H. Ørum

发表

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

S. Kauppinen, M. Lindow, R. Lanford, 2010, Science.

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

C. Wahlestedt, Zicai Liang, M. Westergaard, 2005, Nucleic acids research.

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

M. Lindholm, H. Ørum, E. Straarup, 2010, Nucleic acids research.

SPC3042: a proapoptotic survivin inhibitor

M. Westergaard, H. Ørum, H. Hansen, 2008, Molecular Cancer Therapeutics.

On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti‐H‐Ras Antisense Oligonucleotide

F. Baas, K. Fluiter, H. Ørum, 2005, Chembiochem : a European journal of chemical biology.

Pna Array Technology in Molecular Diagnostics

H. Ørum, A. Geiger, A. Lester, 1998 .

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

H. Soifer, C. Stein, L. Benimetskaya, 2009, Nucleic acids research.

Electronic Structures of LNA Phosphorothioate Oligonucleotides

H. Bohr, C. Stein, H. Ørum, 2017, Molecular therapy. Nucleic acids.

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.

A. Levin, M. Moerland, A. Cohen, 2015, British journal of clinical pharmacology.

The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia

L. Klein-Hitpass, J. Dürig, U. Dührsen, 2011, Leukemia.

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models.

R. Kole, P. Sazani, H. Ørum, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

PNA synthesis using a novel Boc/acyl protecting group strategy

H. Ørum, H. Hansen, T. Koch, 2001, Journal of peptide science : an official publication of the European Peptide Society.

Purification of nucleic acids by hybridization to affinity tagged PNA probes.

H. Ørum, 1999, Current issues in molecular biology.

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models.

R. Kole, P. Sazani, H. Ørum, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Expression in E. coli of the gene encoding phenylalanine ammonia-lyase from Rhodosporidium toruloides

O. Rasmussen, H. Ørum, 1992, Applied Microbiology and Biotechnology.

Long Range Electron Transfer in PNA/DNA Duplexes

B. Armitage, H. Ørum, H. Hansen, 1999 .

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

M. Westergaard, H. Ørum, H. Hansen, 2003, Nucleic acids research.

Peptide Nucleic Acid

H. Ørum, T. Koch, C. Kessler, 1997 .

Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice.

R. Kole, P. Sazani, H. Ørum, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Quantum mechanical studies of DNA and LNA.

H. Bohr, M. Lindow, H. Ørum, 2014, Nucleic acid therapeutics.

Locked Nucleic Acids as MicroRNA Therapeutics

H. Ørum, 2013 .

REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

X. Wang, N. Heegaard, H. Ørum, 2012 .

Silencing expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis

P. Tak, K. Fluiter, J. Hamann, 2010 .

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

M. Lindholm, Joacim Elmén, R. Persson, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

N. Seidah, M. Lindholm, Joacim Elmén, 2010, PloS one.

A novel class of nucleolar RNAs from Tetrahymena

H. Nielsen, J. Engberg, H. Ørum, 1992, FEBS letters.

A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth

M. Westergaard, L. Greenberger, H. Ørum, 2008, Molecular Cancer Therapeutics.

Locked nucleic acid holds promise in the treatment of cancer.

H. Ørum, M. Frieden, 2008, Current pharmaceutical design.

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys.

Robert Persson, R. Persson, E. S. Hildebrandt-Eriksen, 2012, Nucleic acid therapeutics.

Structural organization of the genes encoding the small nuclear RNAs U1 to U6 of Tetrahymena thermophila is very similar to that of plant small nuclear RNA genes.

H. Nielsen, J. Engberg, H. Ørum, 1992, Journal of molecular biology.

Single base pair mutation analysis by PNA directed PCR clamping.

M. Egholm, P. Nielsen, O. Buchardt, 1993, Nucleic acids research.

A formula for thermal stability (Tm) prediction of PNA/DNA duplexes.

P. Nielsen, C. Berding, H. Ørum, 1998, Nucleic acids research.

SPC3042: a proapoptotic survivin inhibitor

M. Westergaard, H. Ørum, H. Hansen, 2008, Molecular Cancer Therapeutics.

Detection of the factor V Leiden mutation by direct allele-specific hybridization of PCR amplicons to photoimmobilized locked nucleic acids.

J. Vuust, M. Jakobsen, H. Ørum, 1999, Clinical chemistry.

Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique.

B. Nordén, P. Nielsen, H. Ørum, 1997, Biochemistry.

Sequence-specific purification of nucleic acids by PNA-controlled hybrid selection.

Christopher B. Stanley, P. Nielsen, H. Ørum, 1995, BioTechniques.

Locked nucleic acids (LNA) and medical applications

H. Ørum, A. Wolter, L. Kongsbak, 2003, Letters in Peptide Science.