Risk

S. Rai, K. Ramos, D. Riggs, 2014, Journal of the American Heart Association.

Urolithiasis in a Large Kindred Deficient in Adenine Phosphoribosyltransferase (Aprt)

M. H. Gault, D. Churchill, T. Ittel, 1985 .

Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells

S. Rai, K. Ramos, D. Riggs, 2015, Arteriosclerosis, thrombosis, and vascular biology.

Platelet glycoprotein IIb-IIIa (alpha IIb beta 3 integrin) confers fibrinogen- and activation-dependent aggregation on heterologous cells.

M. Ginsberg, J. Loftus, T. O’Toole, 1991, Blood.

Acrolein Inhalation Prevents Vascular Endothelial Growth Factor–Induced Mobilization of Flk-1+/Sca-1+ Cells in Mice

Aruni Bhatnagar, A. Bhatnagar, S. Baba, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Exposure to Fine Particulate Matter Air Pollution Alters mRNA and miRNA Expression in Bone Marrow-Derived Endothelial Progenitor Cells from Mice

E. Rouchka, A. Bhatnagar, D. Conklin, 2021, Genes.

Association Between Residential Greenness and Cardiovascular Disease Risk

P. Lorkiewicz, S. Rai, D. Riggs, 2018, Journal of the American Heart Association.

Nucleotide sequence of the human APRT gene.

T. O’Toole, T. Palella, S. Tarlé, 1987, Nucleic acids research.

Significance of Endothelial Dysfunction Amelioration for Sodium–Glucose Cotransporter 2 Inhibitor-Induced Improvements in Heart Failure and Chronic Kidney Disease in Diabetic Patients

H. Katsuyama, T. O’Toole, H. Yanai, 2023, Metabolites.

Activation-enhanced alpha(IIb)beta(3)-integrin-cytoskeleton interactions outside of focal contacts require the alpha-subunit.

E. Brown, T. O’Toole, D. Kucik, 2001, Molecular biology of the cell.

Abstract 225: Electronic Cigarettes Induced Exacerbation of Atherosclerosis: Contribution of MicroRNA-21

Lung-Chi Chen, A. Bhatnagar, D. Conklin, 2018 .

Autocrine transforming growth factor-β controls G0 phase of early human hematopoietic progenitors in serum- or serum-free culture

J. Hatzfeld, A. Hatzfeld, E. Brown, 1991 .

Choice of library size normalization and statistical methods for differential gene expression analysis in balanced two-group comparisons for RNA-seq studies

E. Rouchka, N. Cooper, Xiaohong Li, 2020, BMC Genomics.

Adjusted Sample Size Calculation for RNA-seq Data in the Presence of Confounding Covariates

S. Rai, E. Rouchka, N. Cooper, 2021 .

A combined approach with gene-wise normalization improves the analysis of RNA-seq data in human breast cancer subtypes

E. Rouchka, N. Cooper, Jun Yan, 2018, PloS one.

Subclinical markers of cardiovascular toxicity of benzene inhalation in mice.

A. Bhatnagar, M. Nantz, D. Conklin, 2021, Toxicology and applied pharmacology.

Biomarkers of Cardiovascular Toxicity of Benzene Inhalation in Mice

A. Bhatnagar, M. Nantz, D. Conklin, 2021 .

Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3.

T. O’Toole, C. Abrams, S. Shattil, 1994, The Journal of biological chemistry.

Ligand binding to integrins: dynamic regulation and common mechanisms.

J. Loftus, T. O’Toole, E. Plow, 1992, Cold Spring Harbor symposia on quantitative biology.

Autocrine Transforming Growth-Factor-Beta Controls G0 Phase of Early Human Hematopoietic Progenitors in Serum-Free or Serum-Free Culture

J. Hatzfeld, A. Hatzfeld, E. Brown, 1991 .

Enhanced integrin αααα 4 ββββ 1-mediated adhesion contributes to a mobilization defect of endothelial progenitor cells in diabetes .

A. Bhatnagar, M. Ginsberg, D. Conklin, 2016 .

Inference and Sample Size Calculations Based on Statistical Tests in aNegative Binomial Distribution for Differential Gene Expression in RNAseqData

Eric C. Rouchka, Shesh N. Rai, Nigel G. F. Cooper, 2017 .

Acrolein decreases endothelial cell migration and insulin sensitivity through induction of let-7a.

N. Cooper, A. Bhatnagar, D. Conklin, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Distinct Functions of Integrin ct and/3 Subunit Cytoplasmic Domains in Cell Spreading and Formation of Focal Adhesions

Y. Takada, M. Ginsberg, J. Loftus, 1993 .

Residential Proximity to Major Roadways Is Associated With Increased Levels of AC 133 + Circulating Angiogenic Cells

D. Riggs, S. Prabhu, A. Bhatnagar, 2022 .