P. O'Maille

发表

Triterpene biosynthesis in plants.

A. Osbourn, Ramesha B Thimmappa, Katrin Geisler, 2014, Annual review of plant biology.

The Omics Dashboard for interactive exploration of gene-expression data

Suzanne M. Paley, J. Tomb, P. Karp, 2017, Nucleic acids research.

Structure-based combinatorial protein engineering (SCOPE).

Paul E O'Maille, Ming-Daw Tsai, M. Tsai, 2002, Journal of molecular biology.

Quantifying the thermostability landscape separating plant sesquiterpene synthase orthologs using Maximum Entropy

T. Sharpee, J. Noel, Johnatan Aljadeff, 2017, bioRxiv.

Resources to Discover and Use Short Linear Motifs in Viral Proteins

P. Hraber, B. McMahon, N. Generous, 2019, Trends in Biotechnology.

Variation in Capsidiol Sensitivity between Phytophthora infestans and Phytophthora capsici Is Consistent with Their Host Range

D. Ro, S. Schornack, S. Kamoun, 2014, PloS one.

Sparse epistatic patterns in the evolution of terpene synthases.

A. Morozov, M. Defernez, P. O'Maille, 2020, Molecular biology and evolution.

Interception of the Enzymatic Conversion of Farnesyl Diphosphate to 5‐Epi‐Aristolochene by Using a Fluoro Substrate Analogue: 1‐Fluorogermacrene A from (2E,6Z)‐6‐Fluorofarnesyl Diphosphate

J. Noel, P. O'Maille, R. Coates, 2007, Chembiochem : a European journal of chemical biology.

Sparse epistatic patterns in the evolution of terpene synthases

A. Morozov, P. O'Maille, M. Vardakou, 2019, bioRxiv.

Emergence of terpene cyclization in Artemisia annua

M. Defernez, P. O'Maille, S. Green, 2015, Nature Communications.

Comparative analysis and validation of the malachite green assay for the high throughput biochemical characterization of terpene synthases

P. O'Maille, M. Vardakou, J. Faraldos, 2014, MethodsX.

Ancient origin and conserved gene function in terpene pheromone and defense evolution of stink bugs and hemipteran insects.

Michael E. Sparks, A. Morozov, T. Köllner, 2022, Insect biochemistry and molecular biology.

Functional Characterization of Premnaspirodiene Oxygenase, a Cytochrome P450 Catalyzing Regio- and Stereo-specific Hydroxylations of Diverse Sesquiterpene Substrates*

Shunji Takahashi, J. Noel, J. Chappell, 2007, Journal of Biological Chemistry.

Physical constraints on sesquiterpene diversity arising from cyclization of the eudesm-5-yl carbocation.

B. A. Hess, J. Noel, P. O'Maille, 2011, Journal of the American Chemical Society.

Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate.

J. Noel, N. Dellas, P. O'Maille, 2010, Journal of the American Chemical Society.

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

J. Noel, G. Manning, J. Chappell, 2008, Nature chemical biology.

Lettuce Costunolide Synthase (CYP71BL2) and Its Homolog (CYP71BL1) from Sunflower Catalyze Distinct Regio- and Stereoselective Hydroxylations in Sesquiterpene Lactone Metabolism*

D. Ro, Nobuhiro Ikezawa, P. O'Maille, 2011, The Journal of Biological Chemistry.

A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases

A. Osbourn, A. Hemmings, R. Minto, 2016, Proceedings of the National Academy of Sciences.

Two pockets in the active site of maize sesquiterpene synthase TPS4 carry out sequential parts of the reaction scheme resulting in multiple products.

J. Gershenzon, T. Köllner, W. Boland, 2006, Archives of biochemistry and biophysics.

Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates

J. Noel, N. Dellas, P. O'Maille, 2010, ACS chemical biology.

Evolving biosynthetic tangos negotiate mechanistic landscapes.

M. Austin, J. Noel, P. O'Maille, 2008, Nature chemical biology.

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.

H. J. Kim, M. Tsai, T. Selby, 1998, Molecular cell.

REVIEW: Epistasis and dominance in the emergence of catalytic function as exemplified by the evolution of plant terpene synthases.

P. O'Maille, Jitender Cheema, Juan A. Faraldos, 2017, Plant science : an international journal of experimental plant biology.

Microbiology: Fungus against the wall

P. O'Maille, 2015, Nature.

Discovery of germacrene A synthases in Barnadesia spinosa: The first committed step in sesquiterpene lactone biosynthesis in the basal member of the Asteraceae.

D. Ro, Trinh-Don Nguyen, P. O'Maille, 2016, Biochemical and biophysical research communications.

Kinetic and Molecular Analysis of 5-Epiaristolochene 1,3-Dihydroxylase, a Cytochrome P450 Enzyme Catalyzing Successive Hydroxylations of Sesquiterpenes*

Shunji Takahashi, J. Noel, J. Chappell, 2005, Journal of Biological Chemistry.

Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases.

J. Noel, J. Chappell, P. O'Maille, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals.

A. Morozov, D. Tholl, P. O'Maille, 2023, Natural product reports.

Metabolomics relative quantitation with mass spectrometry using chemical derivatization and isotope labeling

Junefredo V. Apon, G. Siuzdak, E. Go, 2008 .

Emergence of terpene chemical communication in insects: Evolutionary recruitment of isoprenoid metabolism

A. Morozov, Hailey Larose, D. Tholl, 2023, Protein science : a publication of the Protein Society.

Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants

M. Bowman, J. Noel, G. Louie, 2016, The Journal of Antibiotics.

A single-vial analytical and quantitative gas chromatography-mass spectrometry assay for terpene synthases.

J. Noel, J. Chappell, P. O'Maille, 2004, Analytical biochemistry.

Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase.

J. Noel, J. Chappell, P. O'Maille, 2006, Archives of biochemistry and biophysics.

Steady-state kinetic characterization of sesquiterpene synthases by gas chromatography-mass spectroscopy.

R. Morris, P. O'Maille, Steven R Garrett, 2012, Methods in enzymology.

Synthetic biology. 4th New Phytologist Workshop, Bristol, UK, June 2012.

A. Osbourn, K. Lindsey, S. Rosser, 2012, The New phytologist.

Gene library synthesis by structure-based combinatorial protein engineering.

J. Noel, M. Tsai, J. Chappell, 2004, Methods in enzymology.

Pathway collages: personalized multi-pathway diagrams

Daniel S. Weaver, P. Karp, S. Paley, 2016, BMC Bioinformatics.

Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A.

M. Tsai, T. Selby, M. Poi, 1999, Biochemistry.