E. Tramontano

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Integration of SARS-CoV-2 RNA in infected human cells by retrotransposons: an unlikely hypothesis and old viral relationships

B. Berkhout, Nicole Grandi, E. Tramontano, 2021, Retrovirology.

Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: Hide, mask, hit

E. Tramontano, L. Zinzula, 2013, Antiviral Research.

Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.

E. Novellino, G. Greco, M. Artico, 1998, Journal of medicinal chemistry.

Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques.

Federica Moraca, Nicole Grandi, E. Tramontano, 2019, European journal of medicinal chemistry.

Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors

A. Tannapfel, D. Strumberg, P. Dammann, 2021, Communications Biology.

Contribution of Human Retroviruses to Disease Development—A Focus on the HIV– and HERV–Cancer Relationships and Treatment Strategies

Liang-Tzung Lin, Nicole Grandi, E. Tramontano, 2020, Viruses.

Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance.

Y. Cheng, E. Tramontano, G. Im, 1993, Biochemical pharmacology.

Biochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformate.

J. Mellors, P. la Colla, E. Tramontano, 1998, Biochemical pharmacology.

Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.

F. Gago, L. Menéndez-Arias, S. de Castro, 2020, ACS medicinal chemistry letters.

Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

L. Mayol, A. Pepe, E. Tramontano, 2020, International journal of molecular sciences.

High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development

Nicole Grandi, E. Tramontano, Maria Paola Pisano, 2020, Viruses.

Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication.

Lijia Xu, D. Piano, C. Del Vecchio, 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity

P. Di Bonito, L. Accardi, E. Tramontano, 2019, BMC Biotechnology.

Past and Future. Current Drugs Targeting HIV-1 Integrase and Reverse Transcriptase-Associated Ribonuclease H Activity: Single and Dual Active Site Inhibitors

E. Tramontano, F. Esposito, 2014, Antiviral chemistry & chemotherapy.

Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication

M. Scognamiglio, A. Fiorentino, E. Tramontano, 2018, PloS one.

Design, Synthesis, and Biological Evaluation of 1,3‐Diarylpropenones as Dual Inhibitors of HIV‐1 Reverse Transcriptase

M. Fresta, E. Tramontano, S. Alcaro, 2014, ChemMedChem.

RNA-Seq Transcriptome Analysis Reveals Long Terminal Repeat Retrotransposon Modulation in Human Peripheral Blood Mononuclear Cells after In Vivo Lipopolysaccharide Injection

F. Mallet, Nicole Grandi, E. Tramontano, 2020, Journal of Virology.

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

Lijia Xu, D. Piano, C. Del Vecchio, 2015, Journal of Microbiology.

Insights into Ebola Virus VP35 and VP24 Interferon inhibitory functions and their initial exploitation as drug targets

E. Tramontano, A. Corona, A. Frau, 2018, Infectious disorders drug targets.

Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities

Daniela Iaconis, V. Summa, M. Nowotny, 2022, ACS pharmacology & translational science.

Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport

Y. Li, Shilin Chen, Jingyuan Song, 2011, BMC Genomics.

Characterization of the anti-HIV-1 activity of 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), new non-nucleoside reverse transcriptase inhibitors.

A. Mai, M. Artico, P. la Colla, 1994, The new microbiologica.

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

C. Pannecouque, L. Naesens, M. Carcelli, 2017, Front. Microbiol..

Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.

E. Novellino, S. Di Maro, R. Di Santo, 2020, ACS Medicinal Chemistry Letters.

Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion

J. Blomberg, Nicole Grandi, E. Tramontano, 2017, Mobile DNA.

Identification and analysis of HML2 sequences in human genome assembly GRCh37/hg19

P. Rodriguez-Tomé, J. Blomberg, G. Sperber, 2013, Retrovirology.

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

F. Musiani, Daniela Iaconis, V. Summa, 2020, bioRxiv.

A human MMTV-like betaretrovirus linked to breast cancer has been present in humans at least since the copper age

G. Bevilacqua, C. Mazzanti, G. Fornaciari, 2020, Aging.

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

J. Neyts, D. Schols, E. Tramontano, 2022, ACS medicinal chemistry letters.

dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35

D. Pala, E. Tramontano, L. Zinzula, 2011, Antiviral Research.

Purification and functional characterization of the full length recombinant Ebola virus VP35 protein expressed in E. coli.

D. Piano, E. Mühlberger, E. Tramontano, 2009, Protein expression and purification.

Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes

J. Blomberg, Nicole Grandi, E. Tramontano, 2016, Retrovirology.

Quercetin Blocks Ebola Virus Infection by Counteracting the VP24 Interferon-Inhibitory Function

E. Tramontano, E. Maccioni, S. Distinto, 2020, Antimicrobial Agents and Chemotherapy.

5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.

E. Novellino, G. Greco, A. Mai, 1999, Journal of medicinal chemistry.

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

E. Ballana, R. Badia, J. Esté, 2020, Viruses.

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.

S. L. Le Grice, E. Tramontano, A. Corona, 2013, Future medicinal chemistry.

HIV-1 RT-associated RNase H function inhibitors: Recent advances in drug development.

R. Di Santo, E. Tramontano, 2010, Current medicinal chemistry.

Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.

Y. Pommier, R. Di Santo, R. Costi, 2015, Journal of medicinal chemistry.

Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route

M. Brindisi, V. Summa, P. Storici, 2022, European Journal of Medicinal Chemistry.

The use of a new in vitro reaction substrate reproducing both U3 and U5 regions of the HIV-1 3'-ends increases the correlation between the in vitro and in vivo effects of the HIV-1 integrase inhibitors.

P. la Colla, E. Tramontano, R. Badas, 2004, Biochemical pharmacology.

Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

C. Collard, Daniela Iaconis, V. Summa, 2022, Scientific data.

Development and Validation of a Novel Dual Luciferase Reporter Gene Assay to Quantify Ebola Virus VP24 Inhibition of IFN Signaling

E. Tramontano, A. Corona, M. Sgarbanti, 2018, Viruses.

Natural and Nature-Derived Products Targeting Human Coronaviruses

M. Alexis, A. Skaltsounis, E. Tramontano, 2021, Molecules.

Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus.

L. Menéndez-Arias, E. Tramontano, A. Corona, 2019, Antiviral research.

RNase H Polymerase-independent Cleavage Assay for Evaluation of RNase H Activity of Reverse Transcriptase Enzymes

E. Tramontano, A. Corona, 2015 .

Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach

F. Ceccherini‐Silberstein, E. Tramontano, S. Alcaro, 2022, Molecules.

Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs.

P. la Colla, L. Cappellacci, G. Abu Sheikha, 1994, Journal of medicinal chemistry.

HIV-1-inhibiting activity of the essential oil of Ridolfia segetum and Oenanthe crocata.

E. Tramontano, C. Bicchi, L. Zinzula, 2009, Planta medica.

2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays.

M. Artico, R. Costi, R. D. Santo, 2004, Bioorganic & medicinal chemistry.

Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.

Y. Cheng, R. Kilkuskie, E. Tramontano, 1992, Journal of natural products.

A Focus on Severe Acute Respiratory Syndrome ( SARS ) Coronavirus ( SARS‐CoVs ) 1 and 2

V. Summa, E. Tramontano, R. Cannalire, 2021, New Drug Development for Known and Emerging Viruses.

Inhibition of HIV-1 reverse transcriptase associated activities by the hydroalcoholic extract of Casimiroa edulis seeds

E. Tramontano, L. Zinzula, A. Maxia, 2011, Natural product research.

A. Pani, S. Manfredini, E. Tramontano, 1992, Journal of medicinal chemistry.

A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity.

C. Pannecouque, E. Tramontano, O. Tabarrini, 2016, Organic & biomolecular chemistry.

ZnO-mediated regioselective C-arylsulfonylation of indoles: a facile solvent-free synthesis of 2- and 3-sulfonylindoles and preliminary evaluation of their activity against drug-resistant mutant HIV-1 reverse transcriptases (RTs)

P. Caboni, E. Tramontano, M. Begala, 2013 .

6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro.

R. Di Santo, R. Costi, P. la Colla, 2005, Antiviral research.

Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.

E. Tramontano, A. Geronikaki, P. Eleftheriou, 2019, European journal of medicinal chemistry.

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

C. Pannecouque, E. Tramontano, S. Sabatini, 2020, Molecules.

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

E. Novellino, O. Delelis, R. Di Santo, 2014, Antimicrobial Agents and Chemotherapy.

RNA-seq transcriptome analysis reveals LTR-retrotransposons modulation in Human Peripheral Blood Mononuclear Cells (PBMCs) after in vivo Lipopolysaccharides (LPS) injection

F. Mallet, Nicole Grandi, E. Tramontano, 2019, bioRxiv.

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

E. Tramontano, E. Maccioni, S. Distinto, 2016, Journal of enzyme inhibition and medicinal chemistry.

Broad-range potential of Asphodelus microcarpus leaves extract for drug development

C. Santos-Buelga, G. Orrù, A. Fais, 2017, BMC Microbiology.

Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action.

D. Piano, C. Del Vecchio, E. Tramontano, 2017, Pathogens and disease.

Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.

C. Del Vecchio, E. Tramontano, C. Parolin, 2013, Pathogens and disease.

Biological Activities of Aerial Parts Extracts of Euphorbia characias

R. Medda, F. Pintus, E. Tramontano, 2016, BioMed research international.

3,4-Dihydro-2-Alkoxy-6-Benzyl-4-Oxopyrimidines (DABOs): A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1

A. Mai, M. Artico, P. la Colla, 1993 .

The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry

Liang-Tzung Lin, E. Tramontano, A. Corona, 2021, Viruses.

Comprehensive Characterization of the Human Endogenous Retrovirus HERV-K(HML-6) Group: Overview of Structure, Phylogeny, and Contribution to the Human Genome

J. Blomberg, Nicole Grandi, E. Tramontano, 2019, Journal of Virology.

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

E. Novellino, R. Di Santo, R. Costi, 2021, Journal of medicinal chemistry.

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

P. Mátyus, D. Secci, E. Tramontano, 2021, Molecules.

2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication

C. Del Vecchio, E. Tramontano, V. Onnis, 2020, Molecules.

Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H

P. Caboni, S. L. Le Grice, J. Beutler, 2020, Journal of enzyme inhibition and medicinal chemistry.

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2018, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions

E. Tramontano, S. Alcaro, S. Distinto, 2017, Pathogens and disease.

Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase.

C. Floris, E. Tramontano, S. Alcaro, 2017, European journal of medicinal chemistry.

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H.

E. Novellino, O. Delelis, R. Di Santo, 2016, Antiviral research.

Studies on Cycloheptathiophene‐3‐carboxamide Derivatives as Allosteric HIV‐1 Ribonuclease H Inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2016, ChemMedChem.

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

S. L. Le Grice, L. Menéndez-Arias, E. Tramontano, 2016, PloS one.

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.

P. Mátyus, E. Tramontano, S. Alcaro, 2015, European journal of medicinal chemistry.

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.

Y. Pommier, E. Novellino, R. Di Santo, 2013, Journal of medicinal chemistry.

Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.

Stefano Alcaro, Francesca Esposito, Gerhard Wolber, 2012, European journal of medicinal chemistry.

Alizarine derivatives as new dual inhibitors of the HIV‐1 reverse transcriptase‐associated DNA polymerase and RNase H activities effective also on the RNase H activity of non‐nucleoside resistant reverse transcriptases

P. Markt, E. Tramontano, G. Floris, 2011, The FEBS journal.

6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.

M. Artico, R. Di Santo, R. Costi, 2004, Bioorganic & medicinal chemistry letters.

Proceedings of the Frontiers of Retrovirology Conference 2016

R. König, D. Elleder, R. Sachidanandam, 2016, Retrovirology.

Host cell polo ‐ like kinases ( PLKs ) promote early prototype foamy virus ( PFV ) replication

Mareike, Jochen, Yasuyuki, 2016 .

Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity.

V. Barone, E. Novellino, A. Lavecchia, 2002, Journal of medicinal chemistry.

HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions

E. Tramontano, A. Corona, F. Esposito, 2012, Molecular biology international.

Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

C. Tintori, M. Botta, R. Ferrarese, 2017, Chembiochem : a European journal of chemical biology.

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities

L. Naesens, M. Carcelli, D. Rogolino, 2016, International journal of molecular sciences.

New Anthraquinone Derivatives as Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function

E. Tramontano, L. Zinzula, A. Corona, 2012, Chemotherapy.

Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities

E. Tramontano, L. Zinzula, F. Esposito, 2011, Journal of chemotherapy.

Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?

E. Tramontano, A. Corona, F. Esposito, 2014 .

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.

F. Bailly, Z. Debyser, F. Christ, 2012, Bioorganic & medicinal chemistry letters.

Interaction between aspergillic acid and iron(III): A potentiometric, UV–Vis, 1H NMR and quantum chemical study

T. Pivetta, E. Tramontano, J. Lachowicz, 2009 .

Identification of Myricetin as an Ebola Virus VP35-Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay.

O. Taglialatela‐Scafati, E. Tramontano, L. Zinzula, 2018, Biochemistry.

In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase.

J. Mellors, Y. Cheng, E. Tramontano, 1992, Molecular pharmacology.

Antiviral Agents Against Ebola Virus Infection: Repositioning Old Drugs and Finding Novel Small Molecules

E. Tramontano, A. Corona, A. Frau, 2018, Annual Reports in Medicinal Chemistry.

Meeting report: 32nd International Conference on Antiviral Research

M. Bray, R. Jordan, L. Schang, 2013, Antiviral Research.

Inhibition of HIV‐1 Reverse Transcriptase Dimerization by Small Molecules

C. Tintori, M. Botta, M. Clementi, 2016, Chembiochem : a European journal of chemical biology.

Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines.

A. Mai, M. Artico, G. Sbardella, 1995, Journal of medicinal chemistry.

A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150).

J. Mellors, Y. Cheng, E. Tramontano, 1993, Molecular pharmacology.

Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses

Nicole Grandi, E. Tramontano, 2018, Front. Immunol..

Classification and characterization of human endogenous retroviruses; mosaic forms are common

Patricia Rodriguez-Tomé, Göran O. Sperber, Jonas Blomberg, 2016, Retrovirology.

Human Endogenous Retrovirus (HERV) Transcriptome Is Dynamically Modulated during SARS-CoV-2 Infection and Allows Discrimination of COVID-19 Clinical Stages

Nicole Grandi, E. Tramontano, Maria Chiara Erbì, 2023, Microbiology spectrum.

Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes

J. Blomberg, Nicole Grandi, E. Tramontano, 2016, Retrovirology.

Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions

P. Caboni, E. Tramontano, F. Boyom, 2018, Natural product research.

Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology

Nicole Grandi, E. Tramontano, 2017, Viruses.

Retrotransposons as Drivers of Mammalian Brain Evolution

R. Ferrari, Nicole Grandi, E. Tramontano, 2021, Life.

HERV Envelope Proteins: Physiological Role and Pathogenic Potential in Cancer and Autoimmunity

Nicole Grandi, E. Tramontano, 2018, Front. Microbiol..

Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion

J. Blomberg, Nicole Grandi, E. Tramontano, 2017, Mobile DNA.

Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration

V. Calvez, C. Charpentier, O. Delelis, 2022, Journal of virology.

New Anti-Human Immunodeficiency Virus Type 1 6-Aminoquinolones: Mechanism of Action

B. Gatto, T. Pecere, M. Palumbo, 2003, Antimicrobial Agents and Chemotherapy.

HERV-W group evolutionary history in non-human primates: characterization of ERV-W orthologs in Catarrhini and related ERV groups in Platyrrhini

J. Blomberg, J. Mayer, Nicole Grandi, 2018, BMC Evolutionary Biology.

New features of the cell wall of the radio-resistant bacterium Deinococcus radiodurans.

S. McSweeney, Joanna M. Kirkpatrick, M. Bowler, 2014, Biochimica et biophysica acta.

Synthesis and Antiviral Activity of New 3,4-Dihydro-2-Alkoxy-6-Benzyl-4-Oxopyrimidines (DABOs), Specific Inhibitors of Human Immunodeficiency Virus Type 1

A. Mai, M. Artico, G. Sbardella, 1995 .

Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

G. Rossetti, P. Storici, N. Demitri, 2021, International journal of molecular sciences.

Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice

E. Pariani, R. De Francesco, D. Inverso, 2022, bioRxiv.

Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition.

Vincent Lotteau, Claude Sardet, Pierre-Olivier Vidalain, 2019, European journal of medicinal chemistry.

Early Diffusion of SARS-CoV-2 Infection in the Inner Area of the Italian Sardinia Island

M. Monne, Nicole Grandi, E. Tramontano, 2021, Frontiers in Microbiology.

Ebola virus VP35 blocks stress granule assembly.

Valerie Le Sage, A. Mouland, E. Tramontano, 2017, Virology.

Relevance of Ebola virus VP35 homo-dimerization on the type I interferon cascade inhibition

P. Ruggerone, A. Vargiu, E. Tramontano, 2019, Antiviral chemistry & chemotherapy.

Insights into the homo-oligomerization properties of N-terminal coiled-coil domain of Ebola virus VP35 protein.

P. Ruggerone, A. Vargiu, D. Piano, 2018, Virus research.

Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action.

D. Strayer, E. Tramontano, S. Distinto, 2023, Antiviral research.

Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds

C. Del Vecchio, E. Tramontano, C. Parolin, 2018 .

Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production.

C. Salata, A. Mirazimi, O. Taglialatela‐Scafati, 2022, Antiviral research.

Inhibitors of Ebolavirus targeting innate immune evasion

E. Tramontano, A. Corona, A. Paulis, 2021, Annual Reports in Medicinal Chemistry.

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors

R. Di Santo, B. Buchholz, J. Bodem, 2016, Nucleic acids research.

The S-layer Protein DR_2577 Binds Deinoxanthin and under Desiccation Conditions Protects against UV-Radiation in Deinococcus radiodurans

C. Slavov, D. Piano, E. Tramontano, 2016, Front. Microbiol..

A Luciferase Reporter Gene Assay to Measure Ebola Virus Viral Protein 35-Associated Inhibition of Double-Stranded RNA-Stimulated, Retinoic Acid-Inducible Gene 1-Mediated Induction of Interferon β.

E. Tramontano, A. Corona, F. Esposito, 2015, The Journal of infectious diseases.

Identification and characterization of ERV-W-like sequences in Platyrrhini species provides new insights into the evolutionary history of ERV-W in primates

G. Magiorkinis, J. Blomberg, J. Mayer, 2020, Mobile DNA.

Human Endogenous Retroviruses (HERVs) and Mammalian Apparent LTRs Retrotransposons (MaLRs) Are Dynamically Modulated in Different Stages of Immunity

Nicole Grandi, E. Tramontano, Maria Paola Pisano, 2021, Biology.

Biochemical characterization of the HIV-1 integrase 3'-processing activity and its inhibition by phosphorothioate oligonucleotides.

Y. Cheng, E. Tramontano, P. L. Colla, 1998, Biochemistry.

Synthesis and Anti-Human Immunodeficiency Virus Type 1 Integrase Activity of Hydroxybenzoic and Hydroxycinnamic Acid Flavon-3-yl Esters

P. la Colla, E. Tramontano, I. Sestili, 1998, Antiviral chemistry & chemotherapy.

Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors

K. Schweimer, B. Wöhrl, E. Tramontano, 2014, Antimicrobial Agents and Chemotherapy.

Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans

S. McSweeney, M. Bowler, D. Piano, 2015, Front. Microbiol..

Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy)

D. Piano, O. Taglialatela‐Scafati, E. Tramontano, 2019, Natural product research.

Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2

G. Ippolito, M. Capobianchi, F. Carletti, 2021, Virulence.

Unlocking STING as a Therapeutic Antiviral Strategy

E. Tramontano, A. Paulis, 2023, International journal of molecular sciences.

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies.

Vasanthanathan Poongavanam, J. Kongsted, R. Di Santo, 2018, MedChemComm.

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

F. Musiani, Daniela Iaconis, V. Summa, 2021, ACS pharmacology & translational science.

Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata

A. Fiorentino, R. Russo, B. D’Abrosca, 2021, Molecules.

In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds

E. Tramontano, P. Rubiolo, A. Corona, 2021, Plants.

Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function

P. Caboni, C. Floris, E. Tramontano, 2021, Journal of enzyme inhibition and medicinal chemistry.

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.

C. Tintori, M. Botta, F. Morreale, 2015, Bioorganic & medicinal chemistry letters.

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

Lijia Xu, D. Piano, Nicole Grandi, 2015, Journal of Microbiology.

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.

E. Novellino, L. Naesens, R. Di Santo, 2019, Antiviral research.

Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture.

P. Singh, M. Carcelli, E. Tramontano, 2020, ACS medicinal chemistry letters.

Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

C. Tintori, M. Botta, Z. Debyser, 2015, Chembiochem : a European journal of chemical biology.

Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors.

C. Pannecouque, L. Naesens, M. Carcelli, 2014, European journal of medicinal chemistry.

Molecular aspects of the RT/drug interactions. Perspective of dual inhibitors.

E. Tramontano, S. Alcaro, E. Maccioni, 2013, Current pharmaceutical design.

Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor

E. Tramontano, E. Maccioni, S. Distinto, 2013, Retrovirology.

Impact of human immunodeficiency virus type 1 ribonuclease H inhibitors on the polymerase and RNase H function of foamy virus reverse transcriptase

K. Schweimer, B. Wöhrl, E. Tramontano, 2013, Retrovirology.

Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds.

E. Tramontano, R. Schobert, A. Corona, 2023, Bioorganic & medicinal chemistry.

Garcinol from Garcinia indica inhibits HIV‐1 reverse transcriptase‐associated ribonuclease H

Andrea Volkamer, E. Tramontano, R. Schobert, 2021, Archiv der Pharmazie.

HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target.

E. Tramontano, 2006, Mini reviews in medicinal chemistry.

HIV-1 integrase inhibitors that block HIV-1 replication in infected cells. Planning synthetic derivatives from natural products

M. Artico, R. Di Santo, R. Costi, 2003 .

Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach

F. Ceccherini‐Silberstein, E. Tramontano, S. Alcaro, 2023, J. Chem. Inf. Model..

Identification, comprehensive characterization, and comparative genomics of the HERV-K(HML8) integrations in the human genome

Nicole Grandi, E. Tramontano, Sante Scognamiglio, 2022, Virus research.

HERV-K(HML7) Integrations in the Human Genome: Comprehensive Characterization and Comparative Analysis in Non-Human Primates

Nicole Grandi, E. Tramontano, Maria Paola Pisano, 2021, Biology.

Nirmatrelvir treatment of SARS‐CoV‐2‐infected mice blunts antiviral adaptive immune responses

E. Pariani, S. Perlman, R. De Francesco, 2023, EMBO molecular medicine.

5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action

O. Delelis, E. Tramontano, E. Maccioni, 2023, Frontiers in Cellular and Infection Microbiology.

Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase

E. Novellino, P. Grieco, A. Bertamino, 2016, Front. Microbiol..

Mutation of Ebola virus VP35 Ser129 uncouples interferon antagonist and replication functions

E. Tramontano, L. Zinzula, S. Distinto, 2019, bioRxiv.

DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action

Daniela Iaconis, K. Riecken, E. Tramontano, 2023, Viruses.

Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination

M. Brindisi, V. Summa, P. Storici, 2023, European Journal of Medicinal Chemistry.

Identification and characterization of ERV-W-like sequences in Platyrrhini species provides new insights into the evolutionary history of ERV-W in primates

G. Magiorkinis, J. Blomberg, J. Mayer, 2020, Mobile DNA.

The emerging field of human endogenous retroviruses: understanding their physiological role and contribution to diseases

Nicole Grandi, E. Tramontano, Maria Paola Pisano, 2019, Future Virology.

INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation

M. Capobianchi, F. Carletti, Nicole Grandi, 2021, Viruses.

On the S-layer of Thermus thermophilus and the assembling of its main protein SlpA.

Joanna M. Kirkpatrick, D. Piano, E. Tramontano, 2018, Biochimica et biophysica acta. Biomembranes.

Naïve antibody library derived monoclonal antibody against VP35 of Ebola virus.

Y. Choong, T. S. Lim, Jing Yi Lai, 2023, International journal of biological macromolecules.

Impact of human immunodeficiency virus type 1 ribonuclease H inhibitors on the polymerase and RNase H function of foamy virus reverse transcriptase

K. Schweimer, B. Wöhrl, E. Tramontano, 2013, Retrovirology.

HIV-1 reverse transcriptase inhibition by a dipyridodiazepinone derivative: BI-RG-587.

E. Tramontano, Y. Cheng, 1992, Biochemical pharmacology.

Proceedings of the Frontiers of Retrovirology Conference 2016

Sebastian A. Wagner, R. König, D. Elleder, 2016, Retrovirology.

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops

E. Novellino, I. Gomez-Monterrey, S. Haider, 2018, Scientific Reports.

Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication

R. Silverman, B. Jha, Woo-Jin Shin, 2023, Viruses.

Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst

D. Chiriu, P. Ricci, E. Tramontano, 2023, Polymers.

Synthesis of new disoxaril analogues with potent and selective anti-human rhinovirus 14 activity☆

A. Mai, R. Ragno, A. Pani, 1991 .

Overview of human endogenous retroviruses found in human genome assembly GRCh37/hg19

P. Rodriguez-Tomé, J. Blomberg, G. Sperber, 2013, Retrovirology.

Comprehensive Analysis of HERV Transcriptome in HIV+ Cells: Absence of HML2 Activation and General Downregulation of Individual HERV Loci

Nicole Grandi, E. Tramontano, Maria Paola Pisano, 2020, Viruses.

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

F. Musiani, Daniela Iaconis, J. Neyts, 2020 .

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

F. Musiani, Daniela Iaconis, J. Neyts, 2021, ACS Pharmacology & Translational Science.

Envelope Recombination: A Major Driver in Shaping Retroviral Diversification and Evolution within the Host Genome

Liang-Tzung Lin, Nicole Grandi, E. Tramontano, 2023, Viruses.

Prolonged activity of HERV-K(HML2) in Old World Monkeys accounts for recent integrations and novel recombinant variants

Nicole Grandi, E. Tramontano, Saili Chabukswar, 2022, Frontiers in Microbiology.

HERV-W group evolutionary history in non-human primates: characterization of ERV-W orthologs in Catarrhini and related ERV groups in Platyrrhini

J. Blomberg, J. Mayer, Nicole Grandi, 2018, BMC Evolutionary Biology.

Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication.

Daniela Iaconis, R. Di Santo, R. Costi, 2023, Antiviral research.

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops

E. Novellino, I. Gomez-Monterrey, S. Haider, 2018, Scientific Reports.

Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro.

Lydia Siragusa, F. Spyrakis, C. Prandi, 2023, ACS infectious diseases.

Broad-range potential of Asphodelus microcarpus leaves extract for drug development

C. Santos-Buelga, G. Orrù, A. Fais, 2017, BMC Microbiology.

Insights into Ebola Virus VP35 and VP24 Interferon inhibitory functions and their initial exploitation as drug targets

E. Tramontano, A. Corona, A. Frau, 2019, Infectious disorders drug targets.

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.

F. Bailly, Z. Debyser, F. Christ, 2012, Bioorganic & medicinal chemistry letters.

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.

C. Tintori, M. Botta, F. Morreale, 2015, Bioorganic & medicinal chemistry letters.

HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France)

A. Fiorentino, B. D’Abrosca, E. Tramontano, 2023, Pharmaceuticals.

Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex

Daniela Iaconis, E. Tramontano, A. Beccari, 2024, Virus research.

Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function

C. Basquin, E. Tramontano, L. Zinzula, 2023, Virus research.