J. Eichler

发表

ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome

David E. Gloriam, T. Gibson, J. Hoheisel, 2007, Nature Methods.

The Versatility of Nonsupport‐Bound Combinatorial Libraries

Clemencia Pinilla, Richard A. Houghten, Colette T. Dooley, 2007 .

Novel α-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries

R. Houghten, C. Pinilla, J. Eichler, 1996, Molecular Diversity.

Libraries from libraries: Generation and comparison of screening profiles

R. Houghten, S. Blondelle, C. Dooley, 1996, Molecular Diversity.

A review of the utility of soluble peptide combinatorial libraries

Clemencia Pinilla, Barbara Dörner, R. Houghten, 1995, Biopolymers.

Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds

Clemencia Pinilla, Richard A. Houghten, Colette T. Dooley, 1994 .

1 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery

R. Houghten, S. Blondelle, C. Pinilla, 1996 .

HIV-derived peptide mimics.

J. Eichler, K. Moebius, 2009, Drug discovery today. Technologies.

Synthetic mimetics of the CD4 binding site of HIV-1 gp120 for the design of immunogens.

J. Eichler, Raimo Franke, T. Hirsch, 2007, Angewandte Chemie.

A Rationally Designed Synthetic Mimic of the Discontinuous CD4-Binding Site of HIV-1 gp120

J. Eichler, Raimo Franke, T. Hirsch, 2006, Journal of receptor and signal transduction research.

Proteomics' framework for success?

T. Gibson, J. Hoheisel, L. Gold, 2007, Nature Methods.

Loops on loops: generation of complex scaffolded peptides presenting multiple cyclic fragments.

V. Wray, J. Eichler, Raimo Franke, 2004, Organic & biomolecular chemistry.

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains

Y. Yamaoka, S. Backert, H. Sticht, 2016, BMC Microbiology.

Peptide ligation through click chemistry for the generation of assembled and scaffolded peptides

J. Eichler, Raimo Franke, Christian Doll, 2005 .

Optimal peptide length determination using synthetic peptide combinatorial libraries

R. Houghten, S. Blondelle, C. Pinilla, 1994 .

Exploring converse molecular mechanisms of anti-HIV-1 antibodies using a synthetic CXCR4 mimic.

J. Eichler, Christina Haussner, K. Möbius, 2012, Bioorganic & medicinal chemistry letters.

Virtual screening of a milk peptide database for the identification of food-derived antimicrobial peptides.

J. Eichler, M. Pischetsrieder, Yufang Liu, 2015, Molecular nutrition & food research.

Corrigendum: ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome

T. Gibson, J. Hoheisel, L. Gold, 2007, Nature Methods.

Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein

K. Überla, H. Sticht, J. Eichler, 2022, International journal of molecular sciences.

A Peptide Inhibitor of the Human Cytomegalovirus Core Nuclear Egress Complex

M. Marschall, J. Eichler, I. Neundorf, 2022, Pharmaceuticals.

Multiple peptide synthesis using cellulose-based carriers: Synthesis of substance P - diastereoisomers and their histamine-releasing activity

E. Krause, Margit Schmidt, M. Beyermann, 1993 .

Evaluation of cotton as a carrier for solid-phase peptide synthesis.

M. Lebl, M. Bienert, J. Eichler, 1991, Peptide research.

Application of cellulose paper as support material in simultaneous solid phase peptide synthesis

M. Beyermann, M. Bienert, J. Eichler, 1989 .

Domain for Proline-Rich Ligands

W. Wenzel, J. Eichler, T. Hirsch, 2007 .

Structural and Functional Mimicry of the Binding Site of hYAP-WW Domain for Proline-rich Ligands

W. Wenzel, A. Quintilla, J. Eichler, 2007, International Journal of Peptide Research and Therapeutics.

Synthetic Peptides as Protein Mimics

H. Sticht, J. Eichler, C. Hashimoto, 2016, Front. Bioeng. Biotechnol..

Mixture-based synthetic combinatorial libraries.

R A Houghten, C T Dooley, R. Houghten, 1999, Journal of medicinal chemistry.

Peptides as protein binding site mimetics.

J. Eichler, 2008, Current opinion in chemical biology.

Structure‐Based Synthetic Mimicry of Discontinuous Protein Binding Sites: Inhibitors of the Interaction of Mena EVH1 Domain with Proline‐Rich Ligands

J. Eichler, C. Hunke, T. Hirsch, 2006, Chembiochem : a European journal of chemical biology.

Synthetic Mimetics of the gp130 Binding Site for Viral Interleukin‐6 as Inhibitors of the vIL‐6–gp130 Interaction

J. Scheller, S. Rose-John, Werner Müller, 2008, Chemical biology & drug design.

The diversity and utility of amyloid fibrils formed by short amyloidogenic peptides

Louise C. Serpell, Kyle L. Morris, L. Serpell, 2017, Interface Focus.

High-resolution crystal structures of two prototypical β- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity

Y. Muller, H. Sticht, M. Marschall, 2020, The Journal of Biological Chemistry.

Untargeted Proteomics-Based Profiling for the Identification of Novel Processing-Induced Protein Modifications in Milk.

J. Eichler, M. Pischetsrieder, J. Meltretter, 2020, Journal of proteome research.

Proceedings of the Frontiers of Retrovirology Conference 2016

R. König, D. Elleder, R. Sachidanandam, 2016, Retrovirology.

Versatile C(3)-symmetric scaffolds and their use for covalent stabilization of the foldon trimer.

M. Groll, J. Eichler, Melissa A. Gräwert, 2014, Organic & biomolecular chemistry.

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.

U. Klingmüller, J. Scheller, A. Chalaris, 2006, Molecular biology of the cell.

Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects

A. Rosenwald, H. Müller-Hermelink, W. Schmidt-Heck, 2020, Nature Communications.

Abrogation of Viral Interleukin-6 (vIL-6)-Induced Signaling by Intracellular Retention and Neutralization of vIL-6 with an Anti-vIL-6 Single-Chain Antibody Selected by Phage Display

Stefan Rose-John, J. Scheller, S. Rose-John, 2006, Journal of Virology.

Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.

J. Scheller, S. Rose-John, J. Eichler, 2004, Journal of immunological methods.

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains

Y. Yamaoka, S. Backert, H. Sticht, 2016, BMC Microbiology.

The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity

Y. Muller, H. Sticht, M. Marschall, 2021, bioRxiv.

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

Christian Drosten, Susanne Pfefferle, Marcus O. Muench, 2009, Journal of Virology.

Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties

Y. Muller, F. Neipel, H. Sticht, 2020, Viruses.

HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop

Shibo Jiang, B. Fleckenstein, H. Sticht, 2013, PloS one.

The Hard Way towards an Antibody-Based HIV-1 Env Vaccine: Lessons from Other Viruses

U. Dietrich, P. Debré, H. Büning, 2018, Viruses.

Influence of Nonenzymatic Posttranslational Modifications on Constitution, Oligomerization and Receptor Binding of S100A12

J. Eichler, M. Pischetsrieder, W. Utz, 2014, PloS one.

A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

Anselm H. C. Horn, E. Mandelkow, H. Sticht, 2022, Alzheimer's research & therapy.

Multiple peptide synthesis on cotton carriers: Elucidation and characterization of an antibody binding site of CRF

J. Furkert, J. Eichler, Michael Blenert, 2007 .

Inclusion volume solid‐phase synthesis

M. Lebl, R. Houghten, J. Eichler, 1996, Journal of peptide science : an official publication of the European Peptide Society.

Generation and utilization of synthetic combinatorial libraries.

R. Houghten, J. Eichler, 1995, Molecular medicine today.

Cyclic peptide template synthetic combinatorial libraries

R. Houghten, J. Eichler, A. Lucka, 1995 .

Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries.

R A Houghten, R. Houghten, J. Eichler, 1993, Biochemistry.

Simulation of continuous solid phase synthesis: synthesis of methionine enkephalin and its analogs.

M. Lebl, J. Eichler, 1989, Peptide research.

A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model

K. Überla, H. Jäck, S. Ciesek, 2021, bioRxiv.

Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-α binding.

T. Wittenberg, H. Sticht, Jens Milbradt, 2012, The Journal of general virology.

A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure

Y. Muller, J. Eichler, Sewar Alkhashrom, 2021, Scientific Reports.

Inhibition of HIV-1 infection by human pegivirus type 1-derived peptides is affected by human pegivirus type 1 genotype and HIV-1 coreceptor tropism

B. Schmidt, K. Korn, B. Salzberger, 2018, AIDS.

Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)

Y. Muller, J. Nickel, T. Mueller, 2013, PloS one.

Enhancement and Induction of HIV‐1 Infection through an Assembled Peptide Derived from the CD4 Binding Site of gp120

B. Schmidt, J. Münch, J. Eichler, 2015, Chembiochem : a European journal of chemical biology.

Mimicking Protein–Protein Interactions through Peptide–Peptide Interactions: HIV-1 gp120 and CXCR4

B. Schmidt, J. Eichler, N. Donhauser, 2013, Front. Immunol..

Mixture-Based Synthetic Combinatorial Libraries

Clemencia Pinilla, Richard A. Houghten, Colette T. Dooley, 1999 .

Cyclic peptide template combinatorial libraries: synthesis and identification of chymotrypsin inhibitors.

R. Houghten, J. Eichler, A. Lucka, 1994, Peptide research.

Synthetic peptide arrays and peptide combinatorial libraries for the exploration of protein-ligand interactions and the design of protein inhibitors.

J. Eichler, 2005, Combinatorial chemistry & high throughput screening.

A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors.

Mattias Collin, Gordan Lauc, G. Lauc, 2015, Cell reports.

Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule

H. Sticht, M. Marschall, J. Eichler, 2021, Viruses.

The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for paralog-specific binding to Ena/VASP homology (EVH) 1 domains

J. Eichler, Nina M. Link, P. Bayer, 2009, Biological chemistry.

Preparation of synthetic peptide combinatorial libraries on cotton carriers and their application to the identification of trypsin inhibitors

R. Houghten, J. Eichler, 1993 .

Proceedings of the Frontiers of Retrovirology Conference 2016

Sebastian A. Wagner, R. König, D. Elleder, 2016, Retrovirology.

A functionally selective synthetic mimic of the HIV-1 co-receptor CXCR4.

U. Dietrich, J. Eichler, R. Dürr, 2012, Chemistry.

Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides

Heinrich Sticht, Kristin Kassler, Julia Meier, 2012, Adv. Bioinformatics.

Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects

A. Rosenwald, W. Schmidt-Heck, A. Zernecke, 2020, Nature Communications.

Synthetic combinatorial libraries for the study of molecular mimicry: Identification of an all D-amino acid peptide recognized by an anti-carbohydrate antibody

N. Greenspan, R. Houghten, C. Pinilla, 2002 .

Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides

Anselm H. C. Horn, H. Sticht, J. Eichler, 2023, Biology.

Synthetic antibody mimics for the inhibition of protein-ligand interactions.

J. Eichler, Christina Haussner, Johannes Lach, 2017, Current opinion in chemical biology.

Synthesis of cyclic disulfide peptides: comparison of oxidation methods

R. Houghten, J. Eichler, 1997, Protein & Peptide Letters.

Peptide Paratope Mimics of the Broadly Neutralizing HIV‐1 Antibody b12

B. Schmidt, J. Eichler, D. Damm, 2017, Chembiochem : a European journal of chemical biology.

Ligand selectivity of a synthetic CXCR4 mimetic peptide.

B. Schmidt, Nuska Tschammer, J. Eichler, 2015, Bioorganic & medicinal chemistry.

Enhancement and Induction of HIV‐1 Infection through an Assembled Peptide Derived from the CD4 Binding Site of gp120

B. Schmidt, J. Münch, J. Eichler, 2015, Chembiochem : a European journal of chemical biology.

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120

H. Sticht, J. Eichler, J. Meier, 2012, Beilstein journal of organic chemistry.

Author response for "A pair of non‐competing neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model"

K. Überla, H. Jäck, S. Ciesek, 2021 .

Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors

Y. Muller, M. Marschall, J. Eichler, 2021, Viruses.